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1.发明申请公开(公告)号：US20140141077A1
公开(公告)日：2014-05-22
申请号：US13992772
申请日：2012-07-02
申请人： Shyh-Shyan Lin
发明人： Shyh-Shyan Lin
IPC分类号： A61K47/36 , A61K31/606
CPC分类号： A61K47/36 , A61K9/02 , A61K31/606 , A61K31/728 , A61K45/06 , Y10S424/15 , A61K2300/00
摘要： The present invention is related to a use for treating and preventing inflammation related disorder of a composition containing a drug and hyaluronic acid (HA) or HA mixture, whereas the HA or the HA mixture as a delivery vehicle can be a formulation including at least two HAs having different average molecular weights. The composition has been demonstrated to be capable of reducing the therapeutic dose of a drug on the treatment and prevention of inflammation related disorders is acute inflammatory disease, chronic obstructed pulmonary disease, coeliac disease, conjunctivitis, otitis, allergic rhinitis, gingivitis, aphthous ulcer, bronchitis, gastroesophageal reflux disease (GERD), esophagitis, gastritis, enteritis, peptic ulcer, inflammatory bowel disease (IBD), Crohn's Disease, irritable bowel syndrome (IBS), intestinal inflammation or allergy, urethritis, cystitis, vaginitis, proctitis, eosinophilic gastroenteritis, or rheumatoid arthritis.
摘要翻译： 本发明涉及用于治疗和预防含有药物和透明质酸（HA）或HA混合物的组合物的炎症相关病症的用途，而作为递送载体的HA或HA混合物可以是包含至少两种 HAs具有不同的平均分子量。 已经证明该组合物能够降低药物治疗和预防炎症相关疾病的治疗剂量是急性炎性疾病，慢性阻塞性肺病，乳糜泻，结膜炎，耳炎，过敏性鼻炎，牙龈炎，口疮性溃疡， 支气管炎，胃食管反流病（GERD），食管炎，胃炎，肠炎，消化性溃疡，炎性肠病（IBD），克罗恩病，肠易激综合征（IBS），肠道炎症或过敏，尿道炎，膀胱炎，阴道炎，直肠炎，嗜酸性胃肠炎 ，或类风湿性关节炎。
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公开(公告)号：US08196745B2
公开(公告)日：2012-06-12
申请号：US12767839
申请日：2010-04-27
IPC分类号： B65D83/04
CPC分类号： A61M31/00 , A61M31/007 , Y10S424/15 , Y10S514/966
摘要： A suppository delivery device that allows for the insertion of a suppository without having contact with the suppository or rectum. The suppository delivery device includes a stabilizing platform, a stabilizer to which the suppository is mounted, and a package, which protects the user's hands and fingers from the suppository and rectum and prevents germs from contacting the suppository before being inserted into the rectum.
摘要翻译： 一种栓剂递送装置，其允许插入栓剂而不与栓剂或直肠接触。 栓剂递送装置包括稳定平台，安装栓剂的稳定剂和包装，其保护使用者的手和手指免于栓剂和直肠，并防止细菌在插入直肠之前接触栓剂。
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公开(公告)号：US20100204644A1
公开(公告)日：2010-08-12
申请号：US12767839
申请日：2010-04-27
CPC分类号： A61M31/00 , A61M31/007 , Y10S424/15 , Y10S514/966
摘要： A suppository delivery device that allows for the insertion of a suppository without having contact with the suppository or rectum. The suppository delivery device includes a stabilizing platform, a stabilizer to which the suppository is mounted, and a package, which protects the user's hands and fingers from the suppository and rectum and prevents germs from contacting the suppository before being inserted into the rectum.
摘要翻译： 一种栓剂递送装置，其允许插入栓剂而不与栓剂或直肠接触。 栓剂递送装置包括稳定平台，安装栓剂的稳定剂和包装，其保护使用者的手和手指免于栓剂和直肠，并防止细菌在插入直肠之前接触栓剂。
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4.发明授权公开(公告)号：US06635631B2
公开(公告)日：2003-10-21
申请号：US09983656
申请日：2001-10-25
IPC分类号： A61K31295
CPC分类号： A61K31/295 , A61K31/351 , A61K31/555 , C07D307/62 , Y10S424/15 , Y10S514/814 , Y10S514/815
摘要： The present invention is directed to complexes comprising iron in the ferric state and a hydroxypyrone. The present invention is also directed to methods of making such complexes and to the use of such complexes in the treatment and prevention of iron deficiency disorders including iron deficiency anaemia.
