公开(公告)号：US20220081402A1

公开(公告)日：2022-03-17

申请号：US17456368

申请日：2021-11-23

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Alan S. VERKMAN ,  Marc H. LEVIN ,  Onur CIL ,  Sujin LEE

IPC分类号： C07D251/52 ,  C07D251/46 ,  A61P1/10 ,  A61P27/04 ,  A61K31/496 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D403/04 ,  C07D413/12

摘要： Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.

公开(公告)号：US11060027B2

公开(公告)日：2021-07-13

申请号：US16861720

申请日：2020-04-29

申请人： Polnox Corporation

发明人： Ashok L. Cholli ,  Vijayendra Kumar

IPC分类号： C09K15/24 ,  C07C213/00 ,  C07C217/28 ,  C07C217/42 ,  C07C231/02 ,  C07C235/34 ,  C07D251/34 ,  C07D251/52 ,  C07C209/60 ,  C07C213/02 ,  C07C235/38 ,  C07D251/30 ,  C07D251/46 ,  C08K5/20 ,  C10M133/16

摘要： Disclosed are compounds represented by structural formula methods of producing compounds represented by structural formula, and their use in inhibiting oxidation in an oxidizable material.

公开(公告)号：US20200369687A1

公开(公告)日：2020-11-26

申请号：US16988775

申请日：2020-08-10

申请人： National Chi Nan University ,  Great Chain Chemical Ltd.

发明人： Long-Li Lai ,  Cheng-Hua Lee ,  Jhih-Yuan Tong ,  Yan-Chih Lu ,  Yu-You Lin ,  Ya-Lin Chang

IPC分类号： C07F7/08 ,  C07D251/26 ,  C07D251/52 ,  C07D251/54 ,  C07F7/18 ,  C07D251/46

摘要： A process for preparing a triazine-based precursor for producing a micro-particulate complex containing a far infrared-emissive silica particle comprises steps of: a) subjecting 2-4-6-trichloro-1,3,5-triazine and a first nucleophilic compound to a displacement reaction in the presence of a first solvent at a first temperature range to form an intermediate; and b) subjecting the intermediate and a second nucleophilic compound to a further displacement reaction in the presence of a second solvent at a second temperature range higher than the first temperature range.

公开(公告)号：US10683455B2

公开(公告)日：2020-06-16

申请号：US16372594

申请日：2019-04-02

申请人： Polnox Corporation

发明人： Ashok L. Cholli ,  Vijayendra Kumar

IPC分类号： C10M133/16 ,  C09K15/24 ,  C07C213/00 ,  C07C217/28 ,  C07C217/42 ,  C07C231/02 ,  C07C235/34 ,  C07D251/34 ,  C07D251/52 ,  C07C209/60 ,  C07C213/02 ,  C07C235/38 ,  C07D251/30 ,  C07D251/46 ,  C08K5/20

摘要： Disclosed are compounds represented by structural formula methods of producing compounds represented by structural formula, and their use in inhibiting oxidation in an oxidizable material.

公开(公告)号：US20200181097A1

公开(公告)日：2020-06-11

申请号：US16785417

申请日：2020-02-07

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Alan S. VERKMAN ,  Marc H. LEVIN ,  Onur CIL ,  Sujin LEE

IPC分类号： C07D251/52 ,  C07D413/12 ,  C07D403/04 ,  A61K45/06 ,  A61K31/55 ,  A61K31/5377 ,  A61K31/53 ,  A61K31/496 ,  A61P27/04 ,  A61P1/10 ,  C07D251/46

摘要： Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.

公开(公告)号：US09139573B2

公开(公告)日：2015-09-22

申请号：US14102020

申请日：2013-12-10

申请人： Jayhong A. Chong ,  Christopher Fanger ,  Magdalene M. Moran ,  Elisha Singer ,  Timothy Strassmaier ,  Howard Ng

发明人： Jayhong A. Chong ,  Christopher Fanger ,  Magdalene M. Moran ,  Elisha Singer ,  Timothy Strassmaier ,  Howard Ng

IPC分类号： A61K31/00 ,  A61K31/164 ,  A61K31/53 ,  C07D409/12 ,  A61K31/4184 ,  C07D235/30 ,  C07D251/16 ,  C07D251/46 ,  C07D251/52 ,  C07D263/58 ,  C07D405/14 ,  C07D409/06

CPC分类号： A61K31/423 ,  A61K31/00 ,  A61K31/164 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/53 ,  C07D235/30 ,  C07D251/16 ,  C07D251/46 ,  C07D251/52 ,  C07D263/58 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12

摘要： Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.

