公开(公告)号：US09034321B2

公开(公告)日：2015-05-19

申请号：US13696046

申请日：2011-05-03

Applicant: Leslie Ann Greene ,  Kyle P. Chiang ,  Fei Hong ,  Alain Philippe Vasserot ,  Jeffry D. Watkins ,  Cheryl L. Quinn ,  Wing-Sze Lo ,  John D. Mendlein

Inventor： Leslie Ann Greene ,  Kyle P. Chiang ,  Fei Hong ,  Alain Philippe Vasserot ,  Jeffry D. Watkins ,  Cheryl L. Quinn ,  Wing-Sze Lo ,  John D. Mendlein

IPC: A61K38/53 ,  A61K47/48 ,  C07K16/40 ,  C12N9/00 ,  C12N5/071 ,  C12N9/96 ,  G01N33/68

CPC classification number: C12N9/93 ,  A61K38/53 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/92 ,  C12N5/0602 ,  C12N9/96 ,  C12Y601/01 ,  C12Y601/0102 ,  G01N33/573 ,  G01N33/68 ,  G01N2333/9015

Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.

Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。

公开(公告)号：US08969301B2

公开(公告)日：2015-03-03

申请号：US13809750

申请日：2011-07-11

Applicant: Leslie Ann Greene ,  Kyle P. Chiang ,  Fei Hong ,  Alain Philippe Vasserot ,  Wing-Sze Lo ,  Jeffry D. Watkins ,  Cheryl L. Quinn ,  John D. Mendlein

Inventor： Leslie Ann Greene ,  Kyle P. Chiang ,  Fei Hong ,  Alain Philippe Vasserot ,  Wing-Sze Lo ,  Jeffry D. Watkins ,  Cheryl L. Quinn ,  John D. Mendlein

IPC: A61K38/00 ,  C07K1/00 ,  C12N9/00 ,  C07K16/40

CPC classification number: C07K16/40 ,  A61K38/00 ,  A61K38/53 ,  C07K2317/24 ,  C07K2317/92 ,  C07K2319/00 ,  C12N9/93 ,  C12Y601/01 ,  G01N33/573 ,  G01N2333/9015

Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.

Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。

公开(公告)号：US20130230508A1

公开(公告)日：2013-09-05

申请号：US13818929

申请日：2011-08-25

Applicant: Leslie Ann Greene ,  Kyle P. Chiang ,  Fei Hong ,  Alain Philippe Vasserot ,  Wing-Sze Lo ,  Jeffry D. Watkins ,  Cheryl L. Quinn ,  John D. Mendlein

Inventor： Leslie Ann Greene ,  Kyle P. Chiang ,  Fei Hong ,  Alain Philippe Vasserot ,  Wing-Sze Lo ,  Jeffry D. Watkins ,  Cheryl L. Quinn ,  John D. Mendlein

IPC: C12N9/00

CPC classification number: C07K16/40 ,  A61K38/00 ,  A61K38/16 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/92 ,  C12N9/93 ,  C12Y601/01 ,  C12Y601/01001 ,  G01N33/573 ,  G01N2333/9015

Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.

Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。

公开(公告)号：US20130202575A1

公开(公告)日：2013-08-08

申请号：US13697996

申请日：2011-05-12

Applicant: Leslie Ann Greene ,  Kyle P. Chiang ,  Fei Hong ,  Alain Philippe Vasserot ,  Jeffry D. Watkins ,  Cheryl L. Quinn ,  Wing-Sze Lo ,  Zhiwen Xu ,  John D. Mendlein

Inventor： Leslie Ann Greene ,  Kyle P. Chiang ,  Fei Hong ,  Alain Philippe Vasserot ,  Jeffry D. Watkins ,  Cheryl L. Quinn ,  Wing-Sze Lo ,  Zhiwen Xu ,  John D. Mendlein

IPC: C12N9/00 ,  C07K16/40 ,  C12N5/071 ,  C12N9/96 ,  G01N33/68

CPC classification number: A61K38/53 ,  A61K38/00 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/55 ,  C12N5/0602 ,  C12N9/93 ,  C12N9/96 ,  C12Y601/0102 ,  G01N33/573 ,  G01N33/68 ,  G01N2333/9015 ,  G01N2500/00

Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.

