公开(公告)号：US09063121B2

公开(公告)日：2015-06-23

申请号：US13837007

申请日：2013-03-15

Applicant: STAT-DIAGNOSTICA & INNOVATION, S.L.

Inventor： Rafael Bru Gibert ,  Jordi Carrera Fabra ,  Anna Comengés Casas ,  José Antonio García Sánchez

IPC: G01N21/75 ,  G01N33/50 ,  B01L3/00

CPC classification number: B01L3/502 ,  B01L3/5027 ,  B01L2200/0605 ,  B01L2300/0627 ,  B01L2300/0848 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0475 ,  C12Q1/6806 ,  G01N21/75 ,  G01N33/50 ,  G01N33/5306

Abstract: A fluidic testing system is presented that includes a plurality of test chambers, a plurality of inlet channels, and a fluidic network that connects the inlet channels to one or more other chambers. The plurality of test chambers are each characterized by a length and a hydraulic diameter. The length of each test chamber is aligned substantially parallel to a gravity vector. Each of the test chambers has only one opening disposed along the length of the corresponding test chamber. Additionally, each of the test chambers is coupled via its respective opening to only one of the plurality of inlet channels.

Abstract translation: 提出了一种流体测试系统，其包括多个测试室，多个入口通道和将入口通道连接到一个或多个其它室的流体网络。 多个测试室的特征在于长度和水力直径。 每个测试室的长度基本上平行于重力向量排列。 每个测试室仅具有沿着相应测试室的长度设置的一个开口。 此外，每个测试室通过其相应的开口连接到多个入口通道中的仅一个。

公开(公告)号：US09039995B2

公开(公告)日：2015-05-26

申请号：US13555002

申请日：2012-07-20

Applicant: Stephen Daniel Thorogood ,  Paul Saunders

Inventor： Stephen Daniel Thorogood ,  Paul Saunders

IPC: B01L3/00 ,  G01N21/78

CPC classification number: G01N21/78 ,  B01L3/502 ,  B01L3/508 ,  B01L2200/0605 ,  B01L2200/141 ,  B01L2300/045

Abstract: A testing cartridge for metering of a sample to be tested. The testing cartridge includes a casing defining a casing opening and a sliding member defining a sliding member opening. The casing opening or the sliding member opening can define a specified volume, wherein the casing opening and the sliding member opening collectively define a sample application region dimensioned to accommodate receiving an amount of sample exceeding the specified volume. The sliding member is movable transversely to the casing opening by having the sliding member and the casing traverse across each other's respective openings to remove excess sample from the received amount of sample and retain the specified volume from the received amount of sample.

Abstract translation: 用于测量待测试样品的测试盒。 测试盒包括限定壳体开口的壳体和限定滑动构件开口的滑动构件。 壳体开口或滑动构件开口可以限定特定的体积，其中壳体开口和滑动构件开口共同地限定样品施加区域，其尺寸被设计成适应接收超过指定体积的样品量。 滑动构件通过使滑动构件和壳体横过彼此的开口而横向于壳体开口移动，以从接收量的样品中除去多余的样品，并从接收量的样品中保留指定体积。

公开(公告)号：US09011658B2

公开(公告)日：2015-04-21

申请号：US13637801

申请日：2011-03-30

Applicant: Matthew Robert Bryan

Inventor： Matthew Robert Bryan

IPC: G01N27/327 ,  B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/502723 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2300/0636 ,  B01L2300/0822 ,  B01L2300/0825 ,  B01L2300/0887

Abstract: The present invention relates to a sampling plate. In particular the invention relates to a sampling plate for measuring certain selected properties of a liquid sample, such as the glucose levels in a blood sample. Sampling plates of the present invention have a sample zone (20) for receiving a liquid sample and an overflow reservoir (26) linked to the sample zone (20) via an overflow channel (26a), so that excess blood sample can be redirected away from the sample zone (20) and contained.

Abstract translation: 本发明涉及采样板。 特别地，本发明涉及一种用于测量液体样品的某些选定性质的采样板，例如血液样品中的葡萄糖水平。 本发明的采样板具有用于接收液体样品的样品区（20）和经由溢流通道（26a）连接到样品区（20）的溢流容器（26），从而可将过量的血液样品重新导向 从样品区（20）并包含。

公开(公告)号：US20150044696A1

公开(公告)日：2015-02-12

申请号：US13963215

申请日：2013-08-09

Applicant: SHARP KABUSHIKI KAISHA

Inventor： Pamela Ann DOTHIE ,  Daniel Christopher SPENCER

IPC: B01L3/00 ,  C07C231/02 ,  G01N33/569 ,  G01N15/14 ,  F16K99/00 ,  G01N33/49

CPC classification number: B01L3/502738 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0478 ,  B01L2400/0487 ,  B01L2400/0644 ,  C07C231/02 ,  F16K99/0013 ,  F16K99/0028 ,  F16K2099/0084 ,  F16K2099/0086 ,  G01N15/1404 ,  G01N33/4915 ,  G01N33/56972 ,  G01N33/80 ,  Y10T137/0318 ,  Y10T137/85986 ,  Y10T137/86863 ,  Y10T137/86919