摘要翻译： 本发明涉及包含铁状态的铁和羟基吡喃酮的络合物。 本发明还涉及制备这种复合物的方法以及这种复合物在治疗和预防缺铁性贫血（包括缺铁性贫血）中的应用。
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5.发明申请公开(公告)号：US20030069218A1
公开(公告)日：2003-04-10
申请号：US09983656
申请日：2001-10-25
IPC分类号： A61K031/555 , C07F015/00
CPC分类号： A61K31/295 , A61K31/351 , A61K31/555 , C07D307/62 , Y10S424/15 , Y10S514/814 , Y10S514/815
摘要： The present invention is directed to complexes comprising iron in the ferric state and a hydroxypyrone. The present invention is also directed to methods of making such complexes and to the use of such complexes in the treatment and prevention of iron deficiency disorders including iron deficiency anaemia.
摘要翻译： 本发明涉及包含铁状态的铁和羟基吡喃酮的络合物。 本发明还涉及制备这种复合物的方法以及这种复合物在治疗和预防缺铁性贫血（包括缺铁性贫血）中的应用。
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公开(公告)号：US20020068683A1
公开(公告)日：2002-06-06
申请号：US09975093
申请日：2001-10-12
发明人： Minoru Kojima
IPC分类号： C10M101/00
CPC分类号： C10M171/06 , C10M107/28 , Y10S424/15
摘要： The present invention relates to a water-soluble solid composition that produces a lubricating liquid when dissolved in water. The composition is preferably prepared by kneading particles of a solid, such as sodium polyacrylate, with water and one or more optional additives to form a mixture. This kneaded mixture is then molded or otherwise formed into a desired shape, preferably one that is easily held such as a lump, sphere, or rod. The shaped composition may also be provided with a partial cover of a water-insoluble material or other modified surface so that it may be held more securely. In use a dry portion of the solid composition can be held in the hand and applied to an area of moistened skin to apply a lubricating liquid without also applying the lubricating liquid to the hand. Similarly, a portion of the solid composition may be moistened and then rubbed on dry skin to apply a lubricating liquid to the skin.
摘要翻译： 本发明涉及当溶于水时产生润滑液的水溶性固体组合物。 组合物优选通过将诸如聚丙烯酸钠的固体的颗粒与水和一种或多种任选的添加剂捏合以形成混合物来制备。 然后将该捏合的混合物模制或以其它方式形成为所需的形状，优选容易保持的形状，例如块状，球形或棒状。 成形组合物还可以设置有水不溶性材料或其它改性表面的部分覆盖物，使得其可以更牢固地保持。 在使用中，固体组合物的干燥部分可以保持在手中并施加到润湿皮肤的区域以施加润滑液体，而不将润滑液施加到手上。 类似地，固体组合物的一部分可以被润湿，然后在干燥的皮肤上摩擦，以向皮肤施加润滑液体。
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7.发明授权公开(公告)号：US06274132B1
公开(公告)日：2001-08-14
申请号：US09706219
申请日：2000-11-03
申请人： Perry A. Ratcliff
发明人： Perry A. Ratcliff
IPC分类号： A61K900
CPC分类号： A61K9/0014 , A61K8/20 , A61K8/22 , A61K8/24 , A61K33/40 , A61K33/42 , A61K47/02 , A61Q11/00 , A61Q15/00 , Y10S424/15 , Y10S514/887 , Y10S514/931 , Y10S514/934 , Y10S514/937 , Y10S514/944 , Y10S514/966 , Y10S514/967 , Y10S514/968 , A61K2300/00
摘要： A method and solution or gel composition containing activated chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for lubricating the vagina and for treating HIV. The preferred concentration ranges are between about 0.005% to about 2.0% chlorine dioxide, and between about 0.02% to about 3.0% phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of about 6.0 to 7.4, at which pH the chlorine dioxide becomes activated and releases sufficient chlorine dioxide to reduce motility and become lethal to the involved micro-organisms.
摘要翻译： 公开了含有活性二氧化氯和磷酸盐的方法和溶液或凝胶组合物，例如磷酸氢二钠，磷酸二氢钠，磷酸三钠和单氟磷酸钠，用于润滑阴道和治疗HIV。 优选的浓度范围为约0.005％至约2.0％的二氧化氯和约0.02％至约3.0％的磷酸盐。 磷酸盐化合物在约6.0至7.4的pH范围内阻止二氧化氯的逸出，其中二氧化氯在该pH被激活并释放足够的二氧化氯以降低运动性并对所涉及的微生物致死。
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公开(公告)号：US06200590B1
公开(公告)日：2001-03-13
申请号：US09131591
申请日：1998-08-10
申请人： John Graham Eley
发明人： John Graham Eley
IPC分类号： A01N4322
CPC分类号： A61K9/5146 , A61K9/025 , A61K9/5153 , Y10S424/15 , Y10S514/965 , Y10S977/70 , Y10S977/801 , Y10S977/906 , Y10S977/915
摘要： A phased-release suppository delivery system is disclosed wherein microscopic polymeric “nanospheres” ladened with one or more active agents are homogeneously incorporated within a pharmaceutically acceptable suppository base. The preparation of the “nanospheres” allows the spheres to be transported, substantially intact, across fenestrated membranes such as the capillary membranes of the rectum. The method of preparation of the “nanospheres” allows for the controlled release of active agent(s) only after a substantial number of the spheres have been transported across the capillary membrane of the rectum or other body cavity and have been taken up into the systemic circulation system.
