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公开(公告)号：US07713741B2
公开(公告)日：2010-05-11
申请号：US11223202
申请日：2005-09-09
申请人： Ute Resch-Genger , Dietmar Pfeifer , Christian Monte , Angelika Hoffmann , Pierre Nording , Bernhard Schönenberger , Katrin Hoffmann , Monika Spieles , Knut Rurack
发明人： Ute Resch-Genger , Dietmar Pfeifer , Christian Monte , Angelika Hoffmann , Pierre Nording , Bernhard Schönenberger , Katrin Hoffmann , Monika Spieles , Knut Rurack
CPC分类号： G01N21/278 , G01N21/64 , G01N2021/6417 , Y10T436/10 , Y10T436/108331
摘要： The invention is directed to a method and a kit for calibrating a photoluminescence measurement system, in particular a fluorescence measurement system. The kit includes a number of fluorescence standards i and their corrected and certified fluorescence spectra Ii(λ), whereby the fluorescence standards i are selected, so that their spectrally corrected fluorescence spectra Ii(λ) cover a broad spectral range with high intensity. The standards are characterized by large half-widths FWHMi of their bands of at least 1400 cm−1. According to the method of the invention, partial correction functions Fi(λ) are generated by forming the quotient of the measured fluorescence spectra Ji(λ) and the corresponding corrected fluorescence spectra Ii(λ), which are then combined to form a total correction function F(λ) for a broad spectral range. The combination factors αi are hereby computed by statistical averaging of consecutive partial correction functions Fi(λ) over only a predefined, limited overlap region λi/i+1±ΔλOL about the mutual crossover wavelength λi/i+1.
摘要翻译： 本发明涉及用于校准光致发光测量系统，特别是荧光测量系统的方法和试剂盒。 该试剂盒包括许多荧光标准品I及其校准和认证的荧光光谱Ii（λ），从而选择荧光标准品，以使其光谱校正的荧光光谱Ii（λ）覆盖高强度的宽光谱范围。 标准的特征在于它们的至少1400cm-1的带的宽半宽度FWHMi。 根据本发明的方法，通过形成测量的荧光光谱Ji（λ）和对应的校正荧光光谱Ii（λ）的商产生部分校正函数Fi（λ），然后将其组合以形成总校正 函数F（λ）用于宽光谱范围。 因此，通过仅关于相互交叉波长λi/ i + 1的预定义的有限重叠区域λi/ i + 1±＆Dgr;λOL的连续部分校正函数Fi（λ）的统计平均来计算组合因子αi。
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公开(公告)号：US07521670B2
公开(公告)日：2009-04-21
申请号：US11362587
申请日：2006-02-24
申请人： Axel Engel , Rainer Haspel , Ute Resch-Genger , Katrin Hoffmann , Doris Ehrt , Uwe Kolberg , Joseph S. Hayden , Michael Stelzl
发明人： Axel Engel , Rainer Haspel , Ute Resch-Genger , Katrin Hoffmann , Doris Ehrt , Uwe Kolberg , Joseph S. Hayden , Michael Stelzl
CPC分类号： G01N21/6452 , G01N21/278 , G01N2021/6495 , G01N2201/13
摘要： The invention discloses a standard for referencing luminescence signals, having an optically transparent base material comprising a lanthanum phosphate glass, a fluorophosphate glass, a fluor-crown glass, a lanthanum glass, a glass-ceramic formed therefrom or a lithium aluminosilicate glass-ceramic, the base material including a bulk doping with at least one constituent which is luminescent and comprises at least one rare earth and/or a nonferrous metal, in particular cobalt, chromium or manganese.
摘要翻译： 本发明公开了一种用于参考发光信号的标准，其具有光学透明基材，其包含磷酸镧玻璃，氟磷酸盐玻璃，氟 - 冠玻璃，镧玻璃，由其形成的玻璃陶瓷或铝硅酸锂玻璃 - 陶瓷陶瓷， 所述基材包括具有至少一种发光的成分的本体掺杂，并且包含至少一种稀土和/或有色金属，特别是钴，铬或锰。
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3.发明申请Calibration system and dye kit and their uses for characterizing luminescence measurement systems 有权校准系统和染料套件及其用于表征发光测量系统的用途公开(公告)号：US20060233668A1
公开(公告)日：2006-10-19
申请号：US11378966
申请日：2006-03-17
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , B01L3/5025 , B01L3/5027 , B01L2200/148 , B01L2300/0654 , B01L2300/0816 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1033 , C09K2211/1088 , G01N21/278 , Y10T436/109163
摘要： The invention relates to a calibration system (10) for characterizing luminescence measurement systems, in particular spectrally resolving, wide-field and/or confocal imaging systems, with (a) a baseplate (12) with at least one flow-through channel (18), wherein the at least one channel (18) is formed as a sample chamber for the luminescence measurement system, (b) at least one reservoir (20) in communication with the at least one channel (18) and adapted to receive a liquid, and (c) at least one focusing device (24) integrated into a baseplate (12) for setting a defined measurement beam focus of the luminescence measurement system to be calibrated by using a focusing surface (26).
