公开(公告)号：US10004771B2

公开(公告)日：2018-06-26

申请号：US15484842

申请日：2017-04-11

Applicant: Quorum Innovations, LLC

Inventor： Eva A. Berkes ,  Nicholas T. Monsul ,  Frederick T. Boehm

IPC: A01N63/00 ,  A61K35/747 ,  C12N1/20 ,  C12Q1/04 ,  A61K8/99 ,  A61K9/00 ,  A61K8/34 ,  A61K47/10 ,  A01N63/02 ,  A61Q19/00 ,  A61Q19/10

CPC classification number: A61K35/747 ,  A01N63/02 ,  A61K8/34 ,  A61K8/67 ,  A61K8/97 ,  A61K8/981 ,  A61K8/988 ,  A61K8/99 ,  A61K9/0014 ,  A61K9/0043 ,  A61K9/0046 ,  A61K9/0048 ,  A61K9/007 ,  A61K35/644 ,  A61K35/74 ,  A61K35/744 ,  A61K36/61 ,  A61K39/092 ,  A61K45/06 ,  A61K47/10 ,  A61K2300/00 ,  A61K2800/78 ,  A61K2800/782 ,  A61Q11/00 ,  A61Q17/005 ,  A61Q19/007 ,  A61Q19/10 ,  C12N1/20 ,  C12Q1/04 ,  C12Q1/18 ,  G01N2333/315 ,  G01N2333/335 ,  Y02A50/473

Abstract: The subject invention provides materials and methods that effectively support innate immunity and/or disperse pathogenic biofilms using readily available, nontoxic, natural substances, while supporting restoration of normal microbiotic homeostasis. In one embodiment, the subject invention provides anti-biofilm compositions comprising one or more probiotic organisms, anti-microbial honey, and other ingredients such as prebiotic compounds, other hive products, green tea derivatives, other plant derivatives, and vitamin D3.

公开(公告)号：US09919012B2

公开(公告)日：2018-03-20

申请号：US15412712

申请日：2017-01-23

Applicant: Quorum Innovations, LLC

Inventor： Eva A. Berkes ,  Nicholas T. Monsul ,  Frederick T. Boehm

IPC: A01N63/00 ,  A61K35/747 ,  A61K8/99 ,  A01N63/02 ,  A61K35/744 ,  A61Q19/00 ,  A61Q19/10 ,  C12Q1/18

CPC classification number: A61K35/747 ,  A01N63/02 ,  A61K8/34 ,  A61K8/67 ,  A61K8/97 ,  A61K8/981 ,  A61K8/988 ,  A61K8/99 ,  A61K9/0014 ,  A61K9/0043 ,  A61K9/0046 ,  A61K9/0048 ,  A61K9/007 ,  A61K35/644 ,  A61K35/74 ,  A61K35/744 ,  A61K36/61 ,  A61K39/092 ,  A61K45/06 ,  A61K47/10 ,  A61K2300/00 ,  A61K2800/78 ,  A61K2800/782 ,  A61Q11/00 ,  A61Q17/005 ,  A61Q19/007 ,  A61Q19/10 ,  C12N1/20 ,  C12Q1/04 ,  C12Q1/18 ,  G01N2333/315 ,  G01N2333/335 ,  Y02A50/473

Abstract: The subject invention provides materials and methods that effectively support innate immunity and/or disperse pathogenic biofilms using readily available, nontoxic, natural substances, while supporting restoration of normal microbiotic homeostasis. In one embodiment, the subject invention provides anti-biofilm compositions comprising one or more probiotic organisms, anti-microbial honey, and other ingredients such as prebiotic compounds, other hive products, green tea derivatives, other plant derivatives, and vitamin D3.

公开(公告)号：US11826390B2

公开(公告)日：2023-11-28

申请号：US17418440

申请日：2021-06-07

Applicant: Quorum Innovations, LLC

Inventor： Nicholas T. Monsul ,  Eva A. Berkes ,  Frederick T. Boehm ,  Yu-Hsien Liao

IPC: A61K35/747 ,  A61P31/14 ,  C12N1/20 ,  A61K38/16 ,  A61K45/06 ,  C07K14/335 ,  C12R1/225

CPC classification number: A61K35/747 ,  A61K38/164 ,  A61K45/06 ,  A61P31/14 ,  C07K14/335 ,  C12N1/205 ,  C12R2001/225

Abstract: The subject invention provides compositions and methods for inhibiting viral infections. Preferred embodiments of the invention provide pharmaceutical compositions, and the methods of using the same, comprising a strain of Lactobacillus fermentum bacterium, or bioactive extracts thereof.

