公开(公告)号：US5928671A

公开(公告)日：1999-07-27

申请号：US883584

申请日：1997-06-26

Applicant: Philip Domenico

Inventor： Philip Domenico

IPC: A61K33/24 ,  A61K33/36 ,  A61K31/095

CPC classification number: A61K33/245 ,  A61K31/095 ,  A61K33/24

Abstract: A composition comprising a trivalent bismuth salt, particularly bismuth nitrate, and dimercaprol is described. Methods for using the composition as a bacteriocidal and bacteriostatic agent and as a disinfectant and preservative are also provided.

公开(公告)号：US06248371B1

公开(公告)日：2001-06-19

申请号：US09543880

申请日：2000-04-06

Applicant: Philip Domenico

Inventor： Philip Domenico

IPC: A61K31095

CPC classification number: A61K33/36 ,  A61K31/095 ,  A61K31/44 ,  A61K33/24 ,  A61K33/245 ,  A61K2300/00

Abstract: Methods for administering a composition comprising bismuth and a thiol-containing complexing agent as a bacteriocidal, bacteriostatic, antifungal or antiviral agent are provided.

Abstract translation: 提供了包含铋和含巯基络合剂的组合物作为杀菌，抑菌，抗真菌或抗病毒剂的方法。

公开(公告)号：US20110092589A1

公开(公告)日：2011-04-21

申请号：US12920787

申请日：2009-03-10

Applicant: Dhanonjoy Saha ,  Philip Domenico

Inventor： Dhanonjoy Saha ,  Philip Domenico

IPC: A61K31/29 ,  A61P29/00 ,  A61P17/06 ,  A61P11/06 ,  A61P19/02 ,  A61P1/00 ,  A61P25/28 ,  A61P25/16 ,  A61P25/06 ,  A61P25/08

CPC classification number: A61K31/29 ,  A61K31/095 ,  A61K31/285 ,  A61K33/24 ,  A61K33/245 ,  A61K33/36 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides a method for the treatment of a disease or disorder related to an inflammatory condition comprising administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a metal and a thiol. In particular, embodiments of the present invention are directed towards methods of treating inflammatory conditions that are associated with elevated levels of free TNFα. In one embodiment, the present invention can be used to treat and/or ameliorate the effects of a wide variety of diseases or disorders related to an inflammatory condition including one or more of the following inflammation related diseases/disorders: arthritis, rheumatoid arthritis, asthma, psoriasis, systemic lupus erythematosus, inflammatory bowel syndrome, chronic obstructive respiratory diseases (COPD), fibromyalgia and the neurological diseases and disorders multiple sclerosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, vascular dementia, epilepsy, migraines, stroke and trauma.

Abstract translation: 本发明提供了治疗与炎性病症有关的疾病或病症的方法，包括向有需要的患者施用治疗有效量的包含金属和硫醇的药物组合物。 特别地，本发明的实施方案涉及治疗与升高的游离TNFα水平相关的炎性病症的方法。 在一个实施方案中，本发明可用于治疗和/或改善与炎性病症相关的各种疾病或病症的影响，包括以下与炎症相关的疾病/病症中的一种或多种：关节炎，类风湿性关节炎，哮喘 ，银屑病，系统性红斑狼疮，炎性肠综合征，慢性阻塞性呼吸系统疾病（COPD），纤维肌痛和神经系统疾病和病症多发性硬化，阿尔茨海默氏病，帕金森病，亨廷顿病，血管性痴呆，癫痫，偏头痛，中风和创伤。

公开(公告)号：US06380248B1

公开(公告)日：2002-04-30

申请号：US09601491

申请日：2000-12-14

Applicant: Philip Domenico ,  Dhanonjoy Saha

Inventor： Philip Domenico ,  Dhanonjoy Saha

IPC: A61K3129

CPC classification number: A61K33/36 ,  A61K31/095 ,  A61K31/145 ,  A61K31/28 ,  A61K31/285 ,  A61K31/29 ,  A61K31/433 ,  A61K31/53 ,  A61K33/24 ,  A61K33/245 ,  A61K47/54 ,  A61K47/547

Abstract: A method is described to treat or prevent sepsis and septic shock in a subject by administering a Group V metal chelated by a complexing agent such as thiol compounds in the form of a metal:complexing agent, wherein the metal is selected from the group consisting of bismuth, antimony and arsenic. Methods for modulating the immune system are also disclosed.

Abstract translation: 描述了一种治疗或预​​防受试者败血症和败血症休克的方法，该方法是通过施用由络合剂螯合的第V族金属，例如金属络合剂形式的硫醇化合物，其中金属选自 铋，锑和砷。 还公开了调节免疫系统的方法。

公开(公告)号：USRE37793E1

公开(公告)日：2002-07-16

申请号：US09687144

申请日：2000-10-13

Applicant: Philip Domenico

Inventor： Philip Domenico

IPC: A61K3324

CPC classification number: A61K33/245 ,  A61K31/095 ,  A61K33/24 ,  A61K2300/00

Abstract: A composition comprising a trivalent bismuth salt, particularly bismuth nitrate, and dimercaprol is described. Methods for using the composition as a bacteriocidal and bacteriostatic agent and as a disinfectant and preservative are also provided.

Abstract translation: 描述了包含三价铋盐，特别是硝酸铋和二巯基丙酸的组合物。 还提供了使用该组合物作为杀菌和抑菌剂以及作为消毒剂和防腐剂的方法。

公开(公告)号：US6086921A

公开(公告)日：2000-07-11

申请号：US960031

申请日：1997-10-28

Applicant: Philip Domenico

Inventor： Philip Domenico

IPC: A01N55/02 ,  A61K31/095 ,  A61K31/44 ,  A61K33/24 ,  A61K33/36 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A01N59/02 ,  A01N59/16 ,  A61K33/04

CPC classification number: A61K33/36 ,  A61K31/095 ,  A61K31/44 ,  A61K33/24 ,  A61K33/245

Abstract: A composition described wherein bismuth is chelated by a complexing agent such as a pyrithione or certain other thiol compounds in the form a metal:complexing agent complex. Methods for using the composition as a bacteriocidal, bacteriostatic, antibiofilm, antifungal, and antiviral agent and as a disinfectant and preservative are also provided.

Abstract translation: 描述的组合物，其中铋被络合剂例如吡啶硫酮或某些其它硫醇化合物以金属：络合剂络合物的形式螯合。 还提供了使用该组合物作为杀菌，抑菌，抗菌膜，抗真菌剂和抗病毒剂以及作为消毒剂和防腐剂的方法。