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公开(公告)号：US11767520B2
公开(公告)日：2023-09-26
申请号：US16499979
申请日：2018-04-19
申请人： aTyr Pharma, Inc.
发明人： John D. Mendlein , Kathleen Ogilvie
IPC分类号： A61K39/385 , C07K16/46 , C07K19/00 , C12N9/00 , A61P11/00 , A61P29/00 , A61K9/48 , A61K9/51 , A61K31/4418 , A61K31/496 , A61K38/53 , A61M5/178
CPC分类号： C12N9/93 , A61K9/48 , A61K9/5123 , A61K31/4418 , A61K31/496 , A61K38/53 , A61P11/00 , A61P29/00 , C12Y601/01021 , A61M5/178 , C07K2319/30
摘要： Provided are therapies, including combination therapies, for the treatment of lung inflammation, including interstitial lung diseases (ILDs), which include the use of at least one histidyl-tRNA synthetase (HRS) polypeptide or an expressible polynucleotide that encodes the HRS polypeptide, alone or in combination with at least one immunomodulatory agent.
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公开(公告)号：US20220098568A1
公开(公告)日：2022-03-31
申请号：US17344154
申请日：2021-06-10
申请人： aTyr Pharma, Inc.
发明人： Chi-Fang WU , Darin LEE , Jeffry D. WATKINS , Kristi PIEHL , Kyle CHIANG , Marc THOMAS , Minh-Ha DO , Ying BUECHLER , John D. MENDLEIN
摘要： The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.
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公开(公告)号：US20220098327A1
公开(公告)日：2022-03-31
申请号：US17355587
申请日：2021-06-23
发明人： Jie ZHOU , Ching-Fun LAU , Zhiwen XU , Wing-Sze LO , Kristi Helen PIEHL , Leslie Ann GREENE
IPC分类号： C07K16/40 , C12Q1/6886 , G01N33/573 , C12N9/00 , C12N15/113 , C12Q1/6876
摘要： Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
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公开(公告)号：US10196628B2
公开(公告)日：2019-02-05
申请号：US15459875
申请日：2017-03-15
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US10189911B2
公开(公告)日：2019-01-29
申请号：US15365104
申请日：2016-11-30
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/96 , A61K38/53 , C12N9/00 , A61K9/00 , A61K9/19 , C07K16/40 , C12N5/071 , G01N33/50 , G01N33/68 , G01N33/573
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US09822353B2
公开(公告)日：2017-11-21
申请号：US14360573
申请日：2012-12-06
申请人： aTyr Pharma, Inc.
发明人： Ying Ji Buechler , Chi-Fang Wu , Jeffrey Greve , John D. Mendlein
CPC分类号： C12N9/93 , A61K38/00 , A61K38/53 , A61K47/60 , C12N9/96 , C12Y601/01012 , C12Y601/01023 , Y02A50/411
摘要： The present invention provides PEGylated aspartyl-tRNA synthetase (DRS) polypeptides, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The PEGylated DRS polypeptides of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic properties compared to non-PEGylated DRS polypeptides.
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7.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases 有权与精氨酸-trna合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09593322B2
公开(公告)日：2017-03-14
申请号：US14593620
申请日：2015-01-09
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： A61K39/3955 , A61K9/19 , A61K38/00 , A61K38/53 , A61K2039/505 , A61K2121/00 , C07K16/40 , C07K2319/00 , C12N9/1085 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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8.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetasis 有权与甲硫氨酰-tRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09422538B2
公开(公告)日：2016-08-23
申请号：US14619713
申请日：2015-02-11
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C07K16/40 , A61K38/53 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/0101 , G01N33/573 , G01N33/68 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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9.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tryptophanyl-tRNA synthetases 有权与色氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09399770B2
公开(公告)日：2016-07-26
申请号：US13877899
申请日：2011-10-06
申请人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C12N9/93 , A61K38/00 , A61K38/53 , C07K16/40 , C07K2317/21 , C07K2317/92 , C12Y601/01
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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10.发明授权Compositions and methods comprising glycyl-tRNA synthetases having non-canonical biological activities 有权包含具有非规范生物活性的甘氨酰-tRNA合成酶的组合物和方法公开(公告)号：US09157076B2
公开(公告)日：2015-10-13
申请号：US14262247
申请日：2014-04-25
申请人： aTyr Pharma, Inc.
发明人： Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
CPC分类号： A61K38/53 , C07K1/14 , C12N9/93 , C12N9/96 , C12N15/102 , C12Y601/01014
摘要： Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
摘要翻译： 提供了分离的甘氨酰-tRNA合成酶多肽和具有非规范生物学活性的多核苷酸，以及与其相关的组合物和方法。
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