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公开(公告)号：US11903708B2
公开(公告)日：2024-02-20
申请号：US16144174
申请日：2018-09-27
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson Chen , Axel Scherer , Muhammad Musab Jilani , Xiomara L. Madero
IPC: A61B5/1486 , A61B5/1459 , G01N27/419 , G01N27/30 , A61B5/145
CPC classification number: A61B5/14865 , A61B5/1459 , A61B5/14532 , G01N27/30 , G01N27/419
Abstract: A sensor implanted in tissues and including a sensing enzyme takes an electrical measurement and compares it to reference curves for the voltage current relationship. The sensor determines whether molecular compounds are present which interfere with the detection of the molecule of interest. If interfering species are found, the measurement voltage is set in a low range to reduce errors, while if the interfering species are not found, the measurement voltage is set in a high range to increase the detected signal.
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公开(公告)号：US11109784B2
公开(公告)日：2021-09-07
申请号：US16191357
申请日：2018-11-14
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Dvin Adalian , Samson Chen , Muhammad M. Jilani , Axel Scherer , Xiomara Linnette Madero , Richard Smith
IPC: A61B5/1486 , A61B5/145 , A61B5/1473
Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
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公开(公告)号：US11904045B2
公开(公告)日：2024-02-20
申请号：US17321296
申请日：2021-05-14
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson Chen , Axel Scherer , Richard Daniel Smith, Jr.
CPC classification number: A61K9/0009 , A61B5/14532 , A61B5/4839 , A61B5/686 , A61J1/1412 , A61J1/1468 , A61K9/0024 , A61K9/0097
Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.
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公开(公告)号：US11666216B2
公开(公告)日：2023-06-06
申请号：US15987843
申请日：2018-05-23
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Axel Scherer , Peter A Petillo , Samson Chen , Azita Emami
IPC: A61B5/00 , A01K1/03 , A01K11/00 , A01K29/00 , A61B5/11 , H04B5/00 , A61B5/145 , A61B5/1486 , A61B5/01
CPC classification number: A61B5/002 , A01K1/031 , A01K11/006 , A01K29/00 , A61B5/1113 , H04B5/0075 , A61B5/01 , A61B5/1486 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/14546 , A61B5/14865 , A61B5/6832 , A61B5/6868 , A61B2503/40 , A61B2503/42
Abstract: A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.
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5.发明授权公开(公告)号：US09238833B2
公开(公告)日：2016-01-19
申请号：US14028431
申请日：2013-09-16
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson Chen , Aditya Rajagopal , Axel Scherer
CPC classification number: C12Q1/686 , B01L7/52 , B01L2200/12 , B01L2300/0877 , B01L2300/1827 , H05K1/0212 , H05K1/0272 , H05K1/16 , H05K3/4644 , H05K3/4697 , Y10T29/49155
Abstract: Novel methods and systems for polymerase chain reaction (PCR) are disclosed. A PCR device has a bottom heater layer, a central reacting layer, and a top heater layer. The central reacting layer has a PCR reacting chamber connected with fluidics channels. Photoluminescence of a DNA solution in the PCR reactive chamber is carried out through the transparent top layers.
Abstract translation: 公开了用于聚合酶链反应（PCR）的新方法和系统。 PCR装置具有底部加热器层，中央反应层和顶部加热器层。 中央反应层具有与流体通道连接的PCR反应室。 PCR反应室中DNA溶液的光致发光通过透明顶层进行。
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Patent Agency Ranking
公开(公告)号：US11690544B2
公开(公告)日：2023-07-04
申请号：US17314930
申请日：2021-05-07
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson Chen , Axel Scherer , Dvin Adalian , Peter Petillo , Muhammad Musab Jilani , Xiomara L. Madero , Deepan Kishore Kumar
IPC: A61B5/145 , C12N11/02 , A61B5/1486 , C12N9/02 , A61B5/1459 , G01N27/327 , C12N11/14
CPC classification number: A61B5/14865 , A61B5/1459 , A61B5/14532 , C12N9/0004 , C12N11/02 , C12N11/14 , G01N27/3272 , C12Y101/01001 , C12Y101/0301 , C12Y101/0302 , C12Y101/03003 , C12Y101/0303 , C12Y101/0304 , C12Y101/03005 , C12Y101/03007 , C12Y101/03008 , C12Y101/03011 , C12Y101/03012 , C12Y101/03015 , C12Y101/03016 , C12Y101/03018 , C12Y101/03019 , C12Y101/03023 , C12Y101/03027 , C12Y101/03029 , C12Y101/03037 , C12Y101/03038 , C12Y101/03041
Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
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公开(公告)号：US11304893B2
公开(公告)日：2022-04-19
申请号：US16044124
申请日：2018-07-24
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson Chen , Axel Scherer , Richard Daniel Smith, Jr.
Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.
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公开(公告)号：US11026610B2
公开(公告)日：2021-06-08
申请号：US16144079
申请日：2018-09-27
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson Chen , Axel Scherer , Dvin Adalian , Peter Petillo , Muhammad Musab Jilani , Xiomara L. Madero , Deepan Kishore Kumar
IPC: C12N9/02 , C12N9/04 , C12N11/14 , A61B5/1486 , C12N11/02 , A61B5/145 , A61B5/1459 , G01N27/327
Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
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公开(公告)号：US10376892B2
公开(公告)日：2019-08-13
申请号：US15360691
申请日：2016-11-23
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya Rajagopal , Samson Chen , Axel Scherer , Christopher I. Walker
Abstract: PC board fluidic devices for performing a Polymerase Chain Reaction (PCR) are disclosed. The devices comprise a printed circuit board and a PCR chamber. The PCR chamber is a fluidic chamber and is located in, or is part of, the PC board. The PC board can include a coil trace heating element with a temperature sensor and controller.
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10.发明授权公开(公告)号：US09533308B2
公开(公告)日：2017-01-03
申请号：US13763352
申请日：2013-02-08
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya Rajagopal , Samson Chen , Axel Scherer , Christopher I. Walker
CPC classification number: B01L7/52 , B01L3/502707 , B01L2200/147 , B01L2300/0816 , B01L2300/0893 , B01L2300/12 , B01L2300/123 , B01L2300/1827 , B01L2300/1844 , C12Q1/686 , H05K1/0212 , H05K1/0272 , H05K1/028 , H05K3/46 , H05K3/4697 , Y10T29/49124
Abstract: An apparatus for performing a Polymerase Chain Reaction (PCR) is disclosed. The apparatus comprises a PCR chamber for performing a Polymerase Chain Reaction and a printed circuit board (PCB) fluidic device. The PCR chamber is a fluidic chamber and is located in, or is part of, the printed circuit board (PCB) fluidic device. A method for manufacturing an apparatus for performing the Polymerase Chain Reaction and a method for performing the Polymerase Chain Reaction are further disclosed.
Abstract translation: 公开了一种用于进行聚合酶链式反应（PCR）的装置。 该装置包括用于进行聚合酶链式反应的PCR室和印刷电路板（PCB）流体装置。 PCR室是流体室，并且位于印刷电路板（PCB）流体装置中或者是其中的一部分。 进一步公开了进行聚合酶链式反应的装置的制造方法和进行聚合酶链式反应的方法。
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