公开(公告)号：US12061149B2

公开(公告)日：2024-08-13

申请号：US17324423

申请日：2021-05-19

Applicant: YSI, INC.

Inventor： Kevin Flanagan

IPC: G01N21/64 ,  G01N21/47 ,  G01N21/53 ,  G01N21/82 ,  G01N33/08 ,  G01N33/18 ,  H04N25/46

CPC classification number: G01N21/6456 ,  G01N21/4785 ,  G01N21/532 ,  G01N21/64 ,  G01N21/82 ,  G01N33/08 ,  G01N33/18 ,  H04N25/46 ,  G01N2021/6473 ,  G01N2021/6491 ,  G01N2201/061 ,  G01N2201/0633 ,  G01N2201/0636 ,  G01N2201/126 ,  G01N2201/12761 ,  G01N2201/12792

Abstract: A swept frequency fluorometer having a signal processor or processing module configured to:
receive signaling containing information about reflected light off one or more fluorescence species-of-interest in a liquid sample that is swept with light having a variable frequency range, the information including a characteristic optical frequency corresponding to a fluorescence species-of-interest in the liquid, and a characteristic/lifetime optical frequency corresponding to a distinct fluorescence lifetime in which the fluorescence species-of-interest remains in an excited state; and
provide corresponding signaling containing information about an identity of the fluorescence species-of-interest detected and distinguished from overlapping fluorescence species in the liquid using the characteristic/lifetime optical frequency, based upon the signaling received.

公开(公告)号：US11719627B2

公开(公告)日：2023-08-08

申请号：US16419424

申请日：2019-05-22

Applicant: HORIBA, LTD.

Inventor： Eishi Iso ,  Shinsuke Kashiwagi

IPC: G01N21/27 ,  G01N21/65 ,  G01N33/15 ,  G01D5/347 ,  G01N21/31 ,  G06F17/18

CPC classification number: G01N21/274 ,  G01N21/65 ,  G01N33/15 ,  G01D5/347 ,  G01N2021/3133 ,  G01N2201/12761 ,  G06F17/18

Abstract: A calibration curve setting method used at the time of quantitatively analyzing specific components in a drug by a transmission Raman spectrum, the method comprising the steps of: obtaining respective transmission Raman spectra of a plurality of different wave number ranges including Raman hands corresponding to the specific components of a plurality of known drugs of which concentrations or amounts of the specific components are known and the concentrations or the amounts are different from each other; calculating candidate calibration curves which are candidates for calibration curves used for the quantitative analysis respectively from a plurality of transmission. Raman spectra in each of the wave number ranges; and using the most probable candidate calibration curve as a calibration curve for the quantitative analysis of the specific components, among the respective candidate calibration curves.

公开(公告)号：US11860096B2

公开(公告)日：2024-01-02

申请号：US17324385

申请日：2021-05-19

Applicant: YSI, INC.

Inventor： Kevin Flanagan ,  Ronald Metzger ,  Kyle Loges

IPC: G01N21/53 ,  G01N21/64 ,  G01N33/08 ,  G01N21/47 ,  G01N21/82 ,  H04N25/46

CPC classification number: G01N21/6456 ,  G01N21/4785 ,  G01N21/532 ,  G01N21/64 ,  G01N21/82 ,  G01N33/08 ,  H04N25/46 ,  G01N2021/6473 ,  G01N2021/6491 ,  G01N2201/061 ,  G01N2201/0633 ,  G01N2201/0636 ,  G01N2201/126 ,  G01N2201/12761 ,  G01N2201/12792

Abstract: A turbidity sensor featuring a signal processor or processing module configured to: receive signaling containing information about light reflected off suspended matter in a liquid and sensed by a linear sensor array having rows and columns of optical elements; and determine corresponding signaling containing information about a concentration of turbidity of the liquid, based upon the signaling received.

公开(公告)号：US20130252346A1

公开(公告)日：2013-09-26

申请号：US13795554

申请日：2013-03-12

Applicant: SINGULEX, INC.

