公开(公告)号：US20090139618A1

公开(公告)日：2009-06-04

申请号：US10213538

申请日：2002-08-06

Applicant: Mark A. Petrie ,  Jeffrey C. Bottaro ,  Paul E. Penwell ,  Allen L. Dodge

Inventor： Mark A. Petrie ,  Jeffrey C. Bottaro ,  Paul E. Penwell ,  Allen L. Dodge

IPC: C06B45/10

CPC classification number: C06B25/34 ,  C07C291/04

Abstract: Novel compounds are provided in the form of a salt having the structure of formula (I) or formula (II) wherein: R1 is selected from the group consisting of H, C1-C24 alkyl, C2-C24 alkenyl, C2-C24 alkynyl, C5-C20 aryl, C6-C24 alkaryl, and C6-C24 aralkyl; R2 is H, C1-C24 alkyl or nitro; X is O or NR3 in which R3 is H, C1-C24 alkyl or nitro; Zm+ is a monovalent cation, a divalent cation, or a trivalent cation; M+ is an alkali metal cation; and m and n are 1, 2 or 3, with the proviso that the compound contains at least one nitro group. Exemplary such compounds are the ammonium salt of the N-hydroxyl-N′-nitrourea (NHNU) monoanion and the disodium salt of the NHNU dianion. Also provided, as novel compositions of matter, are N-hydroxyl-N′-nitrourea and N-hydroxyl-N-nitroguanidine in electronically neutral form. The compounds are useful in a variety of contexts, but are primarily useful as high energy oxidizing agents in explosive compositions, propellant formulations, gas-generating compositions, and the like. Compositions containing the compounds are also provided, including energetic compositions, as are methods for synthesizing the compounds.

Abstract translation: 提供具有式（I）或式（II）结构的盐形式的新型化合物，其中：R 1选自H，C 1 -C 24烷基，C 2 -C 24烯基，C 2 -C 24炔基， C 5 -C 20芳基，C 6 -C 24烷芳基和C 6 -C 24芳烷基; R2是H，C1-C24烷基或硝基; X是O或NR 3，其中R 3是H，C 1 -C 24烷基或硝基; Zm +是一价阳离子，二价阳离子或三价阳离子; M +是碱金属阳离子; 并且m和n为1,2或3，条件是该化合物含有至少一个硝基。 示例性的这种化合物是N-羟基-N'-硝基脲（NHNU）单阴离子的铵盐和NHNU二价阴离子的二钠盐。 作为物质的新型组合物，还提供N-羟基-N'-硝基脲和N-羟基-N-硝基胍以电子中性形式。 这些化合物可用于各种情况，但主要用作爆炸组合物中的高能氧化剂，推进剂制剂，产气组合物等。 还提供了含有化合物的组合物，包括能量组合物，以及合成化合物的方法。

公开(公告)号：US06617064B2

公开(公告)日：2003-09-09

申请号：US09823379

申请日：2001-03-29

Applicant: Mark A. Petrie ,  Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Paul E. Penwell ,  David C. Bomberger

Inventor： Mark A. Petrie ,  Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Paul E. Penwell ,  David C. Bomberger

IPC: C01B600

CPC classification number: C06B45/10 ,  C01B6/06 ,  H01M4/242 ,  H01M8/065

Abstract: The present invention features methods for preparing stabilized &agr;-AlH3 and &agr;′-AlH3, compositions containing these alane polymorphs, e.g., energetic compositions such as rocket propellants, and methods for using the novel polymorphs as chemical reducing agents, polymerization catalysts, and as a hydrogen source in fuel cells and batteries. The method produces stabilized alane by treating &agr;-AlH3 with an acidic solution that optionally contains a stabilizing agent such as an electron donor, an electron acceptor, or a compound which coordinates the Al3+ ion.

