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公开(公告)号：US20160146714A1
公开(公告)日：2016-05-26
申请号：US14549055
申请日：2014-11-20
Inventor： Keith A. Oberg , Mark D. Dobbs , Ekaterina Tkatchouk , Scott P. Layne , Milton Lee
CPC classification number: C08J9/286 , B01L3/5023 , B01L2200/12 , B01L2200/147 , B01L2300/0825 , B01L2300/161 , C08J2333/06 , C08J2333/08 , C08J2333/10 , C08J2333/14 , C08J2335/02 , C12Q1/6813 , C12Q1/6844 , G01N1/28 , G01N21/49 , G01N21/59 , G01N21/77 , G01N2021/495 , G01N2021/7759 , G01N2021/7786
Abstract: Described herein are monoliths for processing fluid samples, and methods of making and using such monoliths.
Abstract translation: 这里描述的是用于处理流体样品的整料，以及制造和使用这种整料的方法。
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公开(公告)号：US09464969B2
公开(公告)日：2016-10-11
申请号：US14549055
申请日：2014-11-20
Inventor： Keith A. Oberg , Mark D. Dobbs , Ekaterina Tkatchouk , Scott P. Layne , Milton Lee
CPC classification number: C08J9/286 , B01L3/5023 , B01L2200/12 , B01L2200/147 , B01L2300/0825 , B01L2300/161 , C08J2333/06 , C08J2333/08 , C08J2333/10 , C08J2333/14 , C08J2335/02 , C12Q1/6813 , C12Q1/6844 , G01N1/28 , G01N21/49 , G01N21/59 , G01N21/77 , G01N2021/495 , G01N2021/7759 , G01N2021/7786
Abstract: The present invention relates to a monolith for processing fluid samples, and methods of making and using the monolith. The monolith can contain certain monomers or combinations of monomers that can be polymerized to give a polymeric monolith that can efficiently self-wick fluid. The self-wicking polymeric monolith can be used as a convenient tool for point of care on site diagnostics and analytics. The monolith is easily stored and transported, comparatively cost-efficient to make, permits good detection of analyte molecules and is readily functionalizable by impregnation of and/or covalently grafting additional chemical moieties to either the whole monolith or in zones.
Abstract translation: 本发明涉及用于处理流体样品的整料，以及制造和使用整料的方法。 整料可以含有某些单体或单体的组合，其可以被聚合以得到可以有效地自我吸收流体的聚合物整料。 自吸式聚合物整料可用作现场诊断和分析护理点的便捷工具。 整体容易储存和运输，相对成本有效地制备，允许对分析物分子的良好检测，并且可以通过浸渍和/或共价接枝另外的化学部分到整个整料或在区域中而容易地进行官能化。
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3.发明申请SAMPLE HOLDERS AND ANALYTICAL INSTRUMENT FOR POINT-OF-CARE QUALIFICATION OF CLINICAL SAMPLES 审中-公开样本持有人和临床样本点护理资质分析仪公开(公告)号：US20120261256A1
公开(公告)日：2012-10-18
申请号：US13402592
申请日：2012-02-22
Applicant: Chia-Pin CHANG , David J. Nagel
Inventor： Chia-Pin CHANG , David J. Nagel
CPC classification number: G01N21/03 , B01L3/50273 , B01L3/527 , B01L2200/04 , B01L2200/0684 , B01L2200/0689 , B01L2200/141 , B01L2200/142 , B01L2200/148 , B01L2300/023 , B01L2300/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/069 , B01L2300/0822 , B01L2300/0867 , B01L2300/0887 , B01L2300/089 , B01L2300/161 , B01L2300/163 , B01L2400/0406 , B01L2400/0472 , B01L2400/0677 , G01N21/278 , G01N21/51 , G01N21/645 , G01N21/76 , G01N27/3272 , G01N2021/0346 , G01N2021/495 , G01N2021/6421 , G01N2021/6482
Abstract: This invention has two synergistic elements for simultaneous use in point-of-care or field analyses of diverse substances important to clinical medicine and other applications. The first element is a sample holder in which are stored the several reagents need for quantification of target molecules. The onboard storage of reagents in a water soluble plastic obviates the need for purchase, storage, measuring and mixing of the required reagents prior to analyses. The second part of the invention is a compact hand-held analyzer made of modern miniature optical components, into which the holder is inserted right after it is loaded with a sample by capillary action. The combination of the holder and analyzer permits analyses that are ten times faster than those done with current analyzers, and equally accurate. Analyses can be performed by diverse people, who require only a few minutes of training in the use of the entire invention.