公开(公告)号：US09713631B2

公开(公告)日：2017-07-25

申请号：US15349420

申请日：2016-11-11

Applicant: Quorum Innovations, LLC

Inventor： Eva A. Berkes ,  Nicholas T. Monsul ,  Frederick T. Boehm

IPC: G01N33/00 ,  A61K35/74 ,  A61K35/644 ,  A61K35/744 ,  A61K8/67 ,  A61Q11/00 ,  A61Q17/00 ,  A61K8/97 ,  A61K8/98 ,  A61K8/99 ,  A01N63/02 ,  A61K39/09 ,  A61K45/06 ,  A61K9/00 ,  A61K35/747 ,  A61Q19/10 ,  C12N1/20 ,  C12Q1/04 ,  A61K36/61

CPC classification number: A61K35/747 ,  A01N63/02 ,  A61K8/34 ,  A61K8/67 ,  A61K8/97 ,  A61K8/981 ,  A61K8/988 ,  A61K8/99 ,  A61K9/0014 ,  A61K9/0043 ,  A61K9/0046 ,  A61K9/0048 ,  A61K9/007 ,  A61K35/644 ,  A61K35/74 ,  A61K35/744 ,  A61K36/61 ,  A61K39/092 ,  A61K45/06 ,  A61K47/10 ,  A61K2300/00 ,  A61K2800/78 ,  A61K2800/782 ,  A61Q11/00 ,  A61Q17/005 ,  A61Q19/007 ,  A61Q19/10 ,  C12N1/20 ,  C12Q1/04 ,  C12Q1/18 ,  G01N2333/315 ,  G01N2333/335 ,  Y02A50/473

Abstract: The subject invention provides materials and methods that effectively support innate immunity and/or disperse pathogenic biofilms using readily available, nontoxic, natural substances, while supporting restoration of normal microbiotic homeostasis. In one embodiment, the subject invention provides anti-biofilm compositions comprising one or more probiotic organisms, anti-microbial honey, and other ingredients such as prebiotic compounds, other hive products, green tea derivatives, other plant derivatives, and vitamin D3.

公开(公告)号：US12195502B2

公开(公告)日：2025-01-14

申请号：US17312484

申请日：2021-05-06

Applicant: Quorum Innovations, LLC

Inventor： Nicholas T. Monsul ,  Eva A. Berkes ,  Frederick T. Boehm ,  Yu-Hsien Liao

IPC: C07K14/335 ,  A61P31/04 ,  C12N15/70

Abstract: The present invention provides a novel protein and biologically-active fragments and variants thereof with advantageous therapeutic and cosmetic uses. Also provided are methods of using the proteins, as well as methods of producing the proteins using a recombinant cell. Further provided are recombinant host cells transformed with a polynucleotide sequence that encodes the expression of the proteins.

公开(公告)号：US11191277B2

公开(公告)日：2021-12-07

申请号：US16699383

申请日：2019-11-29

Applicant: Quorum Innovations, LLC

Inventor： Eva A. Berkes ,  Nicholas T. Monsul ,  Frederick T. Boehm

IPC: A61M15/00 ,  A01N63/20 ,  A61K35/644 ,  A61K35/744 ,  A61K8/67 ,  A61Q11/00 ,  A61Q17/00 ,  A61K8/98 ,  A61K8/99 ,  A61K35/74 ,  A61K39/09 ,  A61K45/06 ,  A61K9/00 ,  A61K35/747 ,  A61Q19/10 ,  C12N1/20 ,  C12Q1/04 ,  A61Q19/00 ,  C12Q1/18 ,  A61K8/34 ,  A61K47/10 ,  A61K36/61 ,  A61K39/39

Abstract: The subject invention provides materials and methods that effectively support innate immunity and/or disperse pathogenic biofilms using readily available, nontoxic, natural substances, while supporting restoration of normal microbiotic homeostasis. In one embodiment, the subject invention provides anti-biofilm compositions comprising one or more probiotic organisms, anti-microbial honey, and other ingredients such as prebiotic compounds, other hive products, green tea derivatives, other plant derivatives, and vitamin D3.