摘要翻译： 公开了一种分阶段释放栓剂递送系统，其中用一种或多种活性剂负载的微观聚合物“纳米球”均匀地并入药学上可接受的栓剂基质中。 “纳米球”的制备允许将球体基本上完整地输送到诸如直肠毛细血管的开窗膜上。 “纳米球”的制备方法只有在将大量的球体输送穿过直肠或其他体腔的毛细血管膜并且已经被吸收到系统中才能控制释放活性剂 流通系统。
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公开(公告)号：US6110489A
公开(公告)日：2000-08-29
申请号：US71457
申请日：1998-05-01
申请人： Neal R. Cutler
发明人： Neal R. Cutler
CPC分类号： A61K31/47 , Y10S424/15
摘要： Methods for treating male erectile dysfunction are provided. The methods of the present invention comprise the utilization of pharmaceutical compositions to induce erections in males with male erectile dysfunction. The pharmaceutical compositions comprise quinolines and quinolones, as well as derivatives thereof.
摘要翻译： 提供了治疗男性勃起功能障碍的方法。 本发明的方法包括利用药物组合物诱发雄性勃起功能障碍的男性勃起。 药物组合物包含喹啉和喹诺酮以及其衍生物。
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10.发明授权
公开(公告)号：US5834003A
公开(公告)日：1998-11-10
申请号：US831932
申请日：1997-04-02
申请人： Perry A. Ratcliff
发明人： Perry A. Ratcliff
IPC分类号： A61K8/20 , A61K8/22 , A61K8/24 , A61K9/00 , A61K33/40 , A61K33/42 , A61K47/02 , A61Q11/00 , A61Q15/00 , A61Q19/00 , A61K33/00
CPC分类号： A61K47/02 , A61K33/40 , A61K33/42 , A61K8/20 , A61K8/22 , A61K8/24 , A61K9/0014 , A61Q11/00 , A61Q15/00 , Y10S424/15 , Y10S514/944 , Y10S514/945 , Y10S514/966 , Y10S514/967 , Y10S514/968
摘要： A method for oxidatively consuming volatile sulfur compounds selected from the group consisting of dimethylsulfide, hydrogen sulfide, and methylmercaptan at the epithelial barrier of the rectal, vaginal, urethral, oral, nasal, ocular, and auditory canal orifices to maintain the epithelial barrier and reduce penetration of any of Candida, Actinobacillus actinomycetumcomitans, Pseudomonades, and Porphyromonas gingivalis, said method comprising the step of applying to the orifices a composition comprising a topical preparation selected from the group consisting of liquid solutions, suspensions, semi-solids, salves, creams, and suppositories, wherein the topical preparation contains chlorine dioxide in a concentration in the range of about 0.005% to about 2.0% and a phosphate compound selected from the group consisting of disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodiuit phosphate, or sodium monofluorophosphate in a concentration in the range of about 0.02% to about 3.0% to retard escape of chlorine dioxide from the composition at a pH in the range of about 6.0 to about 7.4.
摘要翻译： 在直肠，阴道，尿道，口腔，鼻，眼和耳道孔的上皮屏障上氧化消耗挥发性硫化合物的方法，以维持上皮屏障并减少其中的挥发性硫化合物，其选自二甲硫醚，硫化氢和甲硫醇 任何念珠菌，放线杆菌放线菌素，假单胞菌属和牙龈卟啉单胞菌的任何一种的渗透，所述方法包括向孔口施用包含局部制剂的组合物的步骤，该组合物选自液体溶液，悬浮液，半固体，油膏，霜剂， 和栓剂，其中所述局部制剂含有浓度范围为约0.005％至约2.0％的二氧化氯和选自磷酸氢二钠，磷酸二氢钠，磷酸三钠或单氟磷酸钠的磷酸盐化合物，其中 浓度在约0.02％至约3.0％的范围内 以在约6.0至约7.4的pH范围内阻止二氧化氯从组合物中逸出。
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