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105 条记录 (耗时 0.02 秒)

    N-substituted .alpha.-amino acids and derivatives thereof having pharmaceutical activity
    92.
    发明授权
    N-substituted .alpha.-amino acids and derivatives thereof having pharmaceutical activity 失效
    具有药物活性的N-取代的α-氨基酸及其衍生物

    公开(公告)号：US5179085A

    公开(公告)日：1993-01-12

    申请号：US689726

    申请日：1991-04-22

    申请人： Christopher F. Bigge ,  Graham Johnson

    发明人： Christopher F. Bigge ,  Graham Johnson

    IPC分类号： C07F9/38 ,  C07F9/40

    CPC分类号： C07F9/4056 ,  C07F9/3808 ,  C07F9/3826 ,  C07F9/3834 ,  C07F9/3882 ,  C07F9/4006 ,  C07F9/4015 ,  C07F9/4021

    摘要： N-substituted .alpha.-amino acids and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in selectively blocking the N-methyl-D-aspartate (NMDA) excitatory amino acid receptors in mammals and also are useful in treating cerebrovascular disorders such as cerebral ischemia or cerebral infarction resulting from thromboembolic or hemorrhagic stroke, cerebral vasospasm, hypoglycemia, cardiac arrest, status epilepticus and cerebral trauma as well as for treating schizophrenia, epilepsy, neurodegenerative disorders, Alzheimer's disease or Huntington's disease and also additionally useful as anesthetics in surgical procedures where a finite risk of cerebrovascular damage exists.

    摘要翻译： 描述了N-取代的α-氨基酸及其衍生物，以及其制备方法及其药物组合物，其可用于选择性阻断哺乳动物中的N-甲基-D-天冬氨酸（NMDA）兴奋性氨基酸受体，以及 也可用于治疗由血栓栓塞或出血性脑卒中，脑血管痉挛，低血糖症，心脏骤停，癫痫持续状态和脑损伤引起的脑缺血或脑梗死，以及用于治疗精神分裂症，癫痫，神经退行性疾病，阿尔茨海默病或亨廷顿舞蹈症的脑血管疾病 疾病，另外作为麻醉剂在脑血管损伤存在有限风险的外科手术中也是有用的。

    Substituted 2-carboxylindoles having pharmaceutical activity
    93.
    发明授权
    Substituted 2-carboxylindoles having pharmaceutical activity 失效
    具有药物活性的取代的2-羧基吲哚

    公开(公告)号：US5145845A

    公开(公告)日：1992-09-08

    申请号：US699875

    申请日：1991-05-14

    申请人： Graham Johnson ,  Thomas C. Malone ,  Po-Wai Yuen

    发明人： Graham Johnson ,  Thomas C. Malone ,  Po-Wai Yuen

    IPC分类号： C07D209/42 ,  C07D403/04 ,  C07D403/06

    CPC分类号： C07D403/04 ,  C07D209/42 ,  C07D403/06

    摘要： The present invention relates to novel compounds, which are derivatives of ureas, thioureas, carbamates, sulfonylureas, sulfonamides, amides, and thioamides of 2-carboxyindoles as illustrated by the formula ##STR1## The invention also relates to methods for the preparation of the novel compounds, as well as to pharmaceutical compositions or methods of use for the novel compounds. More specifically, the compounds of the present invention are useful in the treatment of neurodegenerative disorders including cerebrovascular disorders as well as in the treatment of schizophrenia or epilepsy; and as analgesics and anxiolytics.

    摘要翻译： 本发明涉及新型化合物，其是如下式所示的2-羧基吲哚的脲，硫脲，氨基甲酸酯，磺酰脲，磺酰胺，酰胺和硫代酰胺的衍生物。本发明还涉及制备该新颖物质的方法 化合物，以及用于新化合物的药物组合物或使用方法。 更具体地，本发明的化合物可用于治疗神经变性疾病，包括脑血管障碍以及治疗精神分裂症或癫痫; 并作为镇痛药和抗焦虑药。

    Material for cell attachment and growth
    95.
    发明授权
    Material for cell attachment and growth 失效
    用于细胞附着和生长的材料

    公开(公告)号：US5010009A

    公开(公告)日：1991-04-23

    申请号：US477884

    申请日：1990-05-09

    申请人： John Steele ,  Oddvar Johansen ,  Graham Johnson ,  Johnathon Hodgkin

    发明人： John Steele ,  Oddvar Johansen ,  Graham Johnson ,  Johnathon Hodgkin

    IPC分类号： C12M3/00 ,  C08F8/36 ,  C08F259/00 ,  C08F259/08 ,  C12N5/00 ,  C12N5/02 ,  C12N5/06

    CPC分类号： C12N5/0068 ,  C08F259/08 ,  C08F8/36 ,  C08J7/12 ,  C12N2533/30 ,  C12N2533/52 ,  Y10S623/915 ,  Y10S623/921

    摘要： A surface for the attachment and growth of cells is prepared by first grafting polyacrylic acid chains to a fluorocarbon polymer substrate so that its weight increases by between 0.1 % and 20%. The surface is then treated with concentrated sulphuric acid under such conditions that will separately decarboxylate, aromatize and sulphonate an effective proportion of the grafted polyacrylic acid chains before being dried, soaked in a concentrated acid and brought to a substantially neutral pH for cell attachment and growth thereupon. The surface may also be used as a human tissue implant.