摘要翻译： 描述了通过施用有效量的TRPC5拮抗剂（例如本文公开的化合物）来治疗受试者中TRPC5介导的病症的方法。

公开(公告)号：US09073877B2

公开(公告)日：2015-07-07

申请号：US12920730

申请日：2009-02-24

申请人： Giancarlo Sioli

发明人： Giancarlo Sioli

IPC分类号： C07D251/60 ,  C07D251/62 ,  C07D251/46 ,  C07D251/52 ,  B01J19/00 ,  B01J19/18

CPC分类号： C07D251/62 ,  B01D9/0013 ,  B01J19/006 ,  B01J19/18 ,  B01J19/1862 ,  B01J19/1881 ,  B01J2219/00083 ,  B01J2219/00768 ,  C07D251/46 ,  C07D251/52 ,  C07D251/60

摘要： The present invention concerns process for obtaining melamine at high purity characterized by comprising the steps of:—quenching a melamine melt, deprived of off-gases of the melamine synthesis and containing melamine impurities such as ammeline, ammelide and polycondensates, with an aqueous solution comprising ammonia under conditions such to substantially convert polycondensates into melamine, obtaining a melamine solution substantially free of polycondensates, recovering melamine from said melamine solution by melamine crystallization, obtaining melamine crystals and a melamine crystallization mother liquor,—treating said crystallization melamine mother liquor under conditions such to convert at least a portion of its ammeline content into ammelide and melammine, obtaining a treated mother liquid having at least a reduced ammeline content. The invention also concerns a high-pressure non-catalytic plant for the production of high-purity melamine implementing the above process and apparatuses suitable to be used in this plant.

公开(公告)号：US09045439B2

公开(公告)日：2015-06-02

申请号：US13626539

申请日：2012-09-25

申请人： Urea Casale SA

发明人： Giancarlo Sioli

IPC分类号： C07D251/60 ,  C07D251/62 ,  C07D251/52 ,  C07D251/46 ,  B01J19/06 ,  B01J19/18 ,  B01J19/00

CPC分类号： C07D251/62 ,  B01D9/0013 ,  B01J19/006 ,  B01J19/18 ,  B01J19/1862 ,  B01J19/1881 ,  B01J2219/00083 ,  B01J2219/00768 ,  C07D251/46 ,  C07D251/52 ,  C07D251/60

摘要： The present invention concerns process for obtaining melamine at high purity characterized by comprising the steps of:—quenching a melamine melt, deprived of off-gases of the melamine synthesis and containing melamine impurities such as ammeline, ammelide and polycondensates, with an aqueous solution comprising ammonia under conditions such to substantially convert polycondensates into melamine, obtaining a melamine solution substantially free of polycondensates, recovering melamine from said melamine solution by melamine crystallization, obtaining melamine crystals and a melamine crystallization mother liquor,—treating said crystallization melamine mother liquor under conditions such to convert at least a portion of its ammeline content into ammelide and melammine, obtaining a treated mother liquid having at least a reduced ammeline content. The invention also concerns a high-pressure non-catalytic plant for the production of high-purity melamine implementing the above process and apparatuses suitable to be used in this plant.

