公开(公告)号：US10294204B2

公开(公告)日：2019-05-21

申请号：US15497372

申请日：2017-04-26

Applicant: BioActs Co., Ltd.

Inventor： Jin Woo Park ,  Su-Jung Jang ,  Kiwon Kim ,  Gyeong Rim Shin ,  Bongkyu Lee

IPC: G01N21/31 ,  C09B7/02 ,  C07D209/10 ,  C07D251/50 ,  C09B23/06 ,  C09B23/08

Abstract: Provided is a fluorescent compound represented by the following [Chemical Formula 1] and a method for preparing the same: wherein each of X, Y, R1, R2, R3 and n is the same as defined in the specification.

公开(公告)号：US20170313883A1

公开(公告)日：2017-11-02

申请号：US15497372

申请日：2017-04-26

Applicant: BioActs Co., Ltd.

Inventor： Jin Woo PARK ,  Su-Jung JANG ,  Kiwon KIM ,  Gyeong Rim SHIN ,  Bongkyu LEE

IPC: C09B7/02 ,  C07D209/10 ,  C07D251/50 ,  G01N21/31

CPC classification number: C07D209/10 ,  C07D251/50 ,  C09B23/06 ,  C09B23/083 ,  C09B23/086 ,  G01N2021/3155

Abstract: Provided is a fluorescent compound represented by the following [Chemical Formula 1] and a method for preparing the same: wherein each of X, Y, R1, R2, R3 and n is the same as defined in the specification.

公开(公告)号：US09611457B2

公开(公告)日：2017-04-04

申请号：US14346328

申请日：2012-09-21

Applicant: Marko Mihovilovic ,  Michael Schnuerch ,  Karlheinz Hilber ,  Xaver Koenig ,  Thomas Linder ,  Agnes Mike

Inventor： Marko Mihovilovic ,  Michael Schnuerch ,  Karlheinz Hilber ,  Xaver Koenig ,  Thomas Linder ,  Agnes Mike

IPC: C12N5/071 ,  C12N5/077 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50

CPC classification number: C12N5/0657 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C12N2501/999 ,  C12N2506/30

Abstract: A method of inducing differentiation of mammalian cells into cardiomyocyte-like cells by contacting the mammalian cell with a triazine compound of formula (I), wherein X is independently —NR4—or —O—, R4 is hydrogen or C1-6-alkyl; R1 is hydroxy, C1-6-alkyl, C1-6-alkoxy, carboxy, C1-6-alkoxycarbonyl, halo, cyano, nitro, formyl, amino, C1-6-alkylamino, or di-C1-6-alkylamino, the C1-6-alkyl or -alkoxy residue being optionally substituted with one or more R5 substituents selected from hydroxy, halo, cyano, and nitro; n is 0 to 5; R2 is hydrogen, aryl, heteroaryl, or C1-6-alkyl, the aryl or heteroaryl residue being optionally substituted with one or more R1 substituents, and where the C1-6-alkyl is optionally further substituted with one or more R5 substituents; and R3 is selected from hydrogen, halo, NR4R7, OR7, SR7, and R7, where the same options apply for R7 as for R2; with the proviso that the compound of formula (I) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid.

公开(公告)号：US09193696B2

公开(公告)日：2015-11-24

申请号：US14368092

申请日：2012-11-30

Applicant: DALIAN UNIVERSITY OF TECHNOLOGY

Inventor： Bingtao Tang ,  Shufen Zhang ,  Wei Ma

IPC: C07D251/50 ,  C07D251/44 ,  C07D251/38 ,  C09B49/00 ,  D06P1/30

CPC classification number: C07D251/50 ,  C07D251/38 ,  C07D251/44 ,  C09B49/00 ,  D06P1/30

Abstract: The present invention provides a group of water-soluble sulfur dye having carboxyl groups. For the kind of dye, a sulfur dye is first reduced to a leuco compound by sodium sulfide, and the leuco compound reacts with an active compound containing carboxyl groups to obtain a water-soluble sulfur dye containing the carboxyl group. The water-soluble sulfur dye provided by the present invention is applicable to dying of cotton, wool, silk, and leather. Being both water-soluble and carboxyl group reactive, the product has a simple application process and desirable color fastness, thereby having broad application prospects.

