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    Dry powders of metal-containing compounds
    1.
    发明授权
    Dry powders of metal-containing compounds 有权

    公开(公告)号：US06866871B2

    公开(公告)日：2005-03-15

    申请号：US10277298

    申请日：2002-10-22

    申请人： Scott H. Gillis ,  Paul Schechter ,  Robert E. Burrell

    发明人： Scott H. Gillis ,  Paul Schechter ,  Robert E. Burrell

    摘要： Dry powders of metal-containing compounds are disclosed. Methods of preparing and using the dry powders, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

    Process of activating anti-microbial materials
    8.
    发明授权
    Process of activating anti-microbial materials 失效
    活化抗微生物物质的方法

    公开(公告)号：US5454886A

    公开(公告)日：1995-10-03

    申请号：US154490

    申请日：1993-11-18

    申请人： Robert E. Burrell ,  Catherine L. McIntosh ,  Larry R. Morris

    发明人： Robert E. Burrell ,  Catherine L. McIntosh ,  Larry R. Morris

    IPC分类号： A61L2/16 ,  A01N37/50 ,  A01N47/30 ,  A01N59/00 ,  A01N59/16 ,  A01N59/20 ,  A01N59/26 ,  A61L17/14 ,  A61L29/10 ,  C23C14/00 ,  C23C14/02 ,  C23C14/06 ,  C23C14/08 ,  C23C14/14 ,  C23C14/16 ,  C23C14/35 ,  C23C14/58 ,  A61F2/00

    CPC分类号： C23C14/588 ,  A01N59/16 ,  C23C14/0036 ,  C23C14/06 ,  C23C14/0688 ,  C23C14/14 ,  Y10S623/924

    摘要： Anti-microbial coatings and powders and method of forming same on medical devices are provided. The coatings are formed by depositing an anti-microbial biocompatible metal by vapour deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and a lower than normal angle of incidence of coating flux. Anti-microbial powders formed by mechanical working to produce atomic disorder are also provided. The anti-microbial effect of the coatings or powders may be further activated or enhanced by irradiating with a low linear energy transfer form of radiation such as gamma radiation.

    摘要翻译： 提供了抗微生物涂层和粉末及其在医疗装置上的形成方法。 通过气相沉积技术沉积抗微生物生物相容性金属以在涂层中产生原子紊乱形成涂层，从而实现足以产生抗微生物作用的金属离子的持续释放。 实现原子紊乱的优选沉积条件包括低于正常的衬底温度，以及高于正常工作气体压力和低于正常入射角的涂层焊剂的一种或多种。 还提供了通过机械加工形成的产生原子紊乱的抗微生物粉末。 通过用低线性能量转移形式的辐射如γ辐射照射可以进一步激活或增强涂层或粉末的抗微生物作用。