公开(公告)号：US20040262229A1

公开(公告)日：2004-12-30

申请号：US10854244

申请日：2004-05-27

Inventor： Yoshio Okamoto ,  Chiyo Yamamoto ,  Chankvetadze Bezhan

IPC: C08B037/00 ,  C02F001/28 ,  B01D015/08

CPC classification number: B01J20/286 ,  B01D15/3833 ,  B01J20/103 ,  B01J20/28042 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3257 ,  B01J20/3263 ,  B01J20/3274 ,  B01J2220/54 ,  B01J2220/58 ,  B01J2220/82 ,  B01J2220/84 ,  C07B57/00

Abstract: The present invention provides a separating agent for optical isomers having a porous monolithic inorganic type carrier and polysaccharide or a derivative thereof supported on the monolithic inorganic type carrier, and a separation column for optical isomers in which the separating agent for optical isomers is held in a column tube. According to the invention, the separating agent for optical isomers and the separation column for optical isomers which have high asymmetry recognition ability and can be used particularly at a high flow rate when used for the separation of optical isomers is provided.

Abstract translation: 本发明提供一种用于光学异构体的分离剂，其具有多孔单片无机载体和负载在单片无机载体上的多糖或其衍生物，以及用于光学异构体的分离柱，其中旋光异构体的分离剂保持在 柱管。 根据本发明，提供了用于光学异构体的分离剂和具有高不对称识别能力的光学异构体的分离柱，并且当用于分离光学异构体时可以特别以高流速使用。

公开(公告)号：US20040251206A1

公开(公告)日：2004-12-16

申请号：US10857388

申请日：2004-05-28

Inventor： Oleg B. Egorov ,  Matthew J. O'Hara ,  Jay W. Grate ,  Darrell P. Chandler ,  Fred J. Brockman ,  Cynthia J. Bruckner-Lea

IPC: B01D015/08

CPC classification number: G01N30/58 ,  B01D15/206 ,  G01N30/56 ,  G01N2030/565

Abstract: The invention encompasses systems for column-based separations, methods of packing and unpacking columns and methods of separating components of samples. In one aspect, the invention includes a method of packing and unpacking a column chamber, comprising: a) packing a matrix material within a column chamber to form a packed column; and b) after the packing, unpacking the matrix material from the column chamber without moving the column chamber. In another aspect, the invention includes a system for column-based separations, comprising: a) a fluid passageway, the fluid passageway comprising a column chamber and a flow path in fluid communication with the column chamber, the flow path being obstructed by a retaining material permeable to a carrier fluid and impermeable to a column matrix material suspended in the carrier fluid, the flow path extending through the column chamber and through the retaining material, the flow path being configured to form a packed column within the column chamber when a suspension of the fluid and the column matrix material is flowed along the flow path; and b) the fluid passageway extending through a valve intermediate the column chamber and the retaining material.

Abstract translation: 本发明包括用于基于柱的分离的系统，包装和拆包柱的方法以及分离样品组分的方法。 一方面，本发明包括一种包装和拆包柱室的方法，包括：a）在柱室内填充基质材料以形成填充柱; 和b）在包装之后，将基体材料从柱室拆开而不移动柱室。 在另一方面，本发明包括一种用于基于柱的分离的系统，包括：a）流体通道，所述流体通道包括柱室和与所述塔室流体连通的流动路径，所述流动路径被保持 对载体流体可渗透的材料和悬浮在载体流体中的柱状基质材料不可渗透的流动路径，所述流动路径延伸穿过柱室并通过保持材料，所述流动路径构造成当悬浮液 的流体和柱基材料沿着流动路径流动; 以及b）流体通道延伸穿过柱室和保持材料之间的阀。

公开(公告)号：US20040251204A1

公开(公告)日：2004-12-16

申请号：US10787041

申请日：2004-02-25

Applicant: Finnfeeds Finland OY

Inventor： Hannu Paananen ,  Jarmo Kuisma ,  Heikki Heikkila ,  Vili Ravanko ,  Jari Lewandowski ,  Ari Karki

