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公开(公告)号：US20170370931A1
公开(公告)日：2017-12-28
申请号：US15701272
申请日：2017-09-11
发明人： Ravi Kaul , Weiming Zheng , Roger Walker
IPC分类号： G01N33/571 , G01N33/543 , G01N33/92
CPC分类号： G01N33/571 , G01N33/543 , G01N33/54313 , G01N33/92 , G01N2333/20 , G01N2405/04 , G01N2469/20
摘要： Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.
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公开(公告)号：US20190265240A1
公开(公告)日：2019-08-29
申请号：US16405588
申请日：2019-05-07
发明人： Ravi Kaul , Weiming Zheng , Roger Walker
IPC分类号： G01N33/571 , G01N33/92 , G01N33/543
摘要： Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.
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公开(公告)号：US20180172687A1
公开(公告)日：2018-06-21
申请号：US15897040
申请日：2018-02-14
发明人： Ravi Kaul , Weiming Zheng , Roger Walker
IPC分类号： G01N33/576 , G01N33/543
CPC分类号： G01N33/5761 , G01N33/54326
摘要： Provided herein are multiplex assays for determining whether an individual is or has been infected with Hepatitis B virus, and the stage of infection or resolution. In addition, the multiplex system can discriminate between vaccinated subjects and subjects susceptible to Hepatitis B infection.
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公开(公告)号：US09927439B2
公开(公告)日：2018-03-27
申请号：US14261525
申请日：2014-04-25
发明人： Ravi Kaul , Weiming Zheng , Roger Walker
IPC分类号： C12Q1/68 , C12Q1/70 , A61K39/00 , A61K39/29 , C07K14/005 , G01N33/576 , G01N33/543
CPC分类号： G01N33/5761 , G01N33/54326
摘要： Provided herein are multiplex assays for determining whether an individual is or has been infected with Hepatitis B virus, and the stage of infection or resolution. In addition, the multiplex system can discriminate between vaccinated subjects and subjects susceptible to Hepatitis B infection.
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公开(公告)号：US11209431B2
公开(公告)日：2021-12-28
申请号：US15766525
申请日：2016-10-06
IPC分类号： A61K39/02 , C07K14/10 , G01N33/569 , C07K14/20
摘要： The present invention relates to an immunoassay for the detection of Borrelia specific IgG, IgM and IgG/IgM antibodies in biological samples suspected of Lyme infection. The immunoassay can be performed via a standard immunoassay format or on an automated platform. In various embodiments, the immunoassay uses one or more Borrelia specific chimeric peptides VlsE-FlaB (designated pFlaB-mV), VlsE-ErpP (designated pErp59-mV), VlsE-P35 (designated pP35-mV) alone or in combination with one or more outer surface protein C (Osp C) types B or I, p58 and DbpA. Other aspects of the invention provide antigen/substrate combinations and compositions comprising combinations of the disclosed peptides and/or proteins for use in the immunoassays described herein.
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公开(公告)号：US10942182B2
公开(公告)日：2021-03-09
申请号：US16832608
申请日：2020-03-27
发明人： Ravi Kaul , Weiming Zheng , Roger Walker
IPC分类号： G01N33/571 , G01N33/543 , G01N33/92
摘要： Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.
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公开(公告)号：US20140323332A1
公开(公告)日：2014-10-30
申请号：US14261525
申请日：2014-04-25
发明人： Ravi Kaul , Weiming Zheng , Roger Walker
IPC分类号： G01N33/576
CPC分类号： G01N33/5761 , G01N33/54326
摘要： Provided herein are multiplex assays for determining whether an individual is or has been infected with Hepatitis B virus, and the stage of infection or resolution. In addition, the multiplex system can discriminate between vaccinated subjects and subjects susceptible to Hepatitis B infection.
摘要翻译： 本文提供用于确定个体是否已经感染乙型肝炎病毒的多重测定，以及感染或分辨的阶段。 此外，多重系统可以区分接种的受试者和易感乙型肝炎感染的受试者。
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公开(公告)号：US11740240B2
公开(公告)日：2023-08-29
申请号：US17379193
申请日：2021-07-19
发明人： Qian Gao , Ravi Kaul , Shuxia Zhou , Roger P. Walker
IPC分类号： G01N33/569 , G01N21/64
CPC分类号： G01N33/56983 , G01N21/6428 , G01N2021/6439 , G01N2333/165
摘要： The present invention relates to the development of novel immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples. Novel multiplex and singleplex immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples are also provided.
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公开(公告)号：US20210156859A1
公开(公告)日：2021-05-27
申请号：US17170577
申请日：2021-02-08
发明人： Ravi Kaul , Weiming Zheng , Roger Walker
IPC分类号： G01N33/571 , G01N33/543 , G01N33/92
摘要： Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.
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公开(公告)号：US20200225230A1
公开(公告)日：2020-07-16
申请号：US16832608
申请日：2020-03-27
发明人： Ravi Kaul , Weiming Zheng , Roger Walker
IPC分类号： G01N33/571 , G01N33/543 , G01N33/92
摘要： Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.
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