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公开(公告)号：US20180201964A1
公开(公告)日：2018-07-19
申请号：US15898378
申请日：2018-02-16
Applicant: Battelle Energy Alliance, LLC
Inventor： David N. Thompson , William A. Apel , Vicki S. Thompson , David W. Reed , Jeffrey A. Lacey , Emily D. Henriksen
IPC: C12P19/14 , C12N9/88 , C12N9/80 , C12N9/38 , C12N9/40 , C12N9/42 , C12N9/34 , C12N9/24 , C12N9/26 , C12N9/18 , C12N9/16 , C12N9/10 , C12P19/02 , C12P19/00 , C12N15/52
CPC classification number: C12P19/14 , C12N9/1051 , C12N9/16 , C12N9/18 , C12N9/2402 , C12N9/2408 , C12N9/2428 , C12N9/2434 , C12N9/2437 , C12N9/2445 , C12N9/2465 , C12N9/2471 , C12N9/248 , C12N9/2482 , C12N9/2494 , C12N9/80 , C12N9/88 , C12N15/52 , C12P19/00 , C12P19/02 , C12Y204/0102 , C12Y301/01001 , C12Y301/01006 , C12Y301/01073 , C12Y301/02004 , C12Y302/01008 , C12Y302/01015 , C12Y302/0102 , C12Y302/01021 , C12Y302/01022 , C12Y302/01037 , C12Y302/01055 , C12Y302/01078 , C12Y302/01091 , C12Y302/01131 , C12Y302/01133 , C12Y302/01139 , C12Y305/01 , C12Y402/01007 , C12Y402/01008
Abstract: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially degrading, cleaving, or removing polysaccharides, lignocellulose, cellulose, hemicellulose, lignin, starch, chitin, polyhydroxybutyrate, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups using isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius.
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2.发明授权Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same 有权具有α-葡糖醛酸糖苷酶活性的多肽和编码该多肽的多核苷酸公开(公告)号：US09446102B2
公开(公告)日：2016-09-20
申请号：US14395960
申请日：2013-04-22
Applicant: Novoyzmes A/S
Inventor： Johan Börjesson , Anders Viksø-Nielsen , Nikolaj Spodsberg , Kristian Krogh
CPC classification number: C12N9/2402 , A61K38/465 , A61K38/47 , C12N9/2451 , C12N15/8242 , C12N15/8245 , C12N15/8246 , C12N15/8257 , C12Y301/01 , C12Y302/01139
Abstract: The present invention relates to isolated polypeptides having alpha-glucuronidase activity, catalytic domains and polynucleotides encoding the polypeptides, catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides or catalytic domains.
Abstract translation: 本发明涉及具有α-葡糖醛酸糖苷酶活性的分离多肽，催化结构域和编码多肽的催化结构域。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽或催化结构域的方法。
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3.发明授权Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same 有权具有α-葡糖醛酸糖苷酶活性的多肽和编码该多肽的多核苷酸公开(公告)号：US08735128B2
公开(公告)日：2014-05-27
申请号：US12511371
申请日：2009-07-29
Applicant: Michelle Maranta , Kimberly Brown
Inventor： Michelle Maranta , Kimberly Brown
CPC classification number: C12Y302/01139 , C12N9/2402
Abstract: The present invention relates to isolated polypeptides having alpha-glucuronidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Abstract translation: 本发明涉及具有α-葡糖醛酸糖苷酶活性的分离多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。
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公开(公告)号：US08551751B2
公开(公告)日：2013-10-08
申请号：US12205694
申请日：2008-09-05
Applicant: Mark A. Emalfarb , Alexander Vasilievich Gusakov , Peter J. Punt , Jan Cornelis Verdoes , Arkady Panteleimonovich Sinitsyn , Elena Vlasenko , Sandra Wihelmina Agnes Hinz , Mark Gosink , Zhijie Jiang , Jacoba Van der Meij
Inventor： Mark A. Emalfarb , Alexander Vasilievich Gusakov , Peter J. Punt , Jan Cornelis Verdoes , Arkady Panteleimonovich Sinitsyn , Elena Vlasenko , Sandra Wihelmina Agnes Hinz , Mark Gosink , Zhijie Jiang , Jacoba Van der Meij
CPC classification number: C12N9/248 , C07H21/00 , C12N9/2402 , C12N9/2408 , C12N9/2434 , C12N9/2471 , C12Y301/01072 , C12Y302/01023 , C12Y302/01037 , C12Y302/01055 , C12Y302/01139 , C12Y302/01151 , C12Y302/01155 , Y02E50/16 , Y02E50/17
Abstract: This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to a method to convert lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material and novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass. The invention also relates to a method to release cellular content by degradation of cell walls. The invention also relates to methods to use the novel enzymes and compositions of such enzymes in a variety of other processes, including washing of clothing, detergent processes, biorefining, deinking and biobleaching of paper and pulp, and treatment of waste streams.
Abstract translation: 本发明涉及新型酶及其生产方法。 更具体地，本发明涉及各种真菌酶。 描述了编码这种酶，组合物，重组和遗传修饰的宿主细胞的核酸分子和使用方法。 本发明还涉及将木质纤维素生物质转化成可降解木质纤维素材料的酶和酶的新组合（包括提供来自植物生物质的糖的协同释放的酶）的方法。 本发明还涉及通过细胞壁降解释放细胞含量的方法。 本发明还涉及在各种其它方法中使用新型酶和这些酶的组合物的方法，包括洗涤衣物，洗涤剂方法，生物精制，纸和纸浆的脱墨和生物漂白以及废物流的处理。
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5.发明申请Polypeptides Having Alpha-Glucuronidase Activity And Polynucleotides Encoding Same 审中-公开具有α-葡糖醛酸糖苷酶活性的多肽和编码相同的多核苷酸公开(公告)号：US20170015985A1
公开(公告)日：2017-01-19
申请号：US15251846
申请日：2016-08-30
Applicant: Novoyzmes A/S
Inventor： Johan Börjesson , Anders Viksø-Nielsen , Nikolaj Spodsberg , Kristian Krogh
IPC: C12N9/24
CPC classification number: C12N9/2402 , A61K38/465 , A61K38/47 , C12N9/2451 , C12N15/8242 , C12N15/8245 , C12N15/8246 , C12N15/8257 , C12Y301/01 , C12Y302/01139
Abstract: The present invention relates to isolated polypeptides having alpha-glucuronidase activity, catalytic domains and polynucleotides encoding the polypeptides, catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides or catalytic domains.
Abstract translation: 本发明涉及具有α-葡糖醛酸糖苷酶活性的分离多肽，催化结构域和编码多肽的催化结构域。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽或催化结构域的方法。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20160194619A1
公开(公告)日：2016-07-07
申请号：US15074297
申请日：2016-03-18
Applicant: Battelle Energy Alliance, LLC
Inventor： David N. Thompson , William A. Apel , Vicki S. Thompson , Thomas E. Ward
CPC classification number: C12N9/2402 , C12N15/52 , C12P7/065 , C12P7/10 , C12P7/14 , C12P19/02 , C12P19/14 , C12P2201/00 , C12Y302/01139 , Y02E50/16 , Y02E50/17
Abstract: A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from Alicyclobacillus acidocaldarius and encoding a polypeptide involved in at least partially degrading, cleaving, transporting, metabolizing, or removing polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups; and at least one nucleic acid sequence and/or at least one recombinant nucleic acid encoding a polypeptide involved in fermenting sugar molecules to a product. Additionally, enzymatic and/or proteinaceous extracts may be isolated from one or more genetically modified organisms. The extracts are utilized to convert biomass into a product. Further provided are methods of converting biomass into products comprising: placing the genetically modified organism and/or enzymatic extracts thereof in fluid contact with polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, and/or xylan-, glucan-, galactan-, or mannan-decorating groups.
Abstract translation: 一种遗传修饰的生物体，包含：至少一种核酸序列和/或至少一种从酸性脂环酸杆菌分离的重组核酸，并编码参与至少部分降解，切割，转运，代谢或去除多糖，纤维素，木质纤维素， 半纤维素，木质素，淀粉，糖，糖低聚物，碳水化合物，复合碳水化合物，壳多糖，异木聚糖，糖苷，木聚糖，葡聚糖，半乳聚糖或甘露聚糖装饰组; 以及至少一种核酸序列和/或至少一种编码参与将糖分子发酵到产品中的多肽的重组核酸。 此外，酶和/或蛋白质提取物可以从一种或多种遗传修饰的生物体分离。 提取物用于将生物质转化成产物。 还提供了将生物质转化成产物的方法，其包括：将经遗传修饰的生物体和/或其酶提取物与多糖，纤维素，木质纤维素，半纤维素，木质素，淀粉，糖，糖低聚物，碳水化合物，复合碳水化合物，甲壳素， 异构木糖，糖苷和/或木聚糖，葡聚糖，半乳聚糖或甘露聚糖装饰组。
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7.发明申请公开(公告)号：US20150275250A1
公开(公告)日：2015-10-01
申请号：US14727653
申请日：2015-06-01
Applicant: BATTELLE ENERGY ALLIANCE, LLC
Inventor： DAVID N. THOMPSON , WILLIAM A. APEL , VICKI S. THOMPSON , DAVID W. REED , JEFFREY A. LACEY , EMILY D. HENRIKSEN
CPC classification number: C12P19/14 , C12N9/1051 , C12N9/16 , C12N9/18 , C12N9/2402 , C12N9/2408 , C12N9/2428 , C12N9/2434 , C12N9/2437 , C12N9/2445 , C12N9/2465 , C12N9/2471 , C12N9/248 , C12N9/2482 , C12N9/2494 , C12N9/80 , C12N9/88 , C12N15/52 , C12P19/00 , C12P19/02 , C12Y204/0102 , C12Y301/01001 , C12Y301/01006 , C12Y301/01073 , C12Y301/02004 , C12Y302/01008 , C12Y302/01015 , C12Y302/0102 , C12Y302/01021 , C12Y302/01022 , C12Y302/01037 , C12Y302/01055 , C12Y302/01078 , C12Y302/01091 , C12Y302/01131 , C12Y302/01133 , C12Y302/01139 , C12Y305/01 , C12Y402/01007 , C12Y402/01008
Abstract: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially degrading, cleaving, or removing polysaccharides, lignocellulose, cellulose, hemicellulose, lignin, starch, chitin, polyhydroxybutyrate, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups using isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius.
Abstract translation: 提供了分离和/或纯化的多肽和编码来自酸热环酸杆菌的多肽的核酸序列。 还提供了使用分离的至少部分降解，切割或除去多糖，木质纤维素，纤维素，半纤维素，木质素，淀粉，几丁质，聚羟基丁酸酯，异木聚糖，糖苷，木聚糖，葡聚糖，半乳聚糖或甘露聚糖装饰基团的方法 和/或编码来自酸性脂多酸杆菌的多肽的纯化多肽和核酸序列。
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8.发明授权Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same 有权具有α-葡糖醛酸糖苷酶活性的多肽和编码该多肽的多核苷酸公开(公告)号：US07867745B2
公开(公告)日：2011-01-11
申请号：US12742971
申请日：2008-11-26
Applicant: Eva H. Hansen , Domique A. Skovland , Hanne R. Soerensen
Inventor： Eva H. Hansen , Domique A. Skovland , Hanne R. Soerensen
CPC classification number: C12Y302/01139 , C12N9/2402 , Y02E50/17
Abstract: The present invention relates to isolated polypeptides having alpha-glucuronidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Abstract translation: 本发明涉及具有α-葡糖醛酸糖苷酶活性的分离多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。
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9.发明申请Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same 有权具有α-葡糖醛酸糖苷酶活性的多肽和编码该多肽的多核苷酸公开(公告)号：US20100031399A1
公开(公告)日：2010-02-04
申请号：US12511371
申请日：2009-07-29
Applicant: Michelle Maranta , Kimberly Brown
Inventor： Michelle Maranta , Kimberly Brown
CPC classification number: C12Y302/01139 , C12N9/2402
Abstract: The present invention relates to isolated polypeptides having alpha-glucuronidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Abstract translation: 本发明涉及具有α-葡糖醛酸糖苷酶活性的分离多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。
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公开(公告)号：US20060166335A1
公开(公告)日：2006-07-27
申请号：US11373989
申请日：2006-03-14
Applicant: Takeshi Sakai , Kumiko Ishizuka , Kaoru Kojima , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
Inventor： Takeshi Sakai , Kumiko Ishizuka , Kaoru Kojima , Kazuo Shimanaka , Katsushige Ikai , Ikunoshin Kato
CPC classification number: C12Y302/01139 , C08B37/00 , C08B37/006 , C12N9/2402 , C12P19/14 , C12R1/01 , C12Y302/01044
Abstract: Three enzymes degrading sulfated glucuronofucan; processes for producing these enzymes; activators for these enzymes; glucuronofucan sulfate and degradation products thereof; and a novel microorganism.
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