    摘要翻译： PCT No.PCT / AU89 / 00356 Sec。 371日期1990年5月9日 102（e）日期1990年5月9日PCT提交1989年8月22日PCT公布。 出版物WO90 / 02145 1990年3月8日。用于附着和生长细胞的表面是通过首先将聚丙烯酸链接枝到氟碳聚合物基底上制成的，使其重量增加0.1％至20％。 然后将表面用浓硫酸处理，在这样的条件下，其将在干燥之前分别脱羧，芳构化和磺化有效比例的接枝聚丙烯酸链，浸在浓酸中并使其达到基本上中性的pH以使细胞附着和生长 于是。 该表面也可以用作人体组织植入物。

    Benzoic acid and benzoic acid ester derivatives having antiinflammatory and analgesic activity
    96.
    发明授权
    Benzoic acid and benzoic acid ester derivatives having antiinflammatory and analgesic activity 失效
    具有抗炎和止痛活性的苯甲酸和苯甲酸酯衍生物

    公开(公告)号：US5002703A

    公开(公告)日：1991-03-26

    申请号：US929038

    申请日：1986-11-10

    申请人： Michael F. Rafferty ,  Graham Johnson

    发明人： Michael F. Rafferty ,  Graham Johnson

    IPC分类号： C07D257/04

    CPC分类号： C07D257/04

    摘要： Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headache, such as migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.

    摘要翻译： 新型苯甲酸或苯甲酸酯衍生物，药物组合物及其使用方法是本发明。 用于治疗关节炎，哮喘，雷诺氏病，炎性肠病，三叉神经痛或疱疹性神经痛，炎症性眼病，牛皮癣，牙痛和头痛，尤其是血管性头痛，如偏头痛，丛状，混合型血管综合症，以及 作为非血管性紧张性头痛。

    Amide, sulfonamide, urea, carbamate, thiocarbamate, and thiourea derivatives of 4'hydroxybenzylamine having anti-inflammatory and analgesic activity
    97.
    发明授权
    Amide, sulfonamide, urea, carbamate, thiocarbamate, and thiourea derivatives of 4'hydroxybenzylamine having anti-inflammatory and analgesic activity 失效
    酰胺，磺酰胺，脲，氨基甲酸酯，硫代氨基甲酸酯和具有消炎止痛活性的4'-羟基苄胺的硫脲衍生物

    公开(公告)号：US4980366A

    公开(公告)日：1990-12-25

    申请号：US324966

    申请日：1989-03-16

    申请人： Graham Johnson ,  Michael F. Rafferty

    发明人： Graham Johnson ,  Michael F. Rafferty

    IPC分类号： C07C233/18 ,  C07C233/36 ,  C07C323/32

    CPC分类号： C07C323/32 ,  C07C233/18 ,  C07C233/36

    摘要： Novel 4'-hydroxybenzylamine derivatives of the formula ##STR1## pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headache, succh as migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.

    摘要翻译： 下式的新型4'-羟基苄胺衍生物是本发明的药物组合物及其使用方法。 用于治疗关节炎，哮喘，雷诺氏病，炎性肠病，三叉神经痛或疱疹性神经痛，炎症性眼病，牛皮癣，牙痛和头痛，特别是血管性头痛，偏头痛，簇，混合型血管综合征等 作为非血管性紧张性头痛。

    Sodium salt of N-C4-carboxybenzyl nonanamide
    98.
    发明授权
    Sodium salt of N-C4-carboxybenzyl nonanamide 失效
    N-C4-羧苄基壬酰胺的钠盐

    公开(公告)号：US4980095A

    公开(公告)日：1990-12-25

    申请号：US57126

    申请日：1987-06-01

    申请人： Michael F. Rafferty ,  Graham Johnson

    发明人： Michael F. Rafferty ,  Graham Johnson

    IPC分类号： C07D257/04

    CPC分类号： C07D257/04

    摘要： Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headache, such as migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.

    摘要翻译： 新型苯甲酸或苯甲酸酯衍生物，药物组合物及其使用方法是本发明。 用于治疗关节炎，哮喘，雷诺氏病，炎性肠病，三叉神经痛或疱疹性神经痛，炎症性眼病，牛皮癣，牙痛和头痛，尤其是血管性头痛，如偏头痛，丛状，混合型血管综合症，以及 作为非血管性紧张性头痛。

    Benzoic acid and benzoic acid ester derivatives to treat pain
    100.
    发明授权
    Benzoic acid and benzoic acid ester derivatives to treat pain 失效
    苯甲酸和苯甲酸酯衍生物治疗疼痛

    公开(公告)号：US4719233A

    公开(公告)日：1988-01-12

    申请号：US929035

    申请日：1986-11-10

    申请人： Michael F. Rafferty ,  Graham Johnson

    发明人： Michael F. Rafferty ,  Graham Johnson

    IPC分类号： C07D257/04 ,  C07C103/46

    CPC分类号： C07D257/04

    摘要： Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headache, such as migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.

    摘要翻译： 新型苯甲酸或苯甲酸酯衍生物，药物组合物及其使用方法是本发明。 用于治疗关节炎，哮喘，雷诺氏病，炎性肠病，三叉神经痛或疱疹性神经痛，炎症性眼病，牛皮癣，牙痛和头痛，尤其是血管性头痛，如偏头痛，丛状，混合型血管综合症，以及 作为非血管性紧张性头痛。