公开(公告)号：US20230207601A1

公开(公告)日：2023-06-29

申请号：US18175836

申请日：2023-02-28

Applicant: Illumina, Inc.

Inventor： Xiuyu CAI ,  Ali AGAH ,  Tracy H. FUNG ,  Dietrich DEHLINGER

IPC: H01L27/146 ,  G01J1/44 ,  G01J1/02 ,  G01N21/64

CPC classification number: H01L27/14636 ,  H01L27/1462 ,  H01L27/14625 ,  H01L27/14643 ,  H01L27/14629 ,  G01J1/44 ,  H01L27/14609 ,  G01J1/0214 ,  H01L27/14601 ,  G01N21/6454 ,  G01J1/0209 ,  G01N2201/0642 ,  H01L27/14623 ,  G01N21/05

Abstract: An example image sensor structure includes an image layer. The image layer includes an array of light detectors disposed therein. A device stack is disposed over the image layer. An array of light guides is disposed in the device stack. Each light guide is associated with at least one light detector of the array of light detectors. A passivation stack is disposed over the device stack. The passivation stack includes a bottom surface in direct contact with a top surface of the light guides. An array of nanowells is disposed in a top layer of the passivation stack. Each nanowell is associated with a light guide of the array of light guides. A crosstalk blocking metal structure is disposed in the passivation stack. The crosstalk blocking metal structure reduces crosstalk within the passivation stack.

公开(公告)号：US20190198553A1

公开(公告)日：2019-06-27

申请号：US16208862

申请日：2018-12-04

Applicant: Illumina, Inc.

Inventor： Xiuyu CAI ,  Ali AGAH ,  Tracy H. FUNG ,  Dietrich DEHLINGER

IPC: H01L27/146

CPC classification number: H01L27/14636 ,  G01J1/0209 ,  G01J1/0214 ,  G01J1/44 ,  G01N21/05 ,  G01N21/6454 ,  G01N2201/0642 ,  H01L27/14601 ,  H01L27/14609 ,  H01L27/1462 ,  H01L27/14623 ,  H01L27/14625 ,  H01L27/14629 ,  H01L27/14643

Abstract: An example image sensor structure includes an image layer. The image layer includes an array of light detectors disposed therein. A device stack is disposed over the image layer. An array of light guides is disposed in the device stack. Each light guide is associated with at least one light detector of the array of light detectors. A passivation stack is disposed over the device stack. The passivation stack includes a bottom surface in direct contact with a top surface of the light guides. An array of nanowells is disposed in a top layer of the passivation stack. Each nanowell is associated with a light guide of the array of light guides. A crosstalk blocking metal structure is disposed in the passivation stack. The crosstalk blocking metal structure reduces crosstalk within the passivation stack.

公开(公告)号：US20180209904A1

公开(公告)日：2018-07-26

申请号：US15880989

申请日：2018-01-26

Applicant: Hitoshi ITOH ,  Fumihiro NAKASHIGE ,  Kenji KOBAYASHI

Inventor： Hitoshi ITOH ,  Fumihiro NAKASHIGE ,  Kenji KOBAYASHI

IPC: G01N21/57 ,  G03G15/00

CPC classification number: G01N21/57 ,  G01N2021/556 ,  G01N2201/06146 ,  G01N2201/0631 ,  G01N2201/0642 ,  G01N2201/0813 ,  G03G15/5062

Abstract: Alighting device includes: a light emitting device including a plurality of light emitting elements arranged in curve having a first curvature; and a honeycomb member having an extendable and contractible honeycomb structure, arranged in curve having a second curvature larger than the first curvature, in an emission direction of light emitted from the light emitting device.

公开(公告)号：US20180120290A1

公开(公告)日：2018-05-03

申请号：US15686807

申请日：2017-08-25

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Yeong Bae YEO ,  Sil PARK ,  Su Bong BAE

IPC: G01N33/49 ,  G01N21/03 ,  G01N33/50 ,  G01N35/00

CPC classification number: G01N33/49 ,  B01L3/502715 ,  G01N21/0303 ,  G01N21/07 ,  G01N21/59 ,  G01N21/75 ,  G01N33/50 ,  G01N35/00069 ,  G01N35/00722 ,  G01N35/00732 ,  G01N2021/0325 ,  G01N2021/178 ,  G01N2021/8488 ,  G01N2035/00891 ,  G01N2201/0633 ,  G01N2201/064 ,  G01N2201/0642

Abstract: A test device, test system, and control method of the test device, which defines a light irradiating area in a reactor to prevent a decrease in magnitude of a detected signal that may result due to scattering of light that has penetrated other area of the reactor than an area containing an object for detection and improve a dynamic range. A test device may include a light source configured to irradiate light; a reactor configured to include at least one first area to contain an object for detection; and a photo detector configured to receive light that has been irradiated from the light source and has passed the reactor that contains the object for detection, wherein the light source is configured to limitedly irradiate the light to the first area of the reactor.

