公开(公告)号：US20190154672A1

公开(公告)日：2019-05-23

申请号：US16313316

申请日：2017-06-30

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Ivan McConnell ,  Peter Fitzgerald ,  John Lamont ,  Ciaran Richardson

IPC: G01N33/543 ,  G01N33/92 ,  C07K16/18

Abstract: The present invention relates to a multiplexing system comprising a support substrate having immobilised thereto one or more of the following proteins, fragments thereof or a binding molecule, wherein the binding molecule binds specifically to one of the following proteins: E-FABP, B-FABP, IL-FABP, I-FABP, M-FABP, A-FABP, H-FABP, L-FABP or T-FABP. Another aspect is directed to a method for characterising the pattern of FABP antigens existing within a biological sample to reveal information useful in the diagnosis or disease or injury.

公开(公告)号：US09726678B2

公开(公告)日：2017-08-08

申请号：US13263979

申请日：2010-04-15

Applicant: Massimiliano Corsi ,  Stephen Peter Fitzgerald ,  John V. Lamont ,  Paul Innocenzi

Inventor： Massimiliano Corsi ,  Stephen Peter Fitzgerald ,  John V. Lamont ,  Paul Innocenzi

IPC: G01N33/53 ,  C40B30/04 ,  C07K16/00 ,  C12Q1/00 ,  G01N33/68

CPC classification number: G01N33/6896 ,  G01N2800/2821

Abstract: The invention relates to methods of diagnosing Alzheimer's disease (AD) in a subject and methods of determining the prognosis in patients with AD. The adhesion molecules P-selectin and L-selectin are described for the first time for use as biomarkers to aid in the diagnosis of AD. The invention further describes the use of one or more of L-selectin, MCP-1, IL-1α, IL-8 and IFN-γ to aid in the prognosis of either accelerated cognitive decline (ACD) or slow cognitive decline (SCD) in patients with AD.

公开(公告)号：US20170184611A1

公开(公告)日：2017-06-29

申请号：US15457297

申请日：2017-03-13

Applicant: Randox Laboratories Ltd.

Inventor： John Lamont ,  Ivan Mc Connell ,  Peter Fitzgerald

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6842 ,  G01N2333/4737 ,  G01N2333/5412 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2333/70542 ,  G01N2333/70564 ,  G01N2333/7151 ,  G01N2800/2871 ,  G01N2800/32 ,  G01N2800/60

Abstract: The present invention provides biomarker-based methods for diagnosing stroke in a patient suspected of having suffered a stroke, and also for discriminating between ischemic stroke and transient ischemic attack. Substrates comprising probes for specific combinations of biomarkers useful in the methods of the invention are also described.

公开(公告)号：US20170095819A1

公开(公告)日：2017-04-06

申请号：US15360038

申请日：2016-11-23

Applicant: Gareth WILSON ,  Michael HOOKS ,  Peter FITZGERALD ,  John LAMONT ,  Ivan MCCONNELL

Inventor： Gareth WILSON ,  Michael HOOKS ,  Peter FITZGERALD ,  John LAMONT ,  Ivan MCCONNELL

IPC: B01L9/00 ,  B65D71/50 ,  G01N1/28 ,  B65B69/00

Abstract: A biochip well is disclosed, including a vessel containing a well therewithin, the vessel forming at least base and side walls of the well and defining at least one aperture giving access to the well, and further including retaining means for holding a biochip at a predetermined position within the well, the well including a laterally offset region into which the biochip does not protrude when held at the predetermined position by the retaining means. Also disclosed are sealed well assemblies and apparatus and methods for opening sealed wells.

公开(公告)号：US09540129B2

公开(公告)日：2017-01-10

申请号：US13812767

申请日：2011-07-26

Applicant: Gareth Wilson ,  Michael Hooks ,  Peter Fitzgerald ,  John Lamont ,  Ivan McConnell

Inventor： Gareth Wilson ,  Michael Hooks ,  Peter Fitzgerald ,  John Lamont ,  Ivan McConnell

IPC: B65B69/00 ,  G01N1/28 ,  G01N33/50 ,  B01L3/00 ,  B01L9/00

CPC classification number: B01L9/52 ,  B01L3/5085 ,  B01L9/527 ,  B01L2200/025 ,  B01L2300/044 ,  B01L2300/0609 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0822 ,  B65B69/00 ,  B65D71/50 ,  G01N1/28 ,  G01N33/50 ,  Y10T436/2575

Abstract: A biochip well is disclosed, including a vessel containing a well therewithin, the vessel forming at least base and side walls of the well and defining at least one aperture giving access to the well, and further including retaining means for holding a biochip at a predetermined position within the well, the well including a laterally offset region into which the biochip does not protrude when held at the predetermined position by the retaining means. Also disclosed are sealed well assemblies and apparatus and methods for opening sealed wells.