摘要翻译： 本发明涉及获得高纯度三聚氰胺的方法，其特征在于包括以下步骤： - 将三聚氰胺熔体淬灭，剥去三聚氰胺合成物的废气，并含有三聚氰胺杂质如氨米林，ammelide和缩聚物，其中包含 氨，在基本上将缩聚物转化为三聚氰胺，得到基本上不含缩聚物的三聚氰胺溶液，通过三聚氰胺结晶从所述三聚氰胺溶液中回收三聚氰胺，获得三聚氰胺晶体和三聚氰胺结晶母液，在所述三聚氰胺结晶母液条件下， 将其至少一部分的ammeline含量转化成ammelide和melamine，得到至少具有降低的ammeline含量的经处理的母液。 本发明还涉及用于生产高纯度三聚氰胺的高压非催化装置，其实施上述方法和适用于该装置的装置。

公开(公告)号：US20130172317A1

公开(公告)日：2013-07-04

申请号：US13814346

申请日：2011-08-09

申请人： Hiroyuki Kai ,  Takayuki Kameyama ,  Tohru Horiguchi ,  Kentaro Asahi ,  Takeshi Endoh ,  Yasuhiko Fujii ,  Takuya Shintani ,  Ken'ichiroh Nakamura ,  Sae Jikihara ,  Tsuyoshi Hasegawa ,  Miho Oohara ,  Yukio Tada ,  Toshikatsu Maki ,  Akira Iida

发明人： Hiroyuki Kai ,  Takayuki Kameyama ,  Tohru Horiguchi ,  Kentaro Asahi ,  Takeshi Endoh ,  Yasuhiko Fujii ,  Takuya Shintani ,  Ken'ichiroh Nakamura ,  Sae Jikihara ,  Tsuyoshi Hasegawa ,  Miho Oohara ,  Yukio Tada ,  Toshikatsu Maki ,  Akira Iida

IPC分类号： C07D251/46 ,  C07D417/12 ,  C07D413/12 ,  C07D405/06 ,  C07D401/14 ,  C07D251/52 ,  C07D405/14 ,  C07D401/12 ,  C07D403/12 ,  C07D403/04 ,  C07D413/14

CPC分类号： C07D251/46 ,  C07D251/52 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

摘要： The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect.A pharmaceutical composition having an analgesic effect or an improving effect of urination disorder comprising a compound of the formula (I): wherein Rh and Rj are taken together to form a bond; Ra and Rb and/or Rd and Re are taken together to form oxo or the like; Rc is hydrogen, substituted or unsubstituted alkyl or the like; Rf is —(CR4aR4b)n—R2; R4a and R4b are hydrogen, substituted or unsubstituted alkyl or the like; R2 is substituted or unsubstituted cycloalkyl or the like; n is an integer of 1 to 4; —Rg is —X—R3; —X— is —O—, —S— or the like; R3 is substituted or unsubstituted cycloalkyl or the like, or its pharmaceutically acceptable salt or a solvate thereof.

摘要翻译： 本发明提供具有P2X3和/或P2X2 / 3受体拮抗作用的新化合物。 一种具有止痛作用或排尿障碍改善作用的药物组合物，其包含式（I）化合物：其中Rh和Rj一起形成键; Ra和Rb和/或Rd和Re一起形成氧代等; Rc是氢，取代或未取代的烷基等; Rf是 - （CR4aR4b）n-R2; R4a和R4b是氢，取代或未取代的烷基等; R2是取代或未取代的环烷基等; n为1〜4的整数， -Rg为-X-R3; -X-是-O-，-S-等; R3是取代或未取代的环烷基等，或其药学上可接受的盐或溶剂合物。

公开(公告)号：US20120190683A1

公开(公告)日：2012-07-26

申请号：US13188568

申请日：2011-07-22

申请人： Noormohamed M. Niyaz ,  Ricky Hunter ,  Timothy C. Johnson ,  Tony K. Trullinger ,  Annette V. Brown ,  Kristy Bryan

发明人： Noormohamed M. Niyaz ,  Ricky Hunter ,  Timothy C. Johnson ,  Tony K. Trullinger ,  Annette V. Brown ,  Kristy Bryan

IPC分类号： A01N43/54 ,  A01P7/04 ,  A01N43/66 ,  C07D239/52 ,  C07D251/46

CPC分类号： C07D239/52 ,  A01N47/36 ,  C07D213/75 ,  C07D251/46 ,  C07D401/12 ,  C07D403/04

摘要： N-Azinyl-N′-aryl ureas and thioureas derivatives are effective at controlling insects.