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公开(公告)号：US20040259838A1
公开(公告)日：2004-12-23
申请号：US10498070
申请日：2004-06-09
发明人： Joseph G. Joyce , James C. Cook III , Chitrananda Abeygunawardana , Karen M. Grimm , Craig T. Przysiecki , Robert W. Hepler , Charlotte C. Ip , Donald Keith Roper , Qi Wei Xu , Kathrin U. Jansen , Paul M. Keller , Leslie D. Cope
IPC分类号： A61K031/739 , C08B037/00
CPC分类号： A61K39/085
摘要： A high molecular weight polysaccharide intracellular adhesin (SAE) antigen having the general structure of poly-1,6,null-2-amidoglucopyranoside, which is variable substituted with N-acetyl and O-succinyl substituents is described. Also, a method is given for isolating this antigen from Staphylococcus aureus. The SAE can be used in a vaccine, either alone, conjugated to an immunogenic protein, and/or with an immunogenic adjuvant.
摘要翻译： 描述了具有可被N-乙酰基和O-琥珀酰基取代基取代的聚-1,6，β-2-酰胺基吡喃糖苷的一般结构的高分子量多糖细胞内粘附素（SAE）抗原。 此外，给出了用于从金黄色葡萄球菌分离该抗原的方法。 SAE可以单独用于疫苗，与免疫原性蛋白质结合，和/或用免疫原性佐剂使用。
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2.发明申请公开(公告)号：US20040259203A1
公开(公告)日：2004-12-23
申请号：US10850125
申请日：2004-05-19
IPC分类号： C08B037/00 , C07H021/04 , C12N009/10
CPC分类号： C12N9/1241 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12N9/1081 , C12P19/18
摘要： This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an null2,3- and an null2,8-activity. A null1,4-GalNAc transferase and a null1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.
摘要翻译： 本发明提供了原核糖基转移酶，包括具有α2,3-和α2,8-活性的双官能唾液酸转移酶。 本发明还提供β1,4-GalNAc转移酶和β1,3-半乳糖基转移酶，以及参与脂寡糖（LOS）合成的其它糖基转移酶和酶。 糖基转移酶可以从例如弯曲杆菌属物种获得，包括空肠弯曲杆菌。 在另外的实施方案中，本发明提供编码糖基转移酶的核酸，以及用于表达糖基转移酶的表达载体和宿主细胞。
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公开(公告)号：US20040242534A1
公开(公告)日：2004-12-02
申请号：US10333052
申请日：2003-06-09
发明人： Pei Yuan Cheng , Jing Weng , Yi Gong Fang , Guang Cheng
IPC分类号： A61K031/715 , C08B037/00
CPC分类号： A61K9/19 , A61K31/715
摘要： The present invention dicloses an antineoplastic sterile lyophilized powder of lentinan and the process of preparation thereof. The lyophilized powder of lentinan is essentially consisted of 0.50-1.40 parts of lentinan and 50-140 parts of excipient for lyophilization, based on weight. It has good stability. It has improved safety as it does not contain dextran which may cause allergic side effect.
摘要翻译： 本发明涉及香菇多糖的抗肿瘤无菌冻干粉及其制备方法。 香菇多糖的冻干粉基本上由0.50-1.40份香菇多糖和50-140份用于冻干的赋形剂组成，以重量计。 稳定性好 它具有改善的安全性，因为它不含有可能引起过敏性副作用的葡聚糖。
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公开(公告)号：US20040229278A1
公开(公告)日：2004-11-18
申请号：US10470606
申请日：2003-07-03
IPC分类号： G01N033/53 , G01N033/567 , C08B037/00 , C07K014/47
CPC分类号： C07K14/4713 , A61K38/1709
摘要： The invention refers to a protein from plasma membrane of adipocytes. The protein has specific binding affinity to phosphoinositoylglycans. It regulates glucose uptake by circumventing the insulin signaling cascade.
摘要翻译： 本发明涉及脂肪细胞质膜的蛋白质。 该蛋白质对磷酸肌醇蛋白具有特异性结合亲和力。 它通过绕过胰岛素信号级联来调节葡萄糖摄取。
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5.发明申请公开(公告)号：US20040220389A1
公开(公告)日：2004-11-04
申请号：US10774070
申请日：2004-02-06
IPC分类号： C07K014/00 , C08B037/00
CPC分类号： C07H15/18 , C07H15/203 , Y02P20/55
摘要： One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.
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公开(公告)号：US20040214228A9
公开(公告)日：2004-10-28
申请号：US10388868
申请日：2003-03-14
IPC分类号： G01N033/53 , C08B037/00 , C12P021/06 , C07K014/435
CPC分类号： C07H1/00 , C08B37/00 , C08H1/00 , G01N2400/00
摘要： Methods to evaluate and rapidly produce and identify polysaccharides, and other sugar structures, having enhanced activities, have been developed. The methods include producing a molecule, e.g., a therapeutic molecule, which includes a first, non-saccharide moiety (e.g., a protein, polypeptide, peptide, amino acid or lipid) and a second, saccharide, moiety. The method includes: determining the chemical composition and structure of all or a portion of the second, saccharide moiety, and evaluating or screening the molecule, e.g., for a biological activity or other chemical or physical property. In some embodiments, the step of determining the chemical structure and composition of the second moiety includes a comparison of one or more properties of the second moiety with a database, e.g., a database which correlates such one or more properties with structure or function of a polysaccharide.