Abstract translation: 本发明提供一组具有羧基的水溶性硫化染料。 对于这种染料，硫化钠首先通过硫化钠还原成无色化合物，并且无色化合物与含有羧基的活性化合物反应，得到含有羧基的水溶性硫化染料。 本发明提供的水溶性硫化染料适用于棉，羊毛，丝绸和皮革的染色。 既具有水溶性又具有羧基反应性，产品使用简便，色牢度好，具有广泛的应用前景。

公开(公告)号：US08367823B2

公开(公告)日：2013-02-05

申请号：US12233925

申请日：2008-09-19

Applicant: Yuyu Sun ,  Jie Luo

Inventor： Yuyu Sun ,  Jie Luo

IPC: C07D251/00 ,  C07D251/12 ,  C07D251/18 ,  C07D251/40 ,  C07D251/50 ,  A01N25/00 ,  A01N43/66

CPC classification number: A01N25/34 ,  A01N43/38 ,  A01N43/42 ,  A01N43/52 ,  A01N43/54 ,  A01N43/60 ,  A01N43/66 ,  A01N43/90 ,  A01N59/00 ,  A61L15/46 ,  A61L2300/202 ,  A61L2300/204 ,  A61L2300/442 ,  C07D209/56 ,  C07D221/18 ,  C07D241/36 ,  C07D251/50 ,  C07D251/54 ,  C07D403/12 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/16 ,  C09B5/26 ,  C09B7/00 ,  C09B43/16 ,  C09B56/12

Abstract: The present invention includes methods, articles, compositions and colorant dyes and pigments that include biocidal N-halamine dye composition having two or more heterocyclic ring structures attached to one or more N-halamine groups, wherein one or more halogens associate with the one or more one or more N-halamine groups to affect biocidal activity.

Abstract translation: 本发明包括方法，制品，组合物和着色剂染料和颜料，其包括具有连接到一个或多个N-卤胺基团的两个或多个杂环结构的杀生物N-卤胺染料组合物，其中一个或多个卤素与一个或多个 一个或多个N-卤胺基团，以影响杀生物活性。

公开(公告)号：US08227599B2

公开(公告)日：2012-07-24

申请号：US11887503

申请日：2006-03-29

Applicant: Vadiraj Subbanna Ekkundi ,  Narayan S. Punekar ,  Kamalesh Pai Fondekar ,  Georg Roentgen ,  Shilpa S. Korde ,  Ajit B. Shinde ,  Masana Moorthy

Inventor： Vadiraj Subbanna Ekkundi ,  Narayan S. Punekar ,  Kamalesh Pai Fondekar ,  Georg Roentgen ,  Shilpa S. Korde ,  Ajit B. Shinde ,  Masana Moorthy

IPC: C07D251/50 ,  C07D251/52 ,  C07D251/54 ,  A61K31/53 ,  C09B1/20 ,  C09B1/26 ,  C09B62/04

CPC classification number: C09B69/101 ,  C09B62/06

Abstract: A process for the separation of biological materials, such as dye-ligand affinity chromatography, wherein an adsorbent is used, which comprises a reaction product of certain reactive anthroquinone compounds and a substrate having a group capable of reaction with a reactive group in said reactive anthroquinone compounds to form a covalent bond.

Abstract translation: 用于分离生物材料的方法，例如染料 - 配体亲和层析，其中使用吸附剂，其包括某些反应性蒽醌化合物与具有能够与所述反应性蒽醌中的反应性基团反应的基团的反应产物 化合物形成共价键。

公开(公告)号：US07135567B2

公开(公告)日：2006-11-14

申请号：US11083216

申请日：2005-03-18

Applicant: Masayuki Negoro ,  Ken Kawata

Inventor： Masayuki Negoro ,  Ken Kawata

IPC: C07D251/54 ,  C07D251/70 ,  C07D215/44 ,  C07D251/50

CPC classification number: C07D251/70

Abstract: A novel process for producing 2,4,6-tris(hydroxyphenyl amino)-1,3,5-triazine is disclosed. The process comprises reacting a compound represented by a formula (I) and a compound represented by a formula (II) in the presence of a base in a mixed solvent of at least one organic solvent and water, to produce a compound represented by a formula (III): where Y represents a substituent, R1 represents a hydrogen atom or a substituent, m is an integer from 1 to 5, n is an integer from 0 to 4, and when n is 2 or larger, plural Y are same or different each other or plural Y may bond to each other.

Abstract translation: 公开了一种制备2,4,6-三（羟基苯基氨基）-1,3,5-三嗪的新方法。 该方法包括使式（I）表示的化合物和式（II）表示的化合物在碱的存在下在至少一种有机溶剂和水的混合溶剂中反应，得到式 （III）：其中Y表示取代基，R 1表示氢原子或取代基，m为1至5的整数，n为0至4的整数，当n为2时 或更大，多个Y彼此相同或不同，或多个Y可以彼此结合。

公开(公告)号：US06960686B2

公开(公告)日：2005-11-01

申请号：US10946842

申请日：2004-09-22

Applicant: Silvio Iera ,  Christopher A. Demerson ,  Jacqueline F. Lunetta ,  Maria Papamichelakis ,  Michael F. MacEwan ,  Wayne G. McMahon ,  John R. Potoski ,  Arthur G. Mohan ,  Antonia Nikitenko

