公开(公告)号：US20120252052A1

公开(公告)日：2012-10-04

申请号：US13436393

申请日：2012-03-30

Applicant: Shigeru MATSUKAWA ,  Kazumi NARITA ,  Haruki SHIMODAIRA

Inventor： Shigeru MATSUKAWA ,  Kazumi NARITA ,  Haruki SHIMODAIRA

IPC: C12Q1/02 ,  C07D213/20 ,  C07C211/48

CPC classification number: C07C211/48 ,  C07B2200/05 ,  C07D213/04 ,  C07D213/20 ,  G01N33/6806 ,  G01N33/9413 ,  G01N2560/00

Abstract: A method of quantifying a target non-peptidic compound having an amino group contained in one or more biological samples, which comprises a step of producing a difference in the mass of the target non-peptidic compound between samples, by using a combination of two or more kinds of stable isotopes of a compound represented by the formula (I): wherein R1, R2 and R3 are the same or different and each is hydrogen, halogen or alkyl, or a salt thereof, as a labeling compound; and a kit and the like usable for such method.

Abstract translation: 一种定量在一个或多个生物样品中含有氨基的目标非肽化合物的方法，其包括通过使用两种或多种生物样品的组合产生目标非肽化合物的质量差异的步骤 式（I）表示的化合物的更多种稳定同位素：其中R1，R2和R3相同或不同，各自为氢，卤素或烷基或其盐作为标记化合物; 以及可用于这种方法的套件等。