Abstract translation: 本发明具有两个协同元件，用于在临床医学和其他应用中重要的多种物质的同时使用点护理或现场分析。 第一个元素是样品架，其中储存了用于定量靶分子的几种试剂。 试剂在水溶性塑料中的机载存储避免了在分析前对所需试剂的购买，储存，测量和混合的需要。 本发明的第二部分是由现代微型光学部件制成的紧凑型手持式分析仪，在通过毛细管作用装载样品之后，保持器插入其中。 保持器和分析仪的组合允许分析比现有分析仪快10倍，同样准确。 分析可以由不同的人进行，他们只需要几分钟的时间来训练使用整个发明。
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Patent Agency Ranking
公开(公告)号：US5015843A
公开(公告)日：1991-05-14
申请号：US480548
申请日：1990-02-15
Applicant: William R. Seitz , Marian F. McCurley
Inventor： William R. Seitz , Marian F. McCurley
IPC: C08J3/24 , C08J9/00 , C12Q1/00 , G01M3/04 , G01N21/49 , G01N21/77 , G01N21/80 , G01N30/00 , G01N33/543 , G02B6/26 , G02B6/36
CPC classification number: G02B6/241 , C12Q1/001 , G01M3/047 , G01N21/474 , G01N21/77 , G01N33/54373 , G02B6/262 , G01N2021/4709 , G01N2021/4728 , G01N2021/495 , G01N2021/7723 , G01N21/80 , G01N30/00 , G02B6/264 , Y10S435/808 , Y10S435/817 , Y10S436/805
Abstract: Chemical sensors can detect the presence of chemical species in solution based upon polymer swelling in response to the chemical species. Polymer swelling is indirectly determined by measuring light reflected from a reflector affixed directly or indirectly to the polymer. Such that increase or decrease in the size of the polymer changes the distance between the reflector and a light source. Measurements of the light reflected from the reflector indicate the amount of swelling or shrinkage of the polymer in response to the chemical species.
Abstract translation: 化学传感器可以基于化学物质响应聚合物溶胀来检测溶液中化学物质的存在。 通过测量从直接或间接地固定在聚合物上的反射器反射的光来间接确定聚合物溶胀度。 使得聚合物尺寸的增加或减小改变了反射体和光源之间的距离。 从反射器反射的光的测量表明响应于化学物质的聚合物的膨胀或收缩量。
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公开(公告)号：US11867628B2
公开(公告)日：2024-01-09
申请号：US17615079
申请日：2020-04-17
Applicant: Hitachi, Ltd.
Inventor： Sakuichiro Adachi , Takahiro Ando
CPC classification number: G01N21/51 , G01N2021/495
Abstract: A sample measurement device includes: a sample container that stores a sample solution; a light source that irradiates the sample container with irradiation light from a first direction; an imaging part that captures an image of the sample solution based on light scattered by the sample solution from a second direction intersecting the first direction; and a calculator that calculates an absorbance or a concentration of the sample solution based on the image. The calculator calculates a degree of attenuation of a light amount of the image at a constant optical path length along the first direction based on the image, and calculates the absorbance or concentration of the sample solution according to the degree of attenuation.
