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公开(公告)号：US10058493B2
公开(公告)日：2018-08-28
申请号：US15386031
申请日：2016-12-21
发明人： Lisa Manus , Julia Dreifus
IPC分类号： A61Q11/00 , A61K8/88 , A61K8/27 , A61K8/362 , G01N33/50 , A61K8/44 , A61K8/21 , A61K8/70 , A61K8/81
CPC分类号： A61K8/27 , A61K8/21 , A61K8/362 , A61K8/44 , A61K8/70 , A61K8/8152 , A61K8/8164 , A61K8/88 , A61Q11/00 , G01N33/50 , Y10S514/901
摘要： This invention relates to oral care compositions comprising arginine, zinc citrate and zinc oxide, and an orally acceptable carrier, as well as to methods of using and of making these compositions.
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公开(公告)号：US20180168960A1
公开(公告)日：2018-06-21
申请号：US15386031
申请日：2016-12-21
发明人： Lisa MANUS , Julia DREIFUS
CPC分类号： A61K8/27 , A61K8/21 , A61K8/362 , A61K8/44 , A61K8/70 , A61K8/8152 , A61K8/8164 , A61K8/88 , A61Q11/00 , G01N33/50 , Y10S514/901
摘要： This invention relates to oral care compositions comprising arginine, zinc citrate and zinc oxide, and an orally acceptable carrier, as well as to methods of using and of making these compositions.
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公开(公告)号：US08852652B2
公开(公告)日：2014-10-07
申请号：US13691958
申请日：2012-12-03
发明人： Zvi G. Loewy , William Zev Levine , Aron J. Saffer
CPC分类号： A61K9/7015 , A61K8/4926 , A61K8/97 , A61K9/0056 , A61K9/006 , A61K36/23 , A61K36/28 , A61K36/35 , A61Q11/00 , Y10S514/901
摘要： Provided, among other things, is a method of treating or ameliorating an indication of mucosal or adjacent tissue comprising periodically applying to mucosa at or adjacent to disease affected tissue a rinse comprising: an effective amount of appropriate composition of herbal bioactive comprising active(s) of one or more of Sambucus nigra, Centella asiatica or Echinacea purpurea; an antimicrobially effective amount of a quaternary ammonium surfactant; and optionally a polymer or mixture of polymers effective to coat said tissue and entrap said extract(s).
摘要翻译： 提供了一种治疗或改善粘膜或相邻组织的适应症的方法，包括在疾病影响组织或邻近疾病影响组织周期性施用粘膜，包括：有效量的草药生物活性物质的合适组合物， 黑腹果皮，积雪草或紫锥菊中的一种或多种; 抗微生物有效量的季铵表面活性剂; 和任选的聚合物或聚合物混合物，其有效地涂覆所述组织并截留所述提取物。
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公开(公告)号：US20120052022A1
公开(公告)日：2012-03-01
申请号：US13097297
申请日：2011-04-29
申请人： Rebecca Dayanim
发明人： Rebecca Dayanim
IPC分类号： A61C19/06 , A61K8/66 , A61K38/43 , A61C17/00 , A61Q11/00 , A61C5/02 , A61C5/00 , A61K9/68 , A61K38/44
CPC分类号： A61K8/66 , A61C19/063 , A61C19/066 , A61K8/24 , A61K8/36 , A61K8/42 , A61K8/43 , A61K8/55 , A61K8/676 , A61K8/678 , A61K8/97 , A61K31/355 , A61K31/375 , A61K36/185 , A61K38/44 , A61K45/06 , A61K2800/92 , A61Q11/00 , Y10S514/901 , A61K2300/00
摘要： The present invention provides compositions and related methods for oral health treatment of a subject. Compositions of the invention include an anti-oxidant enzyme, an anti-inflammatory agent, and a pharmaceutically acceptable buffer. In certain embodiments, the compositions are administered to the subjection in conjunction with teeth whitening, oral surgery, oral pathology treatment, endodontic therapy, periodontal therapy, dental restoration, preventative tooth cleaning, or subsequent to a pro-oxidant.