公开(公告)号：US20130195832A1

公开(公告)日：2013-08-01

申请号：US13696046

申请日：2011-05-03

Applicant: Leslie Ann Greene ,  Kyle P. Chiang ,  Fei Hong ,  Alain Philippe Vasserot ,  Jeffry D. Watkins ,  Cheryl L. Quinn ,  Wing-Sze Lo ,  John D. Mendlein

Inventor： Leslie Ann Greene ,  Kyle P. Chiang ,  Fei Hong ,  Alain Philippe Vasserot ,  Jeffry D. Watkins ,  Cheryl L. Quinn ,  Wing-Sze Lo ,  John D. Mendlein

IPC: C12N9/00 ,  C12N5/071 ,  G01N33/68 ,  C12N9/96 ,  C07K16/40

CPC classification number: C12N9/93 ,  A61K38/53 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/92 ,  C12N5/0602 ,  C12N9/96 ,  C12Y601/01 ,  C12Y601/0102 ,  G01N33/573 ,  G01N33/68 ,  G01N2333/9015

Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.

公开(公告)号：US07763247B2

公开(公告)日：2010-07-27

申请号：US12070146

申请日：2008-02-15

Applicant: Jeffry D. Watkins ,  William D. Huse ,  Ying Tang ,  Daniel Broek ,  Peter Brooks

Inventor： Jeffry D. Watkins ,  William D. Huse ,  Ying Tang ,  Daniel Broek ,  Peter Brooks

IPC: A61K39/00

CPC classification number: C07K16/30 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565

Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.

Abstract translation: 本发明提供了接枝抗体或其功能片段，其包含一个或多个在重链CDR的一个或多个CDR中具有至少一个氨基酸取代的互补决定区（CDR），其中所述接枝抗体或其功能片段具有特异性 隐形胶原表位的结合活性。 本发明还提供了使用具有对神经胶原表位具有特异性结合活性的抗体的方法，包括抑制血管生成，肿瘤生长和转移的方法。

公开(公告)号：US07740851B2

公开(公告)日：2010-06-22

申请号：US10657363

申请日：2003-09-08

Applicant: James F. Young ,  Leslie S. Johnson ,  William D. Huse ,  Herren Wu ,  Jeffry D. Watkins

Inventor： James F. Young ,  Leslie S. Johnson ,  William D. Huse ,  Herren Wu ,  Jeffry D. Watkins

IPC: A61K39/42 ,  A61K39/395

CPC classification number: C07K16/00 ,  A61K2039/505 ,  C07K16/1027 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: Ultra high affinity antibodies with binding affinities in the range of 1010 M−1, and even 1011 M−1 are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and/or treat disease, especially virus-induced diseases, are also disclosed.

Abstract translation: 公开了具有1010M-1甚至1011M-1范围内的结合亲和力的超高亲和力抗体。 此类抗体包括具有新型高亲和力互补决定区（CDR）的抗体，特别是具有来自人或小鼠的骨架和恒定区的抗体。 还公开了制备和筛选这些抗体的方法，以及使用它们来预防和/或治疗疾病，特别是病毒诱导的疾病的方法。

公开(公告)号：US20080260733A1

公开(公告)日：2008-10-23

申请号：US12117642

申请日：2008-05-08

Applicant: Jeffry D. Watkins ,  William D. Huse ,  Ying Tang ,  Daniel Broek ,  Peter Brooks

Inventor： Jeffry D. Watkins ,  William D. Huse ,  Ying Tang ,  Daniel Broek ,  Peter Brooks

IPC: A61K39/395 ,  C07K16/00 ,  A61P9/00 ,  G01N33/68 ,  C07H21/00

CPC classification number: C07K16/30 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565

Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.

公开(公告)号：US07390885B2

公开(公告)日：2008-06-24

申请号：US10011250

申请日：2001-12-06

Applicant: Jeffry D. Watkins ,  William D. Huse ,  Ying Tang ,  Daniel Broek ,  Peter Brooks

Inventor： Jeffry D. Watkins ,  William D. Huse ,  Ying Tang ,  Daniel Broek ,  Peter Brooks

IPC: C12P21/08

CPC classification number: C07K16/30 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565

Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.

公开(公告)号：US20080050388A1

公开(公告)日：2008-02-28

申请号：US10011250

申请日：2001-12-06

Applicant: Jeffry D. Watkins ,  William D. Huse ,  Ying Tang ,  Daniel Broek ,  Peter Brooks

Inventor： Jeffry D. Watkins ,  William D. Huse ,  Ying Tang ,  Daniel Broek ,  Peter Brooks

IPC: A61K39/395 ,  G01N33/567 ,  C07K16/18

CPC classification number: C07K16/30 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565

Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.

Abstract translation: 本发明提供了接枝抗体或其功能片段，其包含一个或多个在重链CDR的一个或多个CDR中具有至少一个氨基酸取代的互补决定区（CDR），其中所述接枝抗体或其功能片段具有特异性 隐形胶原表位的结合活性。 本发明还提供了使用具有对神经胶原表位具有特异性结合活性的抗体的方法，包括抑制血管发生，肿瘤生长和转移的方法。