公开(公告)号：US09778191B2

公开(公告)日：2017-10-03

申请号：US15422474

申请日：2017-02-02

Applicant: Personal Genomics, Inc.

Inventor： Hsin-Yi Hsieh ,  Sheng-Fu Lin ,  Teng-Chien Yu

IPC: G01N21/64 ,  G02B6/00 ,  F21V8/00

CPC classification number: G01N21/6454 ,  G01N21/648 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/0642 ,  G02B6/0036 ,  G02B6/005 ,  G02B6/0053

Abstract: An optical sensing module is configured to detect a characteristic of a sample. The optical sensing module includes a light source, a light guide plate, a first cladding layer, a light converging layer, a filter layer, and a plurality of sensors. The light source is configured to provide an exciting beam. Positions of the sensors correspond to positions of the holes. After the exciting beam enters the light guide plate, at least one portion of the exciting beam is transmitted to the sample through a portion of the surface of the light guide plate exposed by the holes, the sample is excited by the exciting beam to emit a signal beam, and the signal beam passes through the light converging layer and the filter layer in an order and travels to the sensors. Another optical sensing module is also provided.

公开(公告)号：US20170227465A1

公开(公告)日：2017-08-10

申请号：US15422474

申请日：2017-02-02

Applicant: Personal Genomics Taiwan, Inc.

Inventor： Hsin-Yi Hsieh ,  Sheng-Fu Lin ,  Teng-Chien Yu

IPC: G01N21/64 ,  F21V8/00

CPC classification number: G01N21/6454 ,  G01N21/648 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/0642 ,  G02B6/0036 ,  G02B6/005 ,  G02B6/0053

Abstract: An optical sensing module is configured to detect a characteristic of a sample. The optical sensing module includes a light source, a light guide plate, a first cladding layer, a light converging layer, a filter layer, and a plurality of sensors. The light source is configured to provide an exciting beam. Positions of the sensors correspond to positions of the holes. After the exciting beam enters the light guide plate, at least one portion of the exciting beam is transmitted to the sample through a portion of the surface of the light guide plate exposed by the holes, the sample is excited by the exciting beam to emit a signal beam, and the signal beam passes through the light converging layer and the filter layer in an order and travels to the sensors. Another optical sensing module is also provided.

公开(公告)号：US20160356715A1

公开(公告)日：2016-12-08

申请号：US15175489

申请日：2014-12-09

Applicant: Illumina, Inc.

Inventor： Cheng Frank Zhong ,  Hod Finkelstein ,  Boyan Boyanov ,  Dietrich Dehlinger ,  Darren Segale

IPC: G01N21/64 ,  G01N21/05

CPC classification number: G01N21/645 ,  B01L3/502707 ,  B01L3/502715 ,  G01N21/05 ,  G01N21/6428 ,  G01N21/6454 ,  G01N33/54373 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/061 ,  G01N2201/0642

Abstract: Biosensor including a device base having a sensor array of light sensors and a guide array of light guides. The light guides have input regions that are configured to receive excitation light and light emissions generated by biological or chemical substances. The light guides extend into the device base toward corresponding light sensors and have a filter material. The device base includes device circuitry electrically coupled to the light sensors and configured to transmit data signals. The biosensor also includes a shield layer having apertures that are positioned relative to the input regions of corresponding light guides such that the light emissions propagate through the apertures into the corresponding input regions. The shield layer extends between adjacent apertures and is configured to block the excitation light and the light emissions incident on the shield layer between the adjacent apertures.

Abstract translation: 生物传感器包括具有光传感器的传感器阵列的装置基座和光导的引导阵列。 光导具有被配置为接收由生物或化学物质产生的激发光和发光的输入区域。 光导件延伸到装置底座中朝向相应的光传感器并具有过滤材料。 器件基底包括电耦合到光传感器并被配置为传输数据信号的器件电路。 生物传感器还包括具有相对于相应光导的输入区域定位的孔的屏蔽层，使得光发射通过孔径传播到相应的输入区域。 屏蔽层在相邻的孔之间延伸并且被配置为阻挡入射在相邻孔之间的屏蔽层上的激发光和发光。

