公开(公告)号：US10996185B2

公开(公告)日：2021-05-04

申请号：US15601503

申请日：2017-05-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson Chen ,  Axel Scherer ,  Muhammad M. Jilani

IPC: G01N27/30 ,  G01N27/327

Abstract: A cycle of positive and negative voltage pulses applied to an electrode sensor removes passivation of an electrode surface. The conditioned sensors have improved sensitivity to concentrations for analytes of interest. The electrode surfaces can also be passivated on purpose to reduce sensitivity. The voltages applied are varied according to the solution present.

公开(公告)号：US11109784B2

公开(公告)日：2021-09-07

申请号：US16191357

申请日：2018-11-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dvin Adalian ,  Samson Chen ,  Muhammad M. Jilani ,  Axel Scherer ,  Xiomara Linnette Madero ,  Richard Smith

IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/1473

Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.