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    Therapeutic Use Of Probiotics
    5.
    发明申请
    Therapeutic Use Of Probiotics 审中-公开
    益生菌的治疗用途

    公开(公告)号：US20120087902A1

    公开(公告)日：2012-04-12

    申请号：US13378031

    申请日：2010-07-20

    Applicant: Maria Rescigno ,  Carmelina Loguercio ,  Enzo Grossi

    Inventor： Maria Rescigno ,  Carmelina Loguercio ,  Enzo Grossi

    IPC: A61K35/74 ,  C12Q1/02 ,  G01N33/566 ,  A61P1/16

    CPC classification number: G01N33/5047 ,  G01N2333/195 ,  G01N2333/335 ,  G01N2333/525 ,  G01N2333/5428 ,  G01N2333/5434 ,  G01N2800/065

    Abstract: The involvement of intestinal microbiota in the initiation and perpetuation of inflammatory bowel disease is widely accepted. To reestablish the homeostasis of the gut the use of probiotics has been proposed, with however, limited clinical benefit. This invention relates to an assay based on the modulation of the immunological activity in DCs (dendritic cells) by probiotic strains, in particular L. paracasei and their use in protecting against inflammatory bowel and liver diseases.

    Abstract translation: 肠道微生物群落参与炎症性肠病的发病和持续存在被广泛接受。 为了重新建立肠道的体内平衡，已经提出使用益生菌，但临床益处有限。 本发明涉及一种基于通过益生菌株（特别是副干酪乳杆菌）调节DCs（树突状细胞）的免疫学活性及其在防止炎症性肠和肝脏疾病中的应用的测定。

    Polynucleotide probe and primer for detecting beer-clouding lactic acid bacteria and method of detecting beer-clouding lactic acid bacteria
    6.
    发明授权
    Polynucleotide probe and primer for detecting beer-clouding lactic acid bacteria and method of detecting beer-clouding lactic acid bacteria 失效
    用于检测啤酒乳酸菌的多核苷酸探针和底物以及啤酒蕴含乳酸菌的检测方法

    公开(公告)号：US07553956B2

    公开(公告)日：2009-06-30

    申请号：US10478404

    申请日：2002-05-23

    Applicant: Toshio Fujii

    Inventor： Toshio Fujii

    IPC: C07H21/04 ,  C12Q1/68

    CPC classification number: C12Q1/689 ,  G01N2333/335

    Abstract: An object of the present invention is to provide probes and primers for detecting beer-spoilage lactic acid bacteria with accuracy. The probes and primers for detecting beer-spoilage lactic acid bacteria according to the present invention each comprises a nucleotide sequence consisting of at least 15 nucleotides that hybridizes with the nucleotide sequence of SEQ ID NO: 1 or the complementary sequence thereof.

    Abstract translation: 本发明的目的是提供用于精确检测啤酒腐败乳酸菌的探针和底物。 用于检测根据本发明的啤酒腐败乳酸菌的探针和引物各自包含由与SEQ ID NO：1的核苷酸序列或其互补序列杂交的至少15个核苷酸组成的核苷酸序列。

    BIOSENSOR
    7.
    发明申请
    BIOSENSOR 失效
    生物传感器

    公开(公告)号：US20090087867A1

    公开(公告)日：2009-04-02

    申请号：US12235336

    申请日：2008-09-22

    Applicant: Shizuko ONO ,  Yayoi TAKAHASHI

    Inventor： Shizuko ONO ,  Yayoi TAKAHASHI

    IPC: G01N33/569

    CPC classification number: G01N33/56944 ,  G01N33/5438 ,  G01N33/56955 ,  G01N2333/335

    Abstract: The invention provides a biosensor comprising a microbe-binding aptamer(s) in the substrate recognition element. It is possible to obtain a stabilized biosensor wherein the detection sensitivity for target microbe (target bacterium) is not impaired depending on the storage condition or measuring sample, and target bacterium in a body fluid can be directly measured by insertion of the substrate recognition element of the biosensor.

    Abstract translation: 本发明提供了一种生物传感器，其包含基底识别元件中的微生物结合适体。 可以获得稳定的生物传感器，其中根据储存条件或测量样品不会损害目标微生物（靶细菌）的检测灵敏度，并且可以通过插入基质识别元件直接测量体液中的靶细菌 生物传感器。

    Human Abo Blood Group-Binding Lactobacilli
    8.
    发明申请
    Human Abo Blood Group-Binding Lactobacilli 有权
    人类血型组合乳酸杆菌

    公开(公告)号：US20080160565A1

    公开(公告)日：2008-07-03

    申请号：US11720462

    申请日：2005-12-01

    Applicant: Tadao Saito ,  Yasushi Kawai ,  Hideaki Uchida ,  Katsunori Kimura ,  Kakuhei Isawa ,  Keisuke Furuichi

    Inventor： Tadao Saito ,  Yasushi Kawai ,  Hideaki Uchida ,  Katsunori Kimura ,  Kakuhei Isawa ,  Keisuke Furuichi

    IPC: C12N1/20 ,  C12Q1/02 ,  A23L2/52 ,  A23C9/123

    CPC classification number: A23C9/1234 ,  A23Y2220/37 ,  C12Q1/04 ,  G01N33/54373 ,  G01N33/56911 ,  G01N33/80 ,  G01N2333/335

    Abstract: Lactobacillus screening methods were carried out using surface plasmon resonance spectrums and human intestinal mucin and blood group antigens as probes. A trial to set selection criteria in the above-mentioned methods of screening for lactobacilli was made to adapt the methods to mass screening, and it was discovered that lactobacilli compatible with ABO blood groups can be screened by setting 100 RU as a criterion for judging bacterial binding under certain conditions. Using 238 lactobacillus strains, the above-mentioned screening methods and tests to judge their compatibility for the use of yogurt production were carried out, to at long last specifically discover bacillus strains compatible with blood groups A, B, and O.

    Abstract translation: 使用表面等离子体共振光谱和人肠粘蛋白和血型抗原作为探针进行乳杆菌筛选方法。 对上述筛选乳酸杆菌的方法设定选择标准的试验进行了适应性筛选的方法，发现与ABO血型相容的乳杆菌可以通过设定100RU作为判断细菌的标准进行筛选 在某些条件下结合。 使用238种乳酸杆菌菌株，进行上述筛选方法和测试来判断其与酸奶生产的相容性，最后特别发现与血型A，B和O相容的芽孢杆菌菌株。

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