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公开(公告)号：US09943577B2
公开(公告)日：2018-04-17
申请号：US15365079
申请日：2016-11-30
Applicant: aTyr Pharma, Inc.
Inventor： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kyle P. Chiang , Wei Zhang , Kristi Helen Piehl , Fei Hong , Alina He
CPC classification number: A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
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公开(公告)号：US20170202933A1
公开(公告)日：2017-07-20
申请号：US15365079
申请日：2016-11-30
Applicant: aTyr Pharma, Inc.
Inventor： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kyle P. Chiang , Wei Zhang , Kristi Helen Piehl , Fei Hong , Alina He
CPC classification number: A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
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3.发明申请公开(公告)号：US20170052194A1
公开(公告)日：2017-02-23
申请号：US15255433
申请日：2016-09-02
Applicant: Washington University
Inventor： James J. Havranek , Benjamin Borgo
CPC classification number: G01N33/6824 , C12N9/485 , C12N9/50 , C12N9/52 , C12N9/641 , C12N9/93 , C12Y304/11018 , C12Y601/0101 , C12Y601/0102 , C12Y601/01021
Abstract: Reagents and methods for the digital analysis of proteins or peptides are provided. Specifically provided herein are proteins for identifying the N-terminal amino acid or N-terminal phosphorylated amino acid of a polypeptide. Also, an enzyme for use in the cleavage step of the Edman degradation reaction and a method for using this enzyme are described.
Abstract translation: 提供了蛋白质或肽数字分析的试剂和方法。 本文具体提供的是用于鉴定多肽的N-末端氨基酸或N-末端磷酸化氨基酸的蛋白质。 另外，描述了用于Edman降解反应的切割步骤的酶和使用该酶的方法。
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4.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF HISTIDYL-TRNA SYNTHETASES 有权与HISTIDYL-TRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20150344866A1
公开(公告)日：2015-12-03
申请号：US14675343
申请日：2015-03-31
Applicant: aTyr Pharma, Inc. , Pangu BioPharma Limited
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC: C12N9/00
CPC classification number: C12N9/93 , A61K38/00 , A61K38/53 , C07K16/40 , C12N5/0602 , C12N9/96 , C12Y601/01 , C12Y601/01021 , G01N33/68
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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公开(公告)号：US20150140072A1
公开(公告)日：2015-05-21
申请号：US14541792
申请日：2014-11-14
Applicant: aTyr Pharma, Inc.
Inventor： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kyle P. Chiang , Wei Zhang , Kristi Helen Piehl , Fei Hong , Alina He
IPC: C12N9/00
CPC classification number: A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
Abstract translation: 提供包含氨基-tRNA合成酶多肽的炎症和其它细胞应答调节组合物，包括其活性片段和/或变体。 还提供了使用这些组合物来治疗受益于炎症疾病或病症等炎症调节的病症的方法。
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Patent Agency Ranking
公开(公告)号：US20130344096A1
公开(公告)日：2013-12-26
申请号：US13769100
申请日：2013-02-15
Applicant: PANGU BIOPHARMA LIMITED , ATYR PHARMA, INC.
Inventor： Kyle P. Chiang , Elisabeth Gardiner , Ching-Fun Lau , Wing-Sze Lo , Jeffrey Greve , Melissa Ashlock , John D. Mendlein
IPC: C12N9/00
CPC classification number: C12N9/93 , A61K38/16 , A61K38/17 , A61K38/53 , A61K39/0008 , A61K48/00 , A61K48/005 , C12Q1/6883 , C12Q2600/158 , C12Y601/01021 , G01N33/573 , G01N2333/9015 , G01N2800/52 , Y02A50/473
Abstract: The present invention relates generally to compositions and methods comprising histidyl-tRNA synthetase polypeptides or other specific blocking agents for the treatment autoimmune diseases and other inflammatory diseases, including those related to Jo-1 antibodies.
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公开(公告)号：US20050214773A1
公开(公告)日：2005-09-29
申请号：US10806062
申请日：2004-03-22
Applicant: Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Megan Domagala , Simon Houston , Robert Lam , Qin Li , Kathleen Nethery-Brokx , Ivy Ng , Benjamin Pinder , Cristina Viola , Olga Wrezel , Dhushy Kanagarajah , Kamran Mansoury , Sasha Necakov , Francois Vallee , Merry-Lynn McDonald
Inventor： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Megan Domagala , Simon Houston , Robert Lam , Qin Li , Kathleen Nethery-Brokx , Ivy Ng , Benjamin Pinder , Cristina Viola , Olga Wrezel , Dhushy Kanagarajah , Kamran Mansoury , Sasha Necakov , Francois Vallee , Merry-Lynn McDonald
IPC: A61K38/00 , C07K14/205 , C07K14/21 , C07K14/245 , C07K14/31 , C07K14/315 , C12N9/00 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/80 , G01N33/569 , C12Q1/68 , C07H21/04 , C12N1/21 , C12N15/74
CPC classification number: C07K14/205 , A61K38/00 , C07K14/21 , C07K14/245 , C07K14/31 , C07K14/3156 , C07K2299/00 , C07K2319/00 , C12N9/0006 , C12N9/1077 , C12N9/1085 , C12N9/1205 , C12N9/1217 , C12N9/1229 , C12N9/1241 , C12N9/80 , C12N9/93 , C12Y207/01026 , C12Y207/01069 , C12Y207/02003 , C12Y207/07003 , C12Y601/01001 , C12Y601/0101 , C12Y601/01021 , G01N33/56911 , G01N33/56938 , G01N33/56944
Abstract: The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.
Abstract translation: 本发明涉及致病细菌的多肽靶标。 本发明还提供那些多肽的生物化学和生物物理学特征。
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公开(公告)号：US20190062720A1
公开(公告)日：2019-02-28
申请号：US16122231
申请日：2018-09-05
Applicant: aTyr Pharma Inc.
Inventor： Chi-Fang WU , Darin Lee , Jeffry D. Watkins , Kristi Piehl , Kyle P. Chiang , Marc Thomas , Minh-Ha Do , Ying Buechler , John D. Mendlein
CPC classification number: C12N9/93 , A61P11/00 , A61P29/00 , A61P37/00 , C07K2319/30 , C12N9/96 , C12Y601/01021
Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.
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公开(公告)号：US10017582B2
公开(公告)日：2018-07-10
申请号：US15257353
申请日：2016-09-06
Applicant: aTyr Pharma, Inc. , Pangu BioPharma Limited
Inventor： Jie Zhou , Ching-Fun Lau , Zhiwen Xu , Wing-Sze Lo , Kristi Helen Piehl , Leslie Ann Greene
CPC classification number: C07K16/40 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C12N9/93 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12Q1/6876 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Y601/01021 , G01N33/573 , G01N2333/9015 , G01N2500/04 , G01N2500/10
Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
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公开(公告)号：US09605265B2
公开(公告)日：2017-03-28
申请号：US14262272
申请日：2014-04-25
Applicant: aTyr Pharma, Inc. , Pangu BioPharma Limited
Inventor： Jie Zhou , Ching-Fun Lau , Zhiwen Xu , Wing-Sze Lo , Kristi Helen Piehl , Leslie Ann Greene
IPC: A61K38/00 , A61K38/17 , C12N15/113 , C12N9/00 , C12Q1/68 , G01N33/573
CPC classification number: C07K16/40 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C12N9/93 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12Q1/6876 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Y601/01021 , G01N33/573 , G01N2333/9015 , G01N2500/04 , G01N2500/10
Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
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