Invention Grant
- Patent Title: Aspartyl-tRNA synthetases
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Application No.: US14360576Application Date: 2012-12-06
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Publication No.: US09816084B2Publication Date: 2017-11-14
- Inventor: Ying Ji Buechler , Chi-Fang Wu , Ryan Andrew Adams , Kristi Helen Piehl , Jeffrey Greve , John D. Mendlein
- Applicant: aTyr Pharma, Inc.
- Applicant Address: US CA San Diego
- Assignee: aTyr Pharma, Inc.
- Current Assignee: aTyr Pharma, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Cooley LLP
- International Application: PCT/US2012/068282 WO 20121206
- International Announcement: WO2013/086216 WO 20130613
- Main IPC: C12N9/96
- IPC: C12N9/96 ; A61K38/43 ; C12N9/00 ; A61K38/00
Abstract:
The present invention provides aspartyl-tRNA synthetase derived proteins (DRS polypeptides) with altered cysteine content, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The DRS polypeptides of the invention have immunomodulatory properties, and exhibit improved activity and stability.
Public/Granted literature
- US20140302075A1 ASPARTYL-TRNA SYNTHETASES Public/Granted day:2014-10-09
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