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    Method and arrangement for changing the spectral composition and/or intensity of illumination light and/or specimen light in an adjustable manner
    112.
    发明授权
    Method and arrangement for changing the spectral composition and/or intensity of illumination light and/or specimen light in an adjustable manner 有权
    以可调节的方式改变照明光和/或标本光的光谱组成和/或强度的方法和装置

    公开(公告)号：US07701632B2

    公开(公告)日：2010-04-20

    申请号：US11833761

    申请日：2007-08-03

    Applicant: Ralf Wolleschensky

    Inventor： Ralf Wolleschensky

    IPC: G02B21/06

    CPC classification number: G01N15/1434 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/4406 ,  G01J3/447 ,  G01J2003/1282 ,  G01J2003/1286 ,  G01N21/6445 ,  G01N21/6458 ,  G01N2015/0065 ,  G01N2015/149 ,  G01N2015/1493 ,  G02B21/002

    Abstract: Method and arrangement for changing the spectral composition and/or intensity of illumination light and/or specimen light in an adjustable manner, wherein a spatial separation into radiation components of different polarization is carried out with a first polarizing device, a spectral, spatial splitting of at least one radiation component is carried out with first dispersion device, the polarization state of at least one part of the spectrally spatially split radiation component is changed, and a spatial separation and/or combination of radiation components of different polarization are/is carried out by a second polarizing device, wherein a spatial combination of radiation components which are changed and not changed with respect to their polarization state is advantageously carried out by a second dispersion device.

    Abstract translation: 用于以可调节的方式改变照明光和/或标本光的光谱组成和/或强度的方法和装置，其中利用第一偏振装置，光谱，空间分裂进行不同偏振的辐射分量的空间分离 使用第一分散装置执行至少一个辐射分量，改变光谱空间分裂的辐射分量的至少一部分的偏振状态，并且执行不同极化的辐射分量的空间分离和/或组合 通过第二偏振装置，其中通过第二分散装置有利地进行相对于它们的偏振状态改变而不改变的辐射分量的空间组合。

    ENDOSCOPE SYSTEM
    115.
    发明申请
    ENDOSCOPE SYSTEM 有权
    内窥镜系统

    公开(公告)号：US20100094136A1

    公开(公告)日：2010-04-15

    申请号：US12521224

    申请日：2007-11-26

    Applicant: Masaya Nakaoka ,  Koki Morishita

    Inventor： Masaya Nakaoka ,  Koki Morishita

    IPC: A61B1/06 ,  A61B6/00

    CPC classification number: A61B1/05 ,  A61B1/043 ,  A61B1/0638 ,  A61B5/0071 ,  A61B5/0084 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/6456 ,  G01N2021/6441 ,  G06F19/00

    Abstract: A fluorescence distribution image of each fluorescent agent can be acquired from a fluorescence image that has been captured in a mixed state so as to improve the diagnosability of cancer cells. An endoscope system comprises: a light source section for selectively irradiating two or more types of excitation lights having different spectral characteristics so as to excite two or more types of fluorescent agents having different optical characteristics; an imaging section provided on a part to be inserted into a body cavity, and having a light-receiving sensitivity in the wavelength bands of the two or more types of fluorescence radiated from the observation target by respective types of excitation lights; a storage section for storing relation information between the fluorescence intensity and the concentration of each of the fluorescent agents; a concentration information computing section for computing concentration information of each of the fluorescent agents on the basis of the fluorescence intensities of two or more images captured by the imaging section and the relation information stored in the storage section, and outputting the concentration information; and a mode switching section capable of switching between a first fluorescence observation mode in which at least one of the fluorescence intensity images acquired by the imaging section is presented, and a second fluorescence observation mode in which the concentration information of each of the fluorescent agents computed by the concentration information computing section is presented.

