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公开(公告)号：US11344130B2
公开(公告)日：2022-05-31
申请号：US17215858
申请日：2021-03-29
申请人： Andrew Miller
发明人： Andrew Miller
摘要： The invention is directed to a portable head support designed to fit in the interior of a carry-on article carried by a passenger. The device provides head support for those who prefer sleeping in a face-down position and comprises a base and a head support connected along at least one of their abutting edges by a mechanism which permits the angle between the base and head support to be adjusted by the user.
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公开(公告)号：US20210220043A1
公开(公告)日：2021-07-22
申请号：US17152665
申请日：2021-01-19
申请人： Pajhand IRANITALAB , Casey Andrew MILLER , Thomas Ryan McGRATH , Manuel Arzadon JAVIER, JR. , Anisha BAPNA , Zoar Jacob ENGELMAN , Howard LEVIN , Nicholas C. VanDILLEN , Anne Marie AHONEN
发明人： Pajhand IRANITALAB , Casey Andrew MILLER , Thomas Ryan McGRATH , Manuel Arzadon JAVIER, JR. , Anisha BAPNA , Zoar Jacob ENGELMAN , Howard LEVIN , Nicholas C. VanDILLEN , Anne Marie AHONEN
IPC分类号： A61B18/14
摘要： Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.
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公开(公告)号：US20210212472A1
公开(公告)日：2021-07-15
申请号：US17215858
申请日：2021-03-29
申请人： Andrew Miller
发明人： Andrew Miller
摘要： The invention is directed to a portable head support designed to fit in the interior of a carry-on article carried by a passenger. The device provides head support for those who prefer sleeping in a face-down position and comprises a base and a head support connected along at least one of their abutting edges by a mechanism which permits the angle between the base and head support to be adjusted by the user.
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4.发明申请System and Method for Optimizing Business Performance With Automated Social Discovery 有权用自动社会发现优化业务绩效的系统和方法公开(公告)号：US20150206074A1
公开(公告)日：2015-07-23
申请号：US14030815
申请日：2013-09-18
申请人： Edwin Andrew Miller
发明人： Edwin Andrew Miller
CPC分类号： G06F17/30294 , G06F17/30392 , G06F17/30554 , G06F17/30864 , G06Q10/063 , G06Q10/067 , G06Q40/00
摘要： A system, process and method for automatically collecting, collating and transforming data into useful formats and displaying or otherwise outputting the transformed data into useable information. The system provides outputs that are useful in optimizing the enterprise performance of a business. The system, process and method are grounded in an established logical framework for systematically classifying areas of business concerns.
摘要翻译： 一种用于将数据自动收集，整理和转换为有用格式并显示或以其他方式将转换的数据输出为可用信息的系统，过程和方法。 该系统提供有助于优化业务的企业绩效的输出。 系统，流程和方法基于一个既定的逻辑框架，用于对业务关注领域进行系统分类。
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公开(公告)号：USD710983S1
公开(公告)日：2014-08-12
申请号：US29451550
申请日：2013-04-04
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公开(公告)号：US08779127B2
公开(公告)日：2014-07-15
申请号：US13585861
申请日：2012-08-15
IPC分类号： C07D403/14 , C07D403/12 , C07D417/14
CPC分类号： C07D403/14 , C07D239/34 , C07D401/14 , C07D403/12 , C07D453/02
摘要： The present invention provides a facile process for the preparation of tri- and tetra—substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora—mediated diseases or conditions.
摘要翻译： 本发明提供了制备三取代和四取代嘧啶的简便方法。 该方法可用于制备蛋白激酶抑制剂，特别是Aurora激酶。 这些抑制剂可用于治疗或减轻Aurora介导的疾病或病症的严重性。
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7.发明授权公开(公告)号：US08732025B2
公开(公告)日：2014-05-20
申请号：US11777894
申请日：2007-07-13
申请人： Salih Burak Gokturk , Dan Chiao , Jacquie Phillips , Mark Moran , Vincent Vanhoucke , Azhar Khan , Xiaofan Lin , Munjal Shah , Andrew Miller , Navneet Dalal , Diem Vu
发明人： Salih Burak Gokturk , Dan Chiao , Jacquie Phillips , Mark Moran , Vincent Vanhoucke , Azhar Khan , Xiaofan Lin , Munjal Shah , Andrew Miller , Navneet Dalal , Diem Vu
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0623 , G06F17/30256 , G06K9/62 , G06N99/005 , G06Q30/0625 , G06Q30/0643 , G06Q30/08
摘要： Images are analyzed by programmatic mechanisms for assessing one or more remote web pages to retrieve content on display at remote web pages. The retrieved images may be analyzed to determine information about an object shown in a corresponding images of the content on display. At least a portion of the object shown in the corresponding image of the content on display may be made selectable and associated with the determined information. This determined information may subsequently be used, in for example, search applications.
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公开(公告)号：US08669081B2
公开(公告)日：2014-03-11
申请号：US11786150
申请日：2007-04-11
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M.C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M.C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US08653049B2
公开(公告)日：2014-02-18
申请号：US12922663
申请日：2009-03-17
CPC分类号： C07K9/005 , A61K9/127 , A61K39/39 , A61K2039/5555 , A61K2039/55583
摘要： The invention provides a compound (which can act as an adjuvant) of Formula I or Formula (II), wherein R1 R4 R5 R6 and R7 are each independently selected from hydrogen, acetyl, hydrocarbyl, a lipid moiety and a lipid acyl moiety; R2 is a hydroxyl, a hydrocarbyl, a lipid moiety, a lipid acyl moiety; or an amino hydrocarbyl group optionally substituted with a hydrocarbyl, a lipid moiety or a lipid acyl moiety; R3 and R8 are each independently selected from acetyl, a hydrocarbyl, a lipid moiety and a lipid acyl moiety; X is a peptide chain; The above normuramylglycopeptide compounds can be located in liposomes and micelles and can function as immunomodulators, along with a desired antigen (or DNA encloding the antigen), in (e.g. DNA) vaccines.
摘要翻译： 本发明提供式I或式（II）的化合物（其可以充当佐剂），其中R 1 R 4 R 5 R 6和R 7各自独立地选自氢，乙酰基，烃基，脂质部分和脂质酰基部分; R2是羟基，烃基，脂质部分，脂质酰基部分; 或任选被烃基，脂质部分或脂质酰基部分取代的氨基烃基; R3和R8各自独立地选自乙酰基，烃基，脂质部分和脂质酰基部分; X是肽链; 上述正乳酰甘油化合物可以位于脂质体和胶束中，并且可以作为免疫调节剂，以及在（例如DNA）疫苗中的期望抗原（或包被抗原的DNA）起作用。
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公开(公告)号：US08569337B2
公开(公告)日：2013-10-29
申请号：US12670989
申请日：2010-01-27
申请人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Christopher John Davis , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
发明人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Christopher John Davis , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , A61K31/496 , A61K31/506 , C07D239/24 , C07D241/10 , C07D519/00
摘要： The present invention relates to compounds of tri-cyclic pyrazolopyridine useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions containing such compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的三环吡唑并吡啶化合物。 本发明还提供含有这些化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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