System and method for blood separation by microfluidic acoustic focusing

    公开(公告)号:US09731062B2

    公开(公告)日:2017-08-15

    申请号:US13598401

    申请日:2012-08-29

    Abstract: Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study.

    GRAFTING METHOD TO IMPROVE CHROMATOGRAPHY MEDIA PERFORMANCE
    5.
    发明申请
    GRAFTING METHOD TO IMPROVE CHROMATOGRAPHY MEDIA PERFORMANCE 审中-公开
    提高色谱介质性能的方法

    公开(公告)号:US20130225701A1

    公开(公告)日:2013-08-29

    申请号:US13812965

    申请日:2010-07-29

    Abstract: The invention relates to improved methods of grafting polymer extenders onto porous substrates having diffusive pores, such as those used in protein separations, without filing the diffusive pores of the substrate, and restricting diffusion there through. By changing the grafting conditions and/or monomer composition(s) the resulting porous substrates having polymer extenders grafted thereto have increased protein binding capacity and resin selectivity, thereby enhancing the protein separation effectiveness of the substrate. The grafted polymer extenders provide the substrate with significant binding capacity at higher conductivity. The invention also relates to kits, and methods of using and grafting polymer extenders on porous resin substrates having diffusive pores.

    Abstract translation: 本发明涉及将聚合物增强剂接枝到具有扩散孔的多孔基底上的改进方法,例如蛋白质分离中使用的那些,而不填充底物的扩散孔,并限制其中的扩散。 通过改变接枝条件和/或单体组成,所得到的具有接枝到其上的聚合物延伸剂的多孔基材具有增加的蛋白质结合能力和树脂选择性,从而提高了基材的蛋白质分离效率。 接枝的聚合物增量剂在较高的导电率下为基材提供了显着的结合能力。 本发明还涉及在具有扩散孔的多孔树脂基材上使用和接枝聚合物增强剂的试剂盒和方法。

    PLASMA PURIFYING DEVICE AND METHOD OF CONTROLLING PLASMA PURIFYING DEVICE
    6.
    发明申请
    PLASMA PURIFYING DEVICE AND METHOD OF CONTROLLING PLASMA PURIFYING DEVICE 有权
    等离子体净化装置和控制等离子体净化装置的方法

    公开(公告)号:US20110284467A1

    公开(公告)日:2011-11-24

    申请号:US13129703

    申请日:2009-11-09

    Inventor: Soichiro Okazaki

    Abstract: A plasma purifying device is provided that is capable of recovering blood and plasma remaining within the plasma purifying device easily and without risk of coagulation, following completion of plasma purification therapy. The plasma purifying device has a control unit controls flow rates of the air pump and a plasma pump so that a pressure of the filtration side space of the plasma separator is higher than a pressure of the blood side space while delivering blood to the blood side space of the plasma separator by continuing to operate a blood pump without stopping following completion of plasma purification and then delivers plasma remaining in a filtration side space of a plasma separator to a blood side space of the plasma separator or to a plasma circuit by supplying air from an air pump.

    Abstract translation: 提供了一种等离子体净化装置,其能够在完成血浆纯化治疗后容易地回收血浆和血浆净化装置中剩余的血浆和血浆,而没有凝结的危险。 等离子体净化装置具有控制单元,其控制空气泵和等离子体泵的流量,使得等离子体分离器的过滤侧空间的压力高于血液侧空间的压力,同时将血液输送到血液侧空间 通过在血浆纯化完成后继续操作血液泵而不停止操作血液泵,然后将等离子体分离器的过滤侧空间中剩余的血浆输送到血浆分离器的血液侧空间或等离子体回路中, 一个气泵。

    COMB POLYMERS FOR SUPRAMOLECULAR NANOCONFINEMENT
    7.
    发明申请
    COMB POLYMERS FOR SUPRAMOLECULAR NANOCONFINEMENT 有权
    用于SUPRAMOLECULAR NANOCONFINEMENT的COMB聚合物

    公开(公告)号:US20110178190A1

    公开(公告)日:2011-07-21

    申请号:US12974042

    申请日:2010-12-21

    Abstract: Polymers including pendent hydrophobic groups and pendent proton transfer groups are shown to form nanostructured films exhibiting greatly increased proton conductivity compared with films prepared from corresponding polymers lacking hydrophobic groups. The polymers can include repeating units each of which has both a hydrophobic group and a proton transfer group. Alternatively, the polymers can be the product of copolymerizing a first monomer with at least one hydrophobic group and a second monomer with at least one proton transfer group. The polymers are useful for the preparation of fuel cell proton exchange membranes.