IPC: B01D015/08

CPC classification number: B01D15/361 ,  B01D15/1842 ,  B01D15/362 ,  B01D15/363 ,  B01J20/28004 ,  B01J47/026 ,  B01J47/10 ,  C07C227/40 ,  C07H1/06 ,  C07H1/08 ,  C07H3/02 ,  C07H3/04 ,  C13B20/14 ,  C07C229/12

Abstract: The invention relates to a system and a process for fractionating a solution into two or more fractions. The system of the invention comprises at least two compartments having a diameter of at least about one meter and including a uniform packing of a polymer-based ion exchange resin with a bead size in the range of about 50 to about 250 nullm. The mixing volume of the fluid fronts in the system of the invention is not more than 5% of the volume of the compartment.

Abstract translation: 本发明涉及一种将溶液分馏成两个或多个馏分的系统和方法。 本发明的系统包括至少两个具有至少约一米的直径的隔室，并且包括具有在约50至约250μm范围内的珠粒尺寸的基于聚合物的离子交换树脂的均匀包装。 本发明系统中的流体前面的混合体积不超过隔室体积的5％。

公开(公告)号：US20040195179A1

公开(公告)日：2004-10-07

申请号：US10768869

申请日：2004-01-30

Inventor： Ramesh Varadaraj

IPC: B01D015/08

CPC classification number: C10G31/08 ,  C10G19/02 ,  C10G33/00 ,  C10G53/04 ,  C10G2300/1033 ,  C10G2300/203 ,  C10G2300/206 ,  C10G2300/44 ,  C10G2300/805 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375

Abstract: A method for determination for a given oil the relative stability of a water-in-oil emulsion that will be formed by that oil with water comprises measuring for the given oil the weight fraction of the oil that is most strongly adsorbed on a silica gel column successively eluted with n-hexane, toluene and methylene chloride-methanol mixture solvents and determining whether said weight fraction is greater than about 0.05; with a value above 0.05 being determinative of an emulsion more stable than one with a value less than 0.05.

Abstract translation: 用于测定给定油的方法，将由该油与水形成的油包水乳液的相对稳定性包括测量给定的油，最强吸附在硅胶柱上的油的重量分数 依次用正己烷，甲苯和二氯甲烷 - 甲醇混合溶剂洗脱并测定所述重量分数是否大于约0.05; 其值高于0.05是确定乳剂比值小于0.05的乳液更稳定的值。

公开(公告)号：US20040188353A1

公开(公告)日：2004-09-30

申请号：US10480398

申请日：2003-12-09

Inventor： Atsushi Ohnishi

IPC: B01D015/08

CPC classification number: B01J20/285 ,  B01D15/3833 ,  B01J20/103 ,  B01J20/24 ,  B01J20/26 ,  B01J20/261 ,  B01J20/262 ,  B01J20/264 ,  B01J20/265 ,  B01J20/28004 ,  B01J20/28078 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3257 ,  B01J20/3268 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3276 ,  B01J20/328 ,  B01J2220/52 ,  B01J2220/54 ,  B01J2220/58 ,  C12N9/6418

Abstract: A method of producing a novel separating agent for separating enantiomeric isomers, characterized by including: a step of supporting an optically active polymer compound and a compound having an asymmetric structure of a molecular weight of 1,000 or less on a carrier using a solvent; a step of removing the solvent; and a step of removing the compound having the asymmetric structure of the molecular weight of 1,000 or less by washing.

Abstract translation: 一种制备用于分离对映异构体的新型分离剂的方法，其特征在于包括：使用溶剂在载体上负载光学活性聚合物化合物和分子量为1000以下的不对称结构的化合物的步骤; 除去溶剂的步骤; 以及通过洗涤除去分子量为1000以下的不对称结构的化合物的工序。

公开(公告)号：US20040154969A1

公开(公告)日：2004-08-12

申请号：US10360382

申请日：2003-02-06

Inventor： Robert D. Thompson

IPC: B01D015/08

CPC classification number: G01N30/6004 ,  G01N30/6017 ,  G01N30/6082

Abstract: A closure cap system for glass chromatography columns includes a glass cylinder with unfinished shaping or work on each end, and two sealing caps. The caps have a circumference shoulder with O-rings. The O-rings having the same diameter as the diameter of the glass cylinder unfinished ends. A base and top parts, both containing openings for receiving sealing caps and the glass cylinder. Threaded rods are received by additional openings in said top and base parts. Nuts are affixed at the end of each threaded rod. The combined action of the nuts and threaded rods apply compression forces to the caps and glass cylinder for sealing in a simple and economic manner defining the system as a disposable apparatus.

