发明申请
US20130172317A1 TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION HAVING AN ANALGESIC ACTIVITY COMPRISING THE SAME
有权
具有包括其同源活性的TRIAZINE衍生物和药物组合物
- 专利标题： TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION HAVING AN ANALGESIC ACTIVITY COMPRISING THE SAME
- 专利标题（中）： 具有包括其同源活性的TRIAZINE衍生物和药物组合物
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申请号： US13814346申请日： 2011-08-09
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公开(公告)号： US20130172317A1公开(公告)日： 2013-07-04
- 发明人: Hiroyuki Kai , Takayuki Kameyama , Tohru Horiguchi , Kentaro Asahi , Takeshi Endoh , Yasuhiko Fujii , Takuya Shintani , Ken'ichiroh Nakamura , Sae Jikihara , Tsuyoshi Hasegawa , Miho Oohara , Yukio Tada , Toshikatsu Maki , Akira Iida
- 申请人： Hiroyuki Kai , Takayuki Kameyama , Tohru Horiguchi , Kentaro Asahi , Takeshi Endoh , Yasuhiko Fujii , Takuya Shintani , Ken'ichiroh Nakamura , Sae Jikihara , Tsuyoshi Hasegawa , Miho Oohara , Yukio Tada , Toshikatsu Maki , Akira Iida
- 优先权： JP2010179350 20100810; JP2010182803 20100818; JP2011074763 20110330
- 国际申请： PCT/JP2011/068113 WO 20110809
- 主分类号： C07D251/46
- IPC分类号： C07D251/46 ; C07D417/12 ; C07D413/12 ; C07D405/06 ; C07D401/14 ; C07D251/52 ; C07D405/14 ; C07D401/12 ; C07D403/12 ; C07D403/04 ; C07D413/14
摘要：
The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect.A pharmaceutical composition having an analgesic effect or an improving effect of urination disorder comprising a compound of the formula (I): wherein Rh and Rj are taken together to form a bond; Ra and Rb and/or Rd and Re are taken together to form oxo or the like; Rc is hydrogen, substituted or unsubstituted alkyl or the like; Rf is —(CR4aR4b)n—R2; R4a and R4b are hydrogen, substituted or unsubstituted alkyl or the like; R2 is substituted or unsubstituted cycloalkyl or the like; n is an integer of 1 to 4; —Rg is —X—R3; —X— is —O—, —S— or the like; R3 is substituted or unsubstituted cycloalkyl or the like, or its pharmaceutically acceptable salt or a solvate thereof.
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