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    Valve, especially for fluid handling bodies with microflowchannels
    1.
    发明授权
    Valve, especially for fluid handling bodies with microflowchannels 失效
    阀门，特别是用于具有微流通道的流体处理机构

    公开(公告)号：US5593130A

    公开(公告)日：1997-01-14

    申请号：US605166

    申请日：1996-03-06

    Applicant: Thord Hansson ,  Stefan Sjolander

    Inventor： Thord Hansson ,  Stefan Sjolander

    IPC: F15C3/04 ,  F16K7/12 ,  F16K7/17

    CPC classification number: F15C3/04 ,  F16K7/126

    Abstract: A valve of the membrane valve type comprises a valve body with two fluid flow channels (5, 5') separated by a land portion which forms a valve seat (6) having a sealing surface for co-operation with a flexible membrane (7) mounted over a duct (8) which opens in front of the valve seat and is arranged for fluid pressure actuation of the membrane between a closing position, where the membrane (7) sealingly contacts the valve seat (6), and an opening position where there is a flow channel communicating space ( 11) between the valve seat (6) and the membrane (7). The valve is characterized in that the sealing surface of the valve seat (6) comprises (i) a primary sealing surface (10) located nearest and facing the membrane, and (ii) a secondary sealing surface (12, 12') provided on each fluid channel side of the valve seat, so that when the valve is closing, the membrane (7) successively seals against the primary sealing surface (10) and the secondary sealing surfaces (12, 12'), and, inversely, when the valve is opening, the member (7) is successively separated from the secondary sealing surfaces (12, 12') and the primary sealing surface (10).

    Abstract translation: PCT No.PCT / SE94 / 00824 Sec。 371日期1996年3月6日 102（e）1996年3月6日PCT PCT 1994年9月6日PCT公布。 出版物WO95 / 07425 日期1995年3月16日一种膜阀类型的阀包括阀体，该阀体具有两个流体通道（5,5'），两个流体通道（5,5'）由陆地部分分开，所述陆地部分形成具有密封表面的阀座（6），该密封表面用于与 柔性膜（7）安装在在阀座前面开口的管道（8）上，并布置成用于在膜（7）密封地接触阀座（6）的关闭位置之间的膜的液体压力致动， 以及在阀座（6）和膜（7）之间存在流路连通空间（11）的打开位置。 阀的特征在于，阀座（6）的密封表面包括（i）位于最靠近膜的主密封表面（10），和（ii）设置在第二密封表面上的第二密封表面（12,12'） 阀座的每个流体通道侧，使得当阀门关闭时，膜（7）依次密封主密封表面（10）和第二密封表面（12,12'），相反地，当 阀门打开，构件（7）从次密封表面（12,12'）和主密封表面（10）连续分离。

    Surface plasmon resonance-mass spectrometry
    4.
    发明授权
    Surface plasmon resonance-mass spectrometry 失效
    表面等离子体共振质谱

    公开(公告)号：US5955729A

    公开(公告)日：1999-09-21

    申请号：US708341

    申请日：1996-09-06

    Applicant: Randall W. Nelson ,  Jennifer R. Krone ,  Russell Granzow ,  Osten Jansson ,  Stefan Sjolander

    Inventor： Randall W. Nelson ,  Jennifer R. Krone ,  Russell Granzow ,  Osten Jansson ,  Stefan Sjolander

    IPC: G01N27/62 ,  G01N21/27 ,  G01N21/55 ,  G01N33/543 ,  B01D59/44 ,  H01J49/00

    CPC classification number: H01J49/0418 ,  G01N21/553 ,  H01J49/164

    Abstract: The invention provides surface plasmon resonance-mass spectroscopy for the rapid, sensitive and accurate investigation of molecular interactions coupled with the identification and quantification of the same. Methods of the invention include capturing an analyte present within a sample by an interactive surface layer on a real-time interaction analysis sensor, analyzing the analyte by surface plasmon resonance while the analyte is captured by the interactive surface layer, and identifying the captured analyte by desorbing/ionizing the analyte from the interactive surface layer while under vacuum within a mass spectrometer. Devices of the invention include a transparent material, a conductive material capable of supporting surface plasmon resonance affixed to the transparent material, an interactive surface affixed to the conductive material, and a means for exposing the interactive surface to the interior of a mass spectrometer without breaking the vacuum therein.