摘要翻译： 本发明提供了用于对象的口腔健康治疗的组合物和相关方法。 本发明的组合物包括抗氧化剂酶，抗炎剂和药学上可接受的缓冲剂。 在某些实施方案中，将组合物与牙齿美白，口腔外科，口腔病理学治疗，牙髓治疗，牙周治疗，牙齿修复，预防性牙齿清洁或随后的促氧化剂联合施用于受试者。
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公开(公告)号：US07850996B2
公开(公告)日：2010-12-14
申请号：US10497504
申请日：2002-12-04
申请人： Peter Kössler , Norbert Fuchs , Bodo Kuklinski
发明人： Peter Kössler , Norbert Fuchs , Bodo Kuklinski
CPC分类号： A61K33/04 , A61K31/19 , A61K31/194 , A61K33/00 , Y10S514/90 , Y10S514/901 , Y10S514/902
摘要： The use of selenite- or selenate-containing preparations supplemented with pharmaceutically acceptable or food-compatible acids for the preparation of an agent intended for topical or buccal application or mucosal administration is described.
摘要翻译： 描述了补充有药学上可接受的或食品相容的酸的含亚硒酸盐或含硒酸盐的制剂用于制备用于局部或口腔施用或粘膜施用的药剂的用途。
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公开(公告)号：US07470437B2
公开(公告)日：2008-12-30
申请号：US10985204
申请日：2004-11-10
申请人： Robert E. Burrell , John B. Wright , Kan Lam , Antony G. Naylor , Peter H. Moxham , Scott H. Gillis , Paul Schechter
发明人： Robert E. Burrell , John B. Wright , Kan Lam , Antony G. Naylor , Peter H. Moxham , Scott H. Gillis , Paul Schechter
CPC分类号： A61K8/19 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/0078 , A61K9/14 , A61K9/1682 , A61K9/51 , A61K9/7007 , A61K9/7023 , A61K31/28 , A61K33/24 , A61K33/38 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K2800/413 , A61L15/44 , A61L15/46 , A61L17/145 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/082 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/624 , A61L2300/63 , A61Q17/005 , A61Q19/00 , B82Y5/00 , Y10S514/901 , Y10S514/951 , A61K2300/00
摘要： Methods of treating conditions with a metal-containing material are disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.
摘要翻译： 公开了用含金属材料处理条件的方法。 含金属材料可以是例如抗微生物材料，抗菌材料，抗炎材料，抗真菌材料，抗病毒材料，抗癌材料，原凋亡物质和 /或MMP调节材料。 在某些实施方案中，含金属的材料是原子上无序的含银材料。
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公开(公告)号：US07078021B2
公开(公告)日：2006-07-18
申请号：US10344046
申请日：2001-08-09
CPC分类号： A61Q11/00 , A61K8/64 , A61K38/1709 , Y10S514/899 , Y10S514/90 , Y10S514/901
摘要： Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promoted bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.
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公开(公告)号：US20050271743A1
公开(公告)日：2005-12-08
申请号：US11174104
申请日：2005-07-01
申请人： Robert Burrell , Hua Yin
发明人： Robert Burrell , Hua Yin
IPC分类号： A61K9/02 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/12 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/51 , A61K9/68 , A61K9/70 , A61K33/24 , A61K33/38 , A61K33/40 , A61K47/34 , A61K47/38 , A61L15/44 , A61L15/46 , A61L17/14 , A61L27/30 , A61L29/10 , A61L31/08 , A61P1/00 , A61P1/02 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/04 , A61P13/00 , A61P13/08 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/08 , A61P17/10 , A61P19/00 , A61P19/02 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P35/00 , A61P43/00
CPC分类号： A61K9/0024 , A01N59/16 , A61K9/0019 , A61K9/0075 , A61K9/0078 , A61K9/14 , A61K9/7007 , A61K33/24 , A61K33/38 , A61K33/40 , A61K47/34 , A61K47/38 , A61L15/46 , A61L17/145 , A61L27/30 , A61L29/10 , A61L31/082 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/452 , A61L2300/606 , A61L2300/624 , A61L2300/63 , Y10S424/15 , Y10S514/825 , Y10S514/826 , Y10S514/829 , Y10S514/83 , Y10S514/849 , Y10S514/851 , Y10S514/853 , Y10S514/861 , Y10S514/862 , Y10S514/864 , Y10S514/865 , Y10S514/88 , Y10S514/881 , Y10S514/882 , Y10S514/886 , Y10S514/887 , Y10S514/90 , Y10S514/901 , Y10S514/902 , Y10S514/912 , Y10S514/914 , Y10S514/925 , Y10S514/931 , Y10S514/932 , Y10S514/933 , Y10S514/934 , Y10S514/944 , Y10S514/951 , Y10S514/953 , Y10S514/954 , Y10S514/956 , Y10S514/958 , Y10S514/964 , Y10S514/965 , Y10S514/966 , Y10S514/967 , Y10S514/968 , Y10S514/969 , Y10T428/31855 , A61K2300/00 , A01N25/04 , A01N25/10 , A01N25/12
摘要： The invention relates to the use of one or more antimicrobial metals, most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of inflammatory skin conditions. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.
