公开(公告)号：US20250057878A1

公开(公告)日：2025-02-20

申请号：US18937758

申请日：2024-11-05

Applicant: CORTICALIS AS

Inventor： Ståle Petter Lyngstadaas ,  Håvard J. Haugen

IPC: A61K33/40 ,  A61K9/06 ,  A61K47/12 ,  A61P31/04

Abstract: The present invention relates to a new multifunctional debridement and/or antifouling composition comprising H2O2 at a final concentration of between 0.1-5% v/v, and a composite hydrogel formulation comprising pluronic acid at a concentration of 10-40% w/v, wherein the composition is in liquid form at room temperature. The composition disclosed herein is antimicrobial and/or anti-inflammatory and is particular useful in periimplantitis treatment and implant health maintenance, in periodontitis and periodontal health and in wound care and chronic ulcer care.

公开(公告)号：US12053488B2

公开(公告)日：2024-08-06

申请号：US18169061

申请日：2023-02-14

Applicant: LPOXY THERAPEUTICS, INC

Inventor： Larry D. Sutton

IPC: A61K9/00 ,  A61K9/20 ,  A61K9/48 ,  A61K33/40 ,  C12N9/08

CPC classification number: A61K33/40 ,  A61K9/0053 ,  A61K9/20 ,  A61K9/4808 ,  C12N9/0065 ,  C12Y111/01006

Abstract: Agents, kits, and methods that utilize oxygenation to treat Inflammatory Bowel Disease (IBD) and/or provide prophylaxis against exacerbation of IBD are provided. In several embodiments, the agents, kits, and methods according to several embodiments generate in, or carry to, oxygen in the intestinal lumen to treat IBD and provide prophylaxis against exacerbation of IBD, including those caused by the presence of anaerobic bacteria in the intestine. The agents, kits, and methods provided herein generate an aerobic environment within the intestine to alleviate intestinal inflammation.

公开(公告)号：US11872310B2

公开(公告)日：2024-01-16

申请号：US17148043

申请日：2021-01-13

Applicant: LG Household & Health Care Ltd.

Inventor： Ji-Young Kim ,  Jae-Hyun Ahn ,  In-Ho Lee

IPC: A61K8/02 ,  A61K8/21 ,  A61K8/67 ,  A61K8/97 ,  A61K9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K33/16 ,  A61K47/14 ,  A61K47/38 ,  A61K36/575 ,  A61Q11/00 ,  A61K8/81 ,  A61K31/194 ,  A61K36/23 ,  A61K33/40 ,  A61K33/30 ,  A61K31/355 ,  A61K8/73 ,  A61K8/25 ,  A61K31/055 ,  A61K31/155 ,  A61K33/42 ,  A61K47/10 ,  A61K47/12 ,  A61K47/02 ,  A61K47/32 ,  A61K47/36

CPC classification number: A61K9/06 ,  A61K8/25 ,  A61K8/733 ,  A61K8/8129 ,  A61K9/0056 ,  A61K9/0063 ,  A61K31/055 ,  A61K31/155 ,  A61K31/194 ,  A61K31/355 ,  A61K33/16 ,  A61K33/30 ,  A61K33/40 ,  A61K33/42 ,  A61K36/23 ,  A61K36/575 ,  A61K47/10 ,  A61K47/12 ,  A61Q11/00 ,  A61K47/02 ,  A61K47/32 ,  A61K47/36 ,  A61K31/355 ,  A61K2300/00 ,  A61K36/575 ,  A61K2300/00 ,  A61K36/23 ,  A61K2300/00

Abstract: The present invention provides a preparation for attaching to teeth or tooth peripheries. The preparation for attaching to teeth or tooth peripheries of the present invention can give high adhesive force to the desired site despite interproximal space or curves of teeth. It is easy to hand while controlling drug release.

公开(公告)号：US20240009342A1

公开(公告)日：2024-01-11

申请号：US18155518

申请日：2023-01-17

Applicant: Imbed Biosciences Inc.

Inventor： Ankit Agarwal ,  Gaurav Pranami ,  Tyler B. Nelson ,  Anna M. O'Keefe ,  Nicholas L. Abbott ,  Eric Crawford

IPC: A61L15/44 ,  A61K9/70 ,  A61L15/46 ,  A61K31/155 ,  A61K33/40 ,  A61K31/485 ,  A61K33/24 ,  A61K31/445 ,  A61K31/785 ,  A61K33/18 ,  A61K31/4468 ,  A61K31/19 ,  A61K31/381 ,  A61K31/167 ,  A61F13/02 ,  A61K31/713 ,  A61K33/38 ,  A61K47/32 ,  A61L15/18 ,  A61L15/24 ,  C12N15/113

