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公开(公告)号：US11234915B2
公开(公告)日：2022-02-01
申请号：US16815106
申请日：2020-03-11
发明人： Michael Prencipe , Amy Russo , Hansruedi Stettler , Betty Won , Lisa Manus , Michael Stranick , Peng Yan , Chengkang Tan , Vyoma Patel , André Morgan , Andrei Potanin , Xiao Yi Huang
IPC分类号： A61Q11/00 , A61K8/27 , A61K8/21 , A61K8/25 , A61K33/30 , A61K33/16 , A61K6/00 , A61K31/198 , A61K8/44 , A61K8/24 , A61K8/73 , A61K8/04 , A61K8/37 , A61K8/34 , A61K8/365
摘要： This invention relates to oral care compositions comprising arginine or lysine, zinc citrate and zinc oxide, fluoride source, and a silica abrasive which exhibits an acid pH when measured as an aqueous slurry as well as to methods of using and of making these compositions.
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公开(公告)号：US09718843B2
公开(公告)日：2017-08-01
申请号：US15319423
申请日：2014-06-18
发明人： Michael Fitzgerald , Joseph Convery , Harsh Trivedi , Lisa Manus
IPC分类号： C07F3/06
CPC分类号： C07F3/06 , C07B2200/13 , C07F3/003
摘要： The disclosure provides an improved synthesis for a zinc-lysine complex having the formula [Zn(C6H14N2O2)2Cl]+Cl−, in which a zinc compound selected from ZnO and ZnCl2, is reacted with a lysine compound selected from lysine and lysine.HCl, in aqueous acid. The disclosure also provides oral care and personal care compositions comprising the complex prepared by the synthesis, and methods of using these complexes and compositions.
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公开(公告)号：US20170157013A1
公开(公告)日：2017-06-08
申请号：US14960960
申请日：2015-12-07
摘要： Disclosed herein are methods of promoting the aggregation and/or immune clearance of oral bacteria using oral care compositions comprising metal-amino acid complexes.
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公开(公告)号：US11058622B2
公开(公告)日：2021-07-13
申请号：US16714863
申请日：2019-12-16
发明人： Lisa Manus , Michael Stranick , Donghui Wu
摘要： Provided herein are methods of treating one or more symptoms of a gastric disorder in the oral cavity of a subject in need thereof, wherein the method comprises applying to the subject's teeth an oral care composition comprising a basic amino acid in free or salt form, wherein the basic amino acid is arginine (e.g., free form arginine); zinc oxide and zinc citrate; and an orally acceptable carrier.
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公开(公告)号：US20180344596A1
公开(公告)日：2018-12-06
申请号：US16053893
申请日：2018-08-03
发明人： Lisa Manus , Julia Dreifus
摘要： This invention relates to oral care compositions comprising arginine, zinc citrate and zinc oxide, and an orally acceptable carrier, as well as to methods of using and of making these compositions.
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公开(公告)号：US10130571B2
公开(公告)日：2018-11-20
申请号：US15319757
申请日：2014-06-18
摘要： Disclosed herein are dentifrices comprising a zinc amino acid complex together with soluble phosphate salts. Methods of making and using the dentifrices are also provided.
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公开(公告)号：US10744077B2
公开(公告)日：2020-08-18
申请号：US16053893
申请日：2018-08-03
发明人： Lisa Manus , Julia Dreifus
IPC分类号： A61Q11/00 , A61K8/88 , A61K8/27 , A61K8/362 , G01N33/50 , A61K8/44 , A61K8/21 , A61K8/70 , A61K8/81
摘要： This invention relates to oral care compositions comprising arginine, zinc citrate and zinc oxide, and an orally acceptable carrier, as well as to methods of using and of making these compositions.
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公开(公告)号：US10588840B2
公开(公告)日：2020-03-17
申请号：US15749537
申请日：2017-06-23
发明人： Marcella Mourao , Wilbens Josias , Betty Won , Lisa Manus , Michael Stranick , Xiaoyi Huang , Michael Prencipe , Amy Russo , Hansruedi Stettler , Peng Yan , Chengkang Tan , Vyoma Patel , Andre Michelle Morgan , Andrei Potanin
IPC分类号： A61K8/44 , A61K8/24 , A61K8/21 , A61K8/27 , A61Q11/00 , A61K8/73 , A61K8/04 , A61K8/37 , A61K8/25 , A61K8/34 , A61K8/365
摘要： Described herein are oral care compositions comprising a basic amino acid; a combination of zinc ion sources; and from about 0.75 wt. % to about 2 wt. % of a chelating system; along with methods of making and using same.
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公开(公告)号：US10561590B2
公开(公告)日：2020-02-18
申请号：US16142738
申请日：2018-09-26
摘要： Disclosed herein are dentifrices comprising a zinc amino acid complex together with soluble phosphate salts. Methods of making and using the dentifrices are also provided.
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公开(公告)号：US09913784B2
公开(公告)日：2018-03-13
申请号：US15385054
申请日：2016-12-20
CPC分类号： A61K8/27 , A61K8/21 , A61K8/24 , A61K8/44 , A61K8/8176 , A61K8/8182 , A61K2800/58 , A61Q11/00 , A61Q11/02
摘要： Disclosed herein are oral care compositions comprising a zinc amino acid halide complex, and linear polyvinylpyrrolidone and/or sodium tripolyphosphate, which compositions have improved rheological stability. Methods of making and using the compositions are also provided.
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