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公开(公告)号：US09816084B2
公开(公告)日：2017-11-14
申请号：US14360576
申请日：2012-12-06
Applicant: aTyr Pharma, Inc.
Inventor： Ying Ji Buechler , Chi-Fang Wu , Ryan Andrew Adams , Kristi Helen Piehl , Jeffrey Greve , John D. Mendlein
CPC classification number: C12N9/93 , A61K38/00 , C07K2319/40 , Y02A50/411
Abstract: The present invention provides aspartyl-tRNA synthetase derived proteins (DRS polypeptides) with altered cysteine content, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The DRS polypeptides of the invention have immunomodulatory properties, and exhibit improved activity and stability.
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2.发明授权Compositions and methods comprising glycyl-tRNA synthetases having non-canonical biological activities 有权包含具有非规范生物活性的甘氨酰-tRNA合成酶的组合物和方法公开(公告)号：US09157076B2
公开(公告)日：2015-10-13
申请号：US14262247
申请日：2014-04-25
Applicant: aTyr Pharma, Inc.
Inventor： Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
CPC classification number: A61K38/53 , C07K1/14 , C12N9/93 , C12N9/96 , C12N15/102 , C12Y601/01014
Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Abstract translation: 提供了分离的甘氨酰-tRNA合成酶多肽和具有非规范生物学活性的多核苷酸，以及与其相关的组合物和方法。
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3.发明授权Compositions and methods comprising glycyl-tRNA synthetases having non-canonical biological activities 有权包含具有非规范生物活性的甘氨酰-tRNA合成酶的组合物和方法公开(公告)号：US09585946B2
公开(公告)日：2017-03-07
申请号：US14844666
申请日：2015-09-03
Applicant: aTyr Pharma, Inc.
Inventor： Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
IPC: C12N9/00 , C12N15/00 , C12P21/06 , C12P21/04 , A61K38/43 , A61K38/53 , C12N9/96 , C07K1/14 , C12N15/10
CPC classification number: A61K38/53 , C07K1/14 , C12N9/93 , C12N9/96 , C12N15/102 , C12Y601/01014
Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Abstract translation: 提供了分离的甘氨酰-tRNA合成酶多肽和具有非规范生物学活性的多核苷酸，以及与其相关的组合物和方法。
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公开(公告)号：US09540628B2
公开(公告)日：2017-01-10
申请号：US14541792
申请日：2014-11-14
Applicant: aTyr Pharma, Inc.
Inventor： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kyle P. Chiang , Wei Zhang , Kristi Helen Piehl , Fei Hong , Alina He
IPC: C07H21/04 , C12N9/00 , A61K38/53 , A61K39/395 , A61K45/06
CPC classification number: A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
Abstract translation: 提供包含氨基-tRNA合成酶多肽的炎症和其它细胞应答调节组合物，包括其活性片段和/或变体。 还提供了使用这些组合物来治疗受益于炎症疾病或病症等炎症调节的病症的方法。
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5.发明申请COMPOSITIONS AND METHODS COMPRISING GLYCYL-TRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES 有权包含非经济生物活性的甘氨酸 - 三氮唑合成物的组合物和方法公开(公告)号：US20160114016A1
公开(公告)日：2016-04-28
申请号：US14844666
申请日：2015-09-03
Applicant: aTyr Pharma, Inc.
Inventor： Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
CPC classification number: A61K38/53 , C07K1/14 , C12N9/93 , C12N9/96 , C12N15/102 , C12Y601/01014
Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Abstract translation: 提供了分离的甘氨酰-tRNA合成酶多肽和具有非规范生物学活性的多核苷酸，以及与其相关的组合物和方法。
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Patent Agency Ranking
公开(公告)号：US20140302075A1
公开(公告)日：2014-10-09
申请号：US14360576
申请日：2012-12-06
Applicant: aTyr Pharma, Inc.
Inventor： Ying Ji Buechler , Chi-Fang Wu , Ryan Andrew Adams , Kristi Helen Piehl , Jeffrey Greve , John D. Mendlein
IPC: C12N9/00
CPC classification number: C12N9/93 , A61K38/00 , C07K2319/40 , Y02A50/411
Abstract: The present invention provides aspartyl-tRNA synthetase derived proteins (DRS polypeptides) with altered cysteine content, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The DRS polypeptides of the invention have immunomodulatory properties, and exhibit improved activity and stability.
Abstract translation: 本发明提供具有改变的半胱氨酸含量的天冬氨酰-tRNA合成酶衍生蛋白（DRS多肽），包含其的组合物，以及使用这些多肽和组合物治疗或诊断各种病症的方法。 本发明的DRS多肽具有免疫调节特性，并表现出改进的活性和稳定性。
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公开(公告)号：US20130273045A1
公开(公告)日：2013-10-17
申请号：US13762151
申请日：2013-02-07
Applicant: aTyr Pharma, Inc.
Inventor： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kyle P. Chiang , Wei Zhang , Kristi Helen Piehl , Fei Hong , Alina He
CPC classification number: A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
Abstract translation: 提供包含氨基-tRNA合成酶多肽，包括活性片段和/或变体的炎症和其他细胞应答调节组合物。还提供了使用这些组合物治疗受益于炎症调节的病症的方法，例如炎性疾病 或条件。
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8.发明申请COMPOSITIONS AND METHODS COMPRISING GLYCYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES 有权包含非经典生物活性的GLYCYL-tRNA合成酶的组合物和方法公开(公告)号：US20130236455A1
公开(公告)日：2013-09-12
申请号：US13753272
申请日：2013-01-29
Applicant: ATYR PHARMA, INC.
Inventor： Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
CPC classification number: A61K38/53 , C07K1/14 , C12N9/93 , C12N9/96 , C12N15/102 , C12Y601/01014
Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Abstract translation: 提供了分离的甘氨酰-tRNA合成酶多肽和具有非规范生物学活性的多核苷酸，以及与其相关的组合物和方法。
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公开(公告)号：US09688978B2
公开(公告)日：2017-06-27
申请号：US14368759
申请日：2012-12-27
Applicant: aTyr Pharma, Inc.
Inventor： Ying Ji Buechler , Chi-Fang Wu , Ryan Andrew Adams , Jeffrey D. Watkins , John D. Mendlein
CPC classification number: C12N9/93 , A61K38/00 , C07K16/00 , C07K2319/02 , C07K2319/21 , C07K2319/30 , C07K2319/50 , C12Y601/01002 , C12Y601/01012 , Y02A50/385 , Y02A50/389 , Y02A50/463
Abstract: The present invention provides aspartyl-tRNA synthetase and Fc region conjugate polypeptides (DRS-Fc conjugates), such as DRS-Fc fusion proteins, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The DRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified DRS polypeptides.
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公开(公告)号：US09328340B2
公开(公告)日：2016-05-03
申请号：US13762151
申请日：2013-02-07
Applicant: aTyr Pharma, Inc.
Inventor： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kyle P. Chiang , Wei Zhang , Kristi Helen Piehl , Fei Hong , Alina He
IPC: A61K38/53 , C12N9/00 , A61K39/395 , A61K45/06
CPC classification number: A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
Abstract translation: 提供包含氨基-tRNA合成酶多肽的炎症和其它细胞应答调节组合物，包括其活性片段和/或变体。 还提供了使用这些组合物来治疗受益于炎症疾病或病症等炎症调节的病症的方法。
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