Abstract translation: 本发明的特征在于制备稳定的α-AlH 3和α'-AlH 3的方法，包含这些甲烷多晶型物的组合物，例如能量组合物如火箭推进剂，以及使用新型多晶型物作为化学还原剂，聚合催化剂和作为 燃料电池和电池中的氢源。 该方法通过用任选地含有稳定剂如电子给体，电子受体或调节Al 3+离子的化合物的酸性溶液处理α-AlH 3来产生稳定的丙烷。

公开(公告)号：US06255512B1

公开(公告)日：2001-07-03

申请号：US09414977

申请日：1999-10-07

Applicant: Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Mark A. Petrie ,  Paul E. Penwell

Inventor： Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Mark A. Petrie ,  Paul E. Penwell

IPC: C07C24302

CPC classification number: C07D257/04 ,  C06B25/34 ,  C07C243/02 ,  C07D249/10

Abstract: Novel compounds are provided having the structural formula R[—N(NO2)—L—R1]n wherein R, L, R1 and n are defined herein. The compounds are useful in a variety of contexts, but are primarily to be used as high energy oxidizing agents in explosive compositions, propellant formulations, gas-generating compositions and the like. The compounds are also useful as pharmaceutical agents. Compositions containing the compounds are also provided, including energetic compositions, as are methods for using the novel compounds and compositions.

Abstract translation: 提供具有结构式R [-N（NO 2）-L-R 1] n的新化合物，其中R，L，R 1和n如本文所定义。 这些化合物可用于各种情况，但主要用作爆炸组合物中的高能氧化剂，推进剂制剂，产气组合物等。 这些化合物也可用作药剂。 还提供了含有化合物的组合物，包括能量组合物，以及使用新化合物和组合物的方法。

公开(公告)号：US06228338B1

公开(公告)日：2001-05-08

申请号：US09334359

申请日：1999-06-16

Applicant: Mark A. Petrie ,  Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Paul E. Penwell ,  David C. Bomberger

Inventor： Mark A. Petrie ,  Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Paul E. Penwell ,  David C. Bomberger

IPC: C01B600

CPC classification number: C06B45/10 ,  C01B6/06 ,  H01M4/242 ,  H01M8/065

Abstract: The present invention features methods for preparing stabilized &agr;-AlH3 and &agr;′-AlH3, compositions containing these alane polymorphs, e.g., energetic compositions such as rocket propellants, and methods for using the novel polymorphs as chemical reducing agents, polymerization catalysts, and as a hydrogen source in fuel cells and batteries. The method produces stabilized alane by treating &agr;-AlH3 with an acidic solution that optionally contains a stabilizing agent such as an electron donor, an electron acceptor, or a compound which coordinates the Al3+ ion.

Abstract translation: 本发明的特征在于制备稳定的α-AlH 3和α'-AlH 3的方法，包含这些甲烷多晶型物的组合物，例如能量组合物如火箭推进剂，以及使用新型多晶型物作为化学还原剂，聚合催化剂和作为 燃料电池和电池中的氢源。 该方法通过用任选地含有稳定剂如电子给体，电子受体或调节Al 3+离子的化合物的酸性溶液处理α-AlH 3来产生稳定的丙烷。

公开(公告)号：US06613926B1

公开(公告)日：2003-09-02

申请号：US09705232

申请日：2000-11-01

Applicant: Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Mark A. Petrie ,  Paul E. Penwell

Inventor： Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Mark A. Petrie ,  Paul E. Penwell

IPC: C07F902

CPC classification number: C07H19/06 ,  C07H19/10 ,  C07H19/20

Abstract: Novel compounds are provided in the form of nucleoside pyrophosphate and triphosphate analogs. In these analogs, the pyrophosphate or triphosphate group is replaced with a moiety that is isosterically and electronically identical thereto, but is hydrolytically and enzymatically more stable. The compounds are useful as therapeutic agents, e.g., as antiviral agents, anticancer agents, metabolic moderators and the like. The invention also provides pharmaceutical compositions containing a compound of the invention as an active agent, and in addition provides methods of treating disease, including viral infections, cancer, bacterial infections, inflammatory and/or autoimmune diseases, and the like, by administering a compound of the invention to a patient in need of such treatment.

