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公开(公告)号：US07470437B2
公开(公告)日：2008-12-30
申请号：US10985204
申请日：2004-11-10
申请人： Robert E. Burrell , John B. Wright , Kan Lam , Antony G. Naylor , Peter H. Moxham , Scott H. Gillis , Paul Schechter
发明人： Robert E. Burrell , John B. Wright , Kan Lam , Antony G. Naylor , Peter H. Moxham , Scott H. Gillis , Paul Schechter
CPC分类号： A61K8/19 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/0078 , A61K9/14 , A61K9/1682 , A61K9/51 , A61K9/7007 , A61K9/7023 , A61K31/28 , A61K33/24 , A61K33/38 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K2800/413 , A61L15/44 , A61L15/46 , A61L17/145 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/082 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/624 , A61L2300/63 , A61Q17/005 , A61Q19/00 , B82Y5/00 , Y10S514/901 , Y10S514/951 , A61K2300/00
摘要： Methods of treating conditions with a metal-containing material are disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.
摘要翻译： 公开了用含金属材料处理条件的方法。 含金属材料可以是例如抗微生物材料，抗菌材料，抗炎材料，抗真菌材料，抗病毒材料，抗癌材料，原凋亡物质和 /或MMP调节材料。 在某些实施方案中，含金属的材料是原子上无序的含银材料。
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公开(公告)号：US07078060B2
公开(公告)日：2006-07-18
申请号：US10364983
申请日：2003-02-12
申请人： Robert E. Burrell , John B. Wright , Kan Lam , Hua Qing Yin , Antony G. Naylor , Peter H. Moxham , Scott H. Gillis , Paul Schechter
发明人： Robert E. Burrell , John B. Wright , Kan Lam , Hua Qing Yin , Antony G. Naylor , Peter H. Moxham , Scott H. Gillis , Paul Schechter
CPC分类号： A61K9/0024 , A61K8/19 , A61K9/0019 , A61K9/0078 , A61K9/14 , A61K9/1682 , A61K9/51 , A61K9/7007 , A61K9/7023 , A61K31/28 , A61K33/24 , A61K33/38 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K2800/413 , A61L15/46 , A61L17/145 , A61L27/30 , A61L29/10 , A61L31/082 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/63 , A61Q17/005 , A61Q19/00 , B82Y5/00 , Y10S514/858 , Y10S514/859 , Y10S514/865 , Y10S514/886 , Y10S514/887 , Y10S514/936 , Y10S514/937 , Y10S514/938 , Y10S514/946 , Y10S514/964 , A61K2300/00
摘要： Solutions and aerosols of metal-containing compounds are disclosed. Methods of preparing and using the solutions and aerosols, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.
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公开(公告)号：US20050129624A1
公开(公告)日：2005-06-16
申请号：US10985204
申请日：2004-11-10
申请人： Robert Burrell , Scott Gillis , Paul Schechter , Antony Naylor , Peter Moxham , John Wright , Kan Lam
发明人： Robert Burrell , Scott Gillis , Paul Schechter , Antony Naylor , Peter Moxham , John Wright , Kan Lam
IPC分类号： A61K8/19 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/51 , A61K9/70 , A61K31/28 , A61K33/24 , A61K33/38 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61L15/46 , A61L17/14 , A61L27/30 , A61L29/10 , A61L31/08 , A61Q17/00 , A61Q19/00 , A61L9/04 , A61K33/00
CPC分类号： A61K8/19 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/0078 , A61K9/14 , A61K9/1682 , A61K9/51 , A61K9/7007 , A61K9/7023 , A61K31/28 , A61K33/24 , A61K33/38 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K2800/413 , A61L15/44 , A61L15/46 , A61L17/145 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/082 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/624 , A61L2300/63 , A61Q17/005 , A61Q19/00 , B82Y5/00 , Y10S514/901 , Y10S514/951 , A61K2300/00
摘要： Methods of treating conditions with a metal-containing material are disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.
摘要翻译： 公开了用含金属材料处理条件的方法。 含金属材料可以是例如抗微生物材料，抗菌材料，抗炎材料，抗真菌材料，抗病毒材料，抗癌材料，原凋亡物质和 /或MMP调节材料。 在某些实施方案中，含金属的材料是原子上无序的含银材料。
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公开(公告)号：US07001617B2
公开(公告)日：2006-02-21
申请号：US10159587
申请日：2002-05-30
CPC分类号： A61K9/0024 , A61K9/0014 , A61K9/0075 , A61K9/14 , A61K9/7007 , A61K33/24 , A61K33/38 , A61L15/46 , A61L17/145 , A61L27/30 , A61L29/10 , A61L31/082 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/434 , A61L2300/63 , Y10S514/825 , Y10S514/878 , Y10S514/951 , Y10S514/964 , A61K2300/00
摘要： The invention relates to a method to induce apoptosis and to inhibit matrix metalloproteinases in a disease condition in a human or animal by contacting hyperplastic tissue, tumor tissue, or a cancerous lesion with one or more antimicrobial metals, preferably formed with atomic disorder, and preferably in a nanocrystalline form. In another aspect of the invention, there is provided a method of preventing excessive release of matrix metalloproteinases from an inflammatory cell in a disease condition in a human or an animal by contacting the cell with a therapeutically effective amount of a noble metal in a crystalline form characterized by atomic disorder, or with a solution derived therefrom to provide a modulatory effect on one or more matrix metalloproteinases, wherein the one or more noble metals is formed with atomic disorder, and preferably in a nanocrystalline form. The nanocrystalline antimicrobial or noble metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial or noble metals, a nanocrystalline powder of one or more antimicrobial or noble metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial or noble metals.
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公开(公告)号：US06692773B2
公开(公告)日：2004-02-17
申请号：US09916757
申请日：2001-07-27
IPC分类号： A61K3324
CPC分类号： A61Q17/005 , A61K8/19 , A61K9/0014 , A61K9/7023 , A61K33/38 , A61K47/32 , A61K47/38 , A61K2800/413 , A61Q19/00 , B82Y5/00 , Y10S514/86 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/886 , Y10S514/887 , Y10S514/944 , Y10S514/951 , Y10S514/963
摘要： The invention relates to the use of one or more noble metals selected from silver, gold, platinum, and palladium but most preferably silver, in a nanocrystalline form, for the treatment of a hyperproliferative skin disorder or disease such as psoriasis. Among the noble metals, silver is preferred for such treatment. The nanocrystalline noble metal of choice may be used in the form of a nanocrystalline coating of one or more noble metals, a nanocrystalline powder of one or more noble metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more noble metals.
摘要翻译： 本发明涉及一种或多种选自银，金，铂和钯，但最优选银的贵金属以纳米晶形式用于治疗过度增生性皮肤病或疾病如牛皮癣的用途。 在贵金属中，优选这种处理的银。 所选择的纳米晶体贵金属可以以一种或多种贵金属的纳米晶体涂层，一种或多种贵金属的纳米晶体粉末或含有一种或多种贵金属的纳米晶体粉末或涂层的溶解物质的溶液的形式使用 金属。
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