公开(公告)号：US4002666A

公开(公告)日：1977-01-11

申请号：US516963

申请日：1974-10-22

申请人： Tadashi Shirai ,  Yasuhisa Tashiro ,  Shigeru Aoki

发明人： Tadashi Shirai ,  Yasuhisa Tashiro ,  Shigeru Aoki

IPC分类号： C07B57/00 ,  C07B31/00 ,  C07C19/00 ,  C07C67/00 ,  C07C227/00 ,  C07C227/20 ,  C07C227/34 ,  C07C229/36 ,  C07C231/00 ,  C07C231/12 ,  C07C231/20 ,  C07C233/47 ,  C07C103/46 ,  C07C103/84 ,  C07C125/06

CPC分类号： C07C271/06

摘要： Optically active p-hydroxyphenylglycine is prepared by reacting a racemic compound of a specified p-hydroxyphenylglycine derivative with optically active .alpha.-phenylethylamine to form a corresponding salt, obtaining two types of optically active salts therefrom by fractional crystallization, and obtaining optically active p-hydroxyphenylglycine by decomposition and hydrolysis of at least one of the optically active salts.

摘要翻译： 通过使特定的对羟基苯基甘氨酸衍生物的外消旋化合物与光学活性α-苯乙胺反应形成相应的盐，通过分级结晶获得两种类型的光学活性盐，得到光学活性对羟基苯基甘氨酸，制备光学活性对羟基苯基甘氨酸 通过至少一种光学活性盐的分解和水解。

公开(公告)号：US3763226A

公开(公告)日：1973-10-02

申请号：US3763226D

申请日：1970-07-21

申请人： PHARMACIA AB

发明人： INGELMAN B

IPC分类号： A61K49/04 ,  C07C103/46

CPC分类号： A61K49/0433

摘要： COMPOUNDS OF THE FORMULA:

1-((2,6-DI(I-),3-(R1-N(-R2)-CH2-),5-(HOOC-)PHENYL)-N(-R3)-

A-N(-R3'')-),2,4,6-TRI(I-),3-(R1''-N(-R2'')-CH2-),5-(HOOC-)-

BENZENE

WHEREIN R1 AND R1'' ARE EACH HYDROGEN OR LOWER ALKYL HAVING NO MORE THAN 5 CARBON ATOMS, R2; R2''; R3; AND R3'' ARE EACH LOWER ACYL HAVING NO MORE THAN 5 CARBON ATOMS, AND A IS AN ALKYLENE GROUP SUBSTITUTED BY ONE OR MORE SUBSTITUENTS OF THE FORMULA -O-R4, WHEREIN R4 IS HYDROGEN OR LOWER ALKYL OR ACYL HAVING NO MORE THAN 5 CARBON ATOMS; THE ALKYLENE GROUP CONTAINING 3-20 CARBON ATOMS AND BEING OPTIONALLY BROKEN BY ONE OR MORE OXYGEN BRIDGES, OR PHYSIOLOGICALLY ACCEPTABLE SALTS THEREOF ARE PROVIDED. SUCH COMPOUNDS ARE ESPECIALLY SUITABLE TO BE USED FOR X-RAY VISUALIZATION OF BODY CAVITIES.

公开(公告)号：US4225725A

公开(公告)日：1980-09-30

申请号：US624011

申请日：1975-10-20

申请人： George B. Hoey

发明人： George B. Hoey

IPC分类号： C07H13/04 ,  C07H13/08 ,  C07C103/46 ,  C07C103/76 ,  C07C103/84

CPC分类号： C07H13/04 ,  C07H13/08

摘要： Esters of certain 2,4,6-triiodobenzoic acid derivatives are useful as X-Ray contrast media. Representative compounds are the ethoxymethyl esters of acetrizoic, iothalamic and iodobenzamic acids.

摘要翻译： 某些2,4,6-三碘苯甲酸衍生物的酯可用作X射线造影剂。 代表性化合物是乙酸甲酯，伊马替酸和碘代碘酸的乙氧基甲基酯。

公开(公告)号：US3987084A

公开(公告)日：1976-10-19

申请号：US531994

申请日：1974-12-12

申请人： Walter Morozowich

发明人： Walter Morozowich

IPC分类号： C07C405/00 ,  C07C69/64 ,  C07C69/78 ,  C07C103/46

CPC分类号： C07C405/00

摘要： Substituted phenyl and naphthyl esters of PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub.1, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub.1, and are also useful as a means for obtaining highly purified PGE.sub.1, 15-alkyl-PGE.sub.1, and 15(R)-15-alkyl-PGE.sub.1 products.