公开(公告)号：US09372157B1

公开(公告)日：2016-06-21

申请号：US13174124

申请日：2011-06-30

Applicant: Paul W. Todd ,  Alan Jones ,  Nathan A. Thomas

Inventor： Paul W. Todd ,  Alan Jones ,  Nathan A. Thomas

IPC: G01N33/00 ,  G01N21/80 ,  G01N21/25 ,  G01N21/31

CPC classification number: G01N21/80 ,  G01N21/255 ,  G01N21/314 ,  G01N21/3151 ,  G01N2201/064 ,  G01N2201/0642

Abstract: A method for non-invasively determining a chemical property of an aqueous solution is provided. The method provides the steps of providing a colored solute having a light absorbance spectrum and transmitting light through the colored solute at two different wavelengths. The method further provides the steps of measuring light absorbance of the colored solute at the two different transmitted light wavelengths, and comparing the light absorbance of the colored solute at the two different wavelengths to determine a chemical property of an aqueous solution.

Abstract translation: 提供了非侵入性地确定水溶液的化学性质的方法。 该方法提供了提供具有吸光光谱并且以两种不同波长透过着色溶质透射光的着色溶质的步骤。 该方法还提供了测量两种不同透射光波长下的着色溶质的光吸收率的步骤，并比较了两种不同波长下的着色溶质的吸光度，以确定水溶液的化学性质。

公开(公告)号：US09316577B1

公开(公告)日：2016-04-19

申请号：US14796735

申请日：2015-07-10

Applicant: David E. Doggett

Inventor： David E. Doggett

IPC: G01N15/02 ,  G01N15/14 ,  G01N15/06 ,  B01F11/00

CPC classification number: G01N15/1404 ,  B01F11/0002 ,  B01F11/0005 ,  B01F11/0008 ,  B01F11/0011 ,  B01F15/00006 ,  B01F15/00883 ,  G01N15/0205 ,  G01N15/06 ,  G01N15/0637 ,  G01N15/1434 ,  G01N15/1456 ,  G01N21/51 ,  G01N2201/0642

Abstract: A low cost, compact, opto-mechanical system for particle analysis is disclosed. In embodiments of this disclosure, the system includes: a holder configured to rigidly secure a container that contains a liquid sample; an actuator configured to repetitively rotate the holder N degrees in a first direction and M degrees in a second direction different from the first direction, wherein N and M are real numbers greater than zero; a radiation source configured to generate a beam of radiation, the radiation source being rigidly attached to the holder; and a detector configured to receive radiation that is at least one of scattered, reflected, diffracted, refracted, or radiated from one or more particles within the liquid sample in response to the beam of radiation being incident upon the one or more particles.

Abstract translation: 公开了一种用于颗粒分析的低成本，紧凑的光机械系统。 在本公开的实施例中，系统包括：保持器，其构造成刚性地固定包含液体样品的容器; 致动器，被配置为在第一方向上重复地旋转保持器N度并且在不同于第一方向的第二方向上M度，其中N和M是大于零的实数; 被配置为产生辐射束的辐射源，所述辐射源刚性地附接到所述保持器; 以及检测器，其被配置为响应于入射到所述一个或多个颗粒上的辐射束而接收从所述液体样品内的一个或多个颗粒散射，反射，衍射，折射或辐射中的至少一种的辐射。

公开(公告)号：US20160091420A1

公开(公告)日：2016-03-31

申请号：US14870425

申请日：2015-09-30

Applicant: Ll-COR, Inc.

Inventor： Serguei KOULIKOV

IPC: G01N21/39 ,  G02B5/20 ,  G02B5/30 ,  H01S5/00 ,  H01S3/081

CPC classification number: G01N21/39 ,  G01N2021/1704 ,  G01N2021/399 ,  G01N2201/0642 ,  G02B5/205 ,  G02B5/3066 ,  H01S3/081 ,  H01S5/0014 ,  H01S5/0078

Abstract: Laser-based spectroscopy systems and methods including a laser source that emits a beam of radiation, an optical resonant cavity having at least two cavity mirrors, and at least one beam filtering element positioned along a path of the beam external to the cavity and having a front surface, wherein the front surface is oriented such that an intersection of the beam and the surface is at an angle, such as the Brewster's angle or a pseudo-Brewster's, that reduces or eliminates reflection of a predominant polarization component of the beam by the filtering element.

Abstract translation: 基于激光的光谱系统和方法，包括发射辐射束的激光源，具有至少两个空腔反射镜的光学谐振腔，以及沿着腔外部的光束路径定位的至少一个光束过滤元件， 前表面，其中所述前表面被定向成使得所述光束和所述表面的交叉点成一定角度，例如布鲁斯特角或伪布鲁斯特，以减少或消除所述光束的主要偏振分量的反射。 过滤元件。