摘要翻译： 本发明涉及用于表征发光测量系统，特别是光谱分辨，宽场和/或共焦成像系统的校准系统（10），其具有（a）具有至少一个流通通道（18）的基板（12） ），其中所述至少一个通道（18）形成为用于所述发光测量系统的样品室，（b）与所述至少一个通道（18）连通并适于接收液体的至少一个储存器（20） ，和（c）集成到基板（12）中的至少一个聚焦装置（24），用于通过使用聚焦表面（26）来设置待校准的发光测量系统的限定的测量光束焦点。
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4.发明授权Calibration system and dye kit and their uses for characterizing luminescence measurement systems 有权校准系统和染料套件及其用于表征发光测量系统的用途公开(公告)号：US08361394B2
公开(公告)日：2013-01-29
申请号：US11378966
申请日：2006-03-17
CPC分类号： G01N21/6458 , B01L3/5025 , B01L3/5027 , B01L2200/148 , B01L2300/0654 , B01L2300/0816 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1033 , C09K2211/1088 , G01N21/278 , Y10T436/109163
摘要： A calibration system characterizes luminescence measurement systems, in particular spectrally resolving, wide-field and/or confocal imaging systems. The calibration system has a baseplate with at least one flow-through channel, wherein the at least one channel is formed as a sample chamber for the luminescence measurement system, at least one reservoir in communication with the at least one channel and adapted to receive a liquid, and at least one focusing device integrated into a baseplate for setting a defined measurement beam focus of the luminescence measurement system to be calibrated by using a focusing surface.
摘要翻译： 校准系统表征发光测量系统，特别是光谱分辨，宽场和/或共焦成像系统。 所述校准系统具有至少一个流通通道的基板，其中所述至少一个通道形成为用于所述发光测量系统的样品室，所述至少一个储存器与所述至少一个通道连通并适于接收 液体和集成到基板中的至少一个聚焦装置，用于设置通过使用聚焦表面校准的发光测量系统的限定的测量光束焦点。
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公开(公告)号：US20100219333A1
公开(公告)日：2010-09-02
申请号：US12729614
申请日：2010-03-23
申请人： Ute Resch-Genger , Dietmar Pfeifer , Christian Monte , Angelika Hoffmann , Pierre Nording , Bernhard Schönenberger , Katrin Hoffmann , Monika Spieles , Knut Rurack
发明人： Ute Resch-Genger , Dietmar Pfeifer , Christian Monte , Angelika Hoffmann , Pierre Nording , Bernhard Schönenberger , Katrin Hoffmann , Monika Spieles , Knut Rurack
CPC分类号： G01N21/278 , G01N21/64 , G01N2021/6417 , Y10T436/10 , Y10T436/108331
摘要： The invention is directed to a method and a kit for calibrating a photoluminescence measurement system, in particular a fluorescence measurement system. The kit includes a number of fluorescence standards i and their corrected and certified fluorescence spectra Ii(λ), whereby the fluorescence standards i are selected, so that their spectrally corrected fluorescence spectra Ii(λ) cover a broad spectral range with high intensity. The standards are characterized by large half-widths FWHMi of their bands of at least 1400 cm−1. According to the method of the invention, partial correction functions Fi(λ) are generated by forming the quotient of the measured fluorescence spectra Ji(λ) and the corresponding corrected fluorescence spectra Ii(λ), which are then combined to form a total correction function F(λ) for a broad spectral range. The combination factors αi are hereby computed by statistical averaging of consecutive partial correction functions Fi(λ) over only a predefined, limited overlap region λi/i+1±ΔλOL about the mutual crossover wavelength λi/i+1.