公开(公告)号：US20040144709A1

公开(公告)日：2004-07-29

申请号：US10477898

申请日：2003-11-19

Inventor： Daniel Seydoux ,  Franck Muller

IPC: B01D015/08

CPC classification number: F16L37/20 ,  G01N30/6047

Abstract: The invention concerns a device for mounting an elongated element with axial clamping, characterized in that it consists of a body (3) forming a support base whereon are fixed a stop part (4) including a first support element (5) for one (2null) of the ends of the elongated element (2) and a retaining part (6), said parts (4 and 6) being axially separated and of a removable support block (7) comprising a through passage for receiving the elongated element (2) and capable of being positioned wedged between the retaining part (6) and the stop part (4), and of a mobile part (9) including a second support element (10) for the other end (2null) of the elongated element (2), said mobile part (9) being secured in articulation to two link rods (11, 11null) mounted at their opposite ends, potentially rotatable, on two eccentrics (12, 12null) mounted potentially rotatable on the body (3) forming the support base and rigidly assembled to a pivoting cover or lid (13) provided with a member or a zone (14) for gripping or maneuvering, said cover or lid (13) substantially covering the assembly of said parts (4, 6, 9) and said elements (5, 7, 10) when it is folded down.

Abstract translation: 本发明涉及一种用于安装具有轴向夹紧的细长元件的装置，其特征在于，其由形成支撑基座的主体（3）组成，所述主体固定有止动部分（4），所述止动部分包括第一支撑元件（5） （2）的端部和保持部分（6），所述部分（4和6）在轴向上分开并且具有可移除的支撑块（7），其包括用于接收细长元件（2）的通道 ）并且能够被定位成楔入保持部分（6）和止挡部分（4）之间，并且可移动部分（9）包括用于另一端（2“）的第二支撑元件（10） 元件（2），所述可移动部件（9）以铰接方式被固定到安装在其相对端部处的潜在可旋转的两个连杆（11,11'），所述两个连杆​​（11,11'）可安装在潜在可旋转的主体上的两个偏心件（12,12'）上 3）形成支撑基座并刚性组装到设置有构件或区域（14）的枢转盖或盖（13），用于 所述盖或盖（13）当其向下折叠时基本上覆盖所述部件（4,6和9）和所述元件（5,7,10）的组件。

公开(公告)号：US20040129641A1

公开(公告)日：2004-07-08

申请号：US10373504

申请日：2003-02-25

Applicant: Finnfeeds Finland Oy

Inventor： Hannu Paananen ,  Heikki Heikkila ,  Jari Lewandowski ,  Esko Varteva

IPC: B01D015/08

CPC classification number: B01D15/14 ,  G01N30/6017

Abstract: The present invention relates to a fluid distributing device for distributing fluid into a column and to a fluid collecting device for collecting fluid from a column. The invention relates also to methods of using the devices of the present invention. The distributing device and/or the collecting device of the present invention can be used in fixed or fluidized bed reactors or columns, such as chromatographic separation columns, ion exchange columns, adsorption columns etc. A fluid distributing device comprises a) a first fluid conveying system; and b) a distributing plate, which comprises i) first means for fluid transfer for dividing the fluid flow coming from the delivering points into several partial fluid flows and for distributing the partial fluid flows into the column; and ii) first means for controlling of the partial fluid flows by differential pressure in the first means for fluid transfer.

