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公开(公告)号：US09127268B2
公开(公告)日：2015-09-08
申请号：US13514952
申请日：2010-12-10
Applicant: Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kristi Helen Piehl , Fei Hong , Kyle P. Chiang , Wei Zhang , Alina He
Inventor： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kristi Helen Piehl , Fei Hong , Kyle P. Chiang , Wei Zhang , Alina He
IPC: C12N9/00 , A61K38/53 , A61K39/395 , A61K45/06
CPC classification number: A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
Abstract translation: 提供包含氨基-tRNA合成酶多肽的炎症和其它细胞应答调节组合物，包括其活性片段和/或变体。 还提供了使用这些组合物来治疗受益于炎症疾病或病症等炎症调节的病症的方法。
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2.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases 有权与谷氨酰脯氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09062301B2
公开(公告)日：2015-06-23
申请号：US13696048
申请日：2011-05-04
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
CPC classification number: C07K16/40 , A61K9/0019 , A61K9/14 , A61K38/53 , A61K39/3955 , A61K47/60 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/569 , C07K2317/94 , C12N9/93 , C12N9/96
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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3.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases 有权与酪氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09029506B2
公开(公告)日：2015-05-12
申请号：US13818929
申请日：2011-08-25
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC classification number: C07K16/40 , A61K38/00 , A61K38/16 , C07K2317/24 , C07K2317/622 , C07K2317/92 , C12N9/93 , C12Y601/01 , C12Y601/01001 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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4.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase 有权与半胱氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US08980253B2
公开(公告)日：2015-03-17
申请号：US13643755
申请日：2011-04-26
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC classification number: C07K16/40 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C12N9/93 , C12Y601/01016 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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5.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases 有权创新发现治疗，诊断和抗体组合物相关的精氨酰-tRNA合成酶的蛋白质片段公开(公告)号：US08961961B2
公开(公告)日：2015-02-24
申请号：US13696042
申请日：2011-05-02
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
CPC classification number: A61K39/3955 , A61K9/19 , A61K38/00 , A61K38/53 , A61K2039/505 , A61K2121/00 , C07K16/40 , C07K2319/00 , C12N9/1085 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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Patent Agency Ranking
6.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TRYPTOPHANYL-TRNA SYNTHETASES 有权与TRYPTOPHANYL-TRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20130330312A1
公开(公告)日：2013-12-12
申请号：US13877899
申请日：2011-10-06
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC: C12N9/00
CPC classification number: C12N9/93 , A61K38/00 , A61K38/53 , C07K16/40 , C07K2317/21 , C07K2317/92 , C12Y601/01
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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公开(公告)号：US20130280230A1
公开(公告)日：2013-10-24
申请号：US13809750
申请日：2011-07-11
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC: C12N9/00
CPC classification number: C07K16/40 , A61K38/00 , A61K38/53 , C07K2317/24 , C07K2317/92 , C07K2319/00 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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8.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF METHIONYL-TRNA SYNTHETASES 有权与甲硫氨酸合成酶蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20130236440A1
公开(公告)日：2013-09-12
申请号：US13696044
申请日：2011-05-03
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
CPC classification number: C07K16/40 , A61K38/53 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/0101 , G01N33/573 , G01N33/68 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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公开(公告)号：US20120104427A1
公开(公告)日：2012-05-03
申请号：US13153888
申请日：2011-06-06
Applicant: Chi Keung Chan , Chak Hau Pang , Fei Hong Li , Yue Kwong Lau , Jun Zhang , David Todd Emerson
Inventor： Chi Keung Chan , Chak Hau Pang , Fei Hong Li , Yue Kwong Lau , Jun Zhang , David Todd Emerson
IPC: H01L33/08
CPC classification number: H01L33/486 , H01L23/49861 , H01L25/0753 , H01L33/62 , H01L33/642 , H01L33/647 , H01L2224/48091 , H01L2224/48247 , H01L2924/00012 , H01L2924/00014
Abstract: One embodiment of the surface mount LED package includes a lead frame and a plastic casing at least partially encasing the lead frame. The lead frame includes a plurality of electrically conductive chip carriers. There is an LED disposed on each one of the plurality of electrically conductive chip carriers. A profile height of the surface mount LED package is less than about 1.0 mm.
Abstract translation: 表面贴装LED封装的一个实施例包括引线框架和至少部分地封装引线框架的塑料外壳。 引线框架包括多个导电芯片载体。 设置在多个导电芯片载体的每一个上的LED。 表面贴装LED封装的外形高度小于约1.0mm。
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10.发明申请COMPOSITIONS AND METHODS COMPRISING GLYCYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES 有权包含非经典生物活性的GLYCYL-tRNA合成酶的组合物和方法公开(公告)号：US20100028352A1
公开(公告)日：2010-02-04
申请号：US12492925
申请日：2009-06-26
Applicant: Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
Inventor： Leslie Ann Greene , Ryan Andrew Adams , Fei Hong , Ji Zhao , Eva Rebecka Stephanie Armour , Kristi Helen Piehl
IPC: A61K39/395 , C12N9/00 , C07H21/04 , C12N15/63 , C12N5/00 , C12N5/02 , A61K38/43 , A61K31/7088 , C12Q1/68 , G01N33/53 , G01N33/573
CPC classification number: A61K38/53 , C07K1/14 , C12N9/93 , C12N9/96 , C12N15/102 , C12Y601/01014
Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Abstract translation: 提供了分离的甘氨酰-tRNA合成酶多肽和具有非规范生物学活性的多核苷酸，以及与其相关的组合物和方法。
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