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公开(公告)号：US20170082645A1
公开(公告)日：2017-03-23
申请号：US15229716
申请日：2016-08-05
Applicant: The Curators of the University of Missouri
Inventor： Timothy Glass , Kenneth Hettie
CPC classification number: G01N33/942 , C09B57/02 , C09K11/06 , C09K11/07 , C09K2211/1048 , C09K2211/1051 , G01N33/582 , G01N33/9406 , G01N33/9413
Abstract: A fluorescence sensing compound for separately detecting and visualizing one or more monoamine neurotransmitters in cells, the fluorescence sensing compound having the following formula: wherein R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alkylene, aryl, cycloalkyl; wherein R3 is selected from the group consisting of hydrogen, alkyl, alkylene, aryl, cycloalkyl, cyano, azido; and wherein R4 is selected from the group consisting of (CH3)2Si, O, N, S, and CH2.
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公开(公告)号：US20170045537A1
公开(公告)日：2017-02-16
申请号：US15287301
申请日：2016-10-06
Applicant: Janssen Pharmaceutica NV
Inventor： Eric Hryhorenko , Banumathi Sankaran , Thomas R. DeCory , Theresa Tubbs , Linda Colt , Maarten Vliegen , Peter Rik Haspeslagh
CPC classification number: G01N33/9413 , C07K16/44 , C07K2317/33 , C07K2317/56 , C07K2317/565 , G01N33/9406
Abstract: Disclosed is an antibody which binds to paliperidone, which can be used to detect paliperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of paliperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone/paliperidone in a single lateral flow assay device.
Abstract translation: 公开了结合利培酮的抗体，其可以用于检测样品中的利培酮，例如在竞争性免疫测定法中。 该抗体可以用于侧流测定装置，用于帕立培酮的护理点检测，包括在单个侧流测定装置中多次检测阿立哌唑，喹硫平，奥氮平和利培酮/帕培培酮。
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公开(公告)号：US09465041B2
公开(公告)日：2016-10-11
申请号：US13971416
申请日：2013-08-20
Inventor： Eric Hryhorenko , Banumathi Sankaran , Thomas R. DeCory , Theresa Tubbs , Linda Colt , Maarten Vliegen , Pieter Rik Haspeslagh
CPC classification number: G01N33/9413 , C07K16/44 , C07K2317/33 , C07K2317/56 , C07K2317/565 , G01N33/9406
Abstract: Disclosed is an antibody which binds to paliperidone, which can be used to detect paliperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of paliperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone/paliperidone in a single lateral flow assay device.
Abstract translation: 公开了结合利培酮的抗体，其可以用于检测样品中的利培酮，例如在竞争性免疫测定法中。 该抗体可以用于侧流测定装置，用于帕立培酮的护理点检测，包括在单个侧流测定装置中多次检测阿立哌唑，喹硫平，奥氮平和利培酮/帕培培酮。
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公开(公告)号：US20140057298A1
公开(公告)日：2014-02-27
申请号：US13971416
申请日：2013-08-20
Applicant: Janssen Pharmaceutica NV , Ortho-Clinical Diagnostics, Inc.
Inventor： Eric Hryhorenko , Banumathi Sankaran , Thomas R. DeCory , Theresa Tubbs , Linda Colt , Maarten Vliegen , Pieter Rik Haspeslagh
CPC classification number: G01N33/9413 , C07K16/44 , C07K2317/33 , C07K2317/56 , C07K2317/565 , G01N33/9406
Abstract: Disclosed is an antibody which binds to paliperidone, which can be used to detect paliperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of paliperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone/paliperidone in a single lateral flow assay device.
Abstract translation: 公开了结合利培酮的抗体，其可以用于检测样品中的利培酮，例如在竞争性免疫测定法中。 该抗体可以用于侧流测定装置，用于帕立培酮的护理点检测，包括在单个侧流测定装置中多次检测阿立哌唑，喹硫平，奥氮平和利培酮/帕培酮。
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公开(公告)号：US08580523B2
公开(公告)日：2013-11-12
申请号：US13352241
申请日：2012-01-17
Applicant: Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
Inventor： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
CPC classification number: C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , G01N33/6896 , G01N33/9413 , G01N2800/2835
Abstract: The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for neurodegenerative diseases such as Parkinson's disease, and is useful as a marker for screening agents involved in the induction of dopaminergic neuron differentiation.