摘要翻译： 已经开发了评估并快速产生和鉴定具有增强活性的多糖和其他糖结构的方法。 所述方法包括产生分子，例如治疗分子，其包括第一非糖部分（例如蛋白质，多肽，肽，氨基酸或脂质）和第二糖部分。 该方法包括：确定第二糖部分的全部或部分的化学组成和结构，以及评估或筛选分子，例如生物活性或其它化学或物理性质。 在一些实施方案中，确定第二部分的化学结构和组成的步骤包括将第二部分的一种或多种性质与数据库进行比较，数据库例如将这样的一种或多种性质与结构或功能相关联的数据库 多糖。
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7.发明申请Nucleic acids encoding beta 1,4-N-acetylgalactosaminyltransferases from C. jejuni 有权编码来自空肠弯曲杆菌的β-1,4-N-乙酰半乳糖胺基转移酶的核酸公开(公告)号：US20040203113A1
公开(公告)日：2004-10-14
申请号：US10845412
申请日：2004-05-12
IPC分类号： C12P019/18 , C07H021/04 , C12N009/10 , C08B037/00
CPC分类号： C12N9/1241 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12N9/1081 , C12P19/18
摘要： This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an null2,3- and an null2,8-activity. A null1,4-GalNAc transferase and a null1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.
摘要翻译： 本发明提供了原核糖基转移酶，包括具有α2,3-和α2,8-活性的双官能唾液酸转移酶。 本发明还提供β1,4-GalNAc转移酶和β1,3-半乳糖基转移酶，以及参与脂寡糖（LOS）合成的其它糖基转移酶和酶。 糖基转移酶可以从例如弯曲杆菌属物种获得，包括空肠弯曲杆菌。 在另外的实施方案中，本发明提供编码糖基转移酶的核酸，以及用于表达糖基转移酶的表达载体和宿主细胞。
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公开(公告)号：US20040203112A1
公开(公告)日：2004-10-14
申请号：US10845408
申请日：2004-05-12
IPC分类号： C12P019/18 , C07H021/04 , C08B037/00 , C12N009/10
CPC分类号： C12N9/1241 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12N9/1081 , C12P19/18
摘要： This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an null2,3- and an null2,8-activity. A null1,4-GalNAc transferase and a null1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.
摘要翻译： 本发明提供了原核糖基转移酶，包括具有α2,3-和α2,8-活性的双官能唾液酸转移酶。 本发明还提供β1,4-GalNAc转移酶和β1,3-半乳糖基转移酶，以及参与脂寡糖（LOS）合成的其它糖基转移酶和酶。 糖基转移酶可以从例如弯曲杆菌属物种获得，包括空肠弯曲杆菌。 在另外的实施方案中，本发明提供编码糖基转移酶的核酸，以及用于表达糖基转移酶的表达载体和宿主细胞。
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9.发明申请公开(公告)号：US20040197410A1
公开(公告)日：2004-10-07
申请号：US10484216
申请日：2004-01-20
发明人： Toshiyuki Sugimoto , Toshio Miyake
IPC分类号： C12P019/04 , A61K009/14 , C08B037/00
CPC分类号： C08J3/12 , A23L29/274 , A23P20/20 , A61K8/0212 , A61K8/11 , A61K8/73 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0018 , C08J3/14 , C08J2305/00 , C08K5/15 , C08L5/00 , C08L5/16 , C08L2666/26
摘要： The object of the present invention is to overcome conventional demerits of pullulan powders prepared by conventional techniques, i.e., they could not be homogeneously mixed with non-reducing saccharides composed of glucose units when mixed together, and the resulting mixtures do not easily dissolve in water; and to provide a pullulan-containing powder with an improved rate of water dissolution, as well as to provide preparations and uses thereof. The present invention solves the above object by providing a pullulan-containing powder which uniformly comprises pullulan as a main ingredient and a non-reducing saccharide, and their process and uses; wherein the pullulan-containing powder is prepared by the steps of preparing a solution dissolving pullulan and a non-reducing saccharide homogeneously, pulverizing the solution, and collecting the resulting pullulan-containing powder. The powder has an improved rate of water dissolution, while retaining satisfactory resistance to humidity without fear of causing separation between the pullulan and the non-reducing sccharide.
摘要翻译： 本发明的目的是克服通过常规技术制备的支链淀粉粉末的常规缺点，即当它们混合在一起时不能与由葡萄糖单元组成的非还原性糖类均匀混合，并且所得混合物不容易溶于水 ; 并提供具有改善的水溶解速率的含支链淀粉的粉末，以及提供其制备和用途。 本发明通过提供均匀地包含支链淀粉作为主要成分和非还原性糖的支链淀粉粉末及其工艺和用途来解决上述目的。 其中含有支链淀粉的粉末通过以下步骤制备：均匀地制备溶解支链淀粉和非还原性糖的溶液，粉碎溶液，并收集所得的含支链淀粉粉末。 粉末具有提高的水溶解速率，同时保持令人满意的耐湿性，而不用担心在支链淀粉和非还原性螯合剂之间分离。
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公开(公告)号：US20040180851A1
公开(公告)日：2004-09-16
申请号：US10616278
申请日：2003-07-09
IPC分类号： A61K031/728 , C08B037/00
摘要： Compositions and methods of preparing compositions containing hyaluronic acid derived from eggshell membrane are disclosed. The compositions can contain essentially pure hyaluronic acid or hyaluronic acid in combination with other naturally occurring constituents derived from eggshell membrane. In another aspect, the invention is directed to a method of treating a mammal that will benefit from the administration of hyaluronic acid, which includes administering to the mammal a composition containing hyaluronic acid derived from eggshell membrane.
摘要翻译： 公开了制备含有由蛋壳膜衍生的透明质酸的组合物的组合物和方法。 组合物可以含有基本上纯的透明质酸或透明质酸与其它来自蛋壳膜的天然存在的成分组合。 在另一方面，本发明涉及一种治疗将受益于施用透明质酸的哺乳动物的方法，其包括向哺乳动物施用含有衍生自蛋壳膜的透明质酸的组合物。
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