Abstract translation: 新型化合物以焦磷酸核苷和三磷酸类似物的形式提供。 在这些类似物中，焦磷酸盐或三磷酸基团被等速和电子相同的部分置换，但在水解和酶学上更稳定。 这些化合物可用作治疗剂，例如作为抗病毒剂，抗癌剂，代谢调节剂等。 本发明还提供了含有作为活性剂的本发明化合物的药物组合物，并且还提供了通过给予化合物或其药学上可接受的盐的方法来治疗疾病，包括病毒感染，癌症，细菌感染，炎性和/或自身免疫疾病等， 本发明的患者需要这种治疗。

公开(公告)号：US06552051B2

公开(公告)日：2003-04-22

申请号：US09877319

申请日：2001-06-07

Applicant: Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Mark A. Petrie ,  Paul E. Penwell

Inventor： Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Mark A. Petrie ,  Paul E. Penwell

IPC: A61K314025

CPC classification number: C07D257/04 ,  C06B25/34 ,  C07C243/02 ,  C07D249/10

Abstract: Novel compounds are provided having the structural formula R[—N(NO2)—L—R1]n wherein R, L, R1 and n are defined herein. The compounds are useful in a variety of contexts, but are primarily to be used as high energy oxidizing agents in explosive compositions, propellant formulations, gas-generating compositions and the like. The compounds are also useful as pharmaceutical agents. Compositions containing the compounds are also provided, including energetic compositions, as are methods for using the novel compounds and compositions.

Abstract translation: 提供具有结构式R [-N（NO 2）-L-R 1] n的新化合物，其中R，L，R 1和n如本文所定义。 这些化合物可用于各种情况，但主要用作爆炸组合物中的高能氧化剂，推进剂制剂，产气组合物等。 这些化合物也可用作药剂。 还提供了含有化合物的组合物，包括能量组合物，以及使用新化合物和组合物的方法。

公开(公告)号：US06303774B1

公开(公告)日：2001-10-16

申请号：US09334069

申请日：1999-08-20

Applicant: Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Mark A. Petrie ,  Paul E. Penwell

Inventor： Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Mark A. Petrie ,  Paul E. Penwell

IPC: C07H1920

CPC classification number: C07H19/06 ,  C07H19/10 ,  C07H19/20

Abstract: Novel compounds are provided in the form of nucleoside pyrophosphate and triphosphate analogs. In these analogs, the pyrophosphate or triphosphate group is replaced with a moiety that is isosterically and electronically identical thereto, but is hydrolytically and enzymatically more stable. The compounds are useful as therapeutic agents, e.g., as antiviral agents, anticancer agents, metabolic moderators and the like. The invention also provides pharmaceutical compositions containing a compound of the invention as an active agent, and in addition provides methods of treating disease, including viral infections, cancer, bacterial infections, inflammatory and/or autoimmune diseases, and the like, by administering a compound of the invention to a patient in need of such treatment.

Abstract translation: 新型化合物以焦磷酸核苷和三磷酸类似物的形式提供。 在这些类似物中，焦磷酸盐或三磷酸基团被等速和电子相同的部分置换，但在水解和酶学上更稳定。 这些化合物可用作治疗剂，例如作为抗病毒剂，抗癌剂，代谢调节剂等。 本发明还提供了含有作为活性剂的本发明化合物的药物组合物，并且还提供了通过给予化合物或其药学上可接受的盐的方法来治疗疾病，包括病毒感染，癌症，细菌感染，炎性和/或自身免疫疾病等， 本发明的患者需要这种治疗。

公开(公告)号：US09327974B1

公开(公告)日：2016-05-03

申请号：US13671067

申请日：2012-11-07

Applicant: Mark A. Petrie

Inventor： Mark A. Petrie

IPC: C01B6/06 ,  C07B31/00 ,  C07B41/02 ,  C07C1/22 ,  C07C2/74 ,  C08F4/12 ,  H01M10/26 ,  H01M8/02 ,  H01M8/06

CPC classification number: C01B6/06 ,  C08F4/12 ,  H01M4/383 ,  H01M8/065 ,  Y02P70/56 ,  C08F10/00 ,  C08F4/52 ,  C08F4/60

Abstract: Methods for producing aluminum hydride are provided herein. Exemplary methods may include combining an amount of aluminum with an amount of a metal in such a way that a eutectic mixture is formed and treating the eutectic mixture with hydrogen gas to produce aluminum hydride. Various methods and processes are conducted under anhydrous conditions or within anhydrous systems.