    Abstract translation: 可以从已经以混合状态捕获的荧光图像获得每种荧光剂的荧光分布图像，以提高癌细胞的诊断性。 内窥镜系统包括：光源部，用于选择性地照射具有不同光谱特性的两种以上的激发光，以激发具有不同光学特性的两种或更多种荧光剂; 设置在一个部分的摄像部被插入到体腔内，并具有在两个或更多个类型的荧光从由各自类型的激发光的观察目标辐射的波长带中的光接收灵敏度; 用于存储荧光强度和每种荧光剂浓度之间的关系信息的存储部分; 浓度信息计算部分，用于基于由成像部分捕获的两个或更多个图像的荧光强度和存储在存储部分中的关系信息来计算每个荧光剂的浓度信息，并输出浓度信息; 以及模式切换部，其能够在呈现由成像部获取的至少一个荧光强度图像的第一荧光观察模式与计算出的每个荧光剂的浓度信息的第二荧光观察模式之间切换 由集中信息计算部分呈现。

    Extended dynamic range system design using a photomultiplier tube and solid state detector
    118.
    发明授权
    Extended dynamic range system design using a photomultiplier tube and solid state detector 有权
    使用光电倍增管和固态检测器扩展动态范围系统设计

    公开(公告)号：US07683299B2

    公开(公告)日：2010-03-23

    申请号：US11774938

    申请日：2007-07-09

    Applicant: Paul Patt ,  Joel Talacki

    Inventor： Paul Patt ,  Joel Talacki

    IPC: G01L1/20

    CPC classification number: G01J1/4228 ,  G01J3/4406 ,  G01N21/645

    Abstract: Systems and method for detecting and measuring light emitted from a sample and having a large dynamic range, e.g., a range of luminous intensity covering six or more orders of magnitude, that may be difficult to fully detect using a single detector with a limited detection range. Simultaneous measurement of the emitted light in two intensity ranges is performed using two detectors, e.g., one including a photomultiplier tube (PMT) and the other including a solid state detector such as a photodiode. A beam splitting element directs light emitted from a sample under investigation to both detectors simultaneously such that a portion of the light impinges on the first detector and a second portion of the light impinges on the second detector. A processor receives output signals from the two detectors and provides an output representing the luminous intensity of the sample over a detection range greater than the detection range of each individual detector, thereby providing a detection system having an enhanced dynamic range.

    Abstract translation: 用于检测和测量从样品发射的光并具有大动态范围的系统和方法，例如覆盖六个或更多个数量级的发光强度的范围，这可能难以使用具有有限检测范围的单个检测器进行完全检测 。 使用两个检测器（例如包括光电倍增管（PMT）的两个检测器，另一个包括诸如光电二极管的固态检测器）进行同时测量两个强度范围内的发射光。 分束元件将从被调查样品发射的光引导到两个检测器同时进行，使得一部分光照射在第一检测器上，并且第二部分光照射在第二检测器上。 处理器从两个检测器接收输出信号，并提供一个表示在大于每个检测器的检测范围的检测范围内的样品的发光强度的输出，从而提供具有增强的动态范围的检测系统。

    Time-resolved fluorescence spectrometer for multiple-species analysis
    119.
    发明授权
    Time-resolved fluorescence spectrometer for multiple-species analysis 有权
    用于多物种分析的时间分辨荧光光谱仪

    公开(公告)号：US07679745B2

    公开(公告)日：2010-03-16

    申请号：US11603939

    申请日：2006-11-21

    Applicant: Ricardo Claps ,  Bradley A. Smith

    Inventor： Ricardo Claps ,  Bradley A. Smith

    IPC: G01J3/30

    CPC classification number: G01N21/6408 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/2889 ,  G01J3/4406

    Abstract: A time-resolved, fluorescence spectrometer makes use of a RadiaLight® optical switch and no dispersive optical elements (DOE) like gratings. The structure is unique in its compactness and simplicity of operation. In one embodiment, the spectrometer makes use of only one photo-detector and an efficient linear regression algorithm. The structure offers a time resolution, for multiple species measurements, of less than 1 s. The structure can also be used to perform fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy.

    Abstract translation: 时间分辨的荧光光谱仪利用RadiaLight®光开关，不使用像光栅这样的色散光学元件（DOE）。 该结构在其紧凑性和操作简单性方面是独一无二的。 在一个实施例中，光谱仪仅使用一个光电检测器和有效的线性回归算法。 该结构提供时间分辨率，用于多种物种测量，小于1秒。 该结构也可用于进行荧光相关光谱和荧光互相关光谱。

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