CPC classification number: A61L15/44 ,  A61K9/7007 ,  A61L15/46 ,  A61K31/155 ,  A61K33/40 ,  A61K31/485 ,  A61K33/24 ,  A61K31/445 ,  A61K31/785 ,  A61K33/18 ,  A61K31/4468 ,  A61K31/19 ,  A61K31/381 ,  A61K31/167 ,  A61F13/0289 ,  A61K9/7092 ,  A61K31/713 ,  A61K33/38 ,  A61K47/32 ,  A61L15/18 ,  A61L15/24 ,  C12N15/113 ,  A61L2300/42 ,  A61L2300/41 ,  A61L2300/414 ,  A61F2240/001 ,  A61L2300/104 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2400/12 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2420/08 ,  C12N2310/14

Abstract: The present invention relates to large scale manufacture of nanoscale microsheets for use in applications such as wound healing or modification of a biological or medical surface.

公开(公告)号：US11850303B2

公开(公告)日：2023-12-26

申请号：US16949376

申请日：2020-10-27

Applicant: Uqora, Inc.

Inventor： Spencer Gordon

IPC: A61K9/06 ,  A61K9/02 ,  A61K31/191 ,  A61K31/7016 ,  A61K31/702 ,  A61K33/40 ,  A61K35/747

CPC classification number: A61K9/06 ,  A61K9/02 ,  A61K31/191 ,  A61K31/702 ,  A61K31/7016 ,  A61K33/40 ,  A61K35/747

Abstract: A gel and suppository and method to provide the gel and the suppository, are disclosed herein. The gel comprising: between 50 and 150 millimolar of lactic acid concentrate; and between 0.5 and 10 millimolar of hydrogen peroxide concentrate. The suppository comprising: between 22.5 and 67.5 milligrams of lactic acid concentrate; and between 1 and 20 milligrams of hydrogen peroxide concentrate.

公开(公告)号：US11844832B2

公开(公告)日：2023-12-19

申请号：US16994500

申请日：2020-08-14

Applicant: Najít Technologies, Inc.

Inventor： Ian J. Amanna ,  Elizabeth A. Poore

IPC: A61K39/12 ,  C12N7/00 ,  A61P31/14 ,  A61K39/145 ,  A61K39/02 ,  A61K33/40 ,  A61P31/16 ,  A61K39/112 ,  A61K39/275 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61K33/40 ,  A61K39/02 ,  A61K39/0283 ,  A61K39/105 ,  A61K39/12 ,  A61K39/275 ,  A61P31/14 ,  A61P31/16 ,  C12N7/00 ,  A61K2039/521 ,  A61K2039/5252 ,  C12N2760/16131 ,  C12N2760/16134 ,  C12N2760/16163 ,  C12N2760/16171 ,  C12N2770/24134 ,  C12N2770/24163 ,  C12N2770/24171 ,  C12N2770/36134 ,  C12N2770/36163 ,  C12N2770/36171 ,  Y02A50/30

Abstract: Provided are methods for rapidly inactivating a pathogen, or for producing a vaccine composition containing an inactivated noninfectious pathogen having retained antigenicity and/or immunogenicity, comprising exposing the pathogen to a chemical inactivating agent (e.g., one or more chemical oxidizing, alkylating or crosslinking agents) in the presence of inorganic polyatomic oxyanions in an amount and for a time sufficient to render the pathogen noninfectious while enhancing retention of pathogen antigenicity and/or immunogenicity relative to that retained by contacting the pathogen with the chemical inactivating agent alone. The methods are broadly applicable to pathogens having RNA or DNA genomes (e.g., including viruses, bacteria, fungi, and parasites). Also provided are vaccine compositions (medicaments) containing a pathogen inactivated by exposure to an inactivating agent in the presence of elevated concentrations of inorganic polyatomic oxyanions, and methods for eliciting an immune response in a subject by administering the vaccine compositions.

公开(公告)号：US11839608B2

公开(公告)日：2023-12-12

申请号：US16894723

申请日：2020-06-05

Applicant: Richard Steven Trela

Inventor： Richard Steven Trela

IPC: A61K31/455 ,  A61P31/04 ,  A61K9/08 ,  A61K9/00 ,  A61K8/49 ,  A61K8/22 ,  A61Q11/00 ,  A61K33/40 ,  A61K9/68 ,  A61K9/70 ,  A61K9/06 ,  A61Q7/00

CPC classification number: A61K31/455 ,  A61K8/22 ,  A61K8/4926 ,  A61K9/0014 ,  A61K9/0058 ,  A61K9/06 ,  A61K9/08 ,  A61K9/7015 ,  A61K33/40 ,  A61P31/04 ,  A61Q7/00 ,  A61Q11/00 ,  A61K2800/70 ,  A61K2800/87 ,  A61K2800/92