Abstract translation: 本发明鉴定了在细胞周期退出至细胞周期后出现的细胞周期性增殖的多巴胺能神经元祖细胞中，在所有分化阶段的多巴胺能神经元中表达的Lmx1a基因。 当选择适合于帕金森病等神经变性疾病的移植治疗的细胞时，细胞中的Lmx1a表达可用作指示剂，并且可用作参与多巴胺能神经元分化诱导的筛选剂的标记。
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Patent Agency Ranking
公开(公告)号：US08552152B2
公开(公告)日：2013-10-08
申请号：US13645780
申请日：2012-10-05
Applicant: Centre for Addiction and Mental Health
Inventor： Fang Liu
CPC classification number: C07K14/001 , A61K31/7088 , C07K14/705 , G01N33/9413 , G01N2800/044 , G01N2800/2835 , G01N2800/2864 , G01N2800/304
Abstract: The present invention provides for diagnosis or treatment of neurological or neuropsychiatric disorders involving abnormal dopamine neurotransmission. Methods and agents are provided for modulating dopamine transporter activity and modulating dopaminergic neurotransmission. Agents of the present invention include fragments of D2 receptor or dopamine transporter (DAT) that can disrupt D2-DAT coupling.
Abstract translation: 本发明提供诊断或治疗涉及异常多巴胺神经传递的神经或神经精神障碍。 提供了调节多巴胺转运蛋白活性和调节多巴胺能神经传递的方法和试剂。 本发明的试剂包括可破坏D2-DAT偶联的D2受体或多巴胺转运蛋白（DAT）的片段。
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公开(公告)号：US08304519B2
公开(公告)日：2012-11-06
申请号：US12904834
申请日：2010-10-14
Applicant: Fang Liu
Inventor： Fang Liu
CPC classification number: C07K14/001 , A61K31/7088 , C07K14/705 , G01N33/9413 , G01N2800/044 , G01N2800/2835 , G01N2800/2864 , G01N2800/304
Abstract: The present invention provides for diagnosis or treatment of neurological or neuropsychiatric disorders involving abnormal dopamine neurotransmission. Methods and agents are provided for modulating dopamine transporter activity and modulating dopaminergic neurotransmission. Agents of the present invention include fragments of D2 receptor or dopamine transporter (DAT) that can disrupt D2-DAT coupling.
Abstract translation: 本发明提供诊断或治疗涉及异常多巴胺神经传递的神经或神经精神障碍。 提供了调节多巴胺转运蛋白活性和调节多巴胺能神经传递的方法和试剂。 本发明的试剂包括可以破坏D2-DAT偶联的D2受体或多巴胺转运蛋白（DAT）的片段。
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8.发明申请METHOD FOR MULTIPLE QUANTIFICATION OF AMINO GROUP-CONTAINING NON-PEPTIDIC COMPOUND WITH HIGH EFFICIENCY AND HIGH SENSITIVITY AND KIT THEREFOR 审中-公开具有高效率和高灵敏度的氨基含氨基非对映体化合物的多元定量方法及其制备方法公开(公告)号：US20120252052A1
公开(公告)日：2012-10-04
申请号：US13436393
申请日：2012-03-30
Applicant: Shigeru MATSUKAWA , Kazumi NARITA , Haruki SHIMODAIRA
Inventor： Shigeru MATSUKAWA , Kazumi NARITA , Haruki SHIMODAIRA
IPC: C12Q1/02 , C07D213/20 , C07C211/48
CPC classification number: C07C211/48 , C07B2200/05 , C07D213/04 , C07D213/20 , G01N33/6806 , G01N33/9413 , G01N2560/00
Abstract: A method of quantifying a target non-peptidic compound having an amino group contained in one or more biological samples, which comprises a step of producing a difference in the mass of the target non-peptidic compound between samples, by using a combination of two or more kinds of stable isotopes of a compound represented by the formula (I): wherein R1, R2 and R3 are the same or different and each is hydrogen, halogen or alkyl, or a salt thereof, as a labeling compound; and a kit and the like usable for such method.