公开(公告)号：US10925908B2

公开(公告)日：2021-02-23

申请号：US16105017

申请日：2018-08-20

Applicant: Quorum Innovations, LLC

Inventor： Eva A. Berkes ,  Nicholas T. Monsul ,  Frederick T. Boehm

IPC: A01N63/00 ,  A61K47/00 ,  A61K45/00 ,  A61K35/747 ,  A61K35/644 ,  A61K35/744 ,  A61K8/67 ,  A61Q11/00 ,  A61Q17/00 ,  A61K8/98 ,  A61K8/99 ,  A01N63/10 ,  A61K35/74 ,  A61K39/09 ,  A61K45/06 ,  A61K9/00 ,  A61Q19/10 ,  C12N1/20 ,  C12Q1/04 ,  A61Q19/00 ,  C12Q1/18 ,  A61K8/34 ,  A61K47/10 ,  A61K36/61 ,  A61K39/39

Abstract: The subject invention provides materials and methods that effectively support innate immunity and/or disperse pathogenic biofilms using readily available, nontoxic, natural substances, while supporting restoration of normal microbiotic homeostasis. In one embodiment, the subject invention provides anti-biofilm compositions comprising one or more probiotic organisms, anti-microbial honey, and other ingredients such as prebiotic compounds, other hive products, green tea derivatives, other plant derivatives, and vitamin D3.

公开(公告)号：US10086025B2

公开(公告)日：2018-10-02

申请号：US15626971

申请日：2017-06-19

Applicant: Quorum Innovations, LLC

Inventor： Eva A. Berkes ,  Nicholas T. Monsul ,  Frederick T. Boehm

IPC: A61M15/00 ,  A61K35/747 ,  A61K35/644 ,  A61K35/744 ,  A61K8/67 ,  A61Q11/00 ,  A61Q17/00 ,  A61K8/97 ,  A61K8/98 ,  A61K8/99 ,  A01N63/02 ,  A61K35/74 ,  A61K39/09 ,  A61K45/06 ,  A61K9/00 ,  A61Q19/10 ,  C12N1/20 ,  C12Q1/04 ,  A61Q19/00 ,  C12Q1/18 ,  A61K8/34 ,  A61K47/10 ,  A61K36/61

Abstract: The subject invention provides materials and methods that effectively support innate immunity and/or disperse pathogenic biofilms using readily available, nontoxic, natural substances, while supporting restoration of normal microbiotic homeostasis. In one embodiment, the subject invention provides anti-biofilm compositions comprising one or more probiotic organisms, anti-microbial honey, and other ingredients such as prebiotic compounds, other hive products, green tea derivatives, other plant derivatives, and vitamin D3.

公开(公告)号：US11564957B2

公开(公告)日：2023-01-31

申请号：US16806000

申请日：2020-03-02

Applicant: Quorum Innovations, LLC

Inventor： Eva A. Berkes ,  Nicholas T. Monsul ,  Frederick T. Boehm

IPC: A61K35/74 ,  A61K35/747 ,  A01N63/20 ,  C12N1/20 ,  A23L33/135 ,  C12R1/225

Abstract: The subject invention provides compositions and methods for treating human dermatological conditions by employing a microbiome-centered treatment approach. Preferred embodiments of the invention provide pharmaceutical and cosmetic compositions, and the methods of using the same, comprising a strain of Lactobacillus fermentum bacterium, or bioactive extracts thereof, derived from human microbiota and capable of growing in biofilm phenotype.

公开(公告)号：US11457633B2

公开(公告)日：2022-10-04

申请号：US17103392

申请日：2020-11-24

Applicant: Quorum Innovations, LLC

Inventor： Nicholas T. Monsul ,  Eva A. Berkes ,  Frederick T. Boehm

IPC: A01N63/20 ,  C09D5/14 ,  A61K35/747 ,  C12R1/225

Abstract: The subject invention provides compositions and methods of enhancing the barrier function of surfaces and/or objects using biochemical-producing microbes and/or byproducts synthesized by the microbes. Preferred embodiments of the invention provide compositions, and the methods of using the same, comprising a Lactobacillus sp., and/or bioactive extracts thereof, derived from human microbiota and capable of growing in biofilm phenotype.