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    Fluorescent compound with cyanuric-hydroxide and preparation method thereof
    2.
    发明授权
    Fluorescent compound with cyanuric-hydroxide and preparation method thereof 有权

    公开(公告)号：US12061203B2

    公开(公告)日：2024-08-13

    申请号：US17536035

    申请日：2021-11-28

    申请人： Bioacts Corporation

    发明人： Jin Woo Park ,  Kiwon Kim ,  Gyeong Rim Shin ,  Eunseo Yu

    IPC分类号： C09B23/06 ,  C09B23/08 ,  C09B23/10 ,  G01N33/58

    CPC分类号： G01N33/582 ,  C09B23/06 ,  C09B23/083 ,  C09B23/107

    摘要： A fluorescent compound in accordance with exemplary embodiments of the present invention has high stability under a water-soluble condition to be easily stored for a long time and improve pH stability and can be more efficiently used for labeling and dyeing of a target material by introducing the triazine substituted with a hydroxyl group as a linker to improve the fluorescent intensity even at a low concentration as compared with the conventional structure. Further, the fluorescent compound is excellent in optical stability and exhibits stable fluorescence in long-term dyeing, and is excellent in fluorescence intensity while being not accumulated in the body, and thus, can be easily dyed and imaged in vivo even in the use of a small amount as compared with the conventional dyes to be economically used.

    Modified nucleotide reagents
    3.
    发明授权
    Modified nucleotide reagents 有权

    公开(公告)号：US12037641B2

    公开(公告)日：2024-07-16

    申请号：US17839412

    申请日：2022-06-13

    申请人： Pacific Biosciences of California, Inc.

    发明人： Gene Shen ,  Stephen Yue ,  Lubomir Sebo ,  Louis Brogley

    IPC分类号： C07H19/052 ,  C07H19/207 ,  C07H21/04 ,  C09B23/06 ,  C09B23/08 ,  C09B69/00 ,  C12Q1/6869 ,  C12Q1/6876

    CPC分类号： C12Q1/6869 ,  C07H19/052 ,  C07H19/207 ,  C07H21/04 ,  C09B23/06 ,  C09B23/083 ,  C09B69/00 ,  C12Q1/6876

    摘要： Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with high sensitivity at desirable wavelengths. They contain structural components that modulate the interactions of the analogs with DNA polymerase, thus decreasing photodamage and improving the kinetic and other properties of the analogs in sequencing reactions. Also provided are nucleotide and dye-labeled compounds of the subject analogs, as well as intermediates useful in the preparation of the compounds and analogs. Compositions comprising the compounds, methods of synthesis of the intermediates, compounds, and analogs, and mutant DNA polymerases are also provided.

    OPTICAL FILTER AND IMAGING DEVICE
    7.
    发明公开
    OPTICAL FILTER AND IMAGING DEVICE 审中-公开

    公开(公告)号：US20230296818A1

    公开(公告)日：2023-09-21

    申请号：US18323010

    申请日：2023-05-24

    申请人： AGC Inc.

    发明人： Kazuhiko SHIONO ,  Nanako NISHIMOTO ,  Sayuri YAMADA ,  Hiroki HOTAKA ,  Satoshi OKADA ,  Keigo MATSUURA

    IPC分类号： G02B5/28 ,  C09B23/08 ,  G02B5/20 ,  C09K3/00

    CPC分类号： G02B5/282 ,  C09B23/083 ,  G02B5/208 ,  C09K3/00

    摘要： An optical filter includes: an absorption layer including a first near-infrared absorbing dye (D1), a second near-infrared absorbing dye (D2), and a transparent resin; and a reflection layer including a dielectric multilayer film. The dye (D1) and the dye (D2) are squarylium compounds satisfying following (1) to (3). (1) The dye (D1) has a maximum absorption wavelength λmax(D1) within a range of 680 to 730 nm, and the difference between a wavelength at which a transmittance is 80% on the shorter wavelength side than λmax(D1) when the concentration is adjusted such that a transmittance at λmax(D1) is 10%, and λmax(D1) is 100 nm or less. (2) The dye (D2) has a maximum absorption wavelength λmax(D2) within a range of 720 to 770 nm. (3) A value obtained by subtracting λmax(D1) from λmax(D2) is 30 nm or more and 85 nm or less.

    Optical filter and imaging device
    8.
    发明授权
    Optical filter and imaging device 有权

    公开(公告)号：US11709298B2

    公开(公告)日：2023-07-25

    申请号：US16808480

    申请日：2020-03-04

    申请人： AGC Inc.

    发明人： Kazuhiko Shiono ,  Nanako Nishimoto ,  Sayuri Yamada ,  Hiroki Hotaka ,  Satoshi Okada ,  Keigo Matsuura

    IPC分类号： G02B5/28 ,  C09B23/08 ,  G02B5/20 ,  C09K3/00

    CPC分类号： G02B5/282 ,  C09B23/083 ,  C09K3/00 ,  G02B5/208

    摘要： An optical filter includes: an absorption layer including a first near-infrared absorbing dye (D1), a second near-infrared absorbing dye (D2), and a transparent resin; and a reflection layer including a dielectric multilayer film. The dye (D1) and the dye (D2) are squarylium compounds satisfying following (1) to (3). (1) The dye (D1) has a maximum absorption wavelength λmax(D1) within a range of 680 to 730 nm, and the difference between a wavelength at which a transmittance is 80% on the shorter wavelength side than λmax(D1) when the concentration is adjusted such that a transmittance at λmax(D1) is 10%, and λmax(D1) is 100 nm or less. (2) The dye (D2) has a maximum absorption wavelength λmax(D2) within a range of 720 to 770 nm. (3) A value obtained by subtracting λmax(D1) from λmax(D2) is 30 nm or more and 85 nm or less.