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    Methods for production of the oxidized glutathione composite with cis-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells
    3.
    发明授权
    Methods for production of the oxidized glutathione composite with cis-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells 有权
    用顺式二氨基二氯铂制备氧化型谷胱甘肽复合物的方法和基于其调节正常和转化细胞的代谢，增殖，分化和凋亡机制的药物组合物

    公开(公告)号：US06312734B1

    公开(公告)日：2001-11-06

    申请号：US09241232

    申请日：1999-02-01

    Applicant: Leonid A. Kozhemyakin ,  Mark B. Balasovski

    Inventor： Leonid A. Kozhemyakin ,  Mark B. Balasovski

    IPC: A61K3324

    CPC classification number: A61K33/24 ,  A61K38/063 ,  A61K38/08 ,  A61K47/54 ,  A61K47/62 ,  C07K5/0215 ,  A61K2300/00

    Abstract: The present invention relates to a composite for the treatment of a variety of medical conditions, the composite comprising an oxidized glutathione-based compound, which has a disulfide bond, and a metal material, in particular where the metal is either platinum or palladium. The oxidized glutathione-based compound and metal material can be present in a ratio of 3000 to 1 and preferably 1000 to 1. The oxidized glutathione-based compound can be oxidized glutathione itself or salts or derivatives. A feature of the invention is that the composite has a more stabilized disulfide bond than the oxidized glutathione-based compound itself. Methods for preparing the composite are provided, such methods being beneficial in that the composite is provided in high yields and at high purity. Methods for treating various medical conditions with the composites of the present invention are also disclosed.

    Abstract translation: 本发明涉及用于治疗各种医学病症的复合物，所述复合物包含具有二硫键的氧化型谷胱甘肽基化合物和金属材料，特别是在金属为铂或钯的情况下。 氧化型谷胱甘肽基化合物和金属材料可以以3000比1，优选1000比1的比例存在。氧化型谷胱甘肽基化合物可以是氧化型谷胱甘肽本身或其盐或衍生物。 本发明的一个特征是复合物比氧化型谷胱甘肽基化合物本身具有更稳定的二硫键。 提供了制备复合材料的方法，这些方法有益于以高产率和高纯度提供复合材料。 还公开了用本发明的复合材料处理各种医疗状况的方法。

    Method and composition for inhibiting bacteria
    8.
    再颁专利
    Method and composition for inhibiting bacteria 有权
    抑制细菌的方法和组成

    公开(公告)号：USRE37793E1

    公开(公告)日：2002-07-16

    申请号：US09687144

    申请日：2000-10-13

    Applicant: Philip Domenico

    Inventor： Philip Domenico

    IPC: A61K3324

    CPC classification number: A61K33/245 ,  A61K31/095 ,  A61K33/24 ,  A61K2300/00

    Abstract: A composition comprising a trivalent bismuth salt, particularly bismuth nitrate, and dimercaprol is described. Methods for using the composition as a bacteriocidal and bacteriostatic agent and as a disinfectant and preservative are also provided.

    Abstract translation: 描述了包含三价铋盐，特别是硝酸铋和二巯基丙酸的组合物。 还提供了使用该组合物作为杀菌和抑菌剂以及作为消毒剂和防腐剂的方法。

    N,N-dinitramide salts as solubilizing agents for biologically active agents
    9.
    发明授权
    N,N-dinitramide salts as solubilizing agents for biologically active agents 失效
    N，N-二硝酸盐作为生物活性剂的增溶剂

    公开(公告)号：US06833478B2

    公开(公告)日：2004-12-21

    申请号：US09905577

    申请日：2001-07-13

    Applicant: Jeffrey C. Bottaro ,  Mark A. Petrie ,  Paul E. Penwell ,  David C. Bomberger

    Inventor： Jeffrey C. Bottaro ,  Mark A. Petrie ,  Paul E. Penwell ,  David C. Bomberger

    IPC: A61K3324

    CPC classification number: C07D453/04 ,  A01N25/02 ,  A61K47/02 ,  A61K47/52 ,  C07C211/32 ,  C07C2603/32

    Abstract: A method is provided for enhancing the solubility of an ionizable compound in a lipophilic medium by admixing the compound with an effective solubility-enhancing amount of an N,N-dinitramide salt. The ionizable compound, upon ionization, gives rise to a biologically active cationic species that ionically associates with the N,N-dinitramide anion N(NO2)2− following admixture with the N,N-dinitramide salt. The biologically active cationic species may be a pharmacologically active cation, in which case the method is useful for enhancing the penetration of the blood-brain barrier by the pharmacologically active cation. In other embodiments, the ionizable compounds are medical imaging or diagnostic agents, or agricultural agents such as pesticides. Salts of biologically active cations and N,N-dinitramide ion are also provided as novel compositions of matter.

    Abstract translation: 提供了一种通过将化合物与有效增加溶解度的N，N-二硝酸盐进行混合来提高可离子化化合物在亲脂性介质中的溶解度的方法。 离子化化合物在与N，N-二硝酸盐混合后产生与N，N-二硝基酰胺阴离子N（NO 2）2 - 离子键合的生物活性阳离子物质。 生物活性阳离子物质可以是药理学活性阳离子，在这种情况下，该方法可用于通过药理学活性阳离子增强血脑屏障的渗透。 在其它实施方案中，可电离化合物是医学成像或诊断剂，或农药如农药。 还提供生物活性阳离子和N，N-二硝酸根离子的盐作为物质的新组合物。

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