公开(公告)号：US20230296598A1

公开(公告)日：2023-09-21

申请号：US17868370

申请日：2022-07-19

申请人： Zhejiang Orient Gene Biotech Co., Ltd

发明人： Siyu LEI ,  Jianqiu FANG

IPC分类号： G01N33/543 ,  B01L3/00 ,  G01N1/10 ,  G01N33/569 ,  B01L9/00

CPC分类号： G01N33/54388 ,  B01L3/5023 ,  B01L3/5029 ,  B01L9/00 ,  G01N1/10 ,  G01N33/56983 ,  B01L2400/0406 ,  G01N2001/1056 ,  G01N2333/165

摘要： The present invention provides a device for detecting an analyte in a sample, including a chamber for receiving a testing element, where the testing element has a first position and a second position in the chamber; the testing element is not in contact with a fluid sample when the testing element is located in the first position, and the testing element is in contact with a fluid sample when the testing element is located in the second position.

公开(公告)号：US20230296551A1

公开(公告)日：2023-09-21

申请号：US18017058

申请日：2021-08-04

申请人： Technische Universität Wien

发明人： Peter ERTL ,  Syed Faheem ALI ,  Silvia SCHOBESBERGER ,  Selina SCHWEINBERGER

IPC分类号： G01N27/327 ,  B01L3/00 ,  G01N33/543 ,  G01N33/569 ,  H01M8/16 ,  H01M8/2455

CPC分类号： G01N27/3276 ,  B01L3/502761 ,  G01N33/5438 ,  G01N33/56983 ,  G01N27/3278 ,  H01M8/16 ,  H01M8/2455 ,  B01L2300/0645 ,  B01L2300/0883 ,  B01L2200/16 ,  B01L2200/0652 ,  G01N2469/10

摘要： Microfluidic device (1) comprising at least one fluid channel (2) comprising at least one inlet (3), wherein said at least one fluid channel (2) is fluidly connected to a first sensor (4) downstream of said at least one fluid inlet (3), wherein the first sensor (4) comprises at least one sensor cathode (5) and at least one sensor anode (6) formed on an essentially electrically isolating substrate (7), wherein the sensor cathode (5) and the sensor anode (6) are spaced apart by a gap (8) formed on the electrically isolating substrate (7), and wherein at least one analyte capturing molecule (9) is immobilized in the gap (8) on the substrate (7), wherein the at least one capturing molecule (9) is adapted to capture at least one analyte (10) of a fluid sample introduced into the inlet (3) and transported to the first sensor (4).

公开(公告)号：US20230288417A1

公开(公告)日：2023-09-14

申请号：US17801511

申请日：2021-02-22

申请人： Idea Bio-Medical Ltd.

发明人： Yael PARAN ,  Shlomo TURGEMAN ,  Daniel Feigelson

IPC分类号： G01N33/569

CPC分类号： G01N33/56983 ,  G01N2333/165 ,  G01N2470/04

摘要： There is provided a method for detecting the presence of cells infected with a coronavirus. A sample obtained from a patient is transferred to a sample vessel and labeled molecules that binding different viral structural proteins are incubated with the sample. An apparatus useful for practicing the method is also discussed. Other embodiments are also disclosed.

公开(公告)号：US20230279512A1

公开(公告)日：2023-09-07

申请号：US18061333

申请日：2022-12-02

申请人： Volta Labs, Inc.

发明人： Liam MASTERS ,  Udayan UMAPATHI ,  Spurti AKKI ,  Magali SOUMILLON ,  William LANGFORD ,  Leonid KRASNOBAEV

IPC分类号： C12Q1/70 ,  B01L3/00 ,  C12Q1/6844 ,  G01N33/569

CPC分类号： C12Q1/701 ,  B01L3/502761 ,  C12Q1/6844 ,  G01N33/56983 ,  B01L2300/0645 ,  B01L2300/0636 ,  B01L2200/0652 ,  B01L2400/0427 ,  G01N2469/20

摘要： Described herein are systems and methods for processing at least one biological sample. The systems and methods may process the biological sample, or plurality thereof, using at least one droplet. The droplet, or plurality thereof, may be manipulated using the systems and methods described herein.

公开(公告)号：US20230279079A1

公开(公告)日：2023-09-07

申请号：US18054594

申请日：2022-11-11

申请人： Chang Gung Memorial Hospital, Linkou ,  Medigen Vaccine Biologics Corporation

发明人： Kuan-Ying HUANG

IPC分类号： C07K16/10 ,  A61P31/14 ,  G01N33/543 ,  G01N33/569

CPC分类号： C07K16/10 ,  A61P31/14 ,  G01N33/54386 ,  G01N33/56983 ,  A61K2039/505

摘要： The present invention provides novel monoclonal antibodies or the antigen-binding fragments thereof, which bind to a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or angiotensin-converting enzyme 2 (ACE2). Also provided are a pharmaceutical composition and a kit for detecting the presence of SARS-CoV-2 in a sample comprising the novel monoclonal antibody or the antigen-binding fragments thereof. Also disclosed herein are methods for detection or prevention and/or treatment of SARS-CoV-2 or a disease mediated by a disease mediated by ACE2.

公开(公告)号：US11740240B2

公开(公告)日：2023-08-29

申请号：US17379193

申请日：2021-07-19

申请人： BIO-RAD LABORATORIES, INC.

发明人： Qian Gao ,  Ravi Kaul ,  Shuxia Zhou ,  Roger P. Walker

IPC分类号： G01N33/569 ,  G01N21/64

CPC分类号： G01N33/56983 ,  G01N21/6428 ,  G01N2021/6439 ,  G01N2333/165

摘要： The present invention relates to the development of novel immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples. Novel multiplex and singleplex immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples are also provided.

