公开(公告)号：US20240417476A1

公开(公告)日：2024-12-19

申请号：US18703912

申请日：2022-10-27

Applicant: aTyr Pharma, Inc.

Inventor： Luke G. BURMAN ,  Yeeting CHONG ,  Kaitlyn RAUCH ,  Leslie A. NANGLE

IPC: C07K16/28

Abstract: Provided are antibodies and antigen-binding fragments thereof that preferentially or selectively bind to human neuropilin-2a (NRP2a) variant 1 (v1) and/or variant 2 (v2), relative to other NRP2a isoforms or NRP2b isoforms, and which modulate binding interactions between NRP2a v1/v2 ligands and downstream signaling events. Also included are related therapeutic compositions and methods for treating diseases such as cancers and inflammatory and autoimmune diseases.

公开(公告)号：US20230312730A1

公开(公告)日：2023-10-05

申请号：US18048345

申请日：2022-10-20

Applicant: aTyr Pharma, Inc.

Inventor： Luke G. BURMAN ,  Yee Ting (Esther) CHONG ,  Yanyan GENG ,  Leslie Nangle GREENE ,  Kristina HAMEL ,  David KING ,  Ann MENEFEE ,  Kaitlyn RAUCH ,  Zhiwen XU ,  Liting ZHAI

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395 ,  G01N33/68

CPC classification number: C07K16/2863 ,  A61K39/3955 ,  A61K45/06 ,  G01N33/6854 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided are antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, for example, human histidyl-tRNA synthetase (HRS), and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.