Abstract translation: 本文提供了生产氢化铝的方法。 示例性的方法可以包括将铝的量与一定量的金属组合，使得形成共晶混合物并用氢气处理共晶混合物以产生氢化铝。 各种方法和方法在无水条件下或在无水体系内进行。

公开(公告)号：US06833478B2

公开(公告)日：2004-12-21

申请号：US09905577

申请日：2001-07-13

Applicant: Jeffrey C. Bottaro ,  Mark A. Petrie ,  Paul E. Penwell ,  David C. Bomberger

Inventor： Jeffrey C. Bottaro ,  Mark A. Petrie ,  Paul E. Penwell ,  David C. Bomberger

IPC: A61K3324

CPC classification number: C07D453/04 ,  A01N25/02 ,  A61K47/02 ,  A61K47/52 ,  C07C211/32 ,  C07C2603/32

Abstract: A method is provided for enhancing the solubility of an ionizable compound in a lipophilic medium by admixing the compound with an effective solubility-enhancing amount of an N,N-dinitramide salt. The ionizable compound, upon ionization, gives rise to a biologically active cationic species that ionically associates with the N,N-dinitramide anion N(NO2)2− following admixture with the N,N-dinitramide salt. The biologically active cationic species may be a pharmacologically active cation, in which case the method is useful for enhancing the penetration of the blood-brain barrier by the pharmacologically active cation. In other embodiments, the ionizable compounds are medical imaging or diagnostic agents, or agricultural agents such as pesticides. Salts of biologically active cations and N,N-dinitramide ion are also provided as novel compositions of matter.

Abstract translation: 提供了一种通过将化合物与有效增加溶解度的N，N-二硝酸盐进行混合来提高可离子化化合物在亲脂性介质中的溶解度的方法。 离子化化合物在与N，N-二硝酸盐混合后产生与N，N-二硝基酰胺阴离子N（NO 2）2 - 离子键合的生物活性阳离子物质。 生物活性阳离子物质可以是药理学活性阳离子，在这种情况下，该方法可用于通过药理学活性阳离子增强血脑屏障的渗透。 在其它实施方案中，可电离化合物是医学成像或诊断剂，或农药如农药。 还提供生物活性阳离子和N，N-二硝酸根离子的盐作为物质的新组合物。

公开(公告)号：US6096774A

公开(公告)日：2000-08-01

申请号：US168308

申请日：1998-10-07

Applicant: Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Mark A. Petrie ,  Paul E. Penwell

Inventor： Jeffrey C. Bottaro ,  Robert J. Schmitt ,  Mark A. Petrie ,  Paul E. Penwell

IPC: C07D249/08 ,  A61K31/132 ,  A61K31/4025 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/4196 ,  A61P1/06 ,  A61P1/16 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P15/00 ,  A61P15/06 ,  A61P15/10 ,  B01J7/00 ,  C06B25/34 ,  C06B43/00 ,  C06D5/00 ,  C07C243/02 ,  C07C251/58 ,  C07D207/335 ,  C07D207/34 ,  C07D207/42 ,  C07D209/44 ,  C07D233/95 ,  C07D249/10 ,  C07D249/14 ,  C07D257/04 ,  C07D257/06

CPC classification number: C07D257/04 ,  C06B25/34 ,  C07C243/02 ,  C07D249/10

Abstract: Novel compounds are provided having the structural formula R[--N(NO.sub.2)--L--R.sup.1 ].sub.n wherein R, L, R.sup.1 and n are defined herein. The compounds are useful in a variety of contexts, but are primarily to be used as high energy oxidizing agents in explosive compositions, propellant formulations, gas-generating compositions and the like. The compounds are also useful as pharmaceutical agents. Compositions containing the compounds are also provided, including energetic compositions, as are methods for using the novel compounds and compositions.

Abstract translation: 提供具有结构式R [-N（NO 2）-L-R 1] n的新化合物，其中R，L，R 1和n如本文所定义。 这些化合物可用于各种情况，但主要用作爆炸组合物中的高能氧化剂，推进剂制剂，产气组合物等。 这些化合物也可用作药剂。 还提供了含有化合物的组合物，包括能量组合物，以及使用新化合物和组合物的方法。