Abstract translation: 一种定量在一个或多个生物样品中含有氨基的目标非肽化合物的方法，其包括通过使用两种或多种生物样品的组合产生目标非肽化合物的质量差异的步骤 式（I）表示的化合物的更多种稳定同位素：其中R1，R2和R3相同或不同，各自为氢，卤素或烷基或其盐作为标记化合物; 以及可用于这种方法的套件等。
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9.发明申请公开(公告)号：US20110195970A1
公开(公告)日：2011-08-11
申请号：US13066255
申请日：2011-04-11
Applicant: Anthony H. Cincotta
Inventor： Anthony H. Cincotta
IPC: A61K31/4985 , A61P3/00 , A61P9/00 , G01N30/02
CPC classification number: A61K31/498 , G01N33/6896 , G01N33/9413 , G01N2800/52 , Y10S436/815 , Y10T436/145555 , Y10T436/173845
Abstract: The present invention is directed to a method of identifying patients to be treated by dopamine agonist therapy comprising the step of analyzing a plasma or urine sample from said patient for concentrations of norepinephrine (NE), norepinephrine metabolites (NE metabolites), dopamine, dopamine metabolites, serotonin, serotonin metabolites, or fasting triglycerides, wherein one or more of: (a) NE metabolites, (b) NE/NE metabolites: dopamine/dopamine metabolites, (c) NE and serotonin, (d) NE/NE metabolites and serotonin, (e) NE and serotonin metabolites, (f) NE/NE metabolites and serotonin metabolites, or (g) NE is/are greater than about 30% over normal level; or dopamine/dopamine metabolites are less than about 30% below normal; or fasting triglycerides are greater than about 150 mg/dl and/or said patient has hypertension. The present invention is also directed to treating identified patients with dopamine agonist therapy.
Abstract translation: 本发明涉及一种通过多巴胺激动剂治疗来鉴定待治疗患者的方法，包括以下步骤：从去甲肾上腺素（NE），去甲肾上腺素代谢物（NE代谢物），多巴胺，多巴胺代谢物的浓度分析来自所述患者的血浆或尿样品 （a）NE代谢产物，（b）NE / NE代谢产物：多巴胺/多巴胺代谢产物，（c）NE和5-羟色胺，（d）NE / NE代谢产物和 5-羟色胺，（e）NE和5-羟色胺代谢物，（f）NE / NE代谢物和5-羟色胺代谢物，或（g）NE比正常水平高大约30％ 或多巴胺/多巴胺代谢物低于正常值的约30％ 或空腹甘油三酸酯大于约150mg / dl和/或所述患者具有高血压。 本发明还涉及治疗多巴胺激动剂治疗的鉴定患者。
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公开(公告)号：US07544511B2
公开(公告)日：2009-06-09
申请号：US10047352
申请日：2002-01-14
Applicant: Renji Yang , Karl K. Johe
Inventor： Renji Yang , Karl K. Johe
CPC classification number: G01N33/5058 , A61K35/12 , A61K35/30 , C12N5/0619 , C12N5/0623 , C12N5/16 , C12N2500/25 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/148 , C12N2501/392 , C12N2501/395 , C12N2501/91 , C12N2506/02 , C12N2510/00 , C12N2510/02 , G01N33/5008 , G01N33/502 , G01N33/5073 , G01N33/9413
Abstract: A systematic and efficient method for establishing stable neural stem cell lines and neuronal progenitor lines is described. The resulting cell lines provide robust, simple, and reproducible cultures of human and other mammalian neurons in commercially useful mass quantities while maintaining normal karyotypes and normal neuronal phenotypes.
Abstract translation: 描述了建立稳定的神经干细胞系和神经祖细胞系的系统有效的方法。 所得细胞系提供稳定，简单且可重复的人和其他哺乳动物神经元的培养物，其商业上可用的质量数量同时保持正常的核型和正常的神经元表型。
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