公开(公告)号：US4535167A

公开(公告)日：1985-08-13

申请号：US497301

申请日：1983-05-23

申请人： Roger M. Freidinger

发明人： Roger M. Freidinger

IPC分类号： C07C233/45 ,  C07C271/06 ,  C07C125/065 ,  C07C103/46

CPC分类号： C07C233/45 ,  C07C271/06

摘要： Chiral N-protected, N-substituted .alpha.-amino acids are described. These compounds are prepared by condensation of an N-protected .alpha.-amino acid with an aldehyde followed by the selective reductive cleavage of an oxazolidinone intermediate.

摘要翻译： 描述了手性N-保护的N-取代的α-氨基酸。 这些化合物通过N-保护的α-氨基酸与醛缩合，然后选择性还原性切割恶唑烷酮中间体来制备。

公开(公告)号：US4365085A

公开(公告)日：1982-12-21

申请号：US9745

申请日：1979-02-05

申请人： James R. Bartels-Keith ,  Eva R. Karger

发明人： James R. Bartels-Keith ,  Eva R. Karger

IPC分类号： G03C5/30 ,  G03C8/36 ,  C07C97/07 ,  C07C102/06 ,  C07C103/44 ,  C07C103/46 ,  C07C119/00 ,  C07C119/06

CPC分类号： G03C8/36 ,  G03C5/30

摘要： The present invention relates to novel bicyclic compounds useful as photographic silver halide developing agents, to the preparation of these compounds and to photographic products, processes and compositions employing the same. The subject compounds may be represented by the formula ##STR1## wherein R.sub.1 and R.sub.2, the same or different, each represents hydrogen, a hydrocarbon moiety, preferably an alkyl group, --COOH or --COOR.sup.1 wherein R.sup.1 is an alkyl group; R.sub.3 and R.sub.4, the same or different, each represent hydrogen or an alkyl group, R.sub.5 represents hydrogen or --COR.sup.2 wherein R.sup.2 is an alkyl group; R.sub.6 represents hydrogen when R.sub.5 is hydrogen and represents hydrogen or --OCOR.sup.3 wherein R.sup.3 is an alkyl group the same as R.sup.2 when R.sub.5 represents --COR.sup.2 ; X represents --OH, --NH.sub.2 or --NHCOR.sup.4 wherein R.sup.4 represents an alkyl group the same as R.sup.2 ; Y represents --OH or --OCOR.sup.5 wherein R.sup.5 represents an alkyl group the same as R.sup.2 ; and Z represents .dbd.O or .dbd.NCOR.sup.6 wherein R.sup.6 is an alkyl group the same as R.sup.2.

摘要翻译： 本发明涉及可用作照相卤化银显影剂的新型双环化合物，这些化合物的制备以及使用其的摄影产品，方法和组合物。 本发明化合物可以由下式表示：其中R 1和R 2相同或不同，各自表示氢，烃部分，优选烷基-COOH或-COOR 1，其中R 1是烷基; R 3和R 4相同或不同，各自表示氢或烷基，R 5表示氢或-COR 2，其中R 2是烷基; 当R 5为氢并且表示氢或-OCOR 3时，R 6表示氢，R 5表示-COR 2时，R 3为与R 2相同的烷基; X表示-OH，-NH 2或-NHCOR 4，其中R 4表示与R 2相同的烷基; Y表示-OH或-OCOR 5，其中R5表示与R2相同的烷基; Z表示= O或= NCOR 6，其中R6是与R2相同的烷基。

公开(公告)号：US4105690A

公开(公告)日：1978-08-08

申请号：US722284

申请日：1976-09-10

申请人： Yani Christidis ,  Alain Schouteeten

发明人： Yani Christidis ,  Alain Schouteeten

IPC分类号： C07C231/00 ,  C07C67/00 ,  C07C231/08 ,  C07C231/12 ,  C07C233/45 ,  C07C233/47 ,  C07C233/49 ,  C07C237/00 ,  C07D307/77 ,  C07C102/00 ,  C07C103/30 ,  C07C103/46 ,  C07C103/66