    Abstract translation: 显示出包括悬挂的疏水基团和悬挂的质子转移基团的聚合物形成与相应的缺乏疏水基团的聚合物制备的膜相比显示出大大提高的质子传导性的纳米结构膜。 聚合物可以包括各自具有疏水基团和质子转移基团的重复单元。 或者,聚合物可以是使第一单体与至少一个疏水基团和第二单体与至少一个质子转移基团共聚的产物。 该聚合物可用于制备燃料电池质子交换膜。

    Catalysts for Olefin Hydration and Method of Preparation
    8.
    发明申请
    Catalysts for Olefin Hydration and Method of Preparation 审中-公开
    烯烃水合催化剂及其制备方法

    公开(公告)号:US20110136926A1

    公开(公告)日:2011-06-09

    申请号:US12962798

    申请日:2010-12-08

    CPC classification number: B01J31/10 B01J2231/645

    Abstract: The present invention is directed to a polystyrene cation exchange resin catalyst for olefin hydration comprises: monomer units of (a) 7.5 to 11.5 wt % at least one polyvinylaromatic monomer and (b) 88.5 to 92.5 wt % at least one monovinylaromatic monomer; (c) 0.75 to 1.20 SO3H moiety on each aromatic ring of the polymer backbone; and (d) 0.70 to 1.20 halogen on each aromatic ring of the polymer backbone. The present invention also provides a method for preparing the catalyst including the steps of copolymerization, sulfonation, halogenation, and post treatment. Optimization of the copolymer crosslinking degree, sulfonation and halogenation extent enables the catalyst with a balance of catalysis activity and thermal stability.

    Abstract translation: 本发明涉及用于烯烃水合的聚苯乙烯阳离子交换树脂催化剂,其包含:(a)7.5至11.5wt%的至少一种聚乙烯基芳族单体和(b)88.5至92.5wt%的至少一种单乙烯基芳族单体的单体单元; (c)在聚合物主链的每个芳环上为0.75至1.20个SO 3 H部分; 和(d)聚合物主链的每个芳香环上的0.70至1.20个卤素。 本发明还提供了一种制备催化剂的方法,包括共聚,磺化,卤化和后处理的步骤。 共聚物交联度,磺化和卤化程度的优化使得催化剂具有催化活性和热稳定性的平衡。

    System and Method for Selectively Removing Ions From Acidic Solutions
    9.
    发明申请
    System and Method for Selectively Removing Ions From Acidic Solutions 有权
    从酸性溶液中选择性去除离子的系统和方法

    公开(公告)号:US20100206814A1

    公开(公告)日:2010-08-19

    申请号:US12372361

    申请日:2009-02-17

    CPC classification number: B01J47/00 B01J39/04 B01J45/00

    Abstract: A system for selectively removing at least one undesirable ion from an acidic solution including a tank receiving the acidic solution, a chiller in fluid communication with the tank, the chiller being configured to reduce a temperature of the acidic solution, and an ion exchanger in fluid communication with the chiller, the ion exchanger including an ion exchange resin that is selective for the undesirable ion.

    Abstract translation: 一种用于选择性地从包括接收酸性溶液的罐的酸性溶液中除去至少一种不需要的离子的系统,与罐流体连通的冷却器,所述冷却器被配置为降低酸性溶液的温度,以及流体中的离子交换剂 与冷却器的通信,离子交换器包括对不期望的离子具有选择性的离子交换树脂。

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