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    Transgenic maize plant exhibiting increased yield and drought tolerance
    1.
    发明授权
    Transgenic maize plant exhibiting increased yield and drought tolerance 有权

    公开(公告)号：US12012608B2

    公开(公告)日：2024-06-18

    申请号：US18046988

    申请日：2022-10-17

    申请人： KWS SAAT SE & Co. KGaA

    发明人： Karl Pioch ,  Wolfgang Koch ,  Stefan Meldau

    IPC分类号： C12N15/82 ,  C12N9/44 ,  C12P5/02 ,  C12P7/10

    CPC分类号： C12N15/8261 ,  C12N9/2451 ,  C12N15/8273 ,  C12P5/023 ,  C12P7/10 ,  C12Y302/01026

    摘要： The present invention is directed to a transgenic maize plant or a part thereof comprising as transgene a nucleic acid capable of expressing a cell wall invertase or a functional part thereof, preferably a Chenopodium rubrum cell wall invertase or a functional part thereof, wherein as a result of the expression of the cell wall invertase or a functional part thereof the transgenic maize plant exhibits an enhanced tolerance to abiotic stress and/or an increased yield, to a method of producing such transgenic maize plant, to method of enhancing the tolerance to abiotic stress of a maize plant and/or of increasing yield potential of a maize plant, to a nucleic acid capable of expressing a cell wall invertase or a functional part thereof, preferably a Chenopodium rubrum cell wall invertase or a functional part thereof, to a vector comprising such nucleic acid, the use of the nucleic acid or vector for enhancing the tolerance to abiotic stress of a maize plant, for increasing yield potential of a maize plant and/or for protecting a maize plant against abiotic stress, and to a method for production of ethanol or methane from transgenic maize plant or a part thereof of the invention.

    Transcription regulatory factors for mannanases or cellulases, and genes for the transcription regulatory factor
    6.
    发明授权
    Transcription regulatory factors for mannanases or cellulases, and genes for the transcription regulatory factor 有权
    甘露聚糖酶或纤维素酶的转录调节因子，以及转录调节因子的基因

    公开(公告)号：US08877915B2

    公开(公告)日：2014-11-04

    申请号：US13202279

    申请日：2010-03-02

    申请人： Masahiro Ogawa ,  Yasuji Koyama ,  Masayuki Machida

    发明人： Masahiro Ogawa ,  Yasuji Koyama ,  Masayuki Machida

    IPC分类号： C07K14/38 ,  C12N9/44 ,  C07H21/04 ,  A23J1/18 ,  C12N9/42

    CPC分类号： C12N9/2434 ,  C07K14/38 ,  C12N9/2451 ,  C12N9/2488

    摘要： Disclosed are: transcription regulatory factors capable of regulating the transcription or expression of genes for mannanases or cellulases, as mentioned below; and others. Specifically disclosed is a protein selected from the following proteins (a), (b) and (c): (a) a protein comprising the amino acid sequence depicted in SEQ ID NO:2; (b) a protein which comprises an amino acid sequence produced by deleting, substituting or adding one or several amino acid residues (e.g., 1 to 5 amino acid residues) in the amino acid sequence depicted in SEQ ID NO:2 and which is capable of regulating the transcription of genes for mannanases or cellulases; and (c) a protein which comprises an amino acid sequence having a 70% or higher sequence identity to the amino acid sequence depicted in SEQ ID NO:2 and which is capable of regulating the transcription of genes for mannanases or cellulases, or a partial fragment of the protein. Also specifically disclosed are a gene encoding the protein, and others.

    摘要翻译： 公开的是：能够调节甘露聚糖酶或纤维素酶基因的转录或表达的转录调节因子，如下所述; 和别的。 具体公开的是选自以下蛋白质（a），（b）和（c）的蛋白质：（a）包含SEQ ID NO：2所示氨基酸序列的蛋白质; （b）包含在SEQ ID NO：2所示的氨基酸序列中缺失，取代或添加一个或几个氨基酸残基（例如1至5个氨基酸残基）而产生的氨基酸序列的蛋白质，其能够 调节甘露聚糖酶或纤维素酶基因的转录; 和（c）蛋白质，其包含与SEQ ID NO：2所示的氨基酸序列具有70％或更高序列同一性的氨基酸序列，并且能够调节甘露聚糖酶或纤维素酶的基因的转录，或部分 蛋白质的片段。 还具体公开了编码蛋白质的基因等。

    Polynucleotides encoding therapeutic inhibitors of PAI-1
    7.
    发明授权
    Polynucleotides encoding therapeutic inhibitors of PAI-1 有权
    编码PAI-1治疗抑制剂的多核苷酸

    公开(公告)号：US08828686B2

    公开(公告)日：2014-09-09

    申请号：US13769144

    申请日：2013-02-15

    申请人： Intrexon Corporation

    发明人： Thomas D. Reed ,  Richard E. Peterson ,  Charles E. Reed ,  Joan Mazzarelli Sopczynski ,  Bethany L. Merenick ,  Jonathan Carson ,  Catherine L. Keaty ,  Elena Tasheva

    IPC分类号： C12N15/63 ,  C12N1/20 ,  C07K14/00 ,  C07K14/81 ,  C07K14/75 ,  C07K14/78 ,  C12N9/72 ,  C12N9/44

    CPC分类号： C07K14/001 ,  C07K14/75 ,  C07K14/78 ,  C07K14/8132 ,  C12N9/2451 ,  C12N9/6459 ,  C12N9/6462 ,  C12Y302/01099 ,  C12Y304/21069 ,  C12Y304/21073

    摘要： The invention relates to mammalian PAI-I ligands and modulators. In particular, the invention relates to polypeptides, polypeptide compositions and polynucleotides that encode polypeptides that are ligands and/or modulators of PAI-I. The invention also relates to polyligands that are homopolyligands or heteropolyligands that modulate PAI-I activity. The invention also relates to ligands and polyligands localized to a region of a cell. The invention also relates to localization tethers and promoter sequences that can be used to provide spatial control of the PAI-I ligands and polyligands. The invention also relates to inducible gene switches that can be used to provide temporal control of the PAI-I ligands and polyligands. The invention also relates to methods of treating or preventing atherosclerosis. The invention also relates to methods of treating or preventing fibrosis.

    摘要翻译： 本发明涉及哺乳动物PAI-1配体和调节剂。 具体地，本发明涉及编码作为PAI-1的配体和/或调节剂的多肽的多肽，多肽组合物和多核苷酸。 本发明还涉及作为调节PAI-1活性的均聚配体或杂多糖的聚合配体。 本发明还涉及位于细胞区域的配体和聚合配体。 本发明还涉及可用于提供PAI-1配体和聚合配体的空间控制的定位系链和启动子序列。 本发明还涉及可用于提供PAI-1配体和聚合配体的时间控制的可诱导基因开关。 本发明还涉及治疗或预防动脉粥样硬化的方法。 本发明还涉及治疗或预防纤维化的方法。