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    Method of Producing Polymeric Phenazonium Compounds
    91.
    发明申请
    Method of Producing Polymeric Phenazonium Compounds 有权
    聚合苯胺化合物的制备方法

    公开(公告)号：US20140163198A1

    公开(公告)日：2014-06-12

    申请号：US14181866

    申请日：2014-02-17

    申请人： MacDermid Acumen, Inc.

    发明人： Andrew M. Krol ,  Ernest Long ,  Lev Taytsas

    IPC分类号： C08G73/06 ,  C07D241/46

    CPC分类号： C08G73/0633 ,  C07D241/46 ,  C08G73/0694 ,  C25D3/38

    摘要： A process of making a polymeric phenazonium compound having the general formula: wherein R1, R2, R4, R5, R6, R8 and R9 are the same or different, and represent hydrogen, a low alkyl or a substituted aryl, R3 starts with NH2 and is diazotized followed by polymerization, R5 and R8 may alternatively represent monomeric or polymeric phenazonium radicals, R7 is a substituted amine, RX and RY represent any combination of CH3, C2H5, and hydrogen, except that RX and RY cannot both be hydrogen, A is an acid radical, and n is an integer from 2 to 100, preferably from 2 to 20 is described. The polymeric phenazonium compound is usable in as an additive in a metal plating bath. The method includes the steps of: a) dissolving an effective amount of an amino compound in a formic acid solution; b) adding a nitrite salt to diazotize the amino compound; and c) adding sulfamic acid to neutralize any excess nitrous acid that may be formed in step b), whereby a polymeric phenazonium compound is produced.

    摘要翻译： 制备具有以下通式的聚合物苯扎嗪化合物的方法：其中R 1，R 2，R 4，R 5，R 6，R 8和R 9相同或不同，并且表示氢，低级烷基或取代的芳基，R 3从NH 2开始， 重氮化后进行聚合，R 5和R 8可以可选地代表单体或聚合苯扎嗪基团，R7是取代的胺，RX和RY代表CH 3，C 2 H 5和氢的任何组合，只是RX和RY不能都是氢，A是 酸基，n为2〜100的整数，优选为2〜20。 聚合物苯扎嗪化合物可用作金属电镀浴中的添加剂。 该方法包括以下步骤：a）将有效量的氨基化合物溶于甲酸溶液中; b）加入亚硝酸盐以重氮化氨基化合物; 和c）加入氨基磺酸以中和步骤b）中可能形成的任何过量的亚硝酸，由此产生聚合的苯扎嗪化合物。

    1,2,3,4-TETRAHYDROQUINOXALINE COMPOUNDS HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY
    93.
    发明申请
    1,2,3,4-TETRAHYDROQUINOXALINE COMPOUNDS HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY 有权
    具有GLUCOCORTICOID受体结合活性的1,2,3,4-四氢喹啉化合物

    公开(公告)号：US20130303537A1

    公开(公告)日：2013-11-14

    申请号：US13937447

    申请日：2013-07-09

    申请人： SANTEN PHARMACEUTICAL CO., LTD.

    发明人： Mamoru MATSUDA ,  Toshiyuki MORI ,  Kenji KAWASHIMA ,  Minoru YAMAMOTO ,  Masatomo KATO ,  Miwa TAKAI ,  Masato NAGATSUKA ,  Sachiko KOBAYASHI

    IPC分类号： C07D241/46 ,  C07D409/14 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12

    CPC分类号： C07D241/46 ,  C07D241/44 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

    摘要： A 1,2,3,4-tetrahydroquinoxaline compound represented by the following formula: In the formula (1), R1 represents substituents such as a halogen, an alkyl, a cycloalkyl, an aryl or a heterocyclic group; p represents 0 to 5; R2 represents substituents such as a halogen, an alkyl, a hydroxyl or an alkoxy group; q represents 0 to 2; R3 represents substituents such as hydrogen, an alkyl, an alkenyl, an alkylcarbonyl or an arylcarbonyl group; R4 and R5 independently represent substituents such as hydrogen, a halogen, an alkyl, an alkenyl, an alkynyl, a cycloalkyl, an aryl or a heterocyclic group; R6 represents substituents such as hydrogen, an alkyl, an alkenyl, an alkynyl, a cycloalkyl, an aryl or a heterocyclic group; A represents an alkylene; R7 represents OR8, NR8R9, SR8, S(O)R8, S(O)2R8; R8 and R9 independently represent substituents such as hydrogen, an alkyl or an alkenyl; and X represents O or S.

    摘要翻译： 由下式表示的1,2,3,4-四氢喹喔啉化合物：式（1）中，R 1表示卤素，烷基，环烷基，芳基或杂环基等取代基。 p表示0〜5; R 2表示取代基，例如卤素，烷基，羟基或烷氧基; q表示0〜2; R3表示取代基，例如氢，烷基，烯基，烷基羰基或芳基羰基; R4和R5独立地表示取代基，例如氢，卤素，烷基，烯基，炔基，环烷基，芳基或杂环基; R6表示取代基，例如氢，烷基，烯基，炔基，环烷基，芳基或杂环基; A表示亚烷基; R 7表示OR 8，NR 8 R 9，SR 8，S（O）R 8，S（O） R8和R9独立地表示取代基，例如氢，烷基或烯基; X表示O或S.

    Phenazine compounds and use thereof in autoimmune and inflammatory diseases
    96.
    发明授权
    Phenazine compounds and use thereof in autoimmune and inflammatory diseases 失效
    吩嗪化合物及其在自身免疫性和炎性疾病中的应用

    公开(公告)号：US08273881B2

    公开(公告)日：2012-09-25

    申请号：US12523304

    申请日：2008-01-16

    申请人： Josefino B. Tunac

    发明人： Josefino B. Tunac

    IPC分类号： C07D241/46

    CPC分类号： C07D241/52

    摘要： The invention discloses compounds, compositions and methods useful for preventing and/or treating autoimmune diseases and inflammatory diseases. The methods and compositions utilize water-soluble phenazine compounds, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent autoimmune diseases and inflammatory diseases such as those caused by arthritis and rheumatoid arthritis.

    摘要翻译： 本发明公开了可用于预防和/或治疗自身免疫性疾病和炎性疾病的化合物，组合物和方法。 该方法和组合物使用水溶性吩嗪化合物或其盐或溶剂合物。 这些分子可以单独递送或与治疗或预防自身免疫性疾病和炎症性疾病如由关节炎和类风湿性关节炎引起的疾病的药物组合递送。