    Abstract translation: 本发明提供表面等离子体共振 - 质谱法，用于快速，灵敏和准确地研究分子相互作用以及其鉴定和定量。 本发明的方法包括通过实时相互作用分析传感器上的交互表面层捕获样品中存在的分析物，通过表面等离子体共振分析分析物，同时通过交互表面层捕获分析物，并通过 在质谱仪内真空下从交互表面层解离/电离分析物。 本发明的装置包括透明材料，能够支撑固定在透明材料上的表面等离子体共振的导电材料，固定在导电材料上的相互作用表面，以及用于将相互作用表面暴露于质谱仪内部而不断裂的装置 其中的真空。

    Optical biosensor system
    6.
    发明授权
    Optical biosensor system 失效
    光学生物传感器系统

    公开(公告)号：US5313264A

    公开(公告)日：1994-05-17

    申请号：US681533

    申请日：1991-05-10

    Applicant: Bengt Ivarsson ,  Jonsson Ulf ,  Stefan Sjolander ,  Ralph St.ang.hlberg ,  Hakan Sjodin

    Inventor： Bengt Ivarsson ,  Jonsson Ulf ,  Stefan Sjolander ,  Ralph St.ang.hlberg ,  Hakan Sjodin

    IPC: G01N21/01 ,  G01N21/03 ,  G01N21/05 ,  G01N21/17 ,  G01N21/21 ,  G01N21/27 ,  G01N21/55 ,  G01N21/59 ,  G01N21/85 ,  G01N33/543 ,  G02B6/26 ,  G02B6/34 ,  G02B21/00 ,  G01N33/53

    CPC classification number: G01N21/648 ,  G01N21/552 ,  G01N21/553 ,  G02B6/34 ,  G01N2021/0346 ,  G01N2021/212 ,  G01N2021/5957 ,  G01N21/0332 ,  G01N21/05

    Abstract: An optical biosensor system using internal reflection versus angle of incidence determination for the detection of biomolecules, the system comprising a sensor unit (10) with at least two sensing surfaces (39A-D), a source of light (1), and lens means (2) for forming a convergent beam of light which is focused in wedge-shape fashion to form a streak of light (5) extending transversely over all the sensing surfaces; a photodetector device (7) in the form of a two-dimensional matrix of individual photodetector; optical imaging instrumentation in the form of an anamorphic lens system (6) for the purpose of imaging rays of reflected light from the sensing surfaces on each its own column of photodetectors, so that for each sensing surface there is a corresponding set of columns of photodetectors; and an evaluation unit (8) for determining the minimum reflectance or the resonance angle at each of the sensing surfaces. The invention also relates to a method for calibrating the biosensor system, a method for correcting for baseline drift as well as a method for temperature regulation of thermostat means in the biosensor system.

    Abstract translation: PCT No.PCT / SE89 / 00641 Sec。 371日期1991年5月10日 102（e）日期1991年5月10日PCT提交1989年11月9日PCT公布。 第WO90 / 05295号公报 日期1990年5月17日。一种使用内部反射与入射角确定用于生物分子检测的光学生物传感器系统，该系统包括具有至少两个感测表面（39A-D）的传感器单元（10），光源 1）和用于形成会聚光束的透镜装置（2），其以楔形方式聚焦以形成横向延伸到所有感测表面上的条纹（5）; 单独光电检测器的二维矩阵形式的光检测器装置（7）; 以变​​形透镜系统（6）的形式的光学成像仪器，用于成像来自每个自身的光电检测器列上的感测表面的反射光的光线，使得对于每个感测表面，存在相应的一组光电检测器 ; 以及用于确定每个感测表面处的最小反射率或共振角的评估单元（8）。 本发明还涉及用于校准生物传感器系统的方法，用于校正基线漂移的方法以及用于生物传感器系统中恒温器装置的温度调节的方法。

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