摘要翻译： 本发明涉及用于校准光致发光测量系统，特别是荧光测量系统的方法和试剂盒。 该试剂盒包括许多荧光标准品I及其校准和认证的荧光光谱Ii（λ），从而选择荧光标准品，以使其光谱校正的荧光光谱Ii（λ）覆盖高强度的宽光谱范围。 标准的特征在于它们的至少1400cm-1的带的宽半宽度FWHMi。 根据本发明的方法，通过形成测量的荧光光谱Ji（λ）和对应的校正荧光光谱Ii（λ）的商产生部分校正函数Fi（λ），然后将其组合以形成总校正 函数F（λ）用于宽光谱范围。 因此，通过仅关于相互交叉波长λi/ i + 1的预定义的有限重叠区域λi/ i + 1±＆Dgr;λOL的连续部分校正函数Fi（λ）的统计平均来计算组合因子αi。
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6.发明申请公开(公告)号：US20100243876A1
公开(公告)日：2010-09-30
申请号：US12505660
申请日：2009-07-20
CPC分类号： G01N21/278 , G01N21/64
摘要： The invention relates to an optical standard (10) for the calibration or characterization of optical measuring devices and as a reference system for intensities and intensity measurements. The standard (10) according to the invention, constructed sandwich-like, comprises a combination of at least two layer-like optical standard modules (12) having defined optical properties, joinable or joined together plane-parallel, wherein the standard modules (12) in each instance differ from each other by at least one optical property, namely, by their absorption, emission, scatter and/or reflection properties, and the standard modules (12) are made so that they enter into physical interaction with electromagnetic radiation striking one of their two principal surfaces (12.1).
摘要翻译： 本发明涉及一种用于光学测量装置的校准或表征的光学标准（10）以及用于强度和强度测量的参考系统。 根据本发明的构造的夹层状的标准（10）包括具有限定的光学性能的至少两层层状光学标准模块（12）的组合，可以平行或并联在一起，其中标准模块（12 ）在每种情况下通过至少一种光学性质，即通过它们的吸收，发射，散射和/或反射特性而彼此不同，并且标准模块（12）被制成使得它们进入与电磁辐射撞击的物理相互作用 他们的两个主表面之一（12.1）。
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7.发明授权公开(公告)号：US07947502B2
公开(公告)日：2011-05-24
申请号：US12729614
申请日：2010-03-23
申请人： Ute Resch-Genger , Dietmar Pfeifer , Christian Monte , Angelika Hoffmann , Pierre Nording , Bernhard Schönenberger , Katrin Hoffmann , Monika Spieles , Knut Rurack
发明人： Ute Resch-Genger , Dietmar Pfeifer , Christian Monte , Angelika Hoffmann , Pierre Nording , Bernhard Schönenberger , Katrin Hoffmann , Monika Spieles , Knut Rurack
CPC分类号： G01N21/278 , G01N21/64 , G01N2021/6417 , Y10T436/10 , Y10T436/108331
摘要： The invention is directed to a method and a kit for calibrating a photoluminescence measurement system, in particular a fluorescence measurement system. The kit includes a number of fluorescence standards i and their corrected and certified fluorescence spectra Ii(λ), whereby the fluorescence standards i are selected, so that their spectrally corrected fluorescence spectra Ii(λ) cover a broad spectral range with high intensity. The standards are characterized by large half-widths FWHMi of their bands of at least 1400 cm−1. According to the method of the invention, partial correction functions Fi(λ) are generated by forming the quotient of the measured fluorescence spectra Ji(λ) and the corresponding corrected fluorescence spectra Ii(λ), which are then combined to form a total correction function F(λ) for a broad spectral range. The combination factors αi are hereby computed by statistical averaging of consecutive partial correction functions Fi(λ) over only a predefined, limited overlap region λi/i+1±ΔλOL about the mutual crossover wavelength λi/i+1.