Inventor： Silvio Iera ,  Christopher A. Demerson ,  Jacqueline F. Lunetta ,  Maria Papamichelakis ,  Michael F. MacEwan ,  Wayne G. McMahon ,  John R. Potoski ,  Arthur G. Mohan ,  Antonia Nikitenko

IPC: C07C303/38 ,  C07C303/40 ,  C07C311/19 ,  C07C311/42 ,  C07D251/50 ,  C07D251/70 ,  C07C303/00 ,  A61K31/18

CPC classification number: C07C303/38 ,  C07C303/40 ,  C07D251/50 ,  C07D251/70 ,  C07C311/19 ,  C07C311/42

Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.

公开(公告)号：US20050137196A1

公开(公告)日：2005-06-23

申请号：US10951316

申请日：2004-09-27

Applicant: Richard Timmer ,  Christopher Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Yeleswarapu ,  Manojit Pal ,  Jangalgar Reddy ,  Velagala Venkata Krishna Reddy ,  Bhatlapenumarthy Sesha Sridevi ,  Potlapally Kumar ,  Gaddam Reddy

Inventor： Richard Timmer ,  Christopher Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Yeleswarapu ,  Manojit Pal ,  Jangalgar Reddy ,  Velagala Venkata Krishna Reddy ,  Bhatlapenumarthy Sesha Sridevi ,  Potlapally Kumar ,  Gaddam Reddy

IPC: A61K31/53 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/6558 ,  C07D251/18 ,  C07D43/02

CPC classification number: A61K31/53 ,  C04B35/632 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

公开(公告)号：US20050043299A1

公开(公告)日：2005-02-24

申请号：US10491794

申请日：2002-10-23

Applicant: David Evans ,  Doreen Ashworth

Inventor： David Evans ,  Doreen Ashworth

IPC: C07D295/18 ,  A61K31/40 ,  A61K31/401 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/53 ,  A61K31/5375 ,  A61K31/54 ,  A61K31/541 ,  A61K31/55 ,  A61P3/10 ,  A61P15/00 ,  A61P31/18 ,  A61P35/04 ,  A61P37/02 ,  A61P43/00 ,  C07D207/10 ,  C07D207/16 ,  C07D207/32 ,  C07D207/335 ,  C07D211/14 ,  C07D211/38 ,  C07D211/62 ,  C07D213/38 ,  C07D213/74 ,  C07D213/82 ,  C07D215/12 ,  C07D251/50 ,  C07D251/52 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07D307/06 ,  C07D307/81 ,  C07D317/66 ,  C07D333/20 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  C07D417/02 ,  C07D413/02 ,  C07D43/02

CPC classification number: C07D207/335 ,  C07D207/10 ,  C07D207/16 ,  C07D211/14 ,  C07D211/38 ,  C07D211/62 ,  C07D213/38 ,  C07D213/74 ,  C07D213/82 ,  C07D215/12 ,  C07D251/50 ,  C07D251/52 ,  C07D277/04 ,  C07D295/185 ,  C07D307/06 ,  C07D307/81 ,  C07D317/66 ,  C07D333/20 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14

Abstract: Novel compounds that are inhibitors of one or most post-proline cleaving proteases, e.g. dipeptidyl peptidase IV, according to general formula (1). R1 is H or CN, X1 is O, S, CH2, CHF, CF2, CH(CH3), C(CH3)2 or CH(CN), and b is 1 or 2. G1 is H or a group according to the formula —CH2—X2—(CH2)a—G3 and G2 is H or a group according to the formula —CH2—(CH29a—G3, provided that one of G1 and G2 is H and the other is not H. X2 is O, S, or CH2, and a is 0, 1 or 2, provided that when a is 1 then X2 is CH2. G3 is a group according to one of general formulae 2-4, where the variables have meaning given in the description. The compounds are useful in the treatment of i.a. type 2 diabetes and impaired glucose tolerance.

Abstract translation: 一种或多种后脯氨酸切割蛋白酶的抑制剂的新型化合物，例如 二肽基肽酶IV，根据通式（1）。 R 1是H或CN，X 1是O，S，CH 2，CHF，CF 2，CH（CH 3），C（CH 3）2或CH（CN），b是1或2.G <1 >是H或根据式-CH 2 -X 2 - （CH 2）aG 3和G 2的基团是H或根据式-CH 2 - 的基团（CH 29 a-G 3， 条件是G 1和G 2中的一个是H，另一个不是H.X 2是O，S或CH 2，a是0,1或2，条件是当a是1时 X 2是CH 2，G 3是根据通式2-4之一的基团，其中变量具有在说明书中给出的含义。该化合物可用于治疗ia2型糖尿病和葡萄糖耐量异常。