Abstract translation: 本发明涉及一种用于将流体分配到塔中的流体分配装置和用于从塔收集流体的流体收集装置。 本发明还涉及使用本发明的装置的方法。 本发明的分配装置和/或收集装置可用于固定床或流化床反应器或柱，例如色谱分离柱，离子交换柱，吸附柱等。流体分配装置包括：a）第一流体输送 系统; 以及b）分配板，其包括i）用于流体转移的第一装置，用于将来自所述输送点的流体流分成若干部分流体流，并将所述部分流体流分配到所述塔中; 以及ii）用于在第一流体传递装置中通过差压控制部分流体流动的第一装置。

公开(公告)号：US20040124142A1

公开(公告)日：2004-07-01

申请号：US10689121

申请日：2003-10-20

Inventor： William Kopaciewicz ,  Phillip Clark ,  David Brewster

IPC: B01D015/08

CPC classification number: B01D67/0009 ,  B01D2323/24 ,  B01D2325/12 ,  B01L3/50255 ,  B01L2200/12 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2400/049 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Sample preparation device and method for desalting and concentrating samples prior to further analysis such as by MALDI TOF and/or electro-spray ionization (ESI) mass spectrometry. The device in accordance with an embodiment of the present invention contains a three dimensional structure preferably comprising a plurality of sorptive particles entrapped in a porous polymer matrix so as to form a device capable of carrying out solid phase extraction. The device is manufactured by introducing casting solution containing polymer and optionally particles into a housing, and subsequently exposing the device to a quench bath for a time sufficient to allow for solvent exchange and precipitation to form the composite structure in the housing. The present invention is also directed towards a method of sample preparation using the device of the present invention.

Abstract translation: 在进一步分析之前，例如通过MALDI TOF和/或电喷雾离子化（ESI）质谱法进行脱盐和浓缩样品的样品制备装置和方法。 根据本发明的实施方案的装置包含三维结构，其优选包含多个捕获在多孔聚合物基质中的吸附颗粒，以形成能够进行固相萃取的装置。 该装置通过将含有聚合物和任选的颗粒的浇铸溶液引入壳体而制造，并且随后将该装置暴露于淬火浴中足以允许溶剂交换和沉淀以在壳体中形成复合结构的时间。 本发明还涉及使用本发明的装置的样品制备方法。

公开(公告)号：US20040118762A1

公开(公告)日：2004-06-24

申请号：US10322863

申请日：2002-12-18

Inventor： Jishou Xu ,  Edmond Bowden

IPC: B01D015/08

CPC classification number: B01J20/20 ,  B01D15/322 ,  B01D15/325 ,  B01D15/361 ,  B01J20/286 ,  B01J20/287 ,  B01J20/288 ,  B01J39/26 ,  B01J41/20

Abstract: Packing materials useful in applications such as liquid chromatography and solid phase extraction, as well as processes for producing such packing materials are described. The packing materials are based on chemically modified diamond powders. The surfaces of the diamond powders are attached with hydrocarbon, amino, carboxylic acid, or sulfonic acid groups through CnullC, CnullN, or CnullS single bonds. The residual groups can be solely hydroxyl groups or solely hydrogen atoms. The stability of the packing materials allows regeneration of columns at pH>14 for protein separation. With hydrogen atoms as the residual groups for reverse phase diamond packings, the non-specific interaction associated with silica, polymeric, or graphitic packings can be largely eliminated. With hydroxyl groups as the residual groups for ion exchangers based on diamond powders, the non-specific interaction associated with hydrophobic sites can be largely eliminated.

Abstract translation: 描述了可用于诸如液相色谱和固相萃取的应用中的包装材料，以及用于生产这种包装材料的方法。 包装材料是基于化学改性的金刚石粉末。 金刚石粉末的表面通过C-C，C-N或C-S单键与烃，氨基，羧酸或磺酸基团连接。 残基可以是单独的羟基或单独的氢原子。 包装材料的稳定性允许在pH> 14的条件下再生塔用于蛋白质分离。 用氢原子作为反相金刚石填料的残留基团，可以大大消除与二氧化硅，聚合物或石墨填料相关的非特异性相互作用。 以羟基作为基于金刚石粉末的离子交换剂的残基，可以大大消除与疏水位点相关的非特异性相互作用。