CPC分类号： C07D307/77 ,  C07C233/45 ,  C07C237/00

摘要： Condensation of the addition product of glyoxylic acid and amides with hydroxyaryl compounds is effected by a first step, wherein the reaction is carried out hot, at a temperature below 60.degree. C, of an aliphatic amide having at the most 4 carbon atoms selected from the group of acetamide, chloracetamide, propionamide, acrylamide and butyramide, on an aqueous solution of glyoxylic acid. Then in a second step, after the addition of acetic acid and gaseous hydrochloric acid, condensation is effected at a temperature below 35.degree. C of the carboxamidoglycolic acid with an excess reaching 500% of hydroxyaryl compound selected from the group comprising phenol and its alkyl derivatives, their halogen derivatives, polyphenols and their ethers and betanaphthol. After the condensation of said second step, the volatile products are removed by vacuum distillation. When the hydroxyaryl compound is phenol, the crude product resulting from this distillation is taken up in nitromethane or water, which are a non-solvent of the N-acyl derivative of parahydroxyphenylglycine but a solvent of the corresponding ortho derivative; the proportion of the para derivative in the resulting compound is then of the order of 100%.

摘要翻译： 乙醛酸和酰胺与羟基芳基化合物的加成产物的缩合是通过第一步进行的，其中反应在低于60℃的温度下进行，所述脂族酰胺选自最多4个碳原子， 乙酰胺，氯乙酰胺，丙酰胺，丙烯酰胺和丁酰胺的组合在乙醛酸水溶液中。 然后在第二步中，在加入乙酸和气态盐酸后，在羧酰胺聚糖酸的低于35℃的温度下进行冷凝，过量的达到500％的选自苯酚及其烷基衍生物的羟基芳基化合物 ，它们的卤素衍生物，多酚及其醚和β-萘酚。 在所述第二步骤冷凝后，通过真空蒸馏除去挥发性产物。 当羟基芳基化合物是苯酚时，由该蒸馏产生的粗产物溶于硝基甲烷或水中，硝基甲烷或水是对羟基苯基甘氨酸的N-酰基衍生物的非溶剂，但是相应的邻位衍生物的溶剂; 所得化合物中对位衍生物的比例为约100％。

公开(公告)号：US3544606A

公开(公告)日：1970-12-01

申请号：US3544606D

申请日：1969-01-21

申请人： GRACE W R & CO

发明人： SINGER JOHN J JR

IPC分类号： A61K31/195 ,  C07C233/45 ,  C07C103/46 ,  C07C103/66

CPC分类号： A61K31/195 ,  C07C233/45

公开(公告)号：US4719233A

公开(公告)日：1988-01-12

申请号：US929035

申请日：1986-11-10

申请人： Michael F. Rafferty ,  Graham Johnson

发明人： Michael F. Rafferty ,  Graham Johnson

IPC分类号： C07D257/04 ,  C07C103/46

CPC分类号： C07D257/04

摘要： Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headache, such as migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.

摘要翻译： 新型苯甲酸或苯甲酸酯衍生物，药物组合物及其使用方法是本发明。 用于治疗关节炎，哮喘，雷诺氏病，炎性肠病，三叉神经痛或疱疹性神经痛，炎症性眼病，牛皮癣，牙痛和头痛，尤其是血管性头痛，如偏头痛，丛状，混合型血管综合症，以及 作为非血管性紧张性头痛。

公开(公告)号：US4568763A

公开(公告)日：1986-02-04

申请号：US627382

申请日：1984-07-03

申请人： Kenneth G. Davenport ,  Charles B. Hilton

发明人： Kenneth G. Davenport ,  Charles B. Hilton

IPC分类号： C07C45/46 ,  C07C45/54 ,  C07C103/46 ,  C07C103/38 ,  C07C103/66 ,  C07C125/065

CPC分类号： C07C45/46 ,  C07C45/54

摘要： N-acyl-acyloxy aromatic amines, e.g. 4-acetoxyacetanilide (AAA), are prepared by reacting a hydroxy aromatic ketone, e.g. 4-hydroxyacetophenone, with hydroxylamine or a hydroxylamine salt and a base to obtain the ketoxime of the ketone, e.g. 4-hydroxyacetophenone oxime, and then subjecting the ketoxime to a Beckmann rearrangement and accompanying acylation by contacting the ketoxime with a carboxylic acid anhydride and a Beckmann rearrangement catalyst to form the N-acyl-acyloxy aromatic amine.

摘要翻译： N-酰基 - 酰氧基芳族胺，例如 4-乙酰氧基乙酰苯胺（AAA），通过使羟基芳族酮例如 4-羟基苯乙酮，与羟胺或羟胺盐和碱反应，得到酮的酮肟。 然后通过使酮肟与羧酸酐和贝克曼重排催化剂接触形成N-酰基酰氧基芳香胺，然后使酮肟进行贝克曼重排和伴随的酰化反应。