Inventor： Philippe Goix ,  Robert Puskas ,  John Todd ,  Richard Livingston ,  Douglas Held ,  Allan H.B. Wu

IPC: G01N33/68

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

Abstract translation: 本发明提供用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。这种方法，组合物，试剂盒和系统可用于诊断，预后和确定涉及心肌肌钙蛋白释放的病症中的治疗方法。

公开(公告)号：US20060152730A1

公开(公告)日：2006-07-13

申请号：US10538752

申请日：2003-09-24

Applicant: Reinhold Schneider

Inventor： Reinhold Schneider

IPC: G01N21/00

CPC classification number: G01N21/8507 ,  G01N15/06 ,  G01N21/274 ,  G01N21/31 ,  G01N21/534 ,  G01N2201/0228 ,  G01N2201/062 ,  G01N2201/12753 ,  G01N2201/12761 ,  G01N2201/128

Abstract: The invention relates to an optical sensor (1) for determining particle and/or dye concentrations in liquid or gaseous media and to a method for operating the same. The optical sensor (1) comprises at least one measuring head. The measuring head consists of an emitter unit (2) with a semiconductor emitting element (9), which emits visible emission light beams (8), and with a receiver unit (3) with a semiconductor receiving element (10). The portion of the emission light beams (8), which pass through an absorption section containing liquid or gaseous medium, is guided onto the receiving element (10). An evaluating unit (6) is coupled to the measuring head via electric leads (4, 4′), and the received signals, which are present at the output of the semiconductor receiving element (10), are evaluated inside said evaluating unit in order to determine the particle or die concentration.

Abstract translation: 本发明涉及一种用于确定液体或气体介质中的颗粒和/或染料浓度的光学传感器（1）及其操作方法。 光学传感器（1）包括至少一个测量头。 测量头由具有发射可见光发射光束（8）的半导体发射元件（9）的发射器单元（2）和具有半导体接收元件（10）的接收器单元（3）组成。 通过包含液体或气体介质的吸收部分的发射光束（8）的部分被引导到接收元件（10）上。 评估单元（6）经由电引线（4,4'）耦合到测量头，并且存在于半导体接收元件（10）的输出处的接收信号按照顺序在所述评估单元内进行评估 以确定颗粒或模具浓度。

公开(公告)号：US11953428B2

公开(公告)日：2024-04-09

申请号：US17077810

申请日：2020-10-22

Applicant: Quidel Corporation

Inventor： David Dickson Booker ,  Jhobe Steadman

IPC: G01N21/27 ,  G01N21/64

CPC classification number: G01N21/274 ,  G01N21/278 ,  G01N21/645 ,  G01N2201/068 ,  G01N2201/10 ,  G01N2201/12746 ,  G01N2201/12753 ,  G01N2201/12761

Abstract: Disclosed herein is a method for improving the precision of a test result from an instrument with an optical system that detects a signal. The method comprises including in the instrument a normalization target disposed directly or indirectly in the optical path of the optical system. Also disclosed are instruments comprising a normalization target, and systems comprising such an instrument and a test device that receives a sample suspected of containing an analyte.

公开(公告)号：US20230266245A1

公开(公告)日：2023-08-24

申请号：US18138837

申请日：2023-04-25

Applicant: Sony Group Corporation

Inventor： Hirokazu Tatsuta ,  Gakuji Hashimoto ,  Tetsuro Kuwayama

IPC: G01N21/64 ,  G02B21/00 ,  G02B21/16 ,  G02B21/36

CPC classification number: G01N21/6458 ,  G02B21/0064 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/367 ,  G01N2021/6419 ,  G01N2021/6423 ,  G01N2201/12761

Abstract: A fluorescence observation apparatus according to an embodiment of the present technology includes a stage, an excitation section, and a spectroscopic imaging section. The stage is capable of supporting a fluorescently stained pathological specimen. The excitation section irradiates the pathological specimen on the stage with a plurality of line illuminations of different wavelengths, the plurality of line illuminations being a plurality of line illuminations situated on different axes and parallel to a certain-axis direction. The spectroscopic imaging section includes at least one imaging device capable of separately receiving pieces of fluorescence respectively excited with the plurality of line illuminations.