摘要翻译： 本发明涉及一种或多种抗微生物金属，最优选银，优选以原子紊乱形成，优选以纳米晶形式用于治疗炎性皮肤病症的用途。 所选择的纳米晶体抗微生物金属可以以一种或多种抗微生物金属的纳米晶体涂层的形式使用，一种或多种抗微生物金属的纳米晶体粉末，或含有来自纳米晶体粉末或一种或多种抗微生物剂 金属。
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公开(公告)号：US06946118B1
公开(公告)日：2005-09-20
申请号：US09661836
申请日：2000-09-14
IPC分类号： A61K9/00 , A61K9/16 , A61K31/65 , A61K47/36 , A61P1/00 , A61K9/14 , A61K7/16 , A61K9/10 , A61K9/20
CPC分类号： A61K31/65 , A61K9/006 , A61K9/0095 , A61K9/1652 , A61K9/1676 , A61K47/36 , Y10S514/901
摘要： Mucositis is treated and/or prevented by administrating to a patient a formulation comprising a tetracycline that is poorly absorbed from the gastro-intestinal tract. The tetracycline may be in the form of a pharmaceutically acceptable salt or a base. The formulations may optionally also contain an antifungal agent to prevent fungal overgrowth due to reduction in the normal oral flora by the tetracycline. Such compositions have the advantage of treating the entire gastro-intestinal tract since the active ingredient is not removed from the tract via absorption. Further, such compositions minimize systemic exposure and accompanying side effects.
摘要翻译： 通过向患者施用包含从胃肠道吸收不良的四环素的制剂来治疗和/或预防粘膜炎。 四环素可以是药学上可接受的盐或碱的形式。 制剂还可任选地含有抗真菌剂，以防止由四环素引起的正常口腔菌群减少引起的真菌过度生长。 这样的组合物具有治疗整个胃肠道的优点，因为活性成分不通过吸收从道路中除去。 此外，这样的组合物使全身暴露和伴随的副作用最小化。
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公开(公告)号：US06939568B2
公开(公告)日：2005-09-06
申请号：US10131511
申请日：2002-04-23
IPC分类号： A61K9/02 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/12 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/51 , A61K9/68 , A61K9/70 , A61K33/24 , A61K33/38 , A61K33/40 , A61K47/34 , A61K47/38 , A61L15/44 , A61L15/46 , A61L17/14 , A61L27/30 , A61L29/10 , A61L31/08 , A61P1/00 , A61P1/02 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/04 , A61P13/00 , A61P13/08 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/08 , A61P17/10 , A61P19/00 , A61P19/02 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P35/00 , A61P43/00 , A61K33/00 , A61K31/28 , A61K31/282 , A61K31/295
CPC分类号： A61K9/0024 , A01N59/16 , A61K9/0019 , A61K9/0075 , A61K9/0078 , A61K9/14 , A61K9/7007 , A61K33/24 , A61K33/38 , A61K33/40 , A61K47/34 , A61K47/38 , A61L15/46 , A61L17/145 , A61L27/30 , A61L29/10 , A61L31/082 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/452 , A61L2300/606 , A61L2300/624 , A61L2300/63 , Y10S424/15 , Y10S514/825 , Y10S514/826 , Y10S514/829 , Y10S514/83 , Y10S514/849 , Y10S514/851 , Y10S514/853 , Y10S514/861 , Y10S514/862 , Y10S514/864 , Y10S514/865 , Y10S514/88 , Y10S514/881 , Y10S514/882 , Y10S514/886 , Y10S514/887 , Y10S514/90 , Y10S514/901 , Y10S514/902 , Y10S514/912 , Y10S514/914 , Y10S514/925 , Y10S514/931 , Y10S514/932 , Y10S514/933 , Y10S514/934 , Y10S514/944 , Y10S514/951 , Y10S514/953 , Y10S514/954 , Y10S514/956 , Y10S514/958 , Y10S514/964 , Y10S514/965 , Y10S514/966 , Y10S514/967 , Y10S514/968 , Y10S514/969 , Y10T428/31855 , A61K2300/00 , A01N25/04 , A01N25/10 , A01N25/12
摘要： The invention relates to the use of one or more antimicrobial metals, most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of inflammatory skin conditions. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.
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