Abstract translation: 公开了一种生物芯片井，包括容纳其中的井的容器，所述容器至少形成井的底壁和侧壁，并且限定了至少一个允许进入井的孔，并且还包括用于将生物芯片保持在预定的 井内的位置，井包括横向偏移区域，当通过保持装置保持在预定位置时，生物芯片不会突出。 还公开了密封井组件以及用于打开密封井的装置和方法。

公开(公告)号：US09447469B2

公开(公告)日：2016-09-20

申请号：US14323775

申请日：2014-07-03

Applicant: RANDOX LABORATORIES LTD.

Inventor： John V. Lamont

IPC: C12Q1/68 ,  C12P19/34 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/517

CPC classification number: C12Q1/6883 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/517 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: The present disclosure provides a method for identifying whether a subject is more or less likely to be responsive to VEGF-based therapy, comprising screening a nucleic acid sample obtained from the subject to provide output information which identifies the presence or absence of an allelic variant, wherein the presence or absence of an allelic variant indicates whether the subject is more or less likely to be responsive to VEGF-based therapy.

Abstract translation: 本公开提供了用于鉴定受试者是或多或少可能对基于VEGF的治疗有反应的方法，其包括筛选从受试者获得的核酸样品以提供识别等位变体的存在或不存在的输出信息， 其中等位基因变体的存在或不存在表明受试者是或多或少可能对基于VEGF的治疗有反应。

公开(公告)号：US20160161508A1

公开(公告)日：2016-06-09

申请号：US15043238

申请日：2016-02-12

Applicant: RANDOX LABORATORIES, LTD.

Inventor： Maria ZELLNER ,  Rudolf OEHLER

IPC: G01N33/68 ,  C12Q1/68

CPC classification number: G01N33/6896 ,  C07K14/4711 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2333/90638 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/2835

Abstract: A method for the diagnosis of Alzheimer's Disease (AD) or Parkinson's Disease (PD), including measuring the level of expression of one or more AD markers (Table 1) or PD markers (Table 2) in a sample of platelets isolated from a person suspected of having AD or PD, and determining whether the levels of expression are altered compared to a control.

Abstract translation: 一种用于诊断阿尔茨海默病（AD）或帕金森病（PD）的方法，包括测量从人分离的血小板样品中的一种或多种AD标志物（表1）或PD标志物（表2）的表达水平 怀疑患有AD或PD，并确定与对照相比，表达水平是否改变。

公开(公告)号：USD676976S1

公开(公告)日：2013-02-26

申请号：US29398092

申请日：2011-07-26

Applicant: Aiden Walsh ,  Gareth Wilson

Designer： Aiden Walsh ,  Gareth Wilson

公开(公告)号：US20120142548A1

公开(公告)日：2012-06-07

申请号：US13263979

申请日：2010-04-15

Applicant: Massimiliano Corsi ,  Stephen P. Fitzgerald ,  John V. Lamont ,  Paul Innocenzi

Inventor： Massimiliano Corsi ,  Stephen P. Fitzgerald ,  John V. Lamont ,  Paul Innocenzi

IPC: C40B30/04 ,  C07K16/18 ,  C07K16/24 ,  C40B40/10

CPC classification number: G01N33/6896 ,  G01N2800/2821

Abstract: The invention relates to methods of diagnosing Alzheimer's disease (AD) in a subject and methods of determining the prognosis in patients with AD. The adhesion molecules P-selectin and L-selectin are described for the first time for use as biomarkers to aid in the diagnosis of AD. The invention further describes the use of one or more of L-selectin, MCP-1, IL-1α, IL-8 and IFN-γ to aid in the prognosis of either accelerated cognitive decline (ACD) or slow cognitive decline (SCD) in patients with AD.

Abstract translation: 本发明涉及诊断受试者中的阿尔茨海默病（AD）的方法和确定AD患者预后的方法。 首次描述了粘附分子P-选择素和L-选择蛋白作为生物标志物用于辅助AD诊断。 本发明还描述了L-选择蛋白，MCP-1，IL-1α，IL-8和IFN-γ中的一种或多种的用途，有助于加速认知衰退（ACD）或缓慢认知衰退（SCD） 在AD患者

公开(公告)号：US20100291600A1

公开(公告)日：2010-11-18

申请号：US12662651

申请日：2010-04-27

Applicant: Stephen P. Fitzgerald ,  Robert I. McConnell ,  Philip A. Lowry ,  Elouard Benchikh

Inventor： Stephen P. Fitzgerald ,  Robert I. McConnell ,  Philip A. Lowry ,  Elouard Benchikh

IPC: G01N33/53 ,  C07K16/16

CPC classification number: G01N33/94 ,  C07K16/16 ,  G01N33/946

Abstract: The present invention provides an immunoassay method for detecting or determining the amount of salvinorin A, salvinorin B and/or analogues thereof in an in vitro sample, an antibody for salvinorin A, salvinorin B and/or analogues thereof and a kit for detecting the presence of or determining the amount of salvinorin A, salvinorin B and its analogues thereof in a sample.

Abstract translation: 本发明提供了用于检测或确定体外样品中salvinorin A，salvinorin B和/或其类似物的量的免疫测定方法，salvinorin A的抗体，salvinorin B和/或其类似物，以及用于检测存在的试剂盒 或确定样品中salvinorin A，salvinorin B及其类似物的量。