公开(公告)号：US11740172B2

公开(公告)日：2023-08-29

申请号：US17580557

申请日：2022-01-20

申请人： AEROVIRUS TECHNOLOGIES INC.

发明人： Norman Marchand ,  Carmine Graziano

IPC分类号： G01N15/06 ,  G01N15/02 ,  B01D11/04 ,  G01N27/00 ,  B01L9/00 ,  B01L3/00 ,  B01L5/00 ,  G01N33/569 ,  C12Q1/70 ,  G01N15/00 ,  G01N27/447 ,  G01N15/04 ,  C12Q1/6804

CPC分类号： G01N15/0656 ,  B01D11/0496 ,  B01L3/50273 ,  B01L3/502715 ,  B01L5/00 ,  B01L9/527 ,  G01N15/0255 ,  G01N15/0266 ,  G01N15/042 ,  G01N15/0606 ,  G01N27/00 ,  G01N33/56983 ,  B01L2300/0636 ,  C12Q1/6804 ,  C12Q1/70 ,  G01N27/44791 ,  G01N2015/0065 ,  G01N2015/0288 ,  C12Q1/6804 ,  C12Q2525/205 ,  C12Q2563/116 ,  C12Q2565/629 ,  C12Q1/70 ,  C12Q2525/205 ,  C12Q2563/116 ,  C12Q2565/629

摘要： Disclosed herein are devices and methods for the real-time detection of aeropathogens. The device includes an aerosampler having an air inlet and at least one collector tube, a microfluidic system which includes a container, piping, a micro-pump for flowing a liquid, and a viral detection chamber. The viral detection chamber has an electrode which may be equipped with functionalized biosensors, a counter electrode, an electronic detection system connectable to the electrodes of the viral detection chamber, and an embedded electronic processing system for processing data from the electronic detection system.

公开(公告)号：US11739388B2

公开(公告)日：2023-08-29

申请号：US16346178

申请日：2017-11-03

申请人： UNIVERSITY OF LEICESTER ,  PHELIX RESEARCH AND DEVELOPMENT LIMITED

发明人： Martha Rebecca Jane Clokie ,  Jinyu Shan ,  Louis Charles Teulieres

IPC分类号： C12Q1/689 ,  C12Q1/6811 ,  C12Q1/6888 ,  G01N33/569

CPC分类号： C12Q1/689 ,  C12Q1/6811 ,  C12Q1/6888 ,  G01N33/56911 ,  G01N33/56983 ,  C12Q2600/112 ,  G01N2333/005 ,  G01N2333/20 ,  G01N2800/26 ,  Y02A50/30

摘要： This invention relates to methods of detecting Borrelia burgdorferi sensu lato or for detecting Borrelia associated with Relapsing Fever (RF), kits for carrying out such methods, and methods of treating Borrelia burgdorferi sensu lato or RF infections in a subject. Uses of phage specific for Borrelia are also provided.

公开(公告)号：US20230251256A1

公开(公告)日：2023-08-10

申请号：US18296328

申请日：2023-04-05

申请人： SAPPHIRE BIOTECH, INC.

发明人： Alim SEIT-NEBI ,  Sergei SVAROVSKY

IPC分类号： G01N33/543 ,  G01N33/569 ,  G01N21/78

CPC分类号： G01N33/54386 ,  G01N33/56983 ,  G01N21/78 ,  G01N2333/165 ,  G01N2469/20

摘要： Molecules, test kits, test kit components and methods for detecting and measuring different first and second antibodies in a test sample using a single test are provided herein. A method includes the steps of obtaining the test specimen from a subject, transferring the test specimen to a sample receiving portion of an assay of a test kit, and reading the results from the assay. The test kit includes a first molecule comprising a first portion of a protein, wherein the first antibody has a first affinity to bind to the first portion, and a second molecule comprising a second portion of the protein different from the first portion, wherein the second antibody has a second affinity to bind to the second portion.

公开(公告)号：US20230250156A1

公开(公告)日：2023-08-10

申请号：US17909621

申请日：2021-03-15

申请人： Quadrucept Bio Limited

发明人： Hanif ALI ,  Jasper CLUBE

IPC分类号： C07K16/10 ,  G01N33/569 ,  A61K9/00 ,  A61K39/42 ,  A61K45/06 ,  A61P31/14 ,  C07K14/725 ,  A61K38/17 ,  C07K14/55 ,  A61K38/20 ,  C07K16/28 ,  A61K39/395 ,  C07K16/24

CPC分类号： C07K16/10 ,  A61K9/0078 ,  A61K38/1774 ,  A61K38/2013 ,  A61K39/42 ,  A61K39/3955 ,  A61K45/06 ,  A61P31/14 ,  C07K14/55 ,  C07K14/7051 ,  C07K16/244 ,  C07K16/2827 ,  C07K16/2875 ,  C07K16/2878 ,  C07K16/2887 ,  G01N33/56983 ,  A61K2039/505 ,  C07K2317/569

摘要： The invention relates to multimers such as multimers comprising 4 copies of a binding site or peptide; tetramers of polypeptides; and tetramers, octamers, dodecamers and hexadecamers of epitopes or effector domains, such as antigen binding sites (eg, antibody or TCR binding sites that specifically bind to antigen or pMHC, or variable domains thereof) or peptides such as incretin, insulin or hormone peptides. The invention also relates to methods and uses to expand antigen specificity of binding sites, as well as vaccines, methods of vaccination and assay methods and reagents.