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公开(公告)号：US20180003604A1
公开(公告)日：2018-01-04
申请号：US15543298
申请日：2015-08-31
Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
Inventor： Kota SHIBA , Genki YOSHIKAWA , Yusuke YAMAUCHI , Norihiro SUZUKI , Gaku IMAMURA , Kosuke MINAMI , Hamish Hei-Man YEUNG
CPC classification number: G01N5/02 , B82Y15/00 , G01G3/13 , G01N21/49 , G01N27/227 , G01N29/022 , G01N29/036 , G01N2021/495 , G01N2291/014 , G01N2291/021 , G01N2291/022 , G01N2291/02433 , G01N2291/0256
Abstract: According to improvement of the receptor layer of various sensors of the type for detecting physical parameters (for example, a surface stress sensor, QCM, and SPR), all of high sensitivity, selectivity, and durability are achieved simultaneously. A porous material or a particulate material, e.g., nanoparticles, is used in place of a uniform membrane which has been conventionally used as a receptor layer. Accordingly, the sensitivity can be controlled by changing the membrane thickness of the receptor layer, the selectivity can be controlled by changing a surface modifying group to be fixed on the porous material or particulate material, and the durability can be controlled by changing the composition and surface properties of the porous material or particulate material.
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公开(公告)号：US20170073492A1
公开(公告)日：2017-03-16
申请号：US15278929
申请日：2016-09-28
Inventor： Keith A. Oberg , Mark D. Dobbs , Ekaterina Tkatchouk , Scott P. Layne , Milton Lee
CPC classification number: C08J9/286 , B01L3/5023 , B01L2200/12 , B01L2200/147 , B01L2300/0825 , B01L2300/161 , C08J2333/06 , C08J2333/08 , C08J2333/10 , C08J2333/14 , C08J2335/02 , C12Q1/6813 , C12Q1/6844 , G01N1/28 , G01N21/49 , G01N21/59 , G01N21/77 , G01N2021/495 , G01N2021/7759 , G01N2021/7786
Abstract: The present invention relates to a monolith for processing fluid samples, and methods of making and using the monolith. The monolith can contain certain monomers or combinations of monomers that can be polymerized to give a polymeric monolith that can efficiently self-wick fluid. The self-wicking polymeric monolith can be used as a convenient tool for point of care/on site diagnostics and analytics. The monolith is easily stored and transported, comparatively cost-efficient to make, permits good detection of analyte molecules and is readily functionalizable by impregnation of and/or covalently grafting additional chemical moieties to either the whole monolith or in zones.
Abstract translation: 本发明涉及用于处理流体样品的整料，以及制造和使用整料的方法。 整料可以含有某些单体或单体的组合，其可以被聚合以得到可以有效地自我吸收流体的聚合物整料。 自吸式聚合物整料可用作护理点/现场诊断和分析的便利工具。 整体容易储存和运输，相对成本有效地制备，允许对分析物分子的良好检测，并且可以通过浸渍和/或共价接枝另外的化学部分到整个整料或在区域中而容易地进行官能化。
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公开(公告)号：US20130057863A1
公开(公告)日：2013-03-07
申请号：US13577736
申请日：2011-02-15
Applicant: Mads Bøkner Christiansen , Sokol Ndoni , Martin Etchells Vigild , Anders Kristensen , Peter Thomsen
Inventor： Mads Bøkner Christiansen , Sokol Ndoni , Martin Etchells Vigild , Anders Kristensen , Peter Thomsen
CPC classification number: G01N21/0303 , G01N2021/0346 , G01N2021/495 , G01N2201/088 , G02B6/02033 , Y10T29/49826
Abstract: A sensor element is disclosed. The sensor element comprises a first element which is nanoporous, and a second element which is nanoporous, the second element enclosing the first element. The surfaces of the nanopores of the first- and second element differ in hydrophilicity, so that the surfaces of the nanopores of one element is generally more hydrophobic while the other is generally more hydrophilic, and hence the sensor element is capable of selectively having the first element filled with a fluid. The sensor element is capable of guiding light through the fluid-filled first element and can act as a nanoporous waveguide. The sensor element according to the invention is particularly useful for spectroscopy on fluids.
Abstract translation: 公开了一种传感器元件。 传感器元件包括纳米多孔的第一元件和纳米孔的第二元件，第二元件包围第一元件。 第一和第二元件的纳米孔的表面的亲水性不同，使得一个元件的纳米孔的表面通常更疏水，而另一个的纳米孔的表面通常更亲水，因此传感器元件能够选择性地具有第一 元素充满流体。 传感器元件能够引导光通过流体填充的第一元件并且可以充当纳米多孔波导。 根据本发明的传感器元件对于流体上的光谱特别有用。
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