公开(公告)号：US20240307876A1

公开(公告)日：2024-09-19

申请号：US18674548

申请日：2024-05-24

Applicant: STMICROELECTRONICS S.r.l.

Inventor： Marco CEREDA ,  Lillo RAIA ,  Danilo PIROLA

IPC: B01L3/00 ,  A61B5/15 ,  A61B5/154 ,  B01F33/30 ,  B01F33/40 ,  B01F33/452 ,  B01L9/00 ,  C12M3/06 ,  C12Q1/6806 ,  C12Q1/6844

CPC classification number: B01L3/502753 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150351 ,  A61B5/154 ,  B01F33/30 ,  B01F33/406 ,  B01F33/452 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/5029 ,  B01L3/508 ,  B01L3/5082 ,  B01L3/52 ,  B01L3/527 ,  B01L9/527 ,  C12M23/16 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150732 ,  B01L3/5023 ,  B01L3/502707 ,  B01L3/50825 ,  B01L3/523 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/0621 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/022 ,  B01L2300/023 ,  B01L2300/044 ,  B01L2300/0609 ,  B01L2300/0681 ,  B01L2300/08 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/0848 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/16 ,  B01L2300/1827 ,  B01L2400/04 ,  B01L2400/0406 ,  B01L2400/043 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0677 ,  C12Q1/6806 ,  C12Q1/6844

Abstract: An analysis unit formed by an analysis body housing an analysis chamber and having a sample inlet and a supply channel configured to fluidically connect the sample inlet to the analysis chamber. Dried assay reagents are arranged in the analysis chamber and are contained in an alveolar mass. For instance, the alveolar mass is a lyophilized mass formed by excipients and by assay-specific reagents.

公开(公告)号：US12071340B2

公开(公告)日：2024-08-27

申请号：US17700299

申请日：2022-03-21

Applicant: Bionano Genomics, Inc.

Inventor： Han Cao ,  Michael David Austin ,  Parikshit A. Deshpande ,  Mark Kunkel ,  Alexey Y. Sharonov ,  Michael Kochersperger

IPC: B01L99/00 ,  B01L3/00 ,  B81C1/00 ,  G01N21/03 ,  G01N21/64

CPC classification number: B81C1/00119 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2300/168 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0442 ,  B01L2400/0487 ,  B01L2400/086 ,  B81B2201/058 ,  B81C2201/019 ,  G01N2021/0346 ,  G01N2021/6439 ,  Y10T29/4981

Abstract: Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices. Related methods of manufacturing these devices and of using these devices are also provided.

公开(公告)号：US20240252155A1

公开(公告)日：2024-08-01

申请号：US18466349

申请日：2023-09-13

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Anjali Saqi ,  Keith Yeager

IPC: A61B10/00 ,  A61B10/02 ,  A61M1/34 ,  B01L3/00 ,  G01N1/40

CPC classification number: A61B10/0096 ,  A61B10/02 ,  A61M1/34 ,  A61M1/3403 ,  B01L3/502 ,  B01L3/5021 ,  G01N1/4077 ,  B01L2300/0618 ,  B01L2300/0681 ,  B01L2300/0851 ,  G01N2001/4088

Abstract: A medical apparatus having an elongate tubular body with a proximal end, an opening at the proximal end, and a distal end defining an interior space therebetween and the distalmost end of the elongate tubular body is configured to matingly engage a filter assembly; a filter assembly configured to matingly engage the distal portion of the elongate tubular body and to provide a seal with the interior space thereof, the filter assembly comprising a filter membrane and a border that is sectionable for mounting on a slide for analysis on a microscope; and a base member configured to releasably engage the distalmost end of the elongate tubular body and to receive the filter assembly therein.

公开(公告)号：US20240246075A1

公开(公告)日：2024-07-25

申请号：US18236226

申请日：2023-08-21

Applicant: North Carolina State University

Inventor： Aram Amassian ,  Nathaniel R. Woodward ,  Mihirsinh Chauhan ,  Boyu Guo

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0851 ,  B01L2300/168

Abstract: Devices, systems, and methods for characterizing material samples. In one aspect, a device for characterizing a sample includes a substrate configured for receiving a sample thereon; an optical fiber probe comprising a first end positioned near the sample and a second end that is bifurcated to include one or more first fiber configured for connection to a first light emitting device and one or more second fiber configured for connection to a spectrometer; a reflectance module coupled to the substrate; and a second light emitting device positioned near the sample. The optical fiber probe is configured for selectively obtaining at the spectrometer both a reflectance absorbance measurement of the sample associated with the first light emitting device and a photoluminescence measurement of the sample associated with the second light emitting device.

公开(公告)号：US11994515B2

公开(公告)日：2024-05-28

申请号：US16467661

申请日：2017-12-01

Applicant: Minq Solutions B.V.

Inventor： Jan Willem Weener ,  Edin Sarajlic

IPC: G01N33/53 ,  B01L3/00 ,  C12M1/32 ,  G01N33/50

CPC classification number: G01N33/5304 ,  B01L3/5085 ,  C12M23/12 ,  G01N33/5008 ,  B01L2200/0647 ,  B01L2300/0829 ,  B01L2300/0851

Abstract: The invention relates to a method of performing an assay for a compound. The method makes use of a device (390) which has a plurality of wells (340) which contain cells, and according to the method a liquid is transferred from the wells (340) to a substrate which is used to perform the assay. Each well (340) of the device comprises a bottom provided with a through-hole (370) extending from the well (340) to the backside of the device (390). Liquid containing the compound is transferred via the through-holes (370) to the substrate.

