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1.发明申请INTEGRIN BINDING MOTIF CONTAINING PEPTIDES AND METHODS OF TREATING SKELETAL DISEASES 审中-公开含有胶原蛋白的蛋白结合胶原和治疗骨质疏松症的方法公开(公告)号：US20090042791A1
公开(公告)日：2009-02-12
申请号：US11925411
申请日：2007-10-26
CPC分类号： A61K8/64 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/16 , A61K38/1709 , A61Q11/00 , C07K14/47 , C07K14/4705 , C07K14/4728 , C07K14/705 , C07K14/78
摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.
摘要翻译： 公开了包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，糖胺聚糖结合基序和钙结合基序中的至少一种，并且与基质细胞外磷酸糖蛋白中的RGD序列连续的氨基酸的其余部分。 这些序列可以配制用于注射或分散在牙膏或漱口剂或牙龈贴片中并且被施用以增强骨/牙齿生长和/或减少体内过量的尿中磷酸盐的损失。
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公开(公告)号：US20090029915A1
公开(公告)日：2009-01-29
申请号：US11926460
申请日：2007-10-29
CPC分类号： A61K38/1703 , Y02A50/473
摘要： A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.
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公开(公告)号：US20090023634A1
公开(公告)日：2009-01-22
申请号：US11926726
申请日：2007-10-29
CPC分类号： A61K38/1703 , Y02A50/473
摘要： A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.
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公开(公告)号：US06306822B1
公开(公告)日：2001-10-23
申请号：US09193214
申请日：1998-11-16
申请人： Yoshinari Kumagai , Akira Otaka
发明人： Yoshinari Kumagai , Akira Otaka
IPC分类号： A61K3800
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , Y10T436/16
摘要： Phosphopeptides which significantly reduce bone loss or weakening are provided by the invention. Also provided is a method for treating or preventing any condition associated with bone loss or weakening by administering the phosphopeptides by oral or injectable means.
摘要翻译： 通过本发明提供显着减少骨丢失或减弱的磷酸肽。 还提供了通过口服或注射方式施用磷酸肽来治疗或预防与骨丢失或减弱有关的任何病状的方法。
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公开(公告)号：US20090163413A1
公开(公告)日：2009-06-25
申请号：US12108374
申请日：2008-04-23
CPC分类号： A61Q11/00 , A61K8/64 , A61K38/1709 , Y10S514/899 , Y10S514/90 , Y10S514/901
摘要： Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promotes bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.
摘要翻译： 公开了诸如牙膏，漱口剂和牙线的牙科产品，其通过在其上溶解，分散或涂覆促进骨生长的化合物来增强产品。 优选的化合物是包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，并且在基质细胞外磷酸糖蛋白中与RGD序列连续的氨基酸残基。 可以将这些序列配制成用于分散在牙膏或漱口剂中并施用以增强骨/牙齿生长。 当牙科产品随着时间的推移被多次使用时，它们可以提高牙齿健康。
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公开(公告)号：US20050065068A1
公开(公告)日：2005-03-24
申请号：US10918082
申请日：2004-08-12
申请人： Yoshinari Kumagai , Akira Otaka
发明人： Yoshinari Kumagai , Akira Otaka
摘要： Peptidic compounds which significantly reduce serum phosphate levels and which, in addition, reduce bone loss or weakening are provided by the invention. Also provided is a method for treating or preventing any condition associated with elevated serum phosphate levels by administering the peptidic compounds by oral or injectable means.
摘要翻译： 本发明提供了显着降低血清磷酸盐水平并且另外减少骨丢失或减弱的肽化合物。 还提供了通过口服或注射方式施用肽化合物来治疗或预防与升高的血清磷酸盐水平相关的任何病症的方法。
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公开(公告)号：US20090062201A1
公开(公告)日：2009-03-05
申请号：US12167491
申请日：2008-07-03
CPC分类号： A61K8/64 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/16 , A61K38/1709 , A61Q11/00 , C07K14/47 , C07K14/4705 , C07K14/4728 , C07K14/705 , C07K14/78
摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.
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公开(公告)号：US20090018064A1
公开(公告)日：2009-01-15
申请号：US11926716
申请日：2007-10-29
CPC分类号： A61K38/1703 , Y02A50/473
摘要： A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.
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公开(公告)号：US20070066514A1
公开(公告)日：2007-03-22
申请号：US11466673
申请日：2006-08-23
IPC分类号： A61K38/22
CPC分类号： A61K38/1703 , Y02A50/473
摘要： A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.
摘要翻译： 公开了一种在患者体内测量钙，磷酸盐和甲状旁腺激素水平的方法。 用包含具有磷酸肌醇蛋白活性的化合物的制剂治疗患者，然后再次进行测量。 基于测量，根据需要，连续重复测量，施用和调整剂量来调节配方的剂量。
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10.发明申请INTEGRIN BINDING MOTIF CONTAINING PEPTIDES AND METHODS OF TREATING SKELETAL DISEASES 审中-公开含有胶原蛋白的蛋白结合胶原和治疗骨质疏松症的方法公开(公告)号：US20070014742A1
公开(公告)日：2007-01-18
申请号：US11531583
申请日：2006-09-13
CPC分类号： A61K8/64 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/16 , A61K38/1709 , A61Q11/00 , C07K14/47 , C07K14/4705 , C07K14/4728 , C07K14/705 , C07K14/78
摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.
摘要翻译： 公开了包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，糖胺聚糖结合基序和钙结合基序中的至少一种，并且与基质细胞外磷酸糖蛋白中的RGD序列连续的氨基酸的其余部分。 这些序列可以配制用于注射或分散在牙膏或漱口剂或牙龈贴片中并且被施用以增强骨/牙齿生长和/或减少体内过量的尿中磷酸盐的损失。
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