Abstract: The disclosed invention provides an antibacterial pro-coagulant formula for assisting in combating the condition of bleeding gums caused by periodontal disease and gingivitis that enhances the natural healing process by assisting in the of cessation of bleeding by providing an “anti-bacterial oral healing environment” accompanied by enhanced blood flow to the affected bleeding area for more rapid blood clotting and increased blood flow to the affected area to assist the body's natural process of rebuilding healthy gum-tissue. Additionally, the disclosed invention with its antibacterial benefits, when used topically, provides for rapid surface skin blood clotting as well as increased blood circulation on the skin surface which greatly aids in the healing of external skin cuts, such as nicks from shaving or against inflammation of the skin from acne vulgaris. Continued use of the product orally and topically has proven to provide a beneficial stability to overall oral and skin health, especially useful in promoting healing in high-bacterial environments, such as is common in a person's mouth or on their face. Further described is a method of promoting hair follicle growth by application of the presented invention to a human scalp to promote blood flow to the scalp through below skin surface blood vessel dilation and below surface anti-bacterial cleansing of the scalp effecting an unrestricted and healthy skin tissue environment conducive to promoting hair follicle re-growth.

公开(公告)号：US20230355664A1

公开(公告)日：2023-11-09

申请号：US18313924

申请日：2023-05-08

Applicant: SOAKNESS LLC

Inventor： Gabriel Zada

IPC: A61K33/00 ,  A61K33/06 ,  A61K33/40 ,  A61K36/899

CPC classification number: A61K33/00 ,  A61K33/06 ,  A61K33/40 ,  A61K36/899

Abstract: Disclosed herein are embodiments of therapeutic substances that contain solid sodium percarbonate for use in a bath, and packaging for the therapeutic substances. The solid sodium percarbonate can be dissolved in a liquid, such as water, to produce a hydrogen peroxide solution. Hydrogen peroxide solutions can be provide beneficial effects to a user. The titrated sodium percarbonate can be mixed with other chemicals/materials in a pre-made packaging for ease of storage and using with a bath.

公开(公告)号：US20230240951A1

公开(公告)日：2023-08-03

申请号：US18113963

申请日：2023-02-24

Applicant: The Research Foundation for the State University of New York

Inventor： Marvin COHEN ,  Susanne COHEN ,  Robert FLYNN

IPC: A61K8/27 ,  A61K8/368 ,  A61K8/19 ,  A61K8/92 ,  A61Q11/00 ,  A61K31/4425 ,  A61K33/40 ,  A61K33/30 ,  A61K9/08 ,  A61K31/435 ,  A61K8/34 ,  A61K9/00 ,  A61K8/49 ,  A61K45/06 ,  A61K33/20 ,  A61K8/36 ,  A61K8/20 ,  A61K8/22 ,  A61K47/10 ,  A61K47/02

CPC classification number: A61K8/27 ,  A61K8/368 ,  A61K8/19 ,  A61K8/922 ,  A61Q11/00 ,  A61K31/4425 ,  A61K33/40 ,  A61K33/30 ,  A61K9/08 ,  A61K31/435 ,  A61K8/345 ,  A61K9/0063 ,  A61K8/4926 ,  A61K45/06 ,  A61K33/20 ,  A61K8/36 ,  A61K8/20 ,  A61K8/22 ,  A61K47/10 ,  A61K47/02 ,  A61K2800/92 ,  A61K2800/882

Abstract: Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.

公开(公告)号：US11712450B2

公开(公告)日：2023-08-01

申请号：US17142610

申请日：2021-01-06

Applicant: LIVELEAF HOLDINGS, LLC

Inventor： Alexander L Huang ,  Gin Wu

IPC: A61K33/40 ,  A61K36/185 ,  A61K36/82 ,  A01N59/00 ,  A61K36/00 ,  A61K31/05

CPC classification number: A61K33/40 ,  A01N59/00 ,  A61K31/05 ,  A61K36/00 ,  A61K36/185 ,  A61K36/82 ,  A01N2300/00 ,  A01N59/00 ,  A01N25/08 ,  A01N25/22 ,  A01N65/08 ,  A01N65/20 ,  A01N65/40 ,  A01N65/42 ,  A01N65/44

Abstract: The present invention is directed to a method and a composition for producing and using a plant-based biocidal solution. The plant-based biocidal solution contains a bioactive material and a plant-based substance formed from the cellular material of a plant. The plant-based substance is capable of binding to the bioactive material. In some embodiments, the bioactive material is hydrogen peroxide. The hydrogen peroxide can be added exogenously or generated endogenously. In accordance with further embodiments, the plant-based biocidal solution can be applied to a target, thereby impairing the target. In some embodiments, the target can be a pathogen. In accordance with another embodiment, the plant-based substance of the plant-based biocidal solution can form a microscopic cluster, a complex, or an aggregate for providing sufficient bioactive material to overcome the defense mechanism of the target.