Abstract: An integrated microfluidic device for carrying out a series of fluidic operations includes a housing including a plurality of n microfluidic conduits, wherein n is at least three, and a rotating valve having an internal channel with an entrance port and an exit port that are angularly separated. The rotating valve is positionable in a first position to connect two of the n fluidic conduits via the internal channel, and upon rotating the valve to a second position, two other of the n fluidic conduits are connected by the internal channel. The device further may include one or more fluidic chambers in fluid communication with respective fluidic conduits. Fluid contained in one fluidic chamber is transferrable by application of positive or negative gas pressure through associated fluidic conduits into another fluidic chamber via the internal channel. The device may be utilized to perform a variety of fluidic operations.

Abstract translation: 用于执行一系列流体操作的集成微流体装置包括：壳体，其包括多个n个微流体导管，其中n至少为三个;以及旋转阀，具有内部通道，该内部通道具有入口端口和出口端口， 。 旋转阀可定位在第一位置以经由内部通道连接两个n个流体管道，并且在将阀旋转到第二位置时，n个流体管道中的另外两个通过内部通道连接。 该装置还可以包括与相应的流体导管流体连通的一个或多个流体室。 包含在一个流体室中的流体可以通过经由内部通道将相关的流体管道施加正或负气体压力传递到另一个流体腔室中来传递。 该装置可用于执行各种流体操作。

公开(公告)号：US20140339082A1

公开(公告)日：2014-11-20

申请号：US14446733

申请日：2014-07-30

Applicant: DUKE UNIVERSITY

Inventor： Michael G. Pollack ,  Vamsee K. Pamula ,  Richard B. Fair

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01F11/0071 ,  B01F13/0071 ,  B01F13/0076 ,  B01F13/0084 ,  B01L3/00 ,  B01L3/5027 ,  B01L3/502784 ,  B01L3/502792 ,  B01L2200/06 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2300/165 ,  B01L2400/0415 ,  B01L2400/0427 ,  B41J2002/14395 ,  C25B9/00 ,  G01N27/44791 ,  G02B26/005

Abstract: Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements, wherein the droplet is disposed on a first one of the electrodes, and the droplet at least partially overlaps a second one of the electrodes and an intervening one of the reference elements disposed between the first and second electrodes. The methods further include activating the first and second electrodes to spread at least a portion of the droplet across the second electrode and deactivating the first electrode to move the droplet from the first electrode to the second electrode.

Abstract translation: 提供了用于操纵液滴的方法。 所述方法包括在包括电极阵列和基本上共平面的参考元件阵列的表面上提供液滴，其中液滴设置在电极的第一个上，并且液滴至少部分地与第二个 电极和设置在第一和第二电极之间的参考元件中的插入件之一。 所述方法还包括激活第一和第二电极以将液滴的至少一部分扩散穿过第二电极，并且去激活第一电极以使液滴从第一电极移动到第二电极。

公开(公告)号：US20140336064A1

公开(公告)日：2014-11-13

申请号：US14177190

申请日：2014-02-10

Applicant: California Institute of Technology ,  University of Chicago

Inventor： Rustem F. Ismagilov ,  Feng Shen ,  Jason E. Kreutz ,  Wenbin Du ,  Bing Sun

IPC: C12Q1/68

CPC classification number: C12Q1/6851 ,  B01F5/0085 ,  B01F13/0094 ,  B01F15/0218 ,  B01L3/5025 ,  B01L3/502738 ,  B01L3/50851 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/045 ,  B01L2300/049 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0644 ,  B01L2400/065 ,  C12Q2531/119 ,  C12Q2537/149 ,  C12Q2563/159 ,  C12Q2565/629

Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.

Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。

公开(公告)号：US20140332380A1

公开(公告)日：2014-11-13

申请号：US14338889

申请日：2014-07-23

Applicant: Advanced Liquid Logic, Inc.

Inventor： Ryan A. Sturmer ,  Michael G. Pollack ,  Vamsee K. Pamula ,  Vijay Srinivasan ,  Philip Y. Paik

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01L3/502715 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0809 ,  B01L2400/0427 ,  G01N27/22 ,  G01N27/223 ,  G01N27/227 ,  G01N2203/00 ,  G01V3/02

Abstract: A method, circuit and apparatus for detecting capacitance on a droplet actuator, inter alia, for determining the presence, partial presence or absence of a droplet at an electrode on a droplet actuator by: (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged on the substrate for conducting droplet operations on a surface of the substrate; (ii) a capacitance detection circuit for detecting capacitance at the droplet operations surface at one or more of the electrodes; (b) detecting capacitance at the droplet operations surface at one or more of the electrodes; and (c) determining from the capacitance the presence, partial presence or absence of a droplet at the droplet operations surface at the electrode.