公开(公告)号：US20230152231A1

公开(公告)日：2023-05-18

申请号：US18094328

申请日：2023-01-06

Applicant: Sony Group Corporation

Inventor： Kazuhiro Nakagawa ,  Ayumu Taguchi ,  Hideya Chubachi

IPC: G01N21/64 ,  G01N33/58

CPC classification number: G01N21/6458 ,  G01N21/6408 ,  G01N21/6428 ,  G01N33/582 ,  G01N2201/12761

Abstract: Provided is an information processing apparatus (100) including: an image acquiring unit (112) that acquires captured image information of a sample (20) dyed with a fluorescent dye reagent (10), an information acquiring unit (111) that acquires information related to the fluorescent dye reagent (10), a correcting unit (131) that corrects the luminance of the captured image information using a fluorescence fading coefficient that represents the rapidness at which the fluorescence intensity of the fluorescent dye reagent (10) drops, the fluorescence fading coefficient being included in the fluorescent dye reagent (10), and a calculating unit (132) that calculates information corresponding to fluorescent molecules in the captured image information, using the corrected luminance.

公开(公告)号：US09494598B2

公开(公告)日：2016-11-15

申请号：US13795554

申请日：2013-03-12

Applicant: Singulex, Inc. ,  The Regents of the University of California

Inventor： Philippe Goix ,  Robert Puskas ,  John Todd ,  Richard Livingston ,  Douglas Held ,  Allan H. B. Wu

IPC: G01N33/00 ,  G01N33/68 ,  G01N21/64 ,  G01N33/58

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

Abstract translation: 本发明提供用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。这种方法，组合物，试剂盒和系统可用于诊断，预后和确定涉及心肌肌钙蛋白释放的病症中的治疗方法。

公开(公告)号：US07359055B2

公开(公告)日：2008-04-15

申请号：US10538752

申请日：2003-09-24

Applicant: Reinhold Schneider

Inventor： Reinhold Schneider

IPC: G01N21/00

CPC classification number: G01N21/8507 ,  G01N15/06 ,  G01N21/274 ,  G01N21/31 ,  G01N21/534 ,  G01N2201/0228 ,  G01N2201/062 ,  G01N2201/12753 ,  G01N2201/12761 ,  G01N2201/128

Abstract: The invention relates to an optical sensor (1) for determining particle and/or dye concentrations in liquid or gaseous media and to a method for operating the same. The optical sensor (1) comprises at least one measuring head. The measuring head consists of an emitter unit (2) with a semiconductor emitting element (9), which emits visible emission light beams (8), and with a receiver unit (3) with a semiconductor receiving element (10). The portion of the emission light beams (8), which pass through an absorption section containing liquid or gaseous medium, is guided onto the receiving element (10). An evaluating unit (6) is coupled to the measuring head via electric leads (4, 4′), and the received signals, which are present at the output of the semiconductor receiving element (10), are evaluated inside said evaluating unit in order to determine the particle or die concentration.

Abstract translation: 本发明涉及一种用于确定液体或气体介质中的颗粒和/或染料浓度的光学传感器（1）及其操作方法。 光学传感器（1）包括至少一个测量头。 测量头由具有发射可见光发射光束（8）的半导体发射元件（9）的发射器单元（2）和具有半导体接收元件（10）的接收器单元（3）组成。 通过包含液体或气体介质的吸收部分的发射光束（8）的部分被引导到接收元件（10）上。 评估单元（6）经由电引线（4,4'）耦合到测量头，并且存在于半导体接收元件（10）的输出处的接收信号按照顺序在所述评估单元内进行评估 以确定颗粒或模具浓度。