公开(公告)号：US11890619B2

公开(公告)日：2024-02-06

申请号：US17308392

申请日：2021-05-05

Applicant: Integra Biosciences AG

Inventor： Terrence Kelly ,  Jonathan Harkins ,  George Kalmakis ,  Gary Nelson

IPC: B01L3/00 ,  B01L3/02

CPC classification number: B01L3/5082 ,  B01L3/505 ,  B01L3/508 ,  B01L3/50853 ,  B01L3/502707 ,  B01L3/021 ,  B01L3/5027 ,  B01L2200/16 ,  B01L2300/028 ,  B01L2300/042 ,  B01L2300/0829 ,  B01L2300/0832 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/16

Abstract: Pipetting containers, such as reservoirs, reservoir liners, microplates, PCR plates, microtubes and PCR tubes, include anti-vacuum channels on the bottom wall of the receptacle to prevent a pipette tip vacuum engaging the wall during aspiration. The groupings of anti-vacuum channels are located on the bottom surface facing upward into the basin that holds liquid samples or reagents. The anti-vacuum channels also lower the required working volume for pipetting and reduce liquid waste.

公开(公告)号：US11840727B2

公开(公告)日：2023-12-12

申请号：US17028367

申请日：2020-09-22

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  David Howard Combs ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Keith Moravick ,  Tyler Moore ,  Byron J. Knight

IPC: C12Q1/686 ,  B01L7/00 ,  G01N21/64 ,  B01L9/06

CPC classification number: C12Q1/686 ,  B01L7/52 ,  G01N21/6452 ,  B01L9/06 ,  B01L2200/141 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/1822 ,  G01N2021/6482 ,  G01N2021/6484

Abstract: Multiple receptacles containing a reaction mixture are transported to corresponding receptacle wells of a thermally-conductive receptacle holder in thermal communication with a support that is in thermal communication with a heat sink. The heat sink is pre-heated to a temperature above ambient temperature, and the temperature of the receptacle holder is cycled. Optical communication is established between each of the receptacle wells and an excitation signal source and an emission signal detector during cycling, and whether an emission signal is emitted from any of the receptacles is determined as an indication of the presence of a target nucleic acid.

公开(公告)号：US20230364612A1

公开(公告)日：2023-11-16

申请号：US18029019

申请日：2021-09-03

Applicant: NOK CORPORATION

Inventor： Takayuki KOMORI

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502753 ,  B01L2200/0631 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/0877 ,  B01L2400/086

Abstract: A fine particle capture device, having a chip that has a plane part and projection parts, and is configured such that fine particle-containing liquid entering from an inlet port passes on the surface of the plane part in the chip and between a projection part and another projection part adjacent thereto and the liquid is discharged from an outlet port. The projection parts are disposed on the plane part in the form of layers. The layers each has a plurality of projection parts, and are configured such that the fine particle-containing liquid having passed through a layer on the inlet port side passes through a layer on the outlet port side adjacent thereto. Each layer has a capture part and a bypass part. The capture part is disposed on the outlet port side of the bypass part in a specific layer as a portion of another layer adjacent thereto.

公开(公告)号：US11732228B2

公开(公告)日：2023-08-22

申请号：US16628449

申请日：2018-07-02

Applicant: ELTEK S.p.A.

Inventor： Marco Pizzi ,  Ilze Aulika

IPC: B01L3/00 ,  C12M1/00 ,  C12M1/32

CPC classification number: C12M23/12 ,  B01L3/50853 ,  C12M23/34 ,  C12M23/38 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/123

Abstract: A device (20) for creating cell-exclusion zones comprises a baseplate (21) having a first major face from which a plurality of exclusion reliefs (22) project, each exclusion relief (22) having at least one distal end (23) configured for contact with a bottom (11b) of a respective well (11) of a multi-well cell-culture plate (10). The baseplate (21) and the plurality of exclusion reliefs (22) are defined at least in part by an elastic or flexible material in such a way that at least the baseplate (21) is elastically deformable at least during removal thereof from a multi-well cell-culture plate (10), the elastic or flexible material preferably being an elastomer.

公开(公告)号：US11712697B2

公开(公告)日：2023-08-01

申请号：US16762244

申请日：2018-11-20

Applicant: BASF Agricultural Solutions Seed US LLC

Inventor： Marion Ellis Driver ,  Justin Jeong Dailey

IPC: B01L3/00

CPC classification number: B01L3/50853 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/123

Abstract: A multi-well microtiter plate is provided designed for high-throughput screening of piercing-sucking arthropods,such as insects exposed to various compounds. The microtiter plates comprise a base comprising a plurality of sample wells, a covering made from pierceable material, a housing unit comprising a plurality of housing wells providing a predetermined fit in the plurality of sample wells, and an air-penetrable seal. Methods for containing, screening, and/or imaging piercing-sucking pests andarthropods utilizing the multi-chambered microtiter plates are also provided.