Abstract translation: 一种用于检测液滴致动器上电容的方法，电路和装置，特别是用于通过以下步骤确定液滴致动器上的电极处的液滴的存在，部分存在或不存在：（a）提供液滴致动器，其包括：（i） 基板，其包括布置在所述基板上的电极，用于在所述基板的表面上进行液滴操作; （ii）电容检测电路，用于检测一个或多个电极处的液滴操作表面处的电容; （b）在一个或多个电极处检测液滴操作表面处的电容; 和（c）根据电容确定在电极处的液滴操作表面处的液滴的存在，部分存在或不存在。

公开(公告)号：US08872527B2

公开(公告)日：2014-10-28

申请号：US12527208

申请日：2008-02-15

Applicant: Ryan A. Sturmer ,  Michael G. Pollack ,  Vamsee K. Pamula ,  Vijay Srinivasan ,  Philip Y. Paik

Inventor： Ryan A. Sturmer ,  Michael G. Pollack ,  Vamsee K. Pamula ,  Vijay Srinivasan ,  Philip Y. Paik

IPC: G01R27/26 ,  G01N27/22

CPC classification number: B01L3/50273 ,  B01L3/502715 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0809 ,  B01L2400/0427 ,  G01N27/22 ,  G01N27/223 ,  G01N27/227 ,  G01N2203/00 ,  G01V3/02

Abstract: A method, circuit and apparatus for detecting capacitance on a droplet actuator, inter alia, for determining the presence, partial presence or absence of a droplet at an electrode on a droplet actuator by: (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged on the substrate for conducting droplet operations on a surface of the substrate; (ii) a capacitance detection circuit for detecting capacitance at the droplet operations surface at one or more of the electrodes; (b) detecting capacitance at the droplet operations surface at one or more of the electrodes; and (c) determining from the capacitance the presence, partial presence or absence of a droplet at the droplet operations surface at the electrode.

Abstract translation: 一种用于检测液滴致动器上电容的方法，电路和装置，特别是用于通过以下步骤确定液滴致动器上的电极处的液滴的存在，部分存在或不存在：（a）提供液滴致动器，其包括：（i） 基板，其包括布置在所述基板上的电极，用于在所述基板的表面上进行液滴操作; （ii）电容检测电路，用于检测一个或多个电极处的液滴操作表面处的电容; （b）在一个或多个电极处检测液滴操作表面处的电容; 和（c）根据电容确定在电极处的液滴操作表面处的液滴的存在，部分存在或不存在。

公开(公告)号：US20140308689A1

公开(公告)日：2014-10-16

申请号：US14285562

申请日：2014-05-22

Applicant: Theranos, Inc.

Inventor： Ian Gibbons ,  Shaunak Roy ,  Edmond Ku

IPC: C12Q1/60

CPC classification number: G01N33/92 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/0605 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/168 ,  C12Q1/60 ,  G01N21/27 ,  G01N21/31 ,  G01N33/525 ,  G01N33/5302 ,  G01N2201/061 ,  G01N2201/062 ,  Y10T436/20

Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

Abstract translation: 本发明在医疗器械领域。 具体地说，本发明提供允许检测来自生物流体的分析物的便携式医疗装置。 所述方法和装置对于为各种医疗应用提供点护理测试特别有用。

公开(公告)号：US08839685B2

公开(公告)日：2014-09-23

申请号：US13211886

申请日：2011-08-17

Applicant: Jürgen Löhn

Inventor： Jürgen Löhn

IPC: G01N1/14 ,  B01L3/02 ,  A61M5/315

CPC classification number: B01L3/0234 ,  A61M5/31513 ,  A61M5/31573 ,  A61M2005/3118 ,  A61M2005/31516 ,  B01L2200/0605 ,  B01L2300/0851

Abstract: A syringe for use with a dosing device with a receiver for a syringe cylinder and an axially displaceable plunger receiver for a syringe plunger with a syringe cylinder, which has a floor with an outlet on the bottom, a cylindrical plunger run area on the inside and has means for being held in the receiver on the top, a syringe plunger, which has a circumferential plunger seal for sealing on the plunger run area on the perimeter and a coupling piece for insertion into the plunger receiver on the top and stop means between the syringe cylinder and the syringe plunger, which restrict the displacement of the syringe plunger towards the floor so that the syringe plunger with the plunger seal can only approach to a certain distance from the floor.

Abstract translation: 一种用于具有用于注射器筒的接收器和用于具有注射器筒的注射器柱塞的轴向移位柱塞接收器的注射器，该注射器柱塞具有位于底部的出口的底板，内侧上的圆柱形柱塞运动区域， 具有用于保持在顶部的接收器中的装置，注射器柱塞，其具有用于密封在周边的柱塞运行区域上的周向柱塞密封件和用于插入顶部的柱塞接收器中的联接件，以及在顶部的止动装置之间的止动装置 注射器筒和注射器柱塞，其限制注射器柱塞朝向地板的位移，使得具有柱塞密封件的注射器柱塞仅能够接近距离地板一定距离。