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公开(公告)号：US09745566B2
公开(公告)日：2017-08-29
申请号：US14484402
申请日：2014-09-12
Applicant: LanzaTech New Zealand Limited
CPC classification number: C12N9/93 , C12N15/74 , C12Y601/0102
Abstract: The present provides selection markers, methods, nucleic acids, and vectors of use in the preparation of recombinant Clostridium spp.
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公开(公告)号：US09687533B2
公开(公告)日：2017-06-27
申请号：US14577510
申请日：2014-12-19
Applicant: aTyr Pharma Inc. , Pangu Biopharma Limited
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , Zhiwen Xu , John D. Mendlein
IPC: C12N9/18 , A61K38/00 , A61K38/53 , C12N9/00 , G01N33/573
CPC classification number: A61K38/53 , A61K38/00 , C07K16/40 , C07K2317/21 , C07K2317/55 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/0102 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/00
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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3.发明申请公开(公告)号：US20170052194A1
公开(公告)日：2017-02-23
申请号：US15255433
申请日：2016-09-02
Applicant: Washington University
Inventor： James J. Havranek , Benjamin Borgo
CPC classification number: G01N33/6824 , C12N9/485 , C12N9/50 , C12N9/52 , C12N9/641 , C12N9/93 , C12Y304/11018 , C12Y601/0101 , C12Y601/0102 , C12Y601/01021
Abstract: Reagents and methods for the digital analysis of proteins or peptides are provided. Specifically provided herein are proteins for identifying the N-terminal amino acid or N-terminal phosphorylated amino acid of a polypeptide. Also, an enzyme for use in the cleavage step of the Edman degradation reaction and a method for using this enzyme are described.
Abstract translation: 提供了蛋白质或肽数字分析的试剂和方法。 本文具体提供的是用于鉴定多肽的N-末端氨基酸或N-末端磷酸化氨基酸的蛋白质。 另外，描述了用于Edman降解反应的切割步骤的酶和使用该酶的方法。
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公开(公告)号：US20120282689A1
公开(公告)日：2012-11-08
申请号：US13443800
申请日：2012-04-10
Applicant: Jason W. Chin , T. Ashton Cropp , J. Christopher Anderson , Peter G. Schultz
Inventor： Jason W. Chin , T. Ashton Cropp , J. Christopher Anderson , Peter G. Schultz
CPC classification number: C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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公开(公告)号：US20240201199A1
公开(公告)日：2024-06-20
申请号：US18524884
申请日：2023-11-30
Applicant: Washington University
Inventor： James J. Havranek , Benjamin Borgo
CPC classification number: G01N33/6824 , C12N9/485 , C12N9/52 , C12N9/641 , C12N9/93 , C12Y304/11018 , C12Y601/0101 , C12Y601/0102 , C12Y601/01021
Abstract: Reagents and methods for the digital analysis of proteins or peptides are provided. Specifically provided herein are proteins for identifying the N-terminal amino acid or N-terminal phosphorylated amino acid of a polypeptide. Also, an enzyme for use in the cleavage step of the Edman degradation reaction and a method for using this enzyme are described.
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Patent Agency Ranking
公开(公告)号：US20150240249A1
公开(公告)日：2015-08-27
申请号：US14574257
申请日：2014-12-17
Applicant: The Scripps Research Institute
Inventor： Jason W. Chin , T. Ashton Cropp , J. Christopher Anderson , Peter G. Schultz
CPC classification number: C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
Abstract translation: 本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，正交对的tRNA /合成酶和非天然氨基酸。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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7.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF PHENYLALANYL-BETA-TRNA SYNTHETASES 有权治疗，诊断和抗体组合物与苯丙氨酸-ATNA-TRNA合成蛋白片段相关的创新发现公开(公告)号：US20150231214A1
公开(公告)日：2015-08-20
申请号：US14577510
申请日：2014-12-19
Applicant: aTyr Pharma Inc. , Pangu Biopharma Limited
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , Zhiwen Xu , John D. Mendlein
IPC: A61K38/53 , G01N33/573 , C12N9/00
CPC classification number: A61K38/53 , A61K38/00 , C07K16/40 , C07K2317/21 , C07K2317/55 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/0102 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/00
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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8.发明申请公开(公告)号：US20140273004A1
公开(公告)日：2014-09-18
申请号：US14211448
申请日：2014-03-14
Applicant: WASHINGTON UNIVERSITY
Inventor： James J. Havranek , Benjamin Borgo
CPC classification number: G01N33/6824 , C12N9/485 , C12N9/50 , C12N9/641 , C12N9/93 , C12Y304/11018 , C12Y601/0101 , C12Y601/0102 , C12Y601/01021
Abstract: Reagents and methods for the digital analysis of proteins or peptides are provided. Specifically provided herein are proteins for identifying the N-terminal amino acid or N-terminal phosphorylated amino acid of a polypeptide. Also, an enzyme for use in the cleavage step of the Edman degradation reaction and a method for using this enzyme are described.
Abstract translation: 提供了蛋白质或肽数字分析的试剂和方法。 本文具体提供的是用于鉴定多肽的N-末端氨基酸或N-末端磷酸化氨基酸的蛋白质。 另外，描述了用于Edman降解反应的切割步骤的酶和使用该酶的方法。
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公开(公告)号：US08357532B2
公开(公告)日：2013-01-22
申请号：US13443800
申请日：2012-04-10
Applicant: Jason W. Chin , T. Ashton Cropp , J. Christopher Anderson , Peter G. Schultz
Inventor： Jason W. Chin , T. Ashton Cropp , J. Christopher Anderson , Peter G. Schultz
CPC classification number: C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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公开(公告)号：US08114628B2
公开(公告)日：2012-02-14
申请号：US11978121
申请日：2007-10-26
Applicant: Jason W. Chin , T. Ashton Cropp , J. Christopher Anderson , Peter G. Schultz
Inventor： Jason W. Chin , T. Ashton Cropp , J. Christopher Anderson , Peter G. Schultz
CPC classification number: C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
Abstract translation: 本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，正交对tRNA /合成酶和非天然氨基酸。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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