公开(公告)号：US12023360B2

公开(公告)日：2024-07-02

申请号：US16780572

申请日：2020-02-03

申请人： OPTIBIOTIX LIMITED

发明人： Stephen Patrick O'Hara ,  Robert Rastall

IPC分类号： A61K35/747 ,  A23L33/10 ,  A23L33/135 ,  A23L33/21 ,  A61K47/36 ,  C12Q1/04 ,  C12Q1/34

CPC分类号： A61K35/747 ,  A23L33/10 ,  A23L33/135 ,  A23L33/21 ,  A61K47/36 ,  C12Q1/04 ,  C12Q1/34 ,  A23V2002/00 ,  G01N2333/938 ,  A23V2002/00 ,  A23V2200/3202 ,  A23V2200/3204

摘要： The present invention relates to a symbiotic composition comprising a probiotic bacterial strain and a prebiotic growth medium which is specific to the growth of the probiotic bacterial strain, wherein the bacterial strain is capable of producing the same growth medium by reverse enzyme reaction. The present invention also relates to methods of producing and screening for such compositions.

公开(公告)号：US20240358730A1

公开(公告)日：2024-10-31

申请号：US18765449

申请日：2024-07-08

申请人： Optibiotix Limited

发明人： Stephen Patrick O'Hara ,  Oswaldo Hernandez ,  Sofia Kolida

IPC分类号： A61K31/702 ,  A23L27/30 ,  A23L33/21 ,  A61K9/14 ,  A61P1/00

CPC分类号： A61K31/702 ,  A23L27/30 ,  A23L33/21 ,  A61K9/14 ,  A61P1/00 ,  A23V2002/00

摘要： The present invention relates to a non-digestible prebiotic oligosaccharide modified so as to incorporate one or more monosaccharide units thereon and have a higher sweetness value than the unmodified oligosaccharide. Uses and methods of producing the non-digestible prebiotic oligosaccharides are also described.

公开(公告)号：US11173170B2

公开(公告)日：2021-11-16

申请号：US15523704

申请日：2015-11-05

申请人： Optibiotix Limited

发明人： Stephen Patrick O'Hara ,  Sofia Kolida

IPC分类号： A61K31/702 ,  A23L33/21 ,  A23L2/52 ,  A61K35/747 ,  A61K45/06 ,  A61K35/741 ,  A23L29/269 ,  A23L33/135 ,  A23L33/26 ,  A61K9/00 ,  A61K9/50 ,  A61K49/00 ,  C12Q1/02 ,  A23L33/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61K31/715

摘要： The present invention relates to a prebiotic composition comprising a galacto oligosaccharide (GOS) produced from Lactobacillus plantarum, wherein the GOS acts as a selective growth medium for a chosen Lactobacillus plantarum probiotic bacterial strain, and wherein the GOS is substantially the same as the form produced by reverse β-galactosidase reaction in the chosen probiotic bacterial strain. The present invention also relates to methods of producing GOS and related composition incorporating the GOS.

公开(公告)号：US20190321419A1

公开(公告)日：2019-10-24

申请号：US16311347

申请日：2017-07-06

申请人： Optibiotix Limited

发明人： Stephen Patrick O'Hara ,  Sofia Kolida ,  Luis Gosalbez

IPC分类号： A61K35/747 ,  A61K31/351 ,  A61K31/575 ,  A61K31/201 ,  A61K31/732 ,  A61K31/722 ,  A61K31/733 ,  A61K31/736

摘要： The present invention relates to compositions comprising one or more probiotic bacterial strains and one or more lipid modifying active ingredients. The compositions can be used in the management of cholesterol and/or hypertension.

公开(公告)号：US20180303857A1

公开(公告)日：2018-10-25

申请号：US15523704

申请日：2015-11-05

申请人： Optibiotix Limited

发明人： Stephen Patrick O'Hara ,  Sofia Kolida

IPC分类号： A61K31/702 ,  A61K35/747 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A23L2/52 ,  A23L33/21

CPC分类号： A61K31/715 ,  A23L2/52 ,  A23L29/269 ,  A23L33/135 ,  A23L33/21 ,  A23L33/26 ,  A23L33/30 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2200/3202 ,  A23V2200/3262 ,  A23V2200/328 ,  A23V2200/332 ,  A23Y2220/00 ,  A23Y2220/35 ,  A23Y2220/71 ,  A61K9/0053 ,  A61K9/50 ,  A61K31/702 ,  A61K35/741 ,  A61K35/747 ,  A61K45/06 ,  A61K49/0004 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  C12Q1/025 ,  G01N2333/335 ,  G01N2333/938 ,  G01N2500/10 ,  A23V2200/30 ,  A23V2200/3204 ,  A23V2250/28 ,  A61K2300/00

摘要： The present invention relates to a prebiotic composition comprising a galacto oligosaccharide (GOS) produced from Lactobacillus plantarum, wherein the GOS acts as a selective growth medium for a chosen Lactobacillus plantarum probiotic bacterial strain, and wherein the GOS is substantially the same as the form produced by reverse β-galactosidase reaction in the chosen probiotic bacterial strain. The present invention also relates to methods of producing GOS and related composition incorporating the GOS.

公开(公告)号：US12042506B2

公开(公告)日：2024-07-23

申请号：US17044946

申请日：2019-04-04

申请人： Optibiotix Limited

发明人： Stephen Patrick O'Hara ,  Oswaldo Hernandez ,  Sofia Kolida

IPC分类号： A61K31/702 ,  A23L27/30 ,  A23L33/21 ,  A61K9/14 ,  A61P1/00

CPC分类号： A61K31/702 ,  A23L27/30 ,  A23L33/21 ,  A61K9/14 ,  A61P1/00 ,  A23V2002/00

摘要： The present invention relates to a non-digestible prebiotic oligosaccharide modified so as to incorporate one or more monosaccharide units thereon and have a higher sweetness value than the unmodified oligosaccharide. Uses and methods of producing the non-digestible prebiotic oligosaccharides are also described.

公开(公告)号：US10898528B2

公开(公告)日：2021-01-26

申请号：US15764970

申请日：2016-11-02

申请人： OPTIBIOTIX LIMITED

发明人： Stephen Patrick O'Hara

IPC分类号： A61K35/747 ,  A61K35/74 ,  A61P9/00 ,  A61K9/19 ,  A61K45/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61K47/36 ,  C12R1/25

摘要： The present invention relates to compositions comprising Lactobacillus plantarum 2830 (ECGC 13110402), or mutant strain or strains thereof, for use in the treatment or prevention of hypercholesterolaemia, and in particular reducing the total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels, in an individual. Specific dosage regimes and methods of production are also claimed and described.

公开(公告)号：US20200337351A1

公开(公告)日：2020-10-29

申请号：US16872213

申请日：2020-05-11

申请人： Optibiotix Limited

发明人： Stephen Patrick O'Hara

IPC分类号： A23L33/135 ,  A61K31/702 ,  A61K31/733 ,  A61K31/736 ,  A61K35/741 ,  A23L29/244 ,  A23L33/00 ,  A23L33/15 ,  A23L33/16 ,  A61K45/06 ,  A23L33/21 ,  A61K33/24 ,  A61K9/48 ,  A23C9/123 ,  A23C9/13 ,  A23C9/133 ,  A23C9/137 ,  A23C17/02 ,  A23C19/06 ,  A61K35/744 ,  A61K35/747

摘要： The present invention relates to compositions for use and formulation as weight management products and in particular fermented dairy foodstuffs. The compositions generally comprise two or more of the following components: a) a microbiome modifying component; b) a satiety modifying component; and c) a metabolic modifying component and at least one of the following: d) Streptococcus thermophilus CBS 139100 and Lactobacillus delbrueckii subsp. bulgaricus CBS 139099 microbial strains or mutant strains or fragments or fractions thereof; e) a combination of Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus microbial strains which together, or individually, are capable of secreting polysaccharides having high levels of galactosamine and no or low levels of rhamnose and glucuronic acid when grown on a dairy substrate; or f) polysaccharides formed of: i) 15-25% galactosamine; ii) 45-60% galactose; and iii) 20-30% glucose. The compositions may also be useful in the management or treatment of obesity, elevated cholesterol, diabetes, hypertension or heart disease.

公开(公告)号：US20170318851A1

公开(公告)日：2017-11-09

申请号：US15524739

申请日：2015-11-05

申请人： Optibiotix Limited

发明人： Stephen Patrick O'Hara

IPC分类号： A23L33/135 ,  A61K35/744 ,  A23C19/06 ,  A23C9/123 ,  A23C9/133 ,  A23C9/13 ,  A23L33/00 ,  A23C17/02 ,  A23C9/137 ,  A61K35/747

CPC分类号： A23L33/135 ,  A23C9/1238 ,  A23C9/1307 ,  A23C9/1322 ,  A23C9/133 ,  A23C9/137 ,  A23C17/02 ,  A23C19/062 ,  A23L29/244 ,  A23L33/15 ,  A23L33/16 ,  A23L33/21 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A23Y2220/15 ,  A23Y2220/29 ,  A23Y2240/75 ,  A61K9/48 ,  A61K31/702 ,  A61K31/733 ,  A61K31/736 ,  A61K33/24 ,  A61K35/741 ,  A61K35/744 ,  A61K35/747 ,  A61K45/06 ,  A61K2035/115 ,  A23V2200/3202 ,  A23V2200/3204 ,  A61K2300/00

摘要： The present invention relates to compositions for use and formulation as weight management products and in particular fermented dairy foodstuffs. The compositions generally comprise two or more of the following components: a) a microbiome modifying component; b) a satiety modifying component; and c) a metabolic modifying 5 component and at least one of the following: d) Streptococcus thermophilus CBS 139100 and Lactobacillus delbrueckii subsp. bulgaricus CBS 139099 microbial strains or mutant strains or fragments or fractions thereof; e) a combination of Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus microbial strains which together, or individually, are capable of secreting polysaccharides having high levels of galactosamine 10 and no or low levels of rhamnose and glucuronic acid when grown on a dairy substrate; or f) polysaccharides formed of: i) 15-25% galactosamine; ii) 45-60% galactose; and iii) 20-30% glucose. The compositions may also be useful in the management or treatment of obesity, elevated cholesterol, diabetes, hypertension or heart disease.

公开(公告)号：US20210100272A1

公开(公告)日：2021-04-08

申请号：US17044870

申请日：2019-04-04

申请人： Optibiotix Limited

发明人： Stephen Patrick O'Hara ,  Oswaldo Hernandez ,  Sofia Kolida

IPC分类号： A23L27/30 ,  A23L27/00 ,  A23L33/125 ,  C12N9/10

摘要： The present invention relates to high intensity sweetener glycosides which have been modified using a glycosyltransferase so as to reduce off-flavours. The invention also relates to uses of the modified high intensity sweetener glycosides and methods of production thereof.