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    Use of nitric oxide scavengers to treat side effects caused by therapeutic administration of sources of nitric oxide
    4.
    发明授权
    Use of nitric oxide scavengers to treat side effects caused by therapeutic administration of sources of nitric oxide 失效
    使用一氧化氮清除剂治疗由一氧化氮来源治疗引起的副作用

    公开(公告)号：US06596733B2

    公开(公告)日：2003-07-22

    申请号：US09912757

    申请日：2001-07-24

    申请人： Ching-San Lai

    发明人： Ching-San Lai

    IPC分类号： A61K31295

    CPC分类号： A61K31/16 ,  A61K31/137 ,  A61K31/194 ,  A61K31/325 ,  A61K31/4162 ,  A61K31/4164 ,  A61K31/444 ,  A61K31/445 ,  A61K31/4745 ,  A61K31/495

    摘要： Nitric oxide scavengers, such as dithiocarbamate-containing compounds, are used to reduce side effects caused by therapeutic administration of nitric oxide sources by administering the nitric oxide scavenger(s) to the subject after the therapeutic effect of the nitric oxide source has been achieved. For example, the nitric oxide source can be coadministered with the nitric oxide scavenger, with the latter formulated in a time release vehicle selected to delay release of the scavenger for a period of time sufficient to ensure that the therapeutic goal of the nitric oxide source has been achieved before release of the scavenger. Formulations and kits, including a bubble pack with pairwise arrangement of unit doses of a desired nitric oxide source and nitric oxide scavenger, are also provided. The side effects of sildenafil citrate (Viagra®), or of simultaneous administration of such a nitric oxide source in combination with another, such as nitroglycerin, are effectively controlled by the methods, formulations and kits of the invention.

    摘要翻译： 一氧化氮清除剂，例如含二硫代氨基甲酸盐的化合物，用于在一氧化氮源的治疗效果达到后，通过给受试者施用一氧化氮清除剂来减少治疗性给予一氧化氮源引起的副作用。 例如，一氧化氮源可以与一氧化氮清除剂共同施用，后者配制在选择的时间释放载体中，以延迟释放剂的释放足以确保一氧化氮源的治疗目标具有 在释放清道夫之前已经实现了。 还提供了制剂和试剂盒，包括具有成对排列的单位剂量的所需一氧化氮源和一氧化氮清除剂的气泡包。 本发明的方法，制剂和试剂盒有效地控制了西地那非柠檬酸盐（Viagra）的副作用或同时给予这种一氧化氮源与另一种硝酸甘油的组合。

    Treatment of septic shock
    5.
    发明授权
    Treatment of septic shock 失效
    脓毒性休克的治疗

    公开(公告)号：US06465511B1

    公开(公告)日：2002-10-15

    申请号：US08921997

    申请日：1997-08-27

    申请人： Wieslaw Mieczyslaw Kazmierski ,  Luis Molina

    发明人： Wieslaw Mieczyslaw Kazmierski ,  Luis Molina

    IPC分类号： A61K31295

    CPC分类号： A61K31/295 ,  A61K31/28 ,  A61K31/30 ,  A61K31/315

    摘要： The use of transition metal complexes in the treatment of septic shock, in particular the hypotension associated therewith and pharmaceutical formulation comprising such complexes are disclosed. The use of such transition metal complexes in the treatment of other conditions caused by pathological NO production are also disclosed.

    摘要翻译： 公开了使用过渡金属络合物治疗败血性休克，特别是与其相关的低血压和包含这种复合物的药物制剂。 还公开了这种过渡金属配合物在治疗由病理性NO产生引起的其他病症中的用途。

    Chelate compound-containing antibacterial agent for Helicobacter pylori
    6.
    发明授权
    Chelate compound-containing antibacterial agent for Helicobacter pylori 失效
    用于幽门螺杆菌的含螯合物的抗菌剂

    公开(公告)号：US06429225B1

    公开(公告)日：2002-08-06

    申请号：US09802270

    申请日：2001-03-08

    申请人： Toshiro Nagai ,  Shigeru Oita

    发明人： Toshiro Nagai ,  Shigeru Oita

    IPC分类号： A61K31295

    CPC分类号： A61K31/198 ,  Y10S514/925

    摘要： An antibacterial agent is provided, which has an action for inhibiting growth of Helicobacter pylori participating to occurrence of chronic gastritis and gastric ulcer, and a highly safe substance is used as an effective component therein. An antibacterial agent for Helicobacter pylori is characterized in that at least one substance selected from the group consisting of ethylenediaminetetraacetic acid and its metal salts is contained as an effective component.

    摘要翻译： 提供了一种抗菌剂，其具有抑制幽门螺杆菌生长的作用，其参与发生慢性胃炎和胃溃疡，并且使用高度安全的物质作为其中的有效成分。 用于幽门螺杆菌的抗菌剂的特征在于，含有选自乙二胺四乙酸及其金属盐的至少一种物质作为有效成分。