摘要翻译： 本发明涉及用于校准光致发光测量系统，特别是荧光测量系统的方法和试剂盒。 该试剂盒包括许多荧光标准品I及其校准和认证的荧光光谱Ii（λ），从而选择荧光标准品，以使其光谱校正的荧光光谱Ii（λ）覆盖高强度的宽光谱范围。 标准的特征在于它们的至少1400cm-1的带的宽半宽度FWHMi。 根据本发明的方法，通过形成测量的荧光光谱Ji（λ）和对应的校正荧光光谱Ii（λ）的商产生部分校正函数Fi（λ），然后将其组合以形成总校正 函数F（λ）用于宽光谱范围。 因此，通过仅关于相互交叉波长λi/ i + 1的预定义的有限重叠区域λi/ i + 1±＆Dgr;λOL的连续部分校正函数Fi（λ）的统计平均来计算组合因子αi。
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公开(公告)号：US20130266605A1
公开(公告)日：2013-10-10
申请号：US13824100
申请日：2011-09-16
IPC分类号： C07K14/195
CPC分类号： C07K14/195 , A61K38/00 , C07K14/21 , C07K14/235 , C07K14/255 , C07K14/36 , C12N9/0071 , C12N9/1007 , C12N9/1205 , C12N9/22 , C12N9/2417 , C12N9/2451 , C12N9/80 , C12N9/88 , C12N9/90 , C12N9/93 , C12Y402/01059 , C12Y601/01014 , C12Y603/05002 , Y02A50/481
摘要： The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signaling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-Cd40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.
摘要翻译： 本发明提供组合物，其包含不衍生自CD40L的天然结合配偶体如CD40或来自天然CD40-CD40L界面的CD40L依赖性信号传导肽基抑制剂。 更具体地，本发明的肽基抑制剂衍生自不表达CD40-Cd40L共刺激途径的天然来源。 本发明还提供具有增强的CD40L结合亲和力的肽基抑制剂的合成衍生物和类似物或相对于其母体分子增强的抑制活性。
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9.发明授权Optical standard for the calibration and characterization of optical measuring devices 有权用于光学测量装置的校准和表征的光学标准公开(公告)号：US07919744B2
公开(公告)日：2011-04-05
申请号：US12505660
申请日：2009-07-20
IPC分类号： G01D18/00
CPC分类号： G01N21/278 , G01N21/64
摘要： The invention relates to an optical standard (10) for the calibration or characterization of optical measuring devices and as a reference system for intensities and intensity measurements. The standard (10) according to the invention, constructed sandwich-like, comprises a combination of at least two layer-like optical standard modules (12) having defined optical properties, joinable or joined together plane-parallel, wherein the standard modules (12) in each instance differ from each other by at least one optical property, namely, by their absorption, emission, scatter and/or reflection properties, and the standard modules (12) are made so that they enter into physical interaction with electromagnetic radiation striking one of their two principal surfaces (12.1).
摘要翻译： 本发明涉及一种用于光学测量装置的校准或表征的光学标准（10）以及用于强度和强度测量的参考系统。 根据本发明的构造的夹层状的标准（10）包括具有限定的光学性能的至少两层层状光学标准模块（12）的组合，可以平行或并联在一起，其中标准模块（12 ）在每种情况下通过至少一种光学性质，即通过它们的吸收，发射，散射和/或反射特性而彼此不同，并且标准模块（12）被制成使得它们进入与电磁辐射撞击的物理相互作用 他们的两个主表面之一（12.1）。
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10.发明授权Multi-functional calibration system and kit, and their uses for characterizing luminescence measurement systems 有权多功能校准系统和套件，以及其用于表征发光测量系统的用途公开(公告)号：US07544926B2
公开(公告)日：2009-06-09
申请号：US11377593
申请日：2006-03-15
申请人： Ute Resch-Genger , Katrin Hoffmann , Roland Nitschke , Axel Engel
发明人： Ute Resch-Genger , Katrin Hoffmann , Roland Nitschke , Axel Engel
IPC分类号： G12B13/00
CPC分类号： G01N21/6458 , G01N21/278 , G02B21/0076
摘要： The invention relates to a multi-functional calibration system (10) for characterizing luminescence measurement systems, in particular spectrally resolving, wide-field and/or confocal imaging systems, with (a) a baseplate (12), (b) at least one calibration module (24) arranged on the baseplate (12) and including at least one calibration and/or characterization function, and (c) at least one focusing device (20) integrated in the baseplate (12) with a focusing surface (22) for setting a defined measurement beam focus of the luminescence measurement systems to be calibrated, the focusing surface (22) arranged in a common plane with the at least one calibration module (24).
摘要翻译： 本发明涉及用于表征发光测量系统，特别是光谱分辨，宽场和/或共焦成像系统的多功能校准系统（10），其中（a）底板（12），（b）至少一个 校准模块（24），其布置在所述基板（12）上并且包括至少一个校准和/或表征功能，以及（c）集成在所述基板（12）中的至少一个聚焦装置（20） 用于设置待校准的发光测量系统的定义的测量束聚焦，所述聚焦表面（22）与所